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HepaRG Cells: A Human Model to Study Mechanisms of Acetaminophen Hepatotoxicity Δσ

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Generation of Endoderm-Derived Human Induced Pluripotent Stem Cells From Primary Hepatocytes

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Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

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Human Hepatocytes in Primary Culture: The Choice to Investigate Drug Metabolism in Man

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Human hepatocytes as a tool for studying toxicity and drug metabolism

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3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies

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Maturation of Induced Pluripotent Stem Cell Derived Hepatocytes by 3D-Culture

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New Technologies and Screening Strategies for Hepatotoxicity: Use of In Vitro Models

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Galactose-carrying polymers as extracellular matrices for liver tissue engineering

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Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells.

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Differentiation and Characterization of Metabolically Functioning Hepatocytes from Human Embryonic Stem Cells

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3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies

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Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

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Liver tissue engineering in the evaluation of drug safety

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Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells

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Opportunities for Use of Human iPS Cells in Predictive Toxicology

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Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity

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Etiologies and Outcomes of Acute Liver Failure in Germany

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Developing High-Fidelity Hepatotoxicity Models From Pluripotent Stem Cells

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Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants

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Micropatterned cell–cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues

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Cytochromes P450 and Species Differences in Xenobiotic Metabolism and Activation of Carcinogen

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Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity

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Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: A study of cell viability, morphology and drug metabolism

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Sandwich-cultured hepatocytes: utility forin vitroexploration of hepatobiliary drug disposition and drug-induced hepatotoxicity

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Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells

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Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs

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Cytotoxic effects of 100 reference compounds on Hep G2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I Mechanistic assays on ROS, glutathione depletion and calcein uptake

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Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology

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Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells

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Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform

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Three-Dimensional HepaRG Model As An Attractive Tool for Toxicity Testing

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Drug-induced liver injury in 2007

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Human and animal hepatocytes in vitro with extrapolation in vivo

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Extending Hepatocyte Functionality for Drug-Testing Applications Using High-Viscosity Alginate–Encapsulated Three-Dimensional Cultures in Bioreactors

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Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes

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Stem cell-derived hepatocytes and their use in toxicology

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Hepatic Cell Lines for Drug Hepatotoxicity Testing: Limitations and Strategies to Upgrade their Metabolic Competence by Gene Engineering

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Maintaining hepatocyte differentiation in vitro through co-culture with hepatic stellate cells

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Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

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Hepatocyte-based in vitro model for assessment of drug-induced cholestasis

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An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics

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An Approach for Formation of Vascularized Liver Tissue by Endothelial Cell–Covered Hepatocyte Spheroid Integration

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HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved

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Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes

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Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans

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An update on metabolism studies using human hepatocytes in primary culture

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Cryopreservation-Induced Nonattachment of Human Hepatocytes: Role of Adhesion Molecules

Terry, C., Hughes, R. D., Mitry, R. R., Lehec, S. C., & Dhawan, A. K. (2007) · Cell Transplantation · doi:10.3727/000000007783465000 · Cited by 79

Mature Human Hepatocytes from Ex Vivo Differentiation of Alginate-Encapsulated Hepatoblasts

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Preparation of stripe-patterned heterogeneous hydrogel sheets using microfluidic devices for high-density coculture of hepatocytes and fibroblasts

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A Correlation Between the In Vitro Drug Toxicity of Drugs to Cell Lines That Express Human P450s and Their Propensity to Cause Liver Injury in Humans

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Evaluation of the Endothelin Receptor Antagonists Ambrisentan, Bosentan, Macitentan, and Sitaxsentan as Hepatobiliary Transporter Inhibitors and Substrates in Sandwich-Cultured Human Hepatocytes

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Functional 3D Human Primary Hepatocyte Spheroids Made by Co-Culturing Hepatocytes from Partial Hepatectomy Specimens and Human Adipose-Derived Stem Cells

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Alvetex®: Polystyrene Scaffold Technology for Routine Three Dimensional Cell Culture

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Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes

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Stem cell‐derived hepatocytes as a predictive model for drug‐induced liver injury: are we there yet?

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Culture Period-Dependent Changes in the Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes

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Cell based approaches for evaluation of drug-induced liver injury

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Classification of Hepatotoxicants Using HepG2 Cells: A Proof of Principle Study

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Generation of proliferating human hepatocytes using upcyte ® technology: characterisation and applications in induction and cytotoxicity assays

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Simple and quick method for whole-liver decellularization: a novel in vitro three-dimensional bioengineering tool?

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