The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Effects of Low- vs. High-Load Resistance Training on Muscle Strength and Hypertrophy in Well-Trained Men
Abstract
The purpose of this study was to compare the effect of low- versus high-load resistance training (RT) on muscular adaptations in well-trained subjects. Eighteen young men experienced in RT were matched according to baseline strength and then randomly assigned to 1 of 2 experimental groups: a low-load RT routine (LL) where 25-35 repetitions were performed per set per exercise (n = 9) or a high-load RT routine (HL) where 8-12 repetitions were performed per set per exercise (n = 9). During each session, subjects in both groups performed 3 sets of 7 different exercises representing all major muscles. Training was performed 3 times per week on nonconsecutive days, for a total of 8 weeks. Both HL and LL conditions produced significant increases in thickness of the elbow flexors (5.3 vs. 8.6%, respectively), elbow extensors (6.0 vs. 5.2%, respectively), and quadriceps femoris (9.3 vs. 9.5%, respectively), with no significant differences noted between groups. Improvements in back squat strength were significantly greater for HL compared with LL (19.6 vs. 8.8%, respectively), and there was a trend for greater increases in 1 repetition maximum (1RM) bench press (6.5 vs. 2.0%, respectively). Upper body muscle endurance (assessed by the bench press at 50% 1RM to failure) improved to a greater extent in LL compared with HL (16.6 vs. -1.2%, respectively). These findings indicate that both HL and LL training to failure can elicit significant increases in muscle hypertrophy among well-trained young men; however, HL training is superior for maximizing strength adaptations.
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“Research into resistance training variables shows that load, volume, frequency, and rest intervals, influence the amount of skeletal muscle hypertrophy induced [33–35].”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [33]
In the citing paper
“Both high-load (> 60% of one-repetition maximum, 1RM) and low-load (< 60% 1RM) protocols can induce hypertrophy of a similar magnitude [33].”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [33]
In the citing paper
“Even resistance-trained individuals show increases in strength when training with very light loads, albeit to a lesser extent than with the use of heavy loads [16,17].”
From Loading recommendations for muscle strength, hypertrophy, and local endurance: a re-examination of the repetition continuum. (2021) · cites this paper as [17]
In the citing paper
“For example, our group [17] reported similar increases in muscle thickness of the biceps, triceps and quadriceps between moderate- (~10RM) and light- (~30RM) loads in a cohort of resistance-trained men performing a total body RT program over 8 weeks.”
From Loading recommendations for muscle strength, hypertrophy, and local endurance: a re-examination of the repetition continuum. (2021) · cites this paper as [17]
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Cites
Progression Models in Resistance Training for Healthy Adults
(2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181915670 · Cited by 4,332 · cited 1×
“These results run contrary to generally accepted hypertrophy training guidelines, which profess that loads of at least 65% are necessary to stimulate muscle growth in welltrained individuals (25,26,31).”
ResultProgression Models in Resistance Training for Healthy Adults
(2002) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200202000-00027 · Cited by 2,979
Fundamentals of Resistance Training: Progression and Exercise Prescription
KRAEMER, W. J., & RATAMESS, N. A. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000121945.36635.61 · Cited by 1,992 · cited 2×
“required to fully recruit higher threshold motor units (26).”
BackgroundResultEssentials of Strength Training and Conditioning
Baechle, T. R., & Earle, R. (1994) · Cited by 1,535
Neural adaptation to resistance training
SALE, D. G. (1988) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198810001-00009 · Cited by 1,421
The mechanisms of muscle hypertrophy and their application to resistance training
Schoenfeld, B. J. (2010) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181e840f3 · Cited by 1,214 · cited 1×
“Early-phase RT strength adaptations are predominantly related to improvements in the ability of the nervous system to efficiently activate and coordinate muscles, whereas the role of hypertrophy for strength becomes increasingly more relevant as one gains experience (51,54).”
BackgroundSelf-citationCampos, G., Luecke, T., Wendeln, H., Toma, K., Hagerman, F., Murray, T., Ragg, K., Ratamess, N., Kraemer, W., & Staron, R. (2002) · European Journal of Applied Physiology · doi:10.1007/s00421-002-0681-6 · Cited by 1,066
Neural Adaptations to Resistive Exercise
Gabriel, D. A., Kamen, G., & Frost, G. (2006) · Sports Medicine · doi:10.2165/00007256-200636020-00004 · Cited by 840
Strength and cross‐sectional area of human skeletal muscle.
Maughan, R. J., Watson, J. S., & Weir, J. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014658 · Cited by 750
A Meta-analysis to Determine the Dose Response for Strength Development
RHEA, M. R., ALVAR, B. A., BURKETT, L. N., & BALL, S. D. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000053727.63505.d4 · Cited by 666
Wilkinson, S. B., Phillips, S. M., Atherton, P. J., Patel, R., Yarasheski, K. E., Tarnopolsky, M. A., & Rennie, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.153916 · Cited by 628
Resistance exercise load does not determine training-mediated hypertrophic gains in young men
Mitchell, C. J., Churchward-Venne, T. A., West, D. W. D., Burd, N. A., Breen, L., Baker, S. K., & Phillips, S. M. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00307.2012 · Cited by 627
Adaptive response of mammalian skeletal muscle to exercise with high loads
McDonagh, M. J. N., & Davies, C. T. M. (1984) · European Journal of Applied Physiology · doi:10.1007/bf00433384 · Cited by 541
Burd, N. A., West, D. W. D., Staples, A. W., Atherton, P. J., Baker, J. M., Moore, D. R., Holwerda, A. M., Parise, G., Rennie, M. J., Baker, S. K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012033 · Cited by 531
Abe, T., DeHoyos, D. V., Pollock, M. L., & Garzarella, L. (2000) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/s004210050027 · Cited by 523
Kosek, D. J., Kim, J.-S., Petrella, J. K., Cross, J. M., & Bamman, M. M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01474.2005 · Cited by 503
Ultrasonographic assessment of human skeletal muscle size
Reeves, N. D., Maganaris, C. N., & Narici, M. V. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-003-0961-9 · Cited by 492
Léger, B., Cartoni, R., Praz, M., Lamon, S., Dériaz, O., Crettenand, A., Gobelet, C., Rohmer, P., Konzelmann, M., Lüthi, F., et al. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.116715 · Cited by 403
Burd, N. A., Andrews, R. J., West, D. W. D., Little, J. P., Cochran, A. J. R., Hector, A. J., Cashaback, J. G. A., Gibala, M. J., Potvin, J. R., Baker, S. K., et al. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.221200 · Cited by 370
Kanehisa, H., Ito, M., Kawakami, Y., Fukunaga, T., & Miyatani, M. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-003-0974-4 · Cited by 350
Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans
Coffey, V. G., Zhong, Z., Shield, A., Canny, B. J., Chibalin, A. V., Zierath, J. R., & Hawley, J. A. (2006) · The FASEB Journal · doi:10.1096/fj.05-4809fje · Cited by 336
Resistance training reduces the acute exercise-induced increase in muscle protein turnover
Phillips, S. M., Tipton, K. D., Ferrando, A. A., & Wolfe, R. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e118 · Cited by 336
Peterson, M. D., Rhea, M. R., & Alvar, B. A. (2005) · The Journal of Strength and Conditioning Research · doi:10.1519/r-16874.1 · Cited by 303
Self-citationIvey, F. M., Roth, S. M., Ferrell, R. E., Tracy, B. L., Lemmer, J. T., Hurlbut, D. E., Martel, G. F., Siegel, E. L., Fozard, J. L., Metter, E. J., et al. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.11.m641 · Cited by 288
Single vs. multiple sets of resistance exercise for muscle hypertrophy: a meta-analysis.
Krieger, J. W. (2010) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181d4d436 · Cited by 276
Tanimoto, M., & Ishii, N. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00741.2005 · Cited by 269
Muscle strength as a predictor of onset of ADL dependence in people aged 75 years.
Rantanen, T., Avlund, K., Suominen, H., Schroll, M., Frändin, K., & Era, P. A. (2002) · PubMed · Cited by 264
Peterson, M. D., Rhea, M. R., & Alvar, B. A. (2004) · The Journal of Strength and Conditioning Research · doi:10.1519/r-12842.1 · Cited by 261
Self-citationEvaluation of the strength-size relationship in vivo using various muscle size indices
Bamman, M. M., Newcomer, B. R., Larson‐Meyer, D. E., Weinsier, R. L., & Hunter, G. R. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200007000-00019 · Cited by 235
Holm, L., Reitelseder, S., Pedersen, T. G., Doessing, S., Petersen, S. G., Flyvbjerg, A., Andersen, J. L., Aagaard, P., & Kjaer, M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90538.2008 · Cited by 218
Vøllestad, N. K., VAAGE, O., & Hermansen, L. (1984) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1984.tb07531.x · Cited by 198
Resistance training alters the response of fed state mixed muscle protein synthesis in young men
Tang, J. E., Perco, J. G., Moore, D. R., Wilkinson, S. B., & Phillips, S. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00636.2007 · Cited by 181
Effect of squat depth and barbell load on relative muscular effort in squatting
Bryanton, M. A., Kennedy, M. D., Carey, J. P., & Chiu, L. Z. F. (2012) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31826791a7 · Cited by 174
IMPACT OF VICOPROFEN ON PLASMA PROENKEPHALIN PEPTIDE F CONCENTRATIONS AFTER
Kraemer, W. J., French, D. N., Gomez, A. L., Rubin, M. R., Scheett, T. P., Volek, J. S., VanHeest, J. L., Ratamess, N. A., Sharman, M. J., Stoppani, J., et al. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200205001-00389 · Cited by 173
Voluntary strength and muscle characteristics in untrained men and women and male bodybuilders
SALE, D. G., MacDOUGALL, J. D., Alway, S. E., & Sutton, J. R. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.62.5.1786 · Cited by 172
Manipulating Resistance Training Program Variables to Optimize Maximum Strength in Men: A Review
TAN, B. (1999) · Journal of Strength and Conditioning Research · doi:10.1519/00124278-199908000-00019 · Cited by 154
Young, A., Stokes, M. J., Round, J. M., & Edwards, R. H. T. (1983) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1983.tb00122.x · Cited by 153
Muscular Fitness and All-Cause Mortality: Prospective Observations
FitzGerald, S. J., Barlow, C. E., Kampert, J. B., Morrow, J. R., Jackson, A. W., & Blair, S. N. (2004) · Journal of Physical Activity and Health · doi:10.1123/jpah.1.1.7 · Cited by 147
Wakahara, T., Fukutani, A., Kawakami, Y., & Yanai, T. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182995349 · Cited by 144
Ogasawara, R., Loenneke, J. P., Thiebaud, R. S., & Abe, T. (2013) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2013.42022 · Cited by 139
Nutrient timing revisited: is there a post-exercise anabolic window?
Aragon, A. A., & Schoenfeld, B. J. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-5 · Cited by 139
Self-citationOgasawara, R., Kobayashi, K., Tsutaki, A., Lee, K., Abe, T., Fujita, S., Nakazato, K., & Ishii, N. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01161.2012 · Cited by 138
Phosphocreatine content in single fibers of human muscle after sustained submaximal exercise
Sahlin, K., Söderlund, K., Tonkonogi, M., & HIRAKOBA, K. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.1.c172 · Cited by 136
Neuromuscular Function after a Bout of Low-Load Blood Flow–Restricted Exercise
Cook, S. B., Murphy, B. G., & LaBarbera, K. E. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31826c6fa8 · Cited by 133
Tanimoto, M., Sanada, K., Yamamoto, K., Kawano, H., Gando, Y., Tabata, I., Ishii, N., & Miyachi, M. (2008) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318185f2b0 · Cited by 130
The contribution of muscle hypertrophy to strength changes following resistance training
Erskine, R. M., Fletcher, G., & Folland, J. P. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2855-4 · Cited by 129
Changes in muscle fiber conduction velocity indicate recruitment of distinct motor unit populations
Houtman, C. J., Stegeman, D. F., Dijk, J. P. V., & Zwarts, M. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00665.2002 · Cited by 128
Functional and structural adaptations in skeletal muscle of trained athletes
Alway, S. E., MacDOUGALL, J. D., SALE, D. G., Sutton, J. R., & McComas, A. J. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.3.1114 · Cited by 127
Maughan, R., Watson, J. S., & Weir, J. P. (1984) · British Journal of Sports Medicine · doi:10.1136/bjsm.18.3.149 · Cited by 127
Wakahara, T., Miyamoto, N., Sugisaki, N., Murata, K., Kanehisa, H., Kawakami, Y., Fukunaga, T., & Yanai, T. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2121-y · Cited by 118
Time course for arm and chest muscle thickness changes following bench press training
Ogasawara, R., Thiebaud, R. S., Loenneke, J. P., Loftin, M., & Abe, T. (2012) · Interventional Medicine and Applied Science · doi:10.1556/imas.4.2012.4.7 · Cited by 111
Schuenke, M. D., Herman, J. R., Gliders, R. M., Hagerman, F. C., Hikida, R. S., Rana, S. R., Ragg, K. E., & Staron, R. S. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2339-3 · Cited by 102
Burd, N. A., Mitchell, C. J., Churchward-Venne, T. A., & Phillips, S. M. (2012) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h2012-022 · Cited by 99
Resistance exercise training influences skeletal muscle immune activation: a microarray analysis.
Gordon, P., Liu, D.-M., Sartor, M., Iglayreger, H., Pistilli, E., Gutmann, L., Nader, G., & Hoffman, E. (2012) · Journal of applied physiology · doi:10.1152/japplphysiol.00860.2011 · Cited by 93
Effects of power training on muscle thickness of older men.
Nogueira, W., Gentil, P., Mello, S., Oliveira, R., Bezerra, A., & Bottaro, M. (2009) · International Journal of Sports Medicine · doi:10.1055/s-0028-1104584 · Cited by 91
Lower Extremity Joint Kinetic Responses to External Resistance Variations
Flanagan, S. P., & Salem, G. J. (2008) · Journal of Applied Biomechanics · doi:10.1123/jab.24.1.58 · Cited by 73
Rana, S. R., Chleboun, G. S., Gilders, R. M., Hagerman, F. C., Herman, J. R., Hikida, R. S., Kushnick, M. R., Staron, R. S., & Toma, K. (2008) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31815f30e7 · Cited by 65
NSCA's essentials of personal training
Coburn, J. W., & Malek, M. H. (2012) · Human Kinetics eBooks · Cited by 49
Neuromuscular function in weight-trainers
SALE, D. G., Upton, A. R. M., McComas, A. J., & MacDOUGALL, J. D. (1983) · Experimental Neurology · doi:10.1016/0014-4886(83)90077-8 · Cited by 48
Validity of real time ultrasound for measuring skeletal muscle size
Pretorius, A., & Keating, J. L. (2008) · Physical Therapy Reviews · doi:10.1179/174328808x356447 · Cited by 47
Weiss, L. W., Coney, H. D., & Clark, F. C. (1999) · The Journal of Strength and Conditioning Research · doi:10.1519/00124278-199908000-00010 · Cited by 46
The Role of Fiber Types in Muscle Hypertrophy
Ogborn, D. I., & Schoenfeld, B. J. (2014) · Strength and conditioning journal · doi:10.1519/ssc.0000000000000030 · Cited by 45
Self-citationPopov, D. V., Swirkun, D. V., Netreba, A. I., Tarasova, O. S., Prostova, A. B., Ларина, И. М., Боровик, А. С., & Виноградова, О. Л. (2006) · Human Physiology · doi:10.1134/s0362119706050161 · Cited by 40
Gross Measures of Exercise-Induced Muscular Hypertrophy
Weiss, L. W., Coney, H. D., & Clark, F. C. (2000) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2000.30.3.143 · Cited by 38
Miyamoto, N., Wakahara, T., Ema, R., & Kawakami, Y. (2013) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12054 · Cited by 35
A comparison of strength and muscle endurance in strength-trained and untrained women
Huczel, H. A., & Clarke, D. H. (1992) · European Journal of Applied Physiology · doi:10.1007/bf00625069 · Cited by 30
(2007) · PubMed · Cited by 13
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Schoenfeld, B. J., Grgic, J., Ogborn, D., & Krieger, J. W. (2017) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002200 · Cited by 851
“(42) Young trained men (n = 18) High load: 3 3 8–12RM 1-0-2 for both groups No 8 wks; 33 Bench press, barbell military press, wide grip pulldowns, seated cable row, barbell back squat, machine leg press, and machine knee Ultrasound Significant preintervention to postintervention increases in muscle thickness in both g…”
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Adaptations to Endurance and Strength TrainingPreprint
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“8 Cite this article as Cold Spring Harb Perspect Med 2018;8:a029769 w w w .p er sp ec ti ve si n m ed ic in e. o rg et al. 2012; Ogasawara et al. 2013; Schoenfeld et al. 2015; Morton et al. 2016).”
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“Recognizing the high interindividual response variability in hypertrophy and strength gain that occurs with RT (13, 27, 28, 48), we conducted the study with a large enough number of participants to allow detection of a 15% difference in hypertrophy via muscle fiber cross-sectional area (CSA) change and a 10% differenc…”
BackgroundMethodResultInfluential
Metadata
- Authors
- Schoenfeld, B. J., Peterson, M. D., Ogborn, D., Contreras, B., & Sonmez, G. T.
- Affiliations
- Lehman College (US)
- Corresponding author
- Schoenfeld, Brad J.
- Venue
- Journal of Strength and Conditioning Research
- Published
- 2015-10
- Volume
- 29
- Issue
- 10
- Pages
- 2954-2963
- ISSN
- 1064-8011 (ISSN-L)
- OpenAlex
- W1995833662
- Cited by
- 418
- References
- 67
- Citations by year
- 2026: 24 · 2025: 40 · 2024: 40 · 2023: 41 · 2022: 43 · 2021: 40 · 2020: 45 · 2019: 40 · 2018: 35 · 2017: 38 · 2016: 24 · 2015: 8
- FWCI
- 35.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Strength and Conditioning Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- resistance training, training load, muscle hypertrophy, muscle strength, trained men, training to failure, muscular endurance, back squat, bench press, elbow flexors, elbow extensors, quadriceps
- MeSH terms
- Adaptation, Physiological, Adult, Humans, Hypertrophy, Male, Physical Fitness, Random Allocation, Muscle, Skeletal, Upper Extremity, Lower Extremity, Muscle Strength, Resistance Training, Young Adult
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