The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Prolonged Disynaptic Inhibition in the Cortex Mediated by Slow, Non-α7 Nicotinic Excitation of a Specific Subset of Cortical Interneurons
Open accessAbstract
Cholinergic activation of nicotinic receptors in the cortex plays a critical role in arousal, attention, and learning. Here we demonstrate that cholinergic axons from the basal forebrain of mice excite a specific subset of cortical interneurons via a remarkably slow, non-α7 nicotinic receptor-mediated conductance. In turn, these inhibitory cells generate a delayed and prolonged wave of disynaptic inhibition in neighboring cortical neurons, altering the spatiotemporal pattern of inhibition in cortical circuits.
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“Anatomical, pharmacological and optogenetic evidence support this view (Acsady et al., 1993; Arroyo et al., 2012; Choi and Callaway, 2011; Ferezou et al., 2002; Lee et al., 2010).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Arroyo et al., 2012
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Expression of high levels of voltage-gated K+ channels with a depolarized activation voltage and fast deactivation rates of the Kv3 subfamily; channels specialized for rapid repolarization with little interference during the inter-spike interval.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as [10]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Kv3 channels also contribute to the generation of a large and fast AHP that facilitates the recovery of Na+ channels from inactivation9–11.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as [10]
Experimental — accuracy not yet measuredIn the citing paper
“The fast inhibition is at least partially mediated by the actions of both nAChRs and mAChRs that increase the excitability and firing rates of dendrite-targeting GABAergic interneurons (Arroyo et al., 2012; Couey et al., 2007; Fanselow et al., 2008; Ferezou et al., 2002; Gulledge et al., 2007; Kawaguchi and Kubota, 1997).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Arroyo et al., 2012
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Citations
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Metadata
- Authors
- Arroyo, S., Bennett, C., Aziz, D., Brown, S. P., & Hestrin, S.
- Affiliations
- University of Arizona (US)
- Stanford Medicine (US)
- Johns Hopkins University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-03-14
- Volume
- 32
- Issue
- 11
- Pages
- 3859-3864
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3320796
- OpenAlex
- W2002108201
- Cited by
- 138
- References
- 33
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 14 · 2017: 9 · 2016: 12 · 2015: 19 · 2014: 27 · 2013: 10 · 2012: 6
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (R01EY012114)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- disynaptic inhibition, nicotinic acetylcholine receptors, cortical interneurons, cholinergic stimulation, basal forebrain, cholinergic axons, cortical circuits
- MeSH terms
- Action Potentials, Animals, Axons, Cerebral Cortex, Female, Interneurons, Male, Mice, Transgenic, Neural Inhibition, Reaction Time, Receptors, Nicotinic, Synapses, Time Factors, Mice, Cholinergic Neurons, alpha7 Nicotinic Acetylcholine Receptor
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