The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Prolonged Disynaptic Inhibition in the Cortex Mediated by Slow, Non-α7 Nicotinic Excitation of a Specific Subset of Cortical Interneurons
Open accessAbstract
Cholinergic activation of nicotinic receptors in the cortex plays a critical role in arousal, attention, and learning. Here we demonstrate that cholinergic axons from the basal forebrain of mice excite a specific subset of cortical interneurons via a remarkably slow, non-α7 nicotinic receptor-mediated conductance. In turn, these inhibitory cells generate a delayed and prolonged wave of disynaptic inhibition in neighboring cortical neurons, altering the spatiotemporal pattern of inhibition in cortical circuits.
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“Anatomical, pharmacological and optogenetic evidence support this view (Acsady et al., 1993; Arroyo et al., 2012; Choi and Callaway, 2011; Ferezou et al., 2002; Lee et al., 2010).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Arroyo et al., 2012
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Expression of high levels of voltage-gated K+ channels with a depolarized activation voltage and fast deactivation rates of the Kv3 subfamily; channels specialized for rapid repolarization with little interference during the inter-spike interval.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as [10]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Kv3 channels also contribute to the generation of a large and fast AHP that facilitates the recovery of Na+ channels from inactivation9–11.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as [10]
Experimental — accuracy not yet measuredIn the citing paper
“The fast inhibition is at least partially mediated by the actions of both nAChRs and mAChRs that increase the excitability and firing rates of dendrite-targeting GABAergic interneurons (Arroyo et al., 2012; Couey et al., 2007; Fanselow et al., 2008; Ferezou et al., 2002; Gulledge et al., 2007; Kawaguchi and Kubota, 1997).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Arroyo et al., 2012
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Cites
The distinct modes of vision offered by feedforward and recurrent processing
Lamme, V. A. F., & Roelfsema, P. R. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01657-x · Cited by 2,338 · cited 1×
“Moreover we propose that, given the delayed kinetics of the IPSC barrage, sensory activation of the BF will preferentially impact long latency intracortical activity over the initial feedforward sensory response (Lamme and Roelfsema, 2000).”
Corbetta, M., Miezin, F. M., Dobmeyer, S., Shulman, G. L., & Petersen, S. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-08-02383.1991 · Cited by 1,590
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
Rudy, B., Fishell, G., Lee, S., & Hjerling‐Leffler, J. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20853 · Cited by 1,420
GABAergic cell subtypes and their synaptic connections in rat frontal cortex
Kawaguchi, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.476 · Cited by 1,416
Tamamaki, N., Yanagawa, Y., Tomioka, R., Miyazaki, J., Obata, K., & Kaneko, T. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10905 · Cited by 1,277
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197
Steinlein, O. K., Mulley, J. C., Propping, P., Wallace, R. H., Phillips, H. A., Sutherland, G. R., Scheffer, I. E., & Berkovic, S. F. (1995) · Nature Genetics · doi:10.1038/ng1095-201 · Cited by 1,134
Gong, S., Doughty, M., Harbaugh, C. R., Cummins, A., Hatten, M. E., Heintz, N., & Gerfen, C. R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2707-07.2007 · Cited by 977
A disinhibitory microcircuit for associative fear learning in the auditory cortex
Letzkus, J. J., Wolff, S. B. E., Meyer, E. M. M., Tovote, P., Courtin, J., Herry, C., & Lüthi, A. (2011) · Nature · doi:10.1038/nature10674 · Cited by 840 · cited 3×
“…acetylcholine receptors (nAChRs) have been shown to play an important role in attention (Howe et al., 2010; Guillem et al., 2011) and learning (Letzkus et al., 2011), and gain of function mutations in a non- 7 receptor subunit has been linked to a heritable form of epilepsy (Steinlein et al.,…”
InfluentialRye, D. B., Wainer, B. H., Mesulam, M.-M., Mufson, E. J., & Saper, C. B. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90083-6 · Cited by 743
Cited by
Sorted by citations
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
Tremblay, R., Lee, S., & Rudy, B. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.033 · Cited by 2,033
Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404
Cortical interneurons that specialize in disinhibitory control
Pi, H.-J., Hangya, B., Kvitsiani, D., Sanders, J. I., Huang, Z. J., & Kepecs, A. (2013) · Nature · doi:10.1038/nature12676 · Cited by 1,136
A Cortical Circuit for Gain Control by Behavioral State
Fu, Y., Tucciarone, J. M., Espinosa, J. S., Sheng, N., Darcy, D. P., Nicoll, R. A., Huang, Z. J., & Stryker, M. P. (2014) · Cell · doi:10.1016/j.cell.2014.01.050 · Cited by 937
“No fast nAChR component like that shown in layer I inhibitory neurons (Letzkus et al., 2011) was evident; our findings showed instead a response with slow kinetics resembling what has been found in ChATpositive bipolar neurons (Arroyo et al., 2012).”
BackgroundResultInfluentialCorticostriatal connectivity and its role in disease
Shepherd, G. M. G. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3469 · Cited by 824
Metadata
- Authors
- Arroyo, S., Bennett, C., Aziz, D., Brown, S. P., & Hestrin, S.
- Affiliations
- University of Arizona (US)
- Stanford Medicine (US)
- Johns Hopkins University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-03-14
- Volume
- 32
- Issue
- 11
- Pages
- 3859-3864
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3320796
- OpenAlex
- W2002108201
- Cited by
- 138
- References
- 33
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 14 · 2017: 9 · 2016: 12 · 2015: 19 · 2014: 27 · 2013: 10 · 2012: 6
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (R01EY012114)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- disynaptic inhibition, nicotinic acetylcholine receptors, cortical interneurons, cholinergic stimulation, basal forebrain, cholinergic axons, cortical circuits
- MeSH terms
- Action Potentials, Animals, Axons, Cerebral Cortex, Female, Interneurons, Male, Mice, Transgenic, Neural Inhibition, Reaction Time, Receptors, Nicotinic, Synapses, Time Factors, Mice, Cholinergic Neurons, alpha7 Nicotinic Acetylcholine Receptor
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