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Cited by 438Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyNeural dynamics and brain function

Cholinergic Switching Within Neocortical Inhibitory Networks

Xiang, Zixiu, Huguenard, John R., Prince, David A.·1998·Science
DOI 10.1126/science.281.5379.985
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Abstract

Differential actions of acetylcholine on the excitability of two subtypes of interneurons in layer V of the rat visual cortex were examined. Acetylcholine excited low-threshold spike (LTS) cells through nicotinic receptors, whereas it elicited hyperpolarization in fast spiking (FS) cells through muscarinic receptors. Axons of LTS cells were mainly distributed vertically to upper layers, and those of FS cells were primarily confined to layer V. Thus, cortical cholinergic activation may reduce some forms of intralaminar inhibition, promote intracolumnar inhibition, and change the direction of information flow within cortical circuits.

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Crossref · 10.1126/science.281.5379.985

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43 of 43 references verified0 citation errors · 0 not checkable

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  • When activated by nAChR stimulation, interneurons can alter activity and plasticity in pyramidal neurons.

    “When activated by nAChR stimulation, interneurons can alter activity and plasticity in pyramidal neurons (Xiang et al. 1998; Alkondon et al. 2000; Ji and Dani 2000; Ji et al. 2001; Couey et al. 2007).”

    From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Xiang et al. 1998

  • Increased inhibition through nAChR activation on interneurons occurs in many brain regions.

    “Increased inhibition through activation of nAChRs expressed by interneurons has been found in many different brain regions (Jones and Yakel 1997; Xiang et al. 1998; McQuiston and Madison 1999; Alkondon et al. 2000; Ji and Dani 2000; Mansvelder et al. 2002; Gulledge et al. 2007).”

    From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Xiang et al. 1998

  • The relative influence of external input can be enhanced by cholinergic depolarization of selective sets of inhibitory interneurons, coupled with cholinergic suppression of evoked GABAergic synaptic transmission.

    “The relative influence of external input can also be enhanced by cholinergic depolarization of selective sets of inhibitory interneurons (Xiang et al., 1998; McQuiston and Madison, 1999a, b, c; Christophe et al., 2002), coupled with the cholinergic suppression of evoked GABAergic synaptic transmission (Pitler and Alger, 1992; Behrends and ten Bruggencate, 1993; Patil and Hasselmo, 1999).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Xiang et al., 1998

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Authors
Xiang, Z., Huguenard, J. R., & Prince, D. A.
Affiliations
Stanford Medicine (US)
Corresponding author
Prince, David A.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1998-08-14
Volume
281
Issue
5379
Pages
985-988
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.281.5379.985
OpenAlex
W2019159182
Cited by
438
References
43
Citations by year
2026: 3 · 2025: 5 · 2024: 15 · 2023: 8 · 2022: 6 · 2021: 13 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 15 · 2016: 15 · 2015: 15 · 2014: 24 · 2013: 19 · 2012: 21
FWCI
8.17
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5t32ns007280-35)
  • National Institute of Neurological Disorders and Stroke (NS07280, NS-06477, R01NS006477, NS12151)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
acetylcholine, cholinergic modulation, interneurons, nicotinic acetylcholine receptors, muscarinic receptors, layer V, visual cortex, axonal projections, information flow, cortical circuits
MeSH terms
Acetylcholine, Animals, Interneurons, Membrane Potentials, Nerve Net, Neural Inhibition, Receptors, Nicotinic, Scopolamine, Visual Cortex, Rats, Sprague-Dawley, Patch-Clamp Techniques, Muscarinic Antagonists, Nicotinic Antagonists, Hexamethonium, Rats, In Vitro Techniques

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