The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Age-Related Decline in Circadian Output
Open accessAbstract
Disruptions in sleep/wake cycles, including decreased amplitude of rhythmic behaviors and fragmentation of the sleep episodes, are commonly associated with aging in humans and other mammals. While there are undoubtedly many factors contributing to these changes, a body of literature is emerging, suggesting that an age-related decline in the central circadian clock in the suprachiasmatic nucleus (SCN) may be a key element responsible. To explore age-related changes in the SCN, we have performed in vivo multiunit neural activity (MUA) recordings from the SCN of freely moving young (3-5 months) and middle-aged (13-18 months) mice. Importantly, the amplitude of day-night difference in MUA was significantly reduced in the older mice. We also found that the neural activity rhythms are clearly degraded in the subparaventricular zone, one of the main neural outputs of the SCN. Surprisingly, parallel studies indicate that the molecular clockwork in the SCN as measured by PER2 exhibited only minor deficits at this same age. Thus, the circadian output measured at the level of neural activity rhythms in the SCN is degraded by aging, and this decline occurs before the disruption of key components of the molecular clockwork.
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“These SCN network changes result in desynchronization and a reduction in the amplitude of neuronal activity rhythms248,249 and, ultimately, physiological and behavioural rhythms241.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [249]
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Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Self-citationStability, precision, and near-24-hour period of the human circadian pacemaker
Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,223
Inouye, S. T., & Kawamura, H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5962 · Cited by 985
Sleep in Normal Aging and Dementia
Bliwise, D. L. (1993) · SLEEP · doi:10.1093/sleep/16.1.40 · Cited by 854
Circadian rhythms in isolated brain regions
Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00350.2002 · Cited by 681
Self-citationDijk, D., Duffy, J. F., Riel, E., Shanahan, T. L., & Czeisler, C. A. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0611v.x · Cited by 467
Sleep states alter activity of suprachiasmatic nucleus neurons
Deboer, T., Vansteensel, M. J., Détári, L., & Meijer, J. H. (2003) · Nature Neuroscience · doi:10.1038/nn1122 · Cited by 328
Effects of aging on central and peripheral mammalian clocks
Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152318499 · Cited by 317
Self-citationAge‐related Changes in the Circadian and Homeostatic Regulation of Human Sleep
Cajochen, C., Münch, M., Knoblauch, V., Blatter, K., & Wirz‐Justice, A. (2006) · Chronobiology International · doi:10.1080/07420520500545813 · Cited by 285
Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain
Wyse, C. A., & Coogan, A. N. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.113 · Cited by 167
CIRCADIAN RHYTHMS AND SLEEP IN HUMAN AGING
Someren, E. J. W. V. (2000) · Chronobiology International · doi:10.1081/cbi-100101046 · Cited by 167
Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease
Kudo, T., Schroeder, A., Loh, D. H., Kuljis, D. A., Jordan, M. C., Roos, K. P., & Colwell, C. S. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.12.011 · Cited by 163
Self-citationAging Alters Circadian and Light-Induced Expression of Clock Genes in Golden Hamsters
Kolker, D. E., Fukuyama, H., Huang, D. S., Takahashi, J. S., Horton, T. H., & Turek, F. W. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403251802 · Cited by 161
Effects of age on the circadian system
Turek, F. W., Penev, P. D., Zhang, Y., Reeth, O. V., & Zee, P. P. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00030-5 · Cited by 159
Do the suprachiasmatic nuclei oscillate in old rats as they do in young ones?
Satinoff, E., Li, H., Tcheng, T. K., Liu, C., McArthur, A. J., Medanic, M., & Gillette, M. U. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.265.5.r1216 · Cited by 159
Asai, M., Yoshinobu, Y., Kaneko, S., Mori, A., Nikaido, T., Moriya, T., Akiyama, M., & Shibata, S. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10010 · Cited by 151
Resetting of central and peripheral circadian oscillators in aged rats
Davidson, A. J., Yamazaki, S., Arble, D. M., Menaker, M., & Block, G. D. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.018 · Cited by 134
Self-citationKrajnak, K., Kashon, M. L., Rosewell, K. L., & Wise, P. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04767.1998 · Cited by 125
Nakamura, T. J., Sellix, M. T., Kudo, T., Nakao, N., Yoshimura, T., Ebihara, S., Colwell, C. S., & Block, G. D. (2010) · Steroids · doi:10.1016/j.steroids.2010.01.007 · Cited by 109
Self-citationAging alters the circadian rhythm of glucose utilization in the suprachiasmatic nucleus.
Wise, P. M., COHEN, I. R., Weiland, N. G., & London, E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5305 · Cited by 103
Watanabe, A., Shibata, S., & Watanabe, S. (1995) · Brain Research · doi:10.1016/0006-8993(95)00713-z · Cited by 99
Aujard, F., Herzog, E. D., & Block, G. D. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00285-8 · Cited by 92
Self-citationIn Vivo Monitoring of Circadian Timing in Freely Moving Mice
Nakamura, W., Yamazaki, S., Nakamura, T. J., Shirakawa, T., Block, G. D., & Takumi, T. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.024 · Cited by 87
Self-citationIMPAIRED EXPRESSION OF THEmPer2CIRCADIAN CLOCK GENE IN THE SUPRACHIASMATIC NUCLEI OF AGING MICE
Weinert, H., Weinert, D., Schurov, I., Maywood, E. S., & Hastings, M. H. (2001) · Chronobiology International · doi:10.1081/cbi-100103976 · Cited by 86
Age-related changes in electrophysiological properties of the mouse suprachiasmatic nucleus in vitro
Nygård, M., Hill, R. H., Wikström, M. A., & Kristensson, K. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.12.006 · Cited by 82
Circadian clock resetting in the mouse changes with age
Biello, S. M. (2009) · AGE · doi:10.1007/s11357-009-9102-7 · Cited by 76
Loss of day-night differences in VIP mRNA levels in the suprachiasmatic nucleus of aged rats
Kawakami, F., Okamura, H., Tamada, Y., Maebayashi, Y., Fukui, K., & Ibata, Y. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)13355-9 · Cited by 74
Duncan, M. J., Herron, J. M., & Hill, S. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00015-8 · Cited by 67
Vansteensel, M. J., Yamazaki, S., Albus, H., Deboer, T., Block, G. D., & Meijer, J. H. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00560-8 · Cited by 67
Self-citationCai, A., Scarbrough, K., Hinkle, D. A., & Wise, P. M. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.5.r1764 · Cited by 66
Suprachiasmatic nucleus grafts restore circadian function in aged hamsters
Viswanathan, N., & Davis, F. C. (1995) · Brain Research · doi:10.1016/0006-8993(95)00423-n · Cited by 54
Reeth, O. V., Zhang, Y., Zee, P. C., & Turek, F. W. (1994) · Brain Research · doi:10.1016/0006-8993(94)90044-2 · Cited by 52
Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice
Kolker, D. E., Vitaterna, M. H., Fruechte, E. M., Takahashi, J. S., & Turek, F. W. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.06.007 · Cited by 50
Asai, M., Yoshinobu, Y., Kaneko, S., et al. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10010.abs · Cited by 13
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Metadata
- Authors
- Nakamura, T. J., Nakamura, W., Yamazaki, S., Kudo, T., Cutler, T., Colwell, C. S., & Block, G. D.
- Affiliations
- University of California, Los Angeles (US)
- The University of Osaka (JP)
- Vanderbilt University (US)
- Corresponding author
- Colwell, C. S.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-07-13
- Volume
- 31
- Issue
- 28
- Pages
- 10201-10205
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3155746
- OpenAlex
- W2094874423
- Cited by
- 386
- References
- 35
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 27 · 2023: 33 · 2022: 25 · 2021: 34 · 2020: 36 · 2019: 31 · 2018: 19 · 2017: 24 · 2016: 21 · 2015: 28 · 2014: 14 · 2013: 23 · 2012: 26
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- CHDI Foundation
- National Institutes of Health (AG028748)
- Japan Society for the Promotion of Science (23659871)
- National Institute on Aging (P30AG028748)
- National Institute of Mental Health (R01MH062517)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- suprachiasmatic nucleus, sleep-wake cycle, Per2, sleep fragmentation, mice
- MeSH terms
- Aging, Animals, Biological Clocks, Circadian Rhythm, Electrodes, Implanted, Electrophysiology, Male, Motor Activity, Suprachiasmatic Nucleus, Mice, Period Circadian Proteins
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