The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Age-Related Decline in Circadian Output
Open accessAbstract
Disruptions in sleep/wake cycles, including decreased amplitude of rhythmic behaviors and fragmentation of the sleep episodes, are commonly associated with aging in humans and other mammals. While there are undoubtedly many factors contributing to these changes, a body of literature is emerging, suggesting that an age-related decline in the central circadian clock in the suprachiasmatic nucleus (SCN) may be a key element responsible. To explore age-related changes in the SCN, we have performed in vivo multiunit neural activity (MUA) recordings from the SCN of freely moving young (3-5 months) and middle-aged (13-18 months) mice. Importantly, the amplitude of day-night difference in MUA was significantly reduced in the older mice. We also found that the neural activity rhythms are clearly degraded in the subparaventricular zone, one of the main neural outputs of the SCN. Surprisingly, parallel studies indicate that the molecular clockwork in the SCN as measured by PER2 exhibited only minor deficits at this same age. Thus, the circadian output measured at the level of neural activity rhythms in the SCN is degraded by aging, and this decline occurs before the disruption of key components of the molecular clockwork.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These SCN network changes result in desynchronization and a reduction in the amplitude of neuronal activity rhythms248,249 and, ultimately, physiological and behavioural rhythms241.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [249]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Self-citationStability, precision, and near-24-hour period of the human circadian pacemaker
Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,223
Inouye, S. T., & Kawamura, H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5962 · Cited by 985
Sleep in Normal Aging and Dementia
Bliwise, D. L. (1993) · SLEEP · doi:10.1093/sleep/16.1.40 · Cited by 854
Circadian rhythms in isolated brain regions
Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00350.2002 · Cited by 681
Self-citationDijk, D., Duffy, J. F., Riel, E., Shanahan, T. L., & Czeisler, C. A. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0611v.x · Cited by 467
Sleep states alter activity of suprachiasmatic nucleus neurons
Deboer, T., Vansteensel, M. J., Détári, L., & Meijer, J. H. (2003) · Nature Neuroscience · doi:10.1038/nn1122 · Cited by 328
Effects of aging on central and peripheral mammalian clocks
Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152318499 · Cited by 317
Self-citation
Cited by
Sorted by citations
Mechanisms linking circadian clocks, sleep, and neurodegeneration
Musiek, E. S., & Holtzman, D. M. (2016) · Science · doi:10.1126/science.aah4968 · Cited by 878
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713
Circadian time signatures of fitness and disease
Bass, J. T., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 635
The aging clock: circadian rhythms and later life
Hood, S., & Amir, S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90328 · Cited by 645
Genomics of circadian rhythms in health and disease
Rijo‐Ferreira, F., & Takahashi, J. S. (2019) · Genome Medicine · doi:10.1186/s13073-019-0704-0 · Cited by 555
Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease
Musiek, E. S., Bhimasani, M., Zangrilli, M. A., Morris, J. C., Holtzman, D. M., & Ju, Y.-E. S. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.4719 · Cited by 465
Linking neural activity and molecular oscillations in the SCN
Colwell, C. S. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3086 · Cited by 474
Self-citationSleep and Circadian Rhythm Regulation in Early Parkinson Disease
Breen, D. P., Vuono, R., Nawarathna, U., Fisher, K., Shneerson, J. M., Reddy, A. B., & Barker, R. A. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.65 · Cited by 440
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 402
Sleep in the Intensive Care Unit
Pisani, M. A., Friese, R. S., Gehlbach, B. K., Schwab, R. J., Weinhouse, G. L., & Jones, S. F. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201411-2099ci · Cited by 404
Duffy, J. F., Zitting, K.-M., & Chinoy, E. D. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.002 · Cited by 367
Circadian Rhythms, Sleep, and Disorders of Aging
Mattis, J., & Sehgal, A. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.02.003 · Cited by 369
Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging
Sato, S., Solanas, G., Peixoto, F. O., Bee, L., Symeonidi, A., Schmidt, M. S., Brenner, C., Masri, S., Benitah, S. A., & Sassone‐Corsi, P. (2017) · Cell · doi:10.1016/j.cell.2017.07.042 · Cited by 366
Circadian rhythms, time-restricted feeding, and healthy aging
Manoogian, E. N. C., & Panda, S. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.006 · Cited by 330
Sleep Disturbance, Cognitive Decline, and Dementia: A Review
Wu, M. N., Rosenberg, P. B., Spira, A. P., & Wennberg, A. M. V. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1604351 · Cited by 325
Coomans, C. P., van den Berg, S. A. A., Houben, T., van Klinken, J., van den Berg, R., Pronk, A. C. M., Havekes, L. M., Romijn, J. A., van Dijk, K. W., Biermasz, N. R., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-210898 · Cited by 252
Yang, S.-B., Tien, A.-C., Boddupalli, G., Xu, A. W., Jan, Y. N., & Jan, L. Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.043 · Cited by 242
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress
Solanas, G., Peixoto, F. O., Perdiguero, E., Jardí, M., Ruiz‐Bonilla, V., Datta, D., Symeonidi, A., Castellanos‐Martín, A., Welz, P.-S., Caballero, J. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.035 · Cited by 234
Evidence for Neuronal Desynchrony in the Aged Suprachiasmatic Nucleus Clock
Farajnia, S., Michel, S., Deboer, T., vanderLeest, H. T., Houben, T., Rohling, J. H. T., Ramkisoensing, A., Yasenkov, R., & Meijer, J. H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0469-12.2012 · Cited by 230
High-fat diet acutely affects circadian organisation and eating behavior
Pendergast, J. S., Branecky, K. L., Yang, W., Ellacott, K. L. J., Niswender, K. D., & Yamazaki, S. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12133 · Cited by 198
Self-citationSchroeder, A., & Colwell, C. S. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.09.002 · Cited by 201
Self-citationA fresh look at the use of nonparametric analysis in actimetry
Gonçalves, B. D. S. B., Adamowicz, T., Louzada, F. M., Moreno, C. R. D. C., & Araújo, J. F. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.06.002 · Cited by 182
The Suprachiasmatic Nucleus Controls Circadian Energy Metabolism and Hepatic Insulin Sensitivity
Coomans, C. P., van den Berg, S. A. A., Lucassen, E. A., Houben, T., Pronk, A. C. M., van der Spek, R. D., Kalsbeek, A., Biermasz, N. R., Willems van Dijk, K., Romijn, J. A., et al. (2013) · Diabetes · doi:10.2337/db12-0507 · Cited by 173
The trouble with circadian clock dysfunction: Multiple deleterious effects on the brain and body
Zelinski, E. L., Deibel, S. H., & McDonald, R. J. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.007 · Cited by 189
Skeldon, A. C., Derks, G., & Dijk, D.-J. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.05.011 · Cited by 165
Jenwitheesuk, A., Nopparat, C., Mukda, S., Wongchitrat, P., & Govitrapong, P. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916848 · Cited by 164
Skeldon, A. C., Phillips, A. J. K., & Dijk, D.-J. (2017) · Scientific Reports · doi:10.1038/srep45158 · Cited by 155
The suprachiasmatic nuclei as a seasonal clock
Coomans, C. P., Ramkisoensing, A., & Meijer, J. H. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.11.002 · Cited by 156
Sellix, M. T., Evans, J. A., Leise, T., Castañón‐Cervantes, O., Hill, D. D., Delisser, P., Block, G. D., Menaker, M., & Davidson, A. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3559-12.2012 · Cited by 153
Self-citationRamkisoensing, A., & Meijer, J. H. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00128 · Cited by 166
Schmidt, C., Peigneux, P., & Cajochen, C. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00118 · Cited by 147
Lananna, B. V., & Musiek, E. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104832 · Cited by 147
Hui, K. Y., & Ripperger, J. A. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_1100-1 · Cited by 139
Circadian Rhythms of the Hypothalamus: From Function to Physiology
Drunen, R. V., & Eckel‐Mahan, K. L. (2021) · Clocks & Sleep · doi:10.3390/clockssleep3010012 · Cited by 146
Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice
Inokawa, H., Umemura, Y. M., Shimba, A., Kawakami, E., Koike, N., Tsuchiya, Y., Ohashi, M., Minami, Y., Cui, G., Asahi, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59541-y · Cited by 137
Environmental 24-hr Cycles Are Essential for Health
Lucassen, E. A., Coomans, C. P., van Putten, M., de Kreij, S. R., van Genugten, J. H. L. T., Sutorius, R. P. M., de Rooij, K. E., van der Velde, M., Verhoeve, S. L., Smit, J. W. A., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.05.038 · Cited by 131
Sex differences in age-related changes in the sleep-wake cycle
Carrier, J., Semba, K., Deurveilher, S., Drogos, L. L., Cyr-Cronier, J., Lord, C., & Sekerovick, Z. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.004 · Cited by 139
Mammalian circadian systems: Organization and modern life challenges
Finger, A., & Kramer, A. (2021) · Acta Physiologica · doi:10.1111/apha.13548 · Cited by 117
The role of melatonin, a multitasking molecule, in retarding the processes of ageing
Majidinia, M., Reiter, R. J., Shakouri, S. K., & Yousefi, B. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.010 · Cited by 126
Cellular mechano-environment regulates the mammary circadian clock
Yang, N., Williams, J. L., Pekovic‐Vaughan, V., Wang, P., Olabi, S., McConnell, J. C., Gossan, N., Hughes, A. T. L., Cheung, J., Streuli, C. H., et al. (2017) · Nature Communications · doi:10.1038/ncomms14287 · Cited by 119
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration
Liang, C., Liu, Z., Song, M., Li, W., Wu, Z., Wang, Z., Wang, Q., Wang, S., Yan, K., Sun, L., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0385-7 · Cited by 119
Neurobiological studies of fatigue
Harrington, M. E. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.07.004 · Cited by 112
“Interestingly, studies of the genes driving circadian oscillators via transcription-translation feedback loops (Ko and Takahashi, 2006) show only relatively minor alterations due to age (Asai et al., 2001; Kolker et al., 2003; Nakamura et al., 2011), neurodegenerative disease (Kudo et al.”
Role of hypothalamus in aging and its underlying cellular mechanisms
Kim, K., & Choe, H. K. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.04.008 · Cited by 116
Age-Related Changes in the Circadian System Unmasked by Constant Conditions
Nakamura, T. J., Nakamura, W., Tokuda, I. T., Ishikawa, T., Kudo, T., Colwell, C. S., & Block, G. D. (2015) · eNeuro · doi:10.1523/eneuro.0064-15.2015 · Cited by 109
Self-citationBonaconsa, M., Malpeli, G., Montaruli, A., Carandente, F., Grassi-Zucconi, G., & Bentivoglio, M. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.011 · Cited by 107
Luo, W., Chen, W., Yue, Z., Chen, D., Sowcik, M., Sehgal, A., & Zheng, X. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00800.x · Cited by 102
Han, S., Yu, F. H., Schwartz, M. D., Linton, J. D., Bosma, M. M., Hurley, J. B., Catterall, W. A., & de la Iglesia, H. O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115729109 · Cited by 98
Feedback actions of locomotor activity to the circadian clock
Hughes, A. T. L., & Piggins, H. D. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59427-3.00018-6 · Cited by 103
Aging of the Suprachiasmatic Clock
Farajnia, S., Deboer, T., Rohling, J. H. T., Meijer, J. H., & Michel, S. H. (2013) · The Neuroscientist · doi:10.1177/1073858413498936 · Cited by 97
Meal timing, aging, and metabolic health
Kessler, K., & Pivovarova-Ramich, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081911 · Cited by 95
Bright daytime light enhances circadian amplitude in a diurnal mammal
Baño‐Otálora, B., Martial, F. P., Harding, C., Bechtold, D. A., Allen, A. E., Brown, T. M., Belle, M. D. C., & Lucas, R. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100094118 · Cited by 96
Aging in Mice Reduces the Ability to Sustain Sleep/Wake States
Wimmer, M. E., Rising, J., Galante, R. J., Wyner, A. J., Pack, A. I., & Abel, T. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081880 · Cited by 100
Synchrony and desynchrony in circadian clocks: impacts on learning and memoryPreprint
Krishnan, H. C., & Lyons, L. C. (2015) · Learning & Memory · doi:10.1101/lm.038877.115 · Cited by 98
Constructing the suprachiasmatic nucleus: a watchmaker's perspective on the central clockworks
Bedont, J. L., & Blackshaw, S. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00074 · Cited by 91
Molecular Connections Between Circadian Clocks and Aging
Welz, P.-S., & Benitah, S. A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.036 · Cited by 90
The suprachiasmatic nucleus: age-related decline in biological rhythms
Nakamura, T. J., Takasu, N. N., & Nakamura, W. (2016) · The Journal of Physiological Sciences · doi:10.1007/s12576-016-0439-2 · Cited by 91
Self-citationCircadian Regulation of Adult Stem Cell Homeostasis and Aging
Benitah, S. A., & Welz, P.-S. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.05.002 · Cited by 81
Voluntary exercise can strengthen the circadian system in aged mice
Leise, T., Harrington, M. E., Molyneux, P. C., Song, I., Queenan, H., Zimmerman, E., Lall, G. S., & Biello, S. M. (2013) · AGE · doi:10.1007/s11357-012-9502-y · Cited by 84
Loh, D. H., Kudo, T., Truong, D. A., Wu, Y., & Colwell, C. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069993 · Cited by 84
Self-citationInterplay between aging and other factors of the pathogenesis of age-related macular degeneration
Błasiak, J., Sobczuk, P., Pawłowska, E., & Kaarniranta, K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101735 · Cited by 86
Loss of dopamine disrupts circadian rhythms in a mouse model of Parkinson's disease
Fifel, K., & Cooper, H. M. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.08.024 · Cited by 80
Circadian regulation of membrane physiology in neural oscillators throughout the brain
Paul, J. R., Davis, J. A., Goode, L. K., Becker, B., Fusilier, A. R., Meador-Woodruff, A., & Gamble, K. L. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14343 · Cited by 81
Longitudinal change of sleep timing: association between chronotype and longevity in older adults
Didikoğlu, A., Maharani, A., Payton, A., Pendleton, N., & Canal, M. M. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1641111 · Cited by 81
Output from VIP cells of the mammalian central clock regulates daily physiological rhythms
Paul, S., Hanna, L., Harding, C., Hayter, E. A., Walmsley, L., Bechtold, D. A., & Brown, T. M. (2020) · Nature Communications · doi:10.1038/s41467-020-15277-x · Cited by 78
Circadian Clocks and Metabolism: Implications for Microbiome and Aging
Paschos, G. K., & FitzGerald, G. A. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.07.010 · Cited by 79
Zhong, H., Yu, B., Luo, D., Yang, L.-Y., Zhang, J., Jiang, S., Hu, S., Luo, Y., Yang, M.-W., Hong, F., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.01.013 · Cited by 77
Fonken, L. K., Kitt, M. M., Gaudet, A. D., Barrientos, R. M., Watkins, L. R., & Maier, S. F. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.019 · Cited by 77
Willison, L. D., Kudo, T., Loh, D. H., Kuljis, D. A., & Colwell, C. S. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.01.014 · Cited by 73
Self-citationMembrane Currents, Gene Expression, and Circadian ClocksPreprint
Allen, C. N., Nitabach, M. N., & Colwell, C. S. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027714 · Cited by 73
Self-citationSleep and Organizational Behavior: Implications for Workplace Productivity and Safety
Pilcher, J. J., & Morris, D. M. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00045 · Cited by 92
Brain-muscle communication prevents muscle aging by maintaining daily physiology
Kumar, A., Vaca-Dempere, M., Mortimer, T., Deryagin, O., Smith, J. G., Petrus, P., Koronowski, K. B., Greco, C. M., Segalés, J., Andrés, E., et al. (2024) · Science · doi:10.1126/science.adj8533 · Cited by 72
Obayashi, K., Saeki, K., & Kurumatani, N. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx290 · Cited by 69
Molecular Clocks in Pharmacology
Musiek, E. S., & FitzGerald, G. A. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_10 · Cited by 71
Physiological links of circadian clock and biological clock of aging
Liu, F., & Chang, H.-C. (2017) · Protein & Cell · doi:10.1007/s13238-016-0366-2 · Cited by 69
The role of the circadian system in the etiology of depression
de Leeuw, M., Verhoeve, S. I., van der Wee, N. J. A., van Hemert, A. M., Vreugdenhil, E., & Coomans, C. P. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105383 · Cited by 81
Cryptochromerestores dampened circadian rhythms and promotes healthspan in agingDrosophila
Rakshit, K., & Giebultowicz, J. M. (2013) · Aging Cell · doi:10.1111/acel.12100 · Cited by 67
Tahara, Y., Takatsu, Y., Shiraishi, T., Kikuchi, Y., Yamazaki, M., Motohashi, H., Muto, A., Sasaki, H., Haraguchi, A., Kuriki, D., et al. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.30 · Cited by 63
Self-citationTakasu, N. N., Nakamura, T. J., Tokuda, I. T., Todo, T., Block, G. D., & Nakamura, W. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.049 · Cited by 65
Self-citationFrench, I. T., & Muthusamy, K. A. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00114 · Cited by 69
Li, X., Yang, S., Wang, S., Shi, Y., Dai, Y., Zhang, X., Liu, Y., Guo, Y., He, J., & Xiu, M. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123632 · Cited by 63
The multi-faceted nature of age-associated osteoporosis
Smit, A. E., Meijer, O. C., & Winter, E. M. (2024) · Bone Reports · doi:10.1016/j.bonr.2024.101750 · Cited by 78
Hossain, M. F., Wang, N., Chen, R., Li, S., Roy, J., Uddin, M. G., Li, Z., Lim, L. W., & Song, Y. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101304 · Cited by 62
Central and peripheral circadian clocks and their role in Alzheimer's disease
Chauhan, R., Chen, K.-F., Kent, B. A., & Crowther, D. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030627 · Cited by 58
“, 2014) and mouse (Nakamura et al., 2011), indicate that communication between clock neurons, and between clock neurons and their output pathways, fails earlier than does the circadian cycling of the molecular components of the clock.”
BackgroundFarajnia, S., Meijer, J. H., & Michel, S. H. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.040 · Cited by 60
Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia
Hu, K., Harper, D. G., Shea, S. A., Stopa, E. G., & Scheer, F. A. J. L. (2013) · Scientific Reports · doi:10.1038/srep02229 · Cited by 60
Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice
Barca‐Mayo, O., Boender, A. J., Armirotti, A., & Tonelli, D. D. P. (2019) · Glia · doi:10.1002/glia.23764 · Cited by 66
Mattam, U., & Jagota, A. (2014) · Biogerontology · doi:10.1007/s10522-014-9495-2 · Cited by 60
Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT
Li, Q., Loh, D. H., Kudo, T., Truong, D. A., Derakhshesh, M., Kaswan, Z. A. M., Ghiani, C. A., Tsoa, R. W., Cheng, Y., Sun, Y. E., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.009 · Cited by 60
Self-citationThe aging brain: sleep, the circadian clock and exercise
Panagiotou, M., Michel, S. H., Meijer, J. H., & Deboer, T. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114563 · Cited by 62
Reciprocal interactions between circadian clocks and aging
Banks, G. T., Nolan, P. M., & Peirson, S. N. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9639-6 · Cited by 60
Serotonergic Integration of Circadian Clock and Ultradian Sleep–Wake Cycles
Miyamoto, H., Nakamaru‐Ogiso, E., Hamada, K., & Hensch, T. K. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0793-12.2012 · Cited by 58
Nagai, N., Ayaki, M., Yanagawa, T., Hattori, A., Negishi, K., Mori, T., Nakamura, T. J., & Tsubota, K. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27195 · Cited by 60
Self-citationLiver regeneration in aged mice: new insights
Pibiri, M. (2018) · Aging · doi:10.18632/aging.101524 · Cited by 57
Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington’s Disease
Whittaker, D. S., Loh, D. H., Wang, H. B., Tahara, Y., Kuljis, D. A., Cutler, T., Ghiani, C. A., Shibata, S., Block, G. D., & Colwell, C. S. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418790401 · Cited by 54
Self-citationInteracting influences of aging and Alzheimer's disease on circadian rhythms
Duncan, M. J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14358 · Cited by 55
Yan, Y., Salazar, T. E., Dominguez, J. M., Nguyen, D. V., Calzi, S. L., Bhatwadekar, A. D., Qi, X., Busik, J. V., Boulton, M. E., & Grant, M. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080029 · Cited by 54
Role of vasoactive intestinal peptide in seasonal encoding by the suprachiasmatic nucleus clock
Lucassen, E. A., van Diepen, H. C., Houben, T., Michel, S. H., Colwell, C. S., & Meijer, J. H. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08054.x · Cited by 52
Self-citationCircadian clock communication during homeostasis and ageing
Mortimer, T., Smith, J. G., Muñoz‐Cánoves, P., & Benitah, S. A. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00802-3 · Cited by 60
Circadian modulation of motivation in mice
Acosta, J., Bussi, I. L., Esquivel, M., Höcht, C., Golombek, D. A., & Agostino, P. V. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112471 · Cited by 52
Paul, J. R., Johnson, R. L., Jope, R. S., & Gamble, K. L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.047 · Cited by 51
Metadata
- Authors
- Nakamura, T. J., Nakamura, W., Yamazaki, S., Kudo, T., Cutler, T., Colwell, C. S., & Block, G. D.
- Affiliations
- University of California, Los Angeles (US)
- The University of Osaka (JP)
- Vanderbilt University (US)
- Corresponding author
- Colwell, C. S.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-07-13
- Volume
- 31
- Issue
- 28
- Pages
- 10201-10205
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3155746
- OpenAlex
- W2094874423
- Cited by
- 386
- References
- 35
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 27 · 2023: 33 · 2022: 25 · 2021: 34 · 2020: 36 · 2019: 31 · 2018: 19 · 2017: 24 · 2016: 21 · 2015: 28 · 2014: 14 · 2013: 23 · 2012: 26
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- CHDI Foundation
- National Institutes of Health (AG028748)
- Japan Society for the Promotion of Science (23659871)
- National Institute on Aging (P30AG028748)
- National Institute of Mental Health (R01MH062517)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- suprachiasmatic nucleus, sleep-wake cycle, Per2, sleep fragmentation, mice
- MeSH terms
- Aging, Animals, Biological Clocks, Circadian Rhythm, Electrodes, Implanted, Electrophysiology, Male, Motor Activity, Suprachiasmatic Nucleus, Mice, Period Circadian Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
