The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Fgf-Dependent Glial Cell Bridges Facilitate Spinal Cord Regeneration in Zebrafish
Open accessAbstract
Adult zebrafish show a remarkable capacity to regenerate their spinal column after injury, an ability that stands in stark contrast to the limited repair that occurs within the mammalian CNS post-injury. The reasons for this interspecies difference in regenerative capacity remain unclear. Here we demonstrate a novel role for Fgf signaling during glial cell morphogenesis in promoting axonal regeneration after spinal cord injury. Zebrafish glia are induced by Fgf signaling, to form an elongated bipolar morphology that forms a bridge between the two sides of the resected spinal cord, over which regenerating axons actively migrate. Loss of Fgf function inhibits formation of this “glial bridge” and prevents axon regeneration. Despite the poor potential for mammalian axonal regeneration, primate astrocytes activated by Fgf signaling adopt a similar morphology to that induced in zebrafish glia. This suggests that differential Fgf regulation, rather than intrinsic cell differences, underlie the distinct responses of mammalian and zebrafish glia to injury.
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Regeneration beyond the glial scar
Silver, J., & Miller, J. H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1326 · Cited by 3,078
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Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury
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Cited by
The zebrafish as a model for complex tissue regeneration
Gemberling, M., Bailey, T. J., Hyde, D. R., & Poss, K. D. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.07.003 · Cited by 566
Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish
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Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs
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Fibroblast growth factors: key players in regeneration and tissue repair.
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Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes
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“P A A uthor M anuscript increased GFAP immunostaining (Cassina et al., 2005), whereas others observe dedifferentiation and adoption of a bipolar morphology (Goldshmit et al., 2012).”
BackgroundInfluential
Metadata
- Authors
- Goldshmit, Y., Sztal, T. E., Jusuf, P. R., Hall, T. E., Nguyen-Chi, M., & Currie, P. D.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-05-30
- Volume
- 32
- Issue
- 22
- Pages
- 7477-7492
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2031649134
- Cited by
- 274
- References
- 50
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Goldshmit, Y., Sztal, T. E., Jusuf, P. R., Hall, T. E., Nguyen-Chi, M., & Currie, P. D. (2012). Fgf-Dependent Glial Cell Bridges Facilitate Spinal Cord Regeneration in Zebrafish. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0758-12.2012
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