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Interleukin-1 is an astroglial growth factor in the developing brain
Open accessAbstract
The immunomodulator interleukin-1 (IL-1) is found to be an astroglial growth factor during development of the mammalian brain. In vitro studies indicate that ameboid microglia, a class of brain mononuclear phagocytes, are the likely source of IL-1. Examination of different brain regions during development shows IL-1 production only after the appearance of ameboid microglia. These observations suggest that brain mononuclear phagocytes secrete growth factors that regulate normal growth and development of the CNS.
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Metadata
- Authors
- Giulian, D., Young, D., Woodward, J., Brown, D., & Lachman, L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1988-02-01
- Volume
- 8
- Issue
- 2
- Pages
- 709-714
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2105469110
- Cited by
- 449
- References
- 2
- FWCI
- 27.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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