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Rapid, Nongenomic Responses to Ecdysteroids and Catecholamines Mediated by a Novel Drosophila G-Protein-Coupled Receptor

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Srivastava, Deepak P., Yu, Esther J., Kennedy, Karen, Chatwin, Heather, Reale, Vincenzina, Hamon, Maureen, Smith, Trevor, Evans, Peter D.·2005·The Journal of Neuroscience

DOI 10.1523/jneurosci.1005-05.2005PMC PMC6725065

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Abstract

Nongenomic response pathways mediate many of the rapid actions of steroid hormones, but the mechanisms underlying such responses remain controversial. In some cases, cell-surface expression of classical nuclear steroid receptors has been suggested to mediate these effects, but, in a few instances, specific G-protein-coupled receptors (GPCRs) have been reported to be responsible. Here, we describe the activation of a novel, neuronally expressed Drosophila GPCR by the insect ecdysteroids ecdysone (E) and 20-hydroxyecdysone (20E). This is the first report of an identified insect GPCR interacting with steroids. The Drosophila melanogaster dopamine/ecdysteroid receptor (DmDopEcR) shows sequence homology with vertebrate β-adrenergic receptors and is activated by dopamine (DA) to increase cAMP levels and to activate the phosphoinositide 3-kinase pathway. Conversely, E and 20E show high affinity for the receptor in binding studies and can inhibit the effects of DA, as well as coupling the receptor to a rapid activation of the mitogen-activated protein kinase pathway. The receptor may thus represent the Drosophila homolog of the vertebrate “γ-adrenergic receptors,” which are responsible for the modulation of various activities in brain, blood vessels, and pancreas. Thus, DmDopEcR can function as a cell-surface GPCR that may be responsible for some of the rapid, nongenomic actions of ecdysteroids, during both development and signaling in the mature adult nervous system.

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Authors: Srivastava, D. P., Yu, E. J., Kennedy, K., Chatwin, H., Reale, V., Hamon, M., Smith, T., & Evans, P. D.
Affiliations: Babraham Institute (GB)
Northwestern University (US)
ORCID: Srivastava, Deepak P.
Smith, Trevor
Evans, Peter D.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2005-06-29
Volume: 25
Issue: 26
Pages: 6145-6155
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1005-05.2005
PMC: PMC6725065
OpenAlex: W2023092335
Cited by: 272
References: 114
Citations by year: 2026: 4 · 2025: 27 · 2024: 24 · 2023: 7 · 2022: 4 · 2021: 13 · 2020: 15 · 2019: 11 · 2018: 13 · 2017: 10 · 2016: 16 · 2015: 9 · 2014: 15 · 2013: 19 · 2012: 15
FWCI: 4.79
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Directorate for Biological Sciences
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: non-genomic steroid action, ecdysteroids, ecdysone, 20-hydroxyecdysone, G protein-coupled receptors, dopamine, catecholamines, cAMP signaling, phosphatidylinositol 3-kinase, mitogen-activated protein kinase, Drosophila melanogaster, neuronal receptors
MeSH terms: Animals, Catecholamines, Drosophila melanogaster, Female, Cricetinae, Oocytes, Transfection, Xenopus laevis, Restriction Mapping, Polymerase Chain Reaction, CHO Cells, DNA Primers, DNA, Complementary, Reverse Transcriptase Polymerase Chain Reaction, Drosophila Proteins, Receptors, G-Protein-Coupled

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Rapid, Nongenomic Responses to Ecdysteroids and Catecholamines Mediated by a Novel Drosophila G-Protein-Coupled Receptor

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