Chronic Interleukin-1β Expression in Mouse Brain Leads to Leukocyte Infiltration and Neutrophil-Independent Blood–Brain Barrier Permeability without Overt Neurodegeneration

Neutrophils and immunity: challenges and opportunities

Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971

Mouse and human dendritic cell subtypes

Shortman, K., & Liu, Y.-J. (2002) · Nature reviews. Immunology · doi:10.1038/nri746 · Cited by 2,289

Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.

Carr, M. W., Roth, S. J., Luther, E., Rose, S. S., & Springer, T. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3652 · Cited by 1,198

Three or more routes for leukocyte migration into the central nervous system

Ransohoff, R. M., Kivisäkk, P., & Kidd, G. (2003) · Nature Reviews Immunology · doi:10.1038/nri1130 · Cited by 1,052

Interleukin-1 and neuronal injury

Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1664 · Cited by 992

Inflammatory response in acute traumatic brain injury: a double-edged sword

Morganti-Kossmann, M., Rancan, M., Stahel, P., & Kossmann, T. (2002) · Current Opinion in Critical Care · doi:10.1097/00075198-200204000-00002 · Cited by 702

Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog

Cacalano, G., Lee, J., Kikly, K. K., Ryan, A. M., Pitts-Meek, S., Hultgren, B., Wood, W. I., & Moore, M. W. (1994) · Science · doi:10.1126/science.8036519 · Cited by 663

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared

Ford, A. L., Goodsall, A. L., Hickey, W. F., & Sedgwick, J. D. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.9.4309 · Cited by 631

Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)

Izikson, L., Klein, R. S., Charo, I. F., Weiner, H. L., & Luster, A. D. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1075 · Cited by 584

Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis

Huang, D., Wang, J., Kivisäkk, P., Rollins, B. J., & Ransohoff, R. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.713 · Cited by 576

Salivary Cytokines as a Minimally-Invasive Measure of Immune Functioning in Young Children: Correlates of Individual Differences and Sensitivity to Laboratory Stress

Riis, J. L., Granger, D., DiPietro, J., Bandeen-Roche, K., & Johnson, S. B. (2015) · Developmental Psychobiology · doi:10.1002/dev.21271 · Cited by 62

The Protective Effect of Exercise in Neurodegenerative Diseases: The Potential Role of Extracellular Vesicles

Fuller, O. K., Whitham, M., Mathivanan, S., & Febbraio, M. A. (2020) · Cells · doi:10.3390/cells9102182 · Cited by 60

Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB−/− mouse model of neurodegeneration

Kyrkanides, S., Miller, A. W., Miller, J. H., Tallents, R. H., Brouxhon, S. M., Olschowka, M. E., O’Banion, M. K., & Olschowka, J. A. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.06.024 · Cited by 61

Effects of early-life adversity on immune function are mediated by prenatal environment: Role of prenatal alcohol exposure

Raineki, C., Bodnar, T. S., Holman, P. J., Baglot, S. L., Lan, N., & Weinberg, J. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.07.001 · Cited by 67

Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain

Choi, S.-H., Aïd, S., Choi, U., & Bosetti, F. (2009) · The Pharmacogenomics Journal · doi:10.1038/tpj.2009.68 · Cited by 57

Editor’s Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice

Martinez, E. M., Young, A. L., Patankar, Y. R., Berwin, B. L., Wang, L., von Herrmann, K. M., Weier, J. M., & Havrda, M. C. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx117 · Cited by 59

Cyclooxygenase‐1 mediates prostaglandin E2 elevation and contextual memory impairment in a model of sustained hippocampal interleukin‐1β expression

Matousek, S. B., Hein, A. M., Shaftel, S. S., Olschowka, J. A., Kyrkanides, S., & O’Banion, M. K. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06759.x · Cited by 55

An integrated cytokine and kynurenine network as the basis of neuroimmune communication

Stone, T. W., Clanchy, F. I. L., Huang, Y., Chiang, N., Darlington, L. G., & Williams, R. O. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1002004 · Cited by 57

A Protective Role for ELR+ Chemokines during Acute Viral Encephalomyelitis

Hosking, M., Liu, L., Ransohoff, R. M., & Lane, T. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000648 · Cited by 54

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

Michailidou, I., Jongejan, A., Vreijling, J. P., Georgakopoulou, T., de Wissel, M. B., Wolterman, R. A., Ruizendaal, P., Klar‐Mohamad, N., Grootemaat, A. E., Picavet, D. I., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0536-y · Cited by 55

The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis

Gharagozloo, M., Mahvelati, T. M., Imbeault, E., Gris, P., Zerif, E., Bobbala, D., Ilangumaran, S., Amrani, A., & Gris, D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0414-5 · Cited by 56

Effect of Immune Stress on Growth Performance and Immune Functions of Livestock: Mechanisms and Prevention

Niu, X., Ding, Y., Chen, S., Gooneratne, R., & Ju, X. (2022) · Animals · doi:10.3390/ani12070909 · Cited by 71

Glial Cell and Inflammatory Responses to Retinal Laser Treatment: Comparison of a Conventional Photocoagulator and a Novel, 3-Nanosecond Pulse Laser

Chidlow, G., Shibeeb, O., Plunkett, M. J., Casson, R. J., & Wood, J. P. M. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-11204 · Cited by 51

PARP 1 enhances inflammatory cytokine expression by alteration of promoter chromatin structure in microglia

Martínez‐Zamudio, R. I., & Ha, H. C. (2014) · Brain and Behavior · doi:10.1002/brb3.239 · Cited by 54

Protective Effects of Phyllanthus amarus Against Lipopolysaccharide-Induced Neuroinflammation and Cognitive Impairment in Rats

Alagan, A., Jantan, I., Kumolosasi, E., Ogawa, S., Abdullah, M. A., & Azmi, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00632 · Cited by 52

Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression

Godoy, M. C. P., Ferrari, C. C., & Pitossi, F. J. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.02.018 · Cited by 50

Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative Stress

Zhang, B., Wang, B., Cao, S.-H., & Wang, Y. (2015) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2015.19.6.491 · Cited by 49

MCP-1/CCR-2-double-deficiency severely impairs the migration of hematogenous inflammatory cells following transient cerebral ischemia in mice

Schuette-Nuetgen, K., Strecker, J., Minnerup, J., Ringelstein, E. B., & Schilling, M. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.12.011 · Cited by 51

Time‐dependent dual effect of NLRP3 inflammasome in brain ischaemia

Palomino‐Antolín, A., Narros‐Fernández, P., Farré‐Alins, V., Sevilla‐Montero, J., Decouty‐Pérez, C., López-Rodríguez, A. B., Fernández, N., Monge, L., Casas, A. I., Calzada, M. J., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15732 · Cited by 48

Neutralizing anti-interleukin-1β antibodies modulate fetal blood–brain barrier function after ischemia

Chen, X. F., Sadowska, G. B., Zhang, J., Kim, J.-E., Cummings, E. E., Bodge, C. A., Lim, Y., Makeyev, O., Besio, W. G., Gaitanis, J. N., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.09.007 · Cited by 47

β2-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations

Laureys, G., Gerlo, S., Spooren, A., Demol, F., Keyser, J. D., & Aerts, J. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-21 · Cited by 47

Effects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in AβPPswe-PS1dE9 Mice

Jansen, D., Zerbi, V., Arnoldussen, I. A. C., Wiesmann, M., Rijpma, A., Fang, X. T., Dederen, P. J. W. C., Mutsaers, M. P. C., Broersen, L. M., Lütjohann, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075393 · Cited by 47

Contribution of astrocytes to metabolic dysfunction in the Alzheimer’s disease brain

Zulfiqar, S., Garg, P., & Nieweg, K. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0140 · Cited by 46

Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's disease

Jha, D., Bakker, E. N. T. P., & Kumar, R. K. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15788 · Cited by 48

The Role of Interleukin-33 in Patients with Mild Cognitive Impairment and Alzheimer's Disease

Liang, C., Su, K., Tsai, C., Lee, J., Chu, C., Yeh, T., Su, M., Lin, G., Lin, Y., Chu, H., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00652-z · Cited by 48

Neuroinflammation and Mitochondrial Dysfunction Link Social Stress to Depression

Hollis, F., Pope, B. S., Gorman‐Sandler, E., & Wood, S. K. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_300 · Cited by 47

The Neuroinflammatory Response to Nanopatterning Parallel Grooves into the Surface Structure of Intracortical Microelectrodes

Ereifej, E. S., Smith, C. S., Meade, S. M., Chen, K., Feng, H., & Capadona, J. R. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201704420 · Cited by 45

P2Y receptors in Alzheimer's disease

Erb, L., Chen, C., Ajit, D., & Weisman, G. A. (2014) · Biology of the Cell · doi:10.1111/boc.201400043 · Cited by 45

Functional Neural–Bone Marrow Pathways

Zubcevic, J. A., Santisteban, M. M., Pitts, T. E., Baekey, D. M., Pérez, P. D., Bolser, D. C., Febo, M., & Raizada, M. K. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.02440 · Cited by 42

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Dean, P. T., & Hooks, S. B. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1116014 · Cited by 43

Tryptophan metabolism as a ‘reflex’ feature of neuroimmune communication: Sensor and effector functions for the indoleamine‐2, 3‐dioxygenase kynurenine pathway

Stone, T. W., & Williams, R. O. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16015 · Cited by 45

The influence of immunological stressors on traumatic brain injury

Sun, M., McDonald, S. J., Brady, R. D., O'Brien, T. J., & Shultz, S. R. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.01.007 · Cited by 41

Social stress during adolescence activates long-term microglia inflammation insult in reward processing nuclei

Rodríguez‐Arias, M., Montagud‐Romero, S., Carrión, A. M. G., Perez, C. F., Pérez‐Villalba, A., Marco, E. M., López‐Gallardo, M., Viveros, M., & Miñarro, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206421 · Cited by 42

Modulation of polymorphonuclear neutrophil functions by astrocytes

Xie, L., Poteet, E. C., Li, W., Scott, A. E., Liu, R., Wen, Y., Ghorpade, A., Simpkins, J. W., & Yang, S.-H. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-53 · Cited by 41

Up‐regulation and activation of the P2Y2 nucleotide receptor mediate neurite extension in IL ‐1β‐treated mouse primary cortical neurons

Peterson, T. S., Thebeau, C. N., Ajit, D., Camden, J. M., Woods, L. T., Wood, W. G., Petris, M. J., Sun, G. Y., Erb, L., & Weisman, G. A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12252 · Cited by 41

Cannabinoid receptor 2 is necessary to induce toll‐like receptor‐mediated microglial activation

Reusch, N., Ravichandran, K. A., Olabiyi, B. F., Komorowska‐Müller, J. A., Hansen, J. N., Ulas, T., Beyer, M., Zimmer, A., & Schmöle, A. (2021) · Glia · doi:10.1002/glia.24089 · Cited by 42

The role of spinal interleukin-1β and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model

Choi, H., Roh, D., Yoon, S. Y., Kwon, S.-G., Choi, S., Kang, S.-Y., Moon, J.-Y., Han, H. J., Kim, H., Beitz, A. J., et al. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.10.012 · Cited by 37

Role of Cytotoxic Protease Granzyme‐b in Neuronal Degeneration During Human Stroke

Chaitanya, G. V., Eeka, P., Munker, R., Alexander, J. S., & Babu, P. P. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00426.x · Cited by 36

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Xu, X., & Jiang, Y. (2014) · BioMed Research International · doi:10.1155/2014/807978 · Cited by 33

Remote neuroimmune signaling: a long-range mechanism of nociceptive network plasticity

Saab, C. Y., & Hains, B. C. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.11.004 · Cited by 34

Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease

Rivera-Escalera, F., Matousek, S. B., Ghosh, S., Olschowka, J. A., & O’Banion, M. K. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.018 · Cited by 34

Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation

Howerton, A. R., Roland, A. V., & Bale, T. L. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0118-14.2014 · Cited by 33

Dual impact of neuroinflammation on cognitive and motor impairments in Alzheimer's disease

Fakorede, S., Lateef, O. M., Garuba, W. A., Akosile, P. O., Okon, D. A., & Aborode, A. T. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251341870 · Cited by 40

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Clarkson, B. D. S., Héninger, E., Harris, M. G., Lee, J., Sándor, M., & Fábry, Z. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0106-3_18 · Cited by 32

Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

Yang, J., Wu, S., & He, M. (2025) · Exploration · doi:10.1002/exp.20240349 · Cited by 31

Caspase-6 Knockout in the 5xFAD Model of Alzheimer’s Disease Reveals Favorable Outcome on Memory and Neurological Hallmarks

Angel, A., Volkman, R., Royal, T. G., & Offen, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031144 · Cited by 30

Inflammation in Alzheimer’s Disease: Do Sex and APOE Matter?

Duarte‐Guterman, P., Initiative, O. B. O. T. A. D. N., Albert, A., Inkster, A. M., Barha, C. K., & Galea, L. A. M. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200982 · Cited by 31

Interleukin-1 β Accelerates the Onset of Stroke in Stroke-Prone Spontaneously Hypertensive Rats

Chiba, T., Itoh, T., Tabuchi, M., Nakazawa, T., & Satou, T. (2012) · Mediators of Inflammation · doi:10.1155/2012/701976 · Cited by 29

Cell-mediated drug delivery to the brain

Batrakova, E. V., & Kabanov, A. V. (2013) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(13)50061-x · Cited by 29

Requirement for interleukin‐1 to drive brain inflammation reveals tissue‐specific mechanisms of innate immunity

Giles, J. A., Greenhalgh, A. D., Davies, C. L., Dénes, Á., Shaw, T. N., Coutts, G., Rothwell, N. J., McColl, B. W., & Allan, S. M. (2014) · European Journal of Immunology · doi:10.1002/eji.201444748 · Cited by 29

Transfer of patient’s peripheral blood mononuclear cells (PBMCs) disrupts blood–brain barrier and induces anti-NMDAR encephalitis: a study of novel humanized PBMC mouse model

Shu, Y., Peng, F., Zhao, B., Liu, C., Li, Q., Li, H., Wang, Y., Jiang, Y., Lü, T., Wang, Q., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02844-4 · Cited by 32

NLRs as Helpline in the Brain: Mechanisms and Therapeutic Implications

Singh, S., & Jha, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0957-4 · Cited by 29

Immune and Imaging Correlates of Mild Cognitive Impairment Conversion to Alzheimer’s Disease

Rosa, F. L., Saresella, M., Baglio, F., Piancone, F., Marventano, I., Calabrese, E., Nemni, R., Ripamonti, E., Cabinio, M., & Clerici, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-16754-y · Cited by 26

Impact of Age on Plasma Inflammatory Biomarkers in the 6 Months Following Mild Traumatic Brain Injury

Thompson, H. J., Martha, S. R., Wang, J., & Becker, K. J. (2020) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000606 · Cited by 28

IL-1β-Induced Mesenchymal Stem Cell Migration Involves MLCK Activation via PKC Signaling

Lin, C., Zu, C.-H., Yang, C.-C., Tsai, P., Shyu, J., Chen, C., Weng, Z.-C., Chen, T.-H., & Wang, H.-S. (2015) · Cell Transplantation · doi:10.3727/096368914x685258 · Cited by 27

3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) disrupts blood-brain barrier integrity through a mechanism involving P2X7 receptors

Rubio‐Araiz, A., Pérez‐Hernández, M., Urrutia, A. A., Porcu, F., Borcel, É., Gutiérrez‐López, M. D., O’Shea, E., & Colado, M. I. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000145 · Cited by 27

Multifaceted roles of neuroinflammation: the need to consider both sides of the coin

Kielian, T. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13530 · Cited by 27

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

Swanton, T., Cook, J., Beswick, J. A., Freeman, S., Lawrence, C. B., & Brough, D. (2018) · SLAS DISCOVERY · doi:10.1177/2472555218786210 · Cited by 26

Human Umbilical Cord Blood Cells Have Trophic Effects on Young and Aging Hippocampal Neurons in Vitro.

Chen, N., Newcomb, J. D., Garbuzova-Davis, S. N., Sanberg, C. D., Sanberg, P. R., & Willing, A. E. (2010) · PubMed Central · Cited by 25

Behavioral, Structural and Molecular Changes following Long-term Hippocampal IL-1β Overexpression in Transgenic Mice

Hein, A. M., Zarcone, T. J., Parfitt, D. B., Matousek, S. B., Carbonari, D. M., Olschowka, J. A., & O’Banion, M. K. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9294-3 · Cited by 24

Indomethacin blocks the increased conditioned rewarding effects of cocaine induced by repeated social defeat

Perez, C. F., Escrivá‐Martínez, T., Montagud‐Romero, S., Ballestín, R., Reguilón, M. D., Miñarro, J., & Rodríguez‐Arias, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209291 · Cited by 24

Functional role for interleukin‐1 in the injured peripheral taste system

Shi, L., He, L., Sarvepalli, P., & McCluskey, L. P. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.22798 · Cited by 23

Microglial Heterogeneity and Its Potential Role in Driving Phenotypic Diversity of Alzheimer’s Disease

Sorrentino, S., Ascari, R., Maderna, E., Catania, M., Ghetti, B. F., Tagliavini, F., Giaccone, G., & Fede, G. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052780 · Cited by 23

Strain-specific susceptibility for neurodegeneration in a rat model of autoimmune optic neuritis

Sättler, M. B., Togni, M., Gadjanski, I., Sühs, K., Meyer, N., Bähr, M., & Diem, R. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.10.021 · Cited by 20

Recent Mechanisms of Neurodegeneration and Photobiomodulation in the Context of Alzheimer’s Disease

Su, M., Nizamutdinov, D., Liu, H., & Huang, J. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119272 · Cited by 26

Experimental pancreatitis results in increased blood‐brain barrier permeability in rats: A potential role of MCP‐1

Ding, Z., Jun, L. I. U., Lin, R., & Hou, X. H. (2011) · Journal of Digestive Diseases · doi:10.1111/j.1751-2980.2011.00568.x · Cited by 19

Correlation of mRNA Expression and Signal Variability in Chronic Intracortical Electrodes

Falcone, J., Carroll, S. L., Saxena, T. K., Mandavia, D., Clark, A., Yarabarla, V., & Bellamkonda, R. V. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00026 · Cited by 19

DNA methylation and gene expression of the chemokine (C-X-C motif) ligand 1 in patients with deficit and non-deficit schizophrenia

Zhou, C., Chen, J., Tang, X., Feng, X., Yu, M., Sha, W., Wang, X., Zhang, X., Yi, H., & Zhang, X. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.06.067 · Cited by 18

Production of IL-8, IL-17, IFN-gamma and IP-10 in human astrocytes correlates with alphavirus attenuation

Peng, B., Borisevich, V., Popov, V. L., Zacks, M. A., Estes, D. M., Campbell, G. A., & Paessler, S. (2013) · Veterinary Microbiology · doi:10.1016/j.vetmic.2012.11.021 · Cited by 17

In vivo administration of corticotropin-releasing hormone at remote intervals following ischemia enhances CA1 neuronal survival and recovery of spatial memory impairments: A role for opioid receptors

Charron, C., Fréchette, S., Proulx, G., & Plamondon, H. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.10.027 · Cited by 17

Blood-Brain Barrier Deterioration and Hippocampal Gene Expression in Polymicrobial Sepsis: An Evaluation of Endothelial MyD88 and the Vagus Nerve

Honig, G., Mader, S., Chen, H., Porat, A., Ochani, M., Wang, P., Volpe, B. T., & Diamond, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144215 · Cited by 18

Cooling Treatment Transiently Increases the Permeability of Brain Capillary Endothelial Cells Through Translocation of Claudin-5

Inamura, A., Adachi, Y., Inoue, T., He, Y., Tokuda, N., Nawata, T., Shirao, S., Nomura, S., Fujii, M., Ikeda, E., et al. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1066-4 · Cited by 17

Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice

Gyengési, E., Liang, H., Millington, C., Sonego, S., Sirijovski, D., Gunawardena, D., Dhananjayan, K., Venigalla, M., Niedermayer, G., & Münch, G. W. (2018) · Pharmaceutical Research · doi:10.1007/s11095-017-2326-9 · Cited by 16

Anti-neuroinflammatory effect of agaves and cantalasaponin-1 in a model of LPS-induced damage

Herrera-Ruiz, M. L., Jiménez‐Ferrer, E., Tortoriello, J., Zamilpa, A., Alegría-Herrera, E., Jiménez–Aparicio, A. R., Arenas-Ocampo, M. L., Martínez-Duncker, I., & Monterrosas‐Brisson, N. (2019) · Natural Product Research · doi:10.1080/14786419.2019.1608537 · Cited by 16

Cytokines and related signaling pathways in traumatic brain injury

Zhu, L., Huang, S., Chen, W., Li, K., & Sheng, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1738589 · Cited by 18

The Orchestra and Its Maestro: Shigella’s Fine-Tuning of the Inflammasome Platforms

Hermansson, A.-K., Paciello, I., & Bernardini, M. L. (2016) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-41171-2_5 · Cited by 17

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