Cited by 251Neuroinflammation and Neurodegeneration MechanismsGalectins and Cancer BiologyNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Galectin-3 Is Required for Resident Microglia Activation and Proliferation in Response to Ischemic Injury

Open access

Lalancette-Hébert, Mélanie, Swarup, Vivek, Beaulieu, Jean Martin, Bohacek, Ivan, Abdelhamid, Essam, Weng, Yuan Cheng, Sato, Sachiko, Kriz, Jasna·2012·The Journal of Neuroscience

DOI 10.1523/jneurosci.1498-12.2012PMC PMC6703730

Open this paper in CoChat — free account Open PDF

Abstract

Growing evidence suggests that galectin-3 is involved in fine tuning of the inflammatory responses at the periphery, however, its role in injured brain is far less clear. Our previous work demonstrated upregulation and coexpression of galectin-3 and IGF-1 in a subset of activated/proliferating microglial cells after stroke. Here, we tested the hypothesis that galectin-3 plays a pivotal role in mediating injury-induced microglial activation and proliferation. By using a galectin-3 knock-out mouse ( Gal-3KO ), we demonstrated that targeted disruption of the galectin-3 gene significantly alters microglia activation and induces ∼4-fold decrease in microglia proliferation. Defective microglia activation/proliferation was further associated with significant increase in the size of ischemic lesion, ∼2-fold increase in the number of apoptotic neurons, and a marked deregulation of the IGF-1 levels. Next, our results revealed that contrary to WT cells, the Gal3-KO microglia failed to proliferate in response to IGF-1. Moreover, the IGF-1-mediated mitogenic microglia response was reduced by N -glycosylation inhibitor tunicamycine while coimmunoprecipitation experiments revealed galectin-3 binding to IGF-receptor 1 (R1), thus suggesting that interaction of galectin-3 with the N -linked glycans of receptors for growth factors is involved in IGF-R1 signaling. While the canonical IGF-1 signaling pathways were not affected, we observed an overexpression of IL-6 and SOCS3, suggesting an overactivation of JAK/STAT3, a shared signaling pathway for IGF-1/IL-6. Together, our findings suggest that galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.1498-12.2012

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Cytokines and acute neurodegeneration
Allan, S. M., & Rothwell, N. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35094583 · Cited by 1,145
Interleukin-1 and neuronal injury
Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1664 · Cited by 992
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
Demetriou, M., Granovsky, M., Quaggin, S., & Dennis, J. W. (2001) · Nature · doi:10.1038/35055582 · Cited by 901
Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
Rabinovich, G. A., & Toscano, M. A. (2009) · Nature reviews. Immunology · doi:10.1038/nri2536 · Cited by 900
Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain
Lalancette-Hébert, M., Gowing, G., Simard, A., Weng, Y. C., & Kriz, J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5360-06.2007 · Cited by 874
Self-citation
Galectins: structure, function and therapeutic potential
Yang, R., Rabinovich, G. A., & Liu, F. (2008) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399408000719 · Cited by 862
SOCS Proteins: Negative Regulators of Cytokine Signaling
Krebs, D. L., & Hilton, D. J. (2001) · Stem Cells · doi:10.1634/stemcells.19-5-378 · Cited by 826
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
Beaulieu, J., Sotnikova, T. D., Yao, W., Kockeritz, L. K., Woodgett, J. R., Gainetdinov, R. R., & Caron, M. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307921101 · Cited by 815
Self-citation
Regulation of Cytokine Receptors by Golgi N-Glycan Processing and Endocytosis
Partridge, E. A., Le Roy, C., Di Guglielmo, G. M., Pawling, J., Cheung, P., Granovsky, M., Nabi, I. R., Wrana, J. L., & Dennis, J. W. (2004) · Science · doi:10.1126/science.1102109 · Cited by 735

Show all 65 references

Sorted by citations

Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed
Cherry, J. D., Olschowka, J. A., & O’Banion, M. K. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-98 · Cited by 1,748
Neuroinflammation: friend and foe for ischemic stroke
Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y., & Rosenberg, G. A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1516-2 · Cited by 1,479
The biphasic function of microglia in ischemic stroke
Ma, Y., Wang, J., Wang, Y., & Yang, G.-Y. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.005 · Cited by 655
Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke
Xiong, X., Liu, L., & Yang, Q. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.05.001 · Cited by 713
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
Holtman, I. R., Raj, D. D., Miller, J. A., Schaafsma, W., Yin, Z., Brouwer, N., Wes, P. D., Möller, T., Orre, M., Kamphuis, W., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0203-5 · Cited by 619
Neuroinflammation in the central nervous system: Symphony of glial cells
Yang, Q., & Zhou, J. (2018) · Glia · doi:10.1002/glia.23571 · Cited by 539
Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage
Taylor, R. A., & Sansing, L. H. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/746068 · Cited by 410
Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z
Sciacchitano, S., Lavra, L., Morgante, A., Ulivieri, A., Magi, F., Francesco, G. P. D., Bellotti, C., Salehi, L. B., & Rícci, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020379 · Cited by 387
Microglia-secreted Galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
Burguillos, M. A., Svensson, M., Schulte, T., Boza-Serrano, A., Garcia-Quintanilla, A., Kavanagh, E., Santiago, M., Viceconte, N., Oliva-Martin, M. J., Osman, A. M., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.012 · Cited by 365
Microglia: Agents of the CNS Pro-Inflammatory Response
Rodríguez-Gómez, J. A., Kavanagh, E., Engskog-Vlachos, P., Engskog, M. K. R., Herrera, A. J., Espinosa-Oliva, A. M., Joseph, B., Hajji, N., Venero, J. L., & Burguillos, M. A. (2020) · Cells · doi:10.3390/cells9071717 · Cited by 365
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
Boza-Serrano, A., Ruiz, R., Sanchez-Varo, R., García-Revilla, J., Yang, Y., Jimenez-Ferrer, I., Paulus, A., Wennström, M., Vilalta, A., Allendorf, D., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02013-z · Cited by 357
Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling
Crotti, A., & Ransohoff, R. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.013 · Cited by 323
Microglia and ischemic stroke: a double-edged sword.
Patel, A. R., Ritzel, R. M., McCullough, L. D., & Liu, F. (2013) · Europe PMC (PubMed Central) · Cited by 363
Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1–Dependent M1 Microglial Polarization
Wang, J., Zhao, H., Fan, Z., Li, G., Ma, Q., Tao, Z., Wang, R., Feng, J., & Luo, Y. (2017) · Stroke · doi:10.1161/strokeaha.117.017387 · Cited by 239
Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease
Siew, J. J., Chen, H., Chen, H., Chen, H.-L., Chen, C., Soong, B., Wu, Y., Chang, C., Chan, Y., Lin, C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11441-0 · Cited by 229
Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke
Mizuma, A., & Yenari, M. A. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00467 · Cited by 228
Phagocytic microglia and macrophages in brain injury and repair
Yu, F., Wang, Y., Stetler, R. A., Leak, R. K., Hu, X., & Chen, J. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13899 · Cited by 213
Toll-like receptors and their role in persistent pain
Lacagnina, M. J., Watkins, L. R., & Grace, P. M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.006 · Cited by 216
Brain pericytes acquire a microglial phenotype after stroke
Özen, Í., Deierborg, T., Miharada, K., Padel, T., Englund, E. M., Genové, G., & Paul, G. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1295-x · Cited by 204
Post-ischemic inflammation regulates neural damage and protection
Shichita, T., Ito, M., & Yoshimura, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00319 · Cited by 188
Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury
Piao, C.-S., Stoica, B. A., Wu, J., Sabirzhanov, B. E., Zhao, Z., Cabatbat, R. M., Loane, D. J., & Faden, A. I. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.017 · Cited by 178
Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice
Alawieh, A. M., Langley, E. F., & Tomlinson, S. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao6459 · Cited by 170
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
García-Revilla, J., Boza-Serrano, A., Espinosa-Oliva, A. M., Soto, M. S., Deierborg, T., Ruiz, R., de Pablos, R. M., Burguillos, M. A., & Venero, J. L. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05058-3 · Cited by 156
Microglia-mediated neuroinflammation and neuroplasticity after stroke
Wang, Y., Leak, R. K., & Cao, G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.980722 · Cited by 164
Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke
Lee, Y., Lee, S., Choi, S. S., Yeo, H.-G., Chang, K., & Lee, H. J. (2014) · BioMed Research International · doi:10.1155/2014/297241 · Cited by 149
Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration
Puigdellívol, M., Allendorf, D. H., & Brown, G. C. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00162 · Cited by 145
Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke
Kołosowska, N., Keuters, M. H., Wojciechowski, S., Keksa-Goldsteine, V., Laine, M. T., Malm, T., Goldsteins, G., Koıstınaho, J., & Dhungana, H. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00761-0 · Cited by 133
Neurobiology of microglial action in CNS injuries: Receptor-mediated signaling mechanisms and functional roles
Hu, X., Liou, A. K. F., Leak, R. K., Xu, M., An, C., Suenaga, J., Shi, Y., Gao, Y., Zheng, P., & Chen, J. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.06.002 · Cited by 139
Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs
Cerliani, J. P., Blidner, A. G., Toscano, M. A., Croci, D. O., & Rabinovich, G. A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.11.003 · Cited by 119
IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1
Gravel, M., Béland, L.-C., Soucy, G., Abdelhamid, E., Rahimian, R., Gravel, C., & Kriz, J. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0854-15.2016 · Cited by 117
Self-citation
Galectin-3 regulates microglial activation and promotes inflammation through TLR4/MyD88/NF-kB in experimental autoimmune uveitis
Liu, Y., Zhao, C., Meng, J., Li, N., Xu, Z., Liu, X., & Hou, S. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.108939 · Cited by 112
Ischemic conditioning-induced endogenous brain protection: Applications pre-, per- or post-stroke
Wang, Y., Reis, C., Applegate, R. L., Stier, G. R., Martin, R., & Zhang, J. H. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.009 · Cited by 116
Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury
Abcouwer, S. F., Shanmugam, S., Muthusamy, A., Lin, C., Kong, D., Hager, H. M., Liu, X., & Antonetti, D. A. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02237-5 · Cited by 108
Molecular pathophysiological mechanisms of ischemia/reperfusion injuries after recanalization therapy for acute ischemic stroke
Jurcău, A., & Ardelean, I. A. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2003078 · Cited by 106
Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease
Tan, Y., Zheng, Y., Xu, D., Sun, Z., Yang, H., & Yin, Q. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00592-7 · Cited by 100
Engineering an inhibitor-resistant human CSF1R variant for microglia replacement
Chadarevian, J. P., Lombroso, S. I., Peet, G. C., Hasselmann, J., Tu, C. H., Marzan, D. E., Capocchi, J. K., Purnell, F. S., Nemec, K. M., Lahian, A., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220857 · Cited by 101
The Diagnostic and Therapeutic Potential of Galectin-3 in Cardiovascular Diseases
Sygitowicz, G., Maciejak, A., & Sitkiewicz, D. (2021) · Biomolecules · doi:10.3390/biom12010046 · Cited by 97
Brain Response to Injuries: When Microglia Go Sexist
Rahimian, R., Cordeau, P., & Križ, J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.048 · Cited by 101
The role of Galectin-3 in ¿-synuclein-induced microglial activation
Boza‐Serrano, A., Reyes, J. F., Rey, N. L., Leffler, H., Bousset, L., Nilsson, U. J., Brundin, P., Venero, J. L., Burguillos, M. Á., & Deierborg, T. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0156-0 · Cited by 111
Delayed decompression exacerbates ischemia-reperfusion injury in cervical compressive myelopathy
Vidal, P. M., Karadimas, S. K., Ulndreaj, A., Laliberté, A. M., Tetreault, L. A., Forner, S., Wang, J., Foltz, W. D., & Fehlings, M. G. (2017) · JCI Insight · doi:10.1172/jci.insight.92512 · Cited by 99
Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases
Soares, L. C., Al‐Dalahmah, O., Hillis, J. M., Young, C. C., Asbed, I., Sakaguchi, M., O’Neill, E. E., & Szele, F. G. (2021) · Cells · doi:10.3390/cells10113047 · Cited by 96
Sex differences in brain protein expression and disease
Wingo, A. P., Liu, Y., Gerasimov, E. S., Vattathil, S. M., Liu, J., Cutler, D. J., Epstein, M. P., Blokland, G. A. M., Thambisetty, M., Troncoso, J. C., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02509-y · Cited by 94
The pleiotropic effects of galectin-3 in neuroinflammation: A review
Shin, T. (2013) · Acta Histochemica · doi:10.1016/j.acthis.2012.11.010 · Cited by 94
The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke
Liang, Z., Wu, G., Fan, C., Xu, J., Jiang, S., Yan, X., Di, S., Ma, Z., Hu, W., & Yang, Y. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.11.001 · Cited by 92
Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration
Ritzel, R. M., Li, Y., Jiao, Y., Lei, Z., Doran, S. J., He, J., Shahror, R. A., Henry, R. J., Khan, R., Tan, C., et al. (2023) · Science Advances · doi:10.1126/sciadv.add1101 · Cited by 90
Diverging mRNA and Protein Networks in Activated Microglia Reveal SRSF3 Suppresses Translation of Highly Upregulated Innate Immune Transcripts
Boutej, H., Rahimian, R., Thammisetty, S. S., Béland, L., Lalancette–Hébert, M., & Križ, J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.058 · Cited by 96
Self-citation
Modified Citrus Pectin Prevents Blood-Brain Barrier Disruption in Mouse Subarachnoid Hemorrhage by Inhibiting Galectin-3
Nishikawa, H., Liu, L., Nakano, F., Kawakita, F., Kanamaru, H., Nakatsuka, Y., Okada, T., & Suzuki, H. (2018) · Stroke · doi:10.1161/strokeaha.118.021757 · Cited by 90
Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury
Bohaček, I., Cordeau, P., Lalancette–Hébert, M., Gorup, D., Weng, Y.-C., Gajović, S., & Križ, J. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-191 · Cited by 89
Self-citation
A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain
Zhan, L., Fan, L., Kodama, L., Sohn, P., Wong, M. Y., Mousa, G. A., Zhou, Y., Li, Y., & Gan, L. (2020) · eLife · doi:10.7554/elife.51796 · Cited by 80
Resident microglia, rather than blood‐derived macrophages, contribute to the earlier and more pronounced inflammatory reaction in the immature compared with the adult hippocampus after hypoxia‐ischemia
Umekawa, T., Osman, A. M., Han, W., Ikeda, T., & Blomgren, K. (2015) · Glia · doi:10.1002/glia.22887 · Cited by 86
Galectin-3: mediator of microglia responses in injured brain
Rahimian, R., Béland, L., & Križ, J. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.11.004 · Cited by 83
Riluzole attenuates neuropathic pain and enhances functional recovery in a rodent model of cervical spondylotic myelopathy
Moon, E. S., Karadimas, S. K., Yu, W., Austin, J. W., & Fehlings, M. G. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.020 · Cited by 78
Galectin-3: Roles in Neurodevelopment, Neuroinflammation, and Behavior
Srejovic, I. M., Selaković, D., Jovicic, N. U., Jakovljevic, V. L., Lukić, M. L., & Rosic, G. L. (2020) · Biomolecules · doi:10.3390/biom10050798 · Cited by 77
Galectin-3-Mediated Glial Crosstalk Drives Oligodendrocyte Differentiation and (Re)myelination
Thomas, L., & Pasquini, L. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00297 · Cited by 76
IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia
Rivera-Escalera, F., Pinney, J. J., Owlett, L., Ahmed, H., Thakar, J., Olschowka, J. A., Elliott, M. R., & O’Banion, M. K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1645-7 · Cited by 75
Complement Drives Synaptic Degeneration and Progressive Cognitive Decline in the Chronic Phase after Traumatic Brain Injury
Alawieh, A. M., Chalhoub, R., Mallah, K., Langley, E. F., York, M., Broome, H., Couch, C., Adkins, D. L., & Tomlinson, S. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1734-20.2020 · Cited by 74
Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats
Nikodémová, M., Small, A. L., Smith, S. M. C., Mitchell, G. S., & Watters, J. J. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.009 · Cited by 76
Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder
Rahimian, R., Belliveau, C., Chen, R., & Mechawar, N. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.871997 · Cited by 77
Regulation of microglia polarization after cerebral ischemia
Wang, H., Li, J., Zhang, H., Wang, M., Xiao, L., Wang, Y., & Cheng, Q. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1182621 · Cited by 81
Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination
Hoyos, H. C., Rinaldi, M., Méndez‐Huergo, S. P., Marder, M., Rabinovich, G. A., Pasquini, J. M., & Pasquini, L. A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.023 · Cited by 79
Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage
Li, T., Zhao, J., Xie, W., Yuan, W., Guo, J., Pang, S., Gan, W.-B., Gómez-Nicola, D., & Zhang, S. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02127-w · Cited by 72
The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu
Huuskonen, M., Tuo, Q.-Z., Loppi, S., Dhungana, H., Korhonen, P., McInnes, L. E., Donnelly, P., Grubman, A., Wojciechowski, S., Lejavová, K., et al. (2017) · Neurotherapeutics · doi:10.1007/s13311-016-0504-9 · Cited by 66
Galectin‐3: an emerging biomarker in stroke and cerebrovascular diseases
Venkatraman, A., Hardas, S., Patel, N., Bajaj, N. S., Arora, G., & Arora, P. K. (2017) · European Journal of Neurology · doi:10.1111/ene.13496 · Cited by 70
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions
OʼShea, T. M., Wollenberg, A. L., Kim, J. H., Ao, Y., Deming, T. J., & Sofroniew, M. V. (2020) · Nature Communications · doi:10.1038/s41467-020-19906-3 · Cited by 70
Galectin-3 enhances angiogenic and migratory potential of microglial cells via modulation of integrin linked kinase signaling
Wesley, U. V., Vemuganti, R., Ayvaci, E. R., & Dempsey, R. J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.12.008 · Cited by 70
Neuroinflammatory responses in experimental and human stroke lesions
Wimmer, I., Zrzavy, T., & Lassmann, H. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.07.003 · Cited by 73
Calycosin Preserves BDNF/TrkB Signaling and Reduces Post-Stroke Neurological Injury after Cerebral Ischemia by Reducing Accumulation of Hypertrophic and TNF-α-Containing Microglia in Rats
Hsu, C., Kuo, T., Liu, W., Chang, C., & Lin, H. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09903-9 · Cited by 68
Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins
McCormick, S. M., & Heller, N. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00549 · Cited by 69
Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice
Mamun, A. A., Chauhan, A., Yu, H., Xu, Y., Sharmeen, R., & Liu, F. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13778 · Cited by 66
Role for microglia in sex differences after ischemic stroke: importance of M2
Bodhankar, S., Lapato, A. S., Chen, Y., Vandenbark, A. A., Saugstad, J. A., & Offner, H. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9714-9 · Cited by 65
Reformulating Pro-Oxidant Microglia in Neurodegeneration
García‐Revilla, J., Alonso-Bellido, I. M., Burguillos, M. Á., Herrera, A. J., Espinosa‐Oliva, A. M., Ruiz, R., Cruz-Hernández, L., García-Domínguez, I., Roca-Ceballos, M. A., Santiago, M., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101719 · Cited by 66
Galectin-3 Inhibition Is Associated with Neuropathic Pain Attenuation after Peripheral Nerve Injury
Ma, Z., Han, Q., Wang, X., Ai, Z., & Zheng, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148792 · Cited by 63
Galectin-3 protects against ischemic stroke by promoting neuro-angiogenesis via apoptosis inhibition and Akt/Caspase regulation
Wesley, U. V., Sutton, I. C., Cunningham, K., Jaeger, J. W., Phan, A. Q., Hatcher, J. F., & Dempsey, R. J. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20931137 · Cited by 60
Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage
Thammisetty, S. S., Pedragosa, J., Weng, Y. C., Calon, F., Planas, A. M., & Križ, J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1350-y · Cited by 61
Self-citation
Molecular imaging of nestin in neuroinflammatory conditions reveals marked signal induction in activated microglia
Krishnasamy, S., Weng, Y.-C., Thammisetty, S. S., Phaneuf, D., Lalancette–Hébert, M., & Križ, J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0816-7 · Cited by 59
Self-citation
The myth of the immature barrier systems in the developing brain: role in perinatal brain injury
Mallard, C. E., Ek, C. J., & Vexler, Z. S. (2018) · The Journal of Physiology · doi:10.1113/jp274938 · Cited by 63
Resident Microglia Activate before Peripheral Monocyte Infiltration and p75NTR Blockade Reduces Microglial Activation and Early Brain Injury after Subarachnoid Hemorrhage
Xu, Z., Shi, W., Xu, L., Shao, M., Chen, Z.-P., Zhu, G.-C., & Hou, Q. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00298 · Cited by 59
Microglial Lectins in Health and Neurological Diseases
Siew, J. J., & Chern, Y. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00158 · Cited by 63
Microglia as therapeutic target in central nervous system disorders
Fatoba, O., Itokazu, T., & Yamashita, T. (2020) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2020.07.004 · Cited by 57
Dual-function hydrogels with sequential release of GSK3β inhibitor and VEGF inhibit inflammation and promote angiogenesis after stroke
Liu, Y., Zhang, F., Long, L., Li, J., Liu, Z., Hu, C., Chen, X., Zan, X., Xu, J., & Wang, Y. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.133671 · Cited by 56
Galectins and Neuroinflammation
Chen, H.-L., Liao, F., Lin, T., & Liu, F. (2014) · Advances in neurobiology · doi:10.1007/978-1-4939-1154-7_24 · Cited by 58
The Role of the Microglial Cx3cr1 Pathway in the Postnatal Maturation of Retinal Photoreceptors
Jobling, A. I., Waugh, M., Vessey, K. A., Phipps, J. A., Trogrlic, L., Greferath, U., Mills, S. A., Tan, Z. L., Ward, M. M., & Fletcher, E. L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2368-17.2018 · Cited by 55
Regulation of microglia population dynamics throughout development, health, and disease
Hammond, B. P., Manek, R., Kerr, B. J., Macauley, M. S., & Plemel, J. R. (2021) · Glia · doi:10.1002/glia.24047 · Cited by 63
Galectins in epithelial functions
Viguier, M., Advedissian, T., Delacour, D., Poirier, F., & Deshayes, F. (2014) · Tissue Barriers · doi:10.4161/tisb.29103 · Cited by 51
Role of galectin-3 in plasma as a predictive biomarker of outcome after acute intracerebral hemorrhage
Yan, X.-J., Yu, G., Jie, Y., Fan, X., Huang, Q., & Dai, W.-M. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.06.071 · Cited by 51
Delayed Galectin-3-Mediated Reprogramming of Microglia After Stroke is Protective
Rahimian, R., Lively, S. S., Abdelhamid, E., Lalancette–Hébert, M., Schlichter, L. C., Sato, S., & Križ, J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1527-0 · Cited by 51
Self-citation
Green Tea Catechin Prevents Hypoxia/Reperfusion-Evoked Oxidative Stress-Regulated Autophagy-Activated Apoptosis and Cell Death in Microglial Cells
Chen, C.-M., Wu, C.-T., Yang, T.-H., Chang, Y.-A., Sheu, M.-L., & Liu, S. H. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b01513 · Cited by 50
Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration
Tabel, M., Wolf, A., Szczepan, M., Xu, H., Jägle, H., Moehle, C., Chen, M., & Langmann, T. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02589-6 · Cited by 51
Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll‐Like Receptor 4 to Lipid Rafts
Xue, J., Yu, Y., Zhang, X., Zhang, C., Zhao, Y., Liu, B., Zhang, L., Wang, L., Chen, R., Gao, X., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012885 · Cited by 50
Possible Role of Inflammation and Galectin-3 in Brain Injury after Subarachnoid Hemorrhage
Nishikawa, H., & Suzuki, H. (2018) · Brain Sciences · doi:10.3390/brainsci8020030 · Cited by 49
Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease
Chagas, L. D. S., Sandre, P. C., Ribeiro, N. C. A. R. E., Marcondes, H., Silva, P. O., Savino, W., & Serfaty, C. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062111 · Cited by 53
Stroke Neuroprotection: Oestrogen and Insulin‐Like Growth Factor ‐1 Interactions and the Role of Microglia
Sohrabji, F., & Williams, M. H. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12059 · Cited by 51
Properties of Glial Cell at the Neuromuscular Junction Are Incompatible with Synaptic Repair in the SOD1 G37R ALS Mouse Model
Martineau, É., Arbour, D., Vallée, J., & Robitaille, R. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1748-18.2020 · Cited by 49
Microglia/Macrophage-Derived Inflammatory Mediators Galectin-3 and Quinolinic Acid are Elevated in Cerebrospinal Fluid from Newborn Infants After Birth Asphyxia
Sävman, K., Heyes, M. P., Svedin, P., & Karlsson, A. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0216-3 · Cited by 47
Barrier mechanisms in neonatal stroke
Kratzer, I., Chip, S., & Vexler, Z. S. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00359 · Cited by 47
IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis
Borovčanin, M., Janicijevic, S. M., Jovanović, I., Gajović, N., Arsenijević, N., & Lukić, M. L. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00271 · Cited by 45
Pivotal role of innate myeloid cells in cerebral post-ischemic sterile inflammation
Tsuyama, J., Nakamura, A., Ooboshi, H., Yoshimura, A., & Shichita, T. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0707-8 · Cited by 45
Microglia‐derived galectin‐3 in neuroinflammation; a bittersweet ligand?
Rahimian, R., Béland, L., Sato, S., & Križ, J. (2021) · Medicinal Research Reviews · doi:10.1002/med.21784 · Cited by 44
Self-citation
Increased Plasma Galectin-3 Preceding the Development of Delayed Cerebral Infarction and Eventual Poor Outcome in Non-Severe Aneurysmal Subarachnoid Hemorrhage
pSEED group, Nishikawa, H., Nakatsuka, Y., Shiba, M., Kawakita, F., Fujimoto, M., & Suzuki, H. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0564-0 · Cited by 43
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia
Shi, H., Yin, Z., Koronyo, Y., Fuchs, D.-T. S., Sheyn, J., Davis, M. R., Wilson, J. W., Margeta, M. A., Pitts, K. M., Herron, S., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01439-z · Cited by 45

Authors: Lalancette-Hébert, M., Swarup, V., Beaulieu, J. M., Bohacek, I., Abdelhamid, E., Weng, Y. C., Sato, S., & Kriz, J.
Affiliations: Centre hospitalier de l'Université Laval (CA)
Université Laval (CA)
ORCID: Beaulieu, Jean Martin
Sato, Sachiko
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2012-07-25
Volume: 32
Issue: 30
Pages: 10383-10395
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1498-12.2012
PMC: PMC6703730
OpenAlex: W2140635355
Cited by: 251
References: 65
Citations by year: 2026: 7 · 2025: 7 · 2024: 10 · 2023: 19 · 2022: 23 · 2021: 32 · 2020: 21 · 2019: 19 · 2018: 24 · 2017: 18 · 2016: 22 · 2015: 21 · 2014: 12 · 2013: 11 · 2012: 4
FWCI: 7.73
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Heart and Stroke Foundation of Canada
Canadian Institutes of Health Research
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: galectin-3, microglial activation, microglial proliferation, ischemic stroke, ischemic injury, insulin-like growth factor I, IGF-1 receptor, N-glycosylation, tunicamycin, JAK/STAT3 signaling, interleukin-6, SOCS3, neuronal apoptosis
MeSH terms: Animals, Brain, Cells, Cultured, Brain Ischemia, Insulin-Like Growth Factor I, Macrophages, Signal Transduction, Interleukin-6, Up-Regulation, Microglia, Mice, Knockout, Galectin 3, Cell Proliferation, STAT3 Transcription Factor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Galectin-3 Is Required for Resident Microglia Activation and Proliferation in Response to Ischemic Injury

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks