Cited by 284Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityEating Disorders and Behaviors

A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine

Avena, N.M., Hoebel, B.G.·2003·Neuroscience

Abstract

Previous research in this laboratory has shown that a diet of intermittent excessive sugar consumption produces a state with neurochemical and behavioral similarities to drug dependency. The present study examined whether female rats on various regimens of sugar access would show behavioral cross-sensitization to a low dose of amphetamine. After a 30-min baseline measure of locomotor activity (day 0), animals were maintained on a cyclic diet of 12-h deprivation followed by 12-h access to 10% sucrose solution and chow pellets (12 h access starting 4 h after onset of the dark period) for 21 days. Locomotor activity was measured again for 30 min at the beginning of days 1 and 21 of sugar access. Beginning on day 22, all rats were maintained on ad libitum chow. Nine days later locomotor activity was measured in response to a single low dose of amphetamine (0.5 mg/kg). The animals that had experienced cyclic sucrose and chow were hyperactive in response to amphetamine compared with four control groups (ad libitum 10% sucrose and chow followed by amphetamine injection, cyclic chow followed by amphetamine injection, ad libitum chow with amphetamine, or cyclic 10% sucrose and chow with a saline injection). These results suggest that a diet comprised of alternating deprivation and access to a sugar solution and chow produces bingeing on sugar that leads to a long lasting state of increased sensitivity to amphetamine, possibly due to a lasting alteration in the dopamine system.

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Crossref · 10.1016/s0306-4522(03)00502-5

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Authors
Avena, N. M., & Hoebel, B. G.
Affiliations
Princeton University (US)
Corresponding author
Hoebel, B.G.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2003-11
Volume
122
Issue
1
Pages
17-20
ISSN
0306-4522 (ISSN-L)
OpenAlex
W2095178182
Cited by
284
References
43
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 15 · 2020: 15 · 2019: 12 · 2018: 17 · 2017: 14 · 2016: 12 · 2015: 18 · 2014: 19 · 2013: 11 · 2012: 24
FWCI
3.13
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH65024, R21MH065024)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
binge eating, amphetamine, locomotor activity, dopaminergic system, sucrose, female rats
MeSH terms
Amphetamine, Central Nervous System Stimulants, Animals, Behavior, Animal, Female, Hyperkinesis, Locomotion, Sucrose, Dopamine Agents, Rats, Sprague-Dawley, Substance-Related Disorders, Amphetamine-Related Disorders, Rats

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