A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine
Abstract
Previous research in this laboratory has shown that a diet of intermittent excessive sugar consumption produces a state with neurochemical and behavioral similarities to drug dependency. The present study examined whether female rats on various regimens of sugar access would show behavioral cross-sensitization to a low dose of amphetamine. After a 30-min baseline measure of locomotor activity (day 0), animals were maintained on a cyclic diet of 12-h deprivation followed by 12-h access to 10% sucrose solution and chow pellets (12 h access starting 4 h after onset of the dark period) for 21 days. Locomotor activity was measured again for 30 min at the beginning of days 1 and 21 of sugar access. Beginning on day 22, all rats were maintained on ad libitum chow. Nine days later locomotor activity was measured in response to a single low dose of amphetamine (0.5 mg/kg). The animals that had experienced cyclic sucrose and chow were hyperactive in response to amphetamine compared with four control groups (ad libitum 10% sucrose and chow followed by amphetamine injection, cyclic chow followed by amphetamine injection, ad libitum chow with amphetamine, or cyclic 10% sucrose and chow with a saline injection). These results suggest that a diet comprised of alternating deprivation and access to a sugar solution and chow produces bingeing on sugar that leads to a long lasting state of increased sensitivity to amphetamine, possibly due to a lasting alteration in the dopamine system.
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Cross-sensitization and the resulting hyper-responsivity of dopaminergic systems also occurs between drugs of abuse and natural rewards.
“Cross-sensitization and the resulting hyper-responsivity of dopaminergic systems also occurs between drugs of abuse and natural rewards (Avena & Hoebel, 2003)”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Avena & Hoebel, 2003
Cites
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953 · see citing works
Molecular and Cellular Basis of Addiction
Nestler, E. J., & Aghajanian, G. K. (1997) · Science · doi:10.1126/science.278.5335.58 · Cited by 1,315 · see citing works
Hernandez, L., & Hoebel, B. G. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90036-7 · Cited by 627 · see citing works
Self-citationEvidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence
Colantuoni, C., Rada, P. V., McCarthy, J., Patten, C. S., Avena, N. M., Chadeayne, A., & Hoebel, B. G. (2002) · Obesity Research · doi:10.1038/oby.2002.66 · Cited by 544 · see citing works
Self-citationExcessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain
Colantuoni, C., Schwenker, J., McCarthy, J., Rada, P., Ladenheim, B., Cadet, J.-L., Schwartz, G. J., Moran, T. H., & Hoebel, B. G. (2001) · Neuroreport · doi:10.1097/00001756-200111160-00035 · Cited by 471 · see citing works
Self-citationMorley, J. E., Levine, A. S., Yim, G. K. W., & Lowy, M. T. (1983) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(83)90020-9 · Cited by 453 · see citing works
Wyvell, C. L., & Berridge, K. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07831.2001 · Cited by 436 · see citing works
Norepinephrine-Dopamine Interactions and Behavior
Antelman, S. M., & Caggiula, A. R. (1977) · Science · doi:10.1126/science.841304 · Cited by 411 · see citing works
Henry, D. J., & White, F. J. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20496-7 · Cited by 365 · see citing works
Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens
Hernandez, L., & Hoebel, B. G. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90324-1 · Cited by 355 · see citing works
Self-citationKalivas, P. W., & Weber, B. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24103-9 · Cited by 334 · see citing works
Repeated social-defeat stress, cocaine or morphine
Covington, H. E., & Miczek, K. A. (2001) · Psychopharmacology · doi:10.1007/s002130100858 · Cited by 326 · see citing works
Taste responses and preferences for sweet high-fat foods: Evidence for opioid involvement☆
Drewnowski, A., Krahn, D. D., Demitrack, M. A., NAIRN, K., & Gosnell, B. A. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90155-u · Cited by 286 · see citing works
Pierce, R. C., & Kalivas, P. W. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12090-9 · Cited by 249 · see citing works
Henry, D., & White, F. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06287.1995 · Cited by 223 · see citing works
(1995) · PubMed · Cited by 208 · see citing works
Tanda, G., & Chiara, G. D. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00135.x · Cited by 197 · see citing works
Salamone, J. D., Cousins, M. S., McCullough, L. D., Carriero, D. L., & Berkowitz, R. J. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90452-9 · Cited by 196 · see citing works
Naltrexone suppresses hyperphagia induced in the rat by a highly palatable diet
Apfelbaum, M., & Mandenoff, A. (1981) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(81)90344-0 · Cited by 186 · see citing works
Opioids and consummatory behavior
Levine, A. S., Morley, J. E., Gosnell, B. A., Billington, C. J., & Bartness, T. J. (1985) · Brain Research Bulletin · doi:10.1016/0361-9230(85)90116-9 · Cited by 180 · see citing works
Avena, N. M., & Hoebel, B. G. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)01050-x · Cited by 170 · see citing works
Self-citationFiorino, D. F., & Phillips, A. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00456.1999 · Cited by 170 · see citing works
Radhakishun, F. S., van Ree, J. M., & Westerink, B. H. C. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90591-5 · Cited by 164 · see citing works
Buspirone augmentation of fluoxetine in patients with obsessive compulsive disorder.
Mitchell, J. E., Specker, S. M., & de Zwaan, M. (1991) · PubMed · Cited by 145 · see citing works
Itzhak, Y., & Martin, J. L. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01260-8 · Cited by 125 · see citing works
The role of the endogenous opiates as regulators of appetite
Morley, J., & Levine, A. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/35.4.757 · Cited by 118 · see citing works
Lee, S., Lee, A. M., Leung, T. Y. S., & Yu, H. H. (1997) · International Journal of Eating Disorders · doi:10.1002/(sici)1098-108x(199703)21:2 · Cited by 117 · see citing works
Fiorino, D. F., & Phillips, A. G. (1999) · Psychopharmacology · doi:10.1007/s002130050880 · Cited by 110 · see citing works
Nocjar, C., & Panksepp, J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00321-7 · Cited by 106 · see citing works
Behavioral sensitization to heroin by cannabinoid pretreatment in the rat
Pontieri, F. E., Monnazzi, P., Scontrini, A., Buttarelli, F. R., & Patacchioli, F. R. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01056-1 · Cited by 85 · see citing works
DeSousa, N. J., Bush, D. E. A., & Vaccarino, F. J. (2000) · Psychopharmacology · doi:10.1007/s002130050024 · Cited by 71 · see citing works
Prasad, B. M., Ulibarri, C., & Sorg, B. A. (1998) · Psychopharmacology · doi:10.1007/s002130050535 · Cited by 68 · see citing works
Bakshi, V. P., & Kelley, A. E. (1994) · Brain Research · doi:10.1016/0006-8993(94)91139-8 · Cited by 68 · see citing works
Schenk, S., Snow, S., & Horger, B. A. (1991) · Psychopharmacology · doi:10.1007/bf02244075 · Cited by 68 · see citing works
Greenberg, B. D., & Segal, D. S. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90137-6 · Cited by 66 · see citing works
Impérato, A., Obinu, M. C., Carta, G., Mascia, M. S., Casu, M. A., & Gessa, G. L. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00742-x · Cited by 44 · see citing works
Sills, T. L., & Vaccarino, F. J. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(96)00024-x · Cited by 35 · see citing works
Weiss, F., Impérato, A., Casu, M. A., Mascia, M. S., & Gessa, G. L. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01264-8 · Cited by 34 · see citing works
Vitale, M. A., Chen, D., & Kanarek, R. B. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)01034-1 · Cited by 28 · see citing works
Effect of the Dopaminergic Neurotoxin MPTP on Cocaine-Induced Locomotor Sensitization
Itzhak, Y., Martin, J. L., Black, M. D., & Ali, S. F. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00246-9 · Cited by 24 · see citing works
Flagged first, then by citations
2 of the 43 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Is there a common molecular pathway for addiction?
Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388 · see citing works
Preliminary validation of the Yale Food Addiction Scale
Gearhardt, A. N., Corbin, W. R., & Brownell, K. D. (2009) · Appetite · doi:10.1016/j.appet.2008.12.003 · Cited by 1,369 · see citing works
Avena, N. M., Rada, P., & Hoebel, B. G. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.019 · Cited by 1,358 · see citing works
Self-citation“Liking” and “wanting” food rewards: Brain substrates and roles in eating disorders
Berridge, K. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.044 · Cited by 1,147 · see citing works
The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders
Berridge, K. C., Ho, C.-Y., Richard, J. M., & DiFeliceantonio, A. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.003 · Cited by 873 · see citing works
Evidence that ‘food addiction’ is a valid phenotype of obesity
Davis, C. A., Curtis, C., Levitan, R. D., Carter, J. C., Kaplan, A. S., & Kennedy, J. L. (2011) · Appetite · doi:10.1016/j.appet.2011.08.017 · Cited by 539 · see citing works
Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell
Rada, P. V., Avena, N. M., & Hoebel, B. G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.043 · Cited by 542 · see citing works
Self-citation(2013) · PubMed · Cited by 538 · see citing works
Compulsive overeating as an addiction disorder. A review of theory and evidence
Davis, C. A., & Carter, J. C. (2009) · Appetite · doi:10.1016/j.appet.2009.05.018 · Cited by 479 · see citing works
Gearhardt, A. N., Corbin, W. R., & Brownell, K. D. (2009) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e318193c993 · Cited by 436 · see citing works
Sugar and Fat Bingeing Have Notable Differences in Addictive-like Behavior
Avena, N. M., Rada, P., & Hoebel, B. G. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.097584 · Cited by 388 · see citing works
Self-citation“Liking” and “wanting” in eating and food reward: Brain mechanisms and clinical implications
Morales, I., & Berridge, K. C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113152 · Cited by 346 · see citing works
Natural rewards, neuroplasticity, and non-drug addictions
Olsen, C. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.010 · Cited by 339 · see citing works
Caffeine use in children: What we know, what we have left to learn, and why we should worry
Temple, J. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.001 · Cited by 328 · see citing works
Feeding and reward: Perspectives from three rat models of binge eating
Corwin, R. L., Avena, N. M., & Boggiano, M. M. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.041 · Cited by 289 · see citing works
Self-citationAvena, N. M., Bocarsly, M. E., Rada, P., Kim, A., & Hoebel, B. G. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.01.008 · Cited by 277 · see citing works
Self-citationThe impact of sugar consumption on stress driven, emotional and addictive behaviors
Jacques, A., Chaaya, N., Beecher, K., Ali, S. A., Belmer, A., & Bartlett, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.021 · Cited by 271 · see citing works
Roles of "wanting" and "liking" in motivating behavior: gambling, food, and drug addictions
Robinson, M. J. F., Fischer, A. M., Ahuja, A., Lesser, E. N., & Maniates, H. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_387 · Cited by 247 · see citing works
The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction
Dileone, R., Taylor, J. R., & Picciotto, M. R. (2012) · Nature Neuroscience · doi:10.1038/nn.3202 · Cited by 244 · see citing works
Leeman, R. F., & Potenza, M. N. (2013) · The Canadian Journal of Psychiatry · doi:10.1177/070674371305800503 · Cited by 235 · see citing works
Avena, N. M., Long, K. A., & Hoebel, B. G. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.12.016 · Cited by 215 · see citing works
Self-citationIs Food Addictive? A Review of the Science
Gearhardt, A. N., & LaFata, E. M. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-110420-111710 · Cited by 222 · see citing works
Sensory processing in the brain related to the control of food intake
Rolls, E. T. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005332 · Cited by 210 · see citing works
Avena, N. M., Rada, P. V., Moise, N., & Hoebel, B. G. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.12.037 · Cited by 195 · see citing works
Self-citationTaste, olfactory and food texture reward processing in the brain and obesity
Rolls, E. T. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.155 · Cited by 186 · see citing works
Chronic food restriction: Enhancing effects on drug reward and striatal cell signaling
Carr, K. D. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.09.021 · Cited by 180 · see citing works
Accumbens dopamine-acetylcholine balance in approach and avoidance
Hoebel, B. G., Avena, N. M., & Rada, P. V. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.014 · Cited by 178 · see citing works
Self-citationDopamine and binge eating behaviors
Bello, N. T., & Hajnal, A. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.04.016 · Cited by 177 · see citing works
Reward systems and food intake: role of opioids
Gosnell, B. A., & Levine, A. S. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.73 · Cited by 173 · see citing works
Bariatric surgery-induced weight loss causes remission of food addiction in extreme obesity
Pepino, M. Y., Stein, R. I., Eagon, J. C., & Klein, S. (2014) · Obesity · doi:10.1002/oby.20797 · Cited by 172 · see citing works
Davis, C. A. (2013) · Current Obesity Reports · doi:10.1007/s13679-013-0049-8 · Cited by 172 · see citing works
Elman, I., Borsook, D., & Lukas, S. E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301051 · Cited by 169 · see citing works
LaFata, E. M., Potenza, M. N., & Gearhardt, A. N. (2016) · Appetite · doi:10.1016/j.appet.2016.10.033 · Cited by 159 · see citing works
Hoebel, B. G., Avena, N. M., Bocarsly, M. E., & Rada, P. V. (2009) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e31819aa621 · Cited by 159 · see citing works
Self-citationSugar-dependent rats show enhanced intake of unsweetened ethanol
Avena, N. M., Carrillo, C. A., Needham, L., Leibowitz, S. F., & Hoebel, B. G. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.09.006 · Cited by 149 · see citing works
Self-citationUnderstanding the mechanisms of food intake and obesity
Rolls, E. T. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2007.00321.x · Cited by 148 · see citing works
The Emotional Impact of Obesity on Children
Cornette, R. E. (2008) · Worldviews on Evidence-Based Nursing · doi:10.1111/j.1741-6787.2008.00127.x · Cited by 149 · see citing works
A Qualitative Study of Binge Eating and Obesity From an Addiction Perspective
Curtis, C., & Davis, C. A. (2013) · Eating Disorders · doi:10.1080/10640266.2014.857515 · Cited by 148 · see citing works
Taste, olfactory and food texture reward processing in the brain and the control of appetite
Rolls, E. T. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000821 · Cited by 149 · see citing works
From Passive Overeating to “Food Addiction”: A Spectrum of Compulsion and Severity
Davis, C. A. (2013) · ISRN Obesity · doi:10.1155/2013/435027 · Cited by 145 · see citing works
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Self-citationK. Garber, A., & H. Lustig, R. (2011) · Current Drug Abuse Reviewse · doi:10.2174/1874473711104030146 · Cited by 143 · see citing works
Vucetic, Z., & Reyes, T. M. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.77 · Cited by 140 · see citing works
Variability in Reward Responsivity and Obesity: Evidence from Brain Imaging Studies
Burger, K. S., & Stice, E. M. (2011) · Current Drug Abuse Reviews · doi:10.2174/1874473711104030182 · Cited by 138 · see citing works
Sugar addiction: the state of the science
Westwater, M. L., Fletcher, P. C., & Ziauddeen, H. (2016) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/s00394-016-1229-6 · Cited by 138 · see citing works
Incubation of sucrose craving: effects of reduced training and sucrose pre-loading
Grimm, J. W., Fyall, A. M., & Osincup, D. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.10.011 · Cited by 131 · see citing works
la Fleur, S. E., Luijendijk, M. C. M., van der Zwaal, E. M., Brans, M. A. D., & Adan, R. A. H. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.159 · Cited by 130 · see citing works
Sugar Addiction: From Evolution to Revolution
Wiss, D. A., Avena, N. M., & Rada, P. V. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00545 · Cited by 138 · see citing works
Self-citationHeymsfield, S. B., Avena, N. M., Baier, L. J., Brantley, P. J., Bray, G. A., Burnett, L. C., Butler, M. G., Driscoll, D. J., Egli, D. M., Elmquist, J. K., et al. (2014) · Obesity · doi:10.1002/oby.20646 · Cited by 129 · see citing works
Self-citation“You Say it's Liking, I Say it's Wanting …”. On the difficulty of disentangling food reward in man
Havermans, R. C. (2011) · Appetite · doi:10.1016/j.appet.2011.05.310 · Cited by 125 · see citing works
Hone‐Blanchet, A., & Fecteau, S. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.019 · Cited by 125 · see citing works
Food reinforcement, energy intake, and macronutrient choice
Epstein, L. H., Carr, K. A., Lin, H. C., & Fletcher, K. D. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.010314 · Cited by 122 · see citing works
Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight
Avena, N. M., Bocarsly, M. E., & Hoebel, B. G. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-458-2_23 · Cited by 124 · see citing works
Self-citationFoods are differentially associated with subjective effect report questions of abuse liability
LaFata, E. M., Smeal, J. K., & Gearhardt, A. N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184220 · Cited by 120 · see citing works
Selective breeding for differential saccharin intake as an animal model of drug abuse
Carroll, M. E., Morgan, A. D., Anker, J. J., Perry, J. L., & Dess, N. K. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32830c3632 · Cited by 118 · see citing works
Sucrose intake enhances behavioral sensitization produced by cocaine
Gosnell, B. A. (2004) · Brain Research · doi:10.1016/j.brainres.2004.10.037 · Cited by 118 · see citing works
Unpredictable saccharin reinforcement enhances locomotor responding to amphetamine
Singer, B. F., Scott-Railton, J., & Vezina, P. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.09.003 · Cited by 117 · see citing works
Krolick, K. N., Zhu, Q., & Shi, H. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.07.008 · Cited by 121 · see citing works
Witek, K., Wydra, K., & Filip, M. (2022) · Nutrients · doi:10.3390/nu14142940 · Cited by 128 · see citing works
Brain reward systems and compulsive drug use
Kenny, P. J. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.01.008 · Cited by 111 · see citing works
Examining the addictive-like properties of binge eating using an animal model of sugar dependence.
Avena, N. M. (2007) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.15.5.481 · Cited by 105 · see citing works
Self-citationMeta‐analysis on drugs in people with eating disorders
Elvira, A. C., Krug, I., Davis, K., López, C., Fernández‐Aranda, F., & Treasure, J. L. (2009) · European Eating Disorders Review · doi:10.1002/erv.936 · Cited by 100 · see citing works
Is there a place for obesity in DSM-V?
Devlin, M. J. (2007) · International Journal of Eating Disorders · doi:10.1002/eat.20430 · Cited by 95 · see citing works
The neurobiological and behavioral overlaps of nicotine and food addiction
Criscitelli, K., & Avena, N. M. (2016) · Preventive Medicine · doi:10.1016/j.ypmed.2016.08.009 · Cited by 95 · see citing works
Self-citationEffects of acute caffeine administration on adolescents
Temple, J. L., Dewey, A. M., & Briatico, L. N. (2010) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0021651 · Cited by 94 · see citing works
Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments
Carroll, M. E., & Smethells, J. R. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00175 · Cited by 93 · see citing works
Impulsivity and history of behavioral addictions are associated with drug use in adolescents
Chuang, C.-W. I., Sussman, S., Stone, M. D., Pang, R. D., Chou, C.-P., Leventhal, A. M., & Kirkpatrick, M. G. (2017) · Addictive Behaviors · doi:10.1016/j.addbeh.2017.05.021 · Cited by 96 · see citing works
Anselme, P., & Robinson, M. J. F. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316823279.009 · Cited by 90 · see citing works
Pretlow, R. A. (2011) · Eating Disorders · doi:10.1080/10640266.2011.584803 · Cited by 90 · see citing works
Avena, N. M., Bocarsly, M. E., Hoebel, B. G., & Gold, M. S. (2011) · Current Drug Abuse Reviews · doi:10.2174/1874473711104030133 · Cited by 88 · see citing works
Self-citationTreasure, J. (2007) · Canadian journal of psychiatry. Revue canadienne de psychiatrie · doi:10.1177/070674370705200402 · Cited by 92 · see citing works
Seymour, K. E., Reinblatt, S. P., Benson, L., & Carnell, S. (2015) · CNS Spectrums · doi:10.1017/s1092852915000383 · Cited by 85 · see citing works
Attention-Deficit/Hyperactivity Disorder: Is it time to Reappraise the Role of Sugar Consumption?
Johnson, R. J., Gold, M. S., Johnson, D. R., Ishimoto, T., Lanaspa, M. A., Zahniser, N. R., & Avena, N. M. (2011) · Postgraduate Medicine · doi:10.3810/pgm.2011.09.2458 · Cited by 83 · see citing works
Self-citationIntermittent access to preferred food reduces the reinforcing efficacy of chow in rats
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Dubé, L. (2010) · Elsevier eBooks · doi:10.1016/c2009-0-01687-0 · Cited by 73 · see citing works
Old and new controversies in the alternative treatment of attention‐deficit hyperactivity disorder
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Puhl, M. D., Cason, A. M., Wojnicki, F. H. E., Corwin, R. L., & Grigson, P. S. (2011) · Behavioral Neuroscience · doi:10.1037/a0025759 · Cited by 66 · see citing works
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“Cross-sensitization and the resulting hyperresponsivity of dopaminergic systems also occurs between drugs of abuse and natural rewards (Avena & Hoebel, 2003) and drugs of abuse and stress (at both behavioral and physiological levels) (Cruz, Marin, Leão, & Planeta, 2011; GarciaKeller et al., 2013;…”
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Hardaway, J. A., Crowley, N. A., Bulik, C. M., & Kash, T. L. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12185 · Cited by 63 · see citing works
Duncan, E. A., Proulx, K., & Woods, S. C. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000167741.42353.10 · Cited by 63 · see citing works
Carr, K. D. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.023 · Cited by 57 · see citing works
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Corwin, R. L., & Hajnal, A. S. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.06.021 · Cited by 57 · see citing works
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Corwin, R. L., & Babbs, R. K. (2012) · ILAR Journal · doi:10.1093/ilar.53.1.23 · Cited by 55 · see citing works
Yau, Y. H. C., Gottlieb, C. D., Krasna, L. C., & Potenza, M. N. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407724-9.00007-0 · Cited by 54 · see citing works
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Umberg, E. N., Shader, R. I., Hsu, L. K. G., & Greenblatt, D. J. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318252464f · Cited by 52 · see citing works
Gotoh, N., Watanabe, H., Osato, R., INAGAKI, K., Iwasawa, A., & Wada, S. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.08.023 · Cited by 52 · see citing works
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LaFata, E. M., Sonneville, K. R., & Gearhardt, A. N. (2019) · Psychology of Addictive Behaviors · doi:10.1037/adb0000441 · Cited by 52 · see citing works
Beecher, K., Cooper, I. A., Wang, J., Walters, S. B., Chehrehasa, F., Bartlett, S. E., & Belmer, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.670430 · Cited by 51 · see citing works
South, T., Westbrook, R. F., & Morris, M. J. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.11.019 · Cited by 50 · see citing works
Sahr, A. E., Sindelar, D. K., Alexander-Chacko, J. T., Eastwood, B. J., Mitch, C. H., & Statnick, M. A. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00390.2007 · Cited by 50 · see citing works
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Holgate, J. Y., Shariff, M. R., Mu, E. W. H., & Bartlett, S. E. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00029 · Cited by 50 · see citing works
- Authors
- Avena, N. M., & Hoebel, B. G.
- Affiliations
- Princeton University (US)
- Corresponding author
- Hoebel, B.G.
- ORCID
- Avena, N.M.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 122
- Issue
- 1
- Pages
- 17-20
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2095178182
- Cited by
- 284
- References
- 43
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 15 · 2020: 15 · 2019: 12 · 2018: 17 · 2017: 14 · 2016: 12 · 2015: 18 · 2014: 19 · 2013: 11 · 2012: 24
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH65024, R21MH065024)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- binge eating, amphetamine, locomotor activity, dopaminergic system, sucrose, female rats
- MeSH terms
- Amphetamine, Central Nervous System Stimulants, Animals, Behavior, Animal, Female, Hyperkinesis, Locomotion, Sucrose, Dopamine Agents, Rats, Sprague-Dawley, Substance-Related Disorders, Amphetamine-Related Disorders, Rats
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