Reduced dopamine d1 receptor binding in the ventral striatum of cigarette smokers

Dagher, Alain; Bleicher, Catherine; Aston, John A.D.; Gunn, Roger N.; Clarke, Paul B.S.; Cumming, Paul

doi:10.1002/syn.1098

Cited by 132Neurotransmitter Receptor Influence on BehaviorSmoking Behavior and CessationNicotinic Acetylcholine Receptors Study

Reduced dopamine d1 receptor binding in the ventral striatum of cigarette smokers

Dagher, Alain, Bleicher, Catherine, Aston, John A.D., Gunn, Roger N., Clarke, Paul B.S., Cumming, Paul·2001·Synapse

DOI 10.1002/syn.1098

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Abstract

Several drugs of abuse, including nicotine, are thought to exert their reinforcing effects through actions on the mesolimbic dopamine system. Animal and human studies suggest that chronic administration of addictive drugs may lead to impaired dopamine neurotransmission in the nucleus accumbens. We measured D1 receptor density in 11 smokers and 18 nonsmokers using positron emission tomography and the D1 receptor ligand [11C]SCH 23390. Ten of the smokers were scanned twice, once after overnight abstinence from cigarettes, and once while smoking at their usual rate, to account for possible acute effects of cigarette smoking on D1 receptor binding. In addition, eight control subjects were scanned twice to assess the reproducibility of the method. We used compartmental modeling to measure [11C]SCH 23390 binding potential, a measure of D1 receptor density. There were no differences in binding between abstinent and nonabstinent scans in smokers or in the two scans in controls. However, there was a significant reduction in [11C]SCH 23390 binding potential in smokers compared to nonsmokers in the striatum, most prominently in the ventral striatum. This suggests that there is a reduction in dopamine D1 receptor density in the ventral striatum of human cigarette smokers relative to nonsmokers, which implies that the postsynaptic mesolimbic dopamine system may be chronically underactive in smokers, either as an antecedent or consequence of addiction to cigarettes. Such a hypodopaminergic state may play an important role in sustaining nicotine-seeking behavior. Alternatively, an inherited reduction in dopamine receptors in the striatum may be associated with an increased risk of addictive behavior.

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Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works
Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199403000-00005 · Cited by 3,431 · cited 1× · see citing works
“The MRI images were transformed into standardized stereotaxic space (Collins et al., 1994) based on the atlas of Talairach and Tournoux (1988).”
Method
Simplified Reference Tissue Model for PET Receptor Studies
Lammertsma, A. A., & Hume, S. P. (1996) · NeuroImage · doi:10.1006/nimg.1996.0066 · Cited by 2,025 · see citing works
Addiction, Dopamine, and the Molecular Mechanisms of Memory
Berke, J. D., & Hyman, S. E. (2000) · Neuron · doi:10.1016/s0896-6273(00)81056-9 · Cited by 1,167 · see citing works
Parametric Imaging of Ligand-Receptor Binding in PET Using a Simplified Reference Region Model
Gunn, R. N., Lammertsma, A. A., Hume, S. P., & Cunningham, V. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0303 · Cited by 1,085 · see citing works
Self-citation
Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs.
Pontieri, F. E., Tanda, G., Orzi, F., & Chiara, G. D. (1996) · Nature · doi:10.1038/382255a0 · Cited by 1,073 · see citing works
Neurobiology of addiction
Wise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072 · see citing works
Neuroscience of addiction
Koob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026 · see citing works
FRONTO-STRIATAL COGNITIVE DEFICITS AT DIFFERENT STAGES OF PARKINSON'S DISEASE
Owen, A. M., James-Galton, M., Leigh, P. N., Summers, B. A., MARSDEN, C. D., Quinn, N. P., Lange, K. W., & Robbins, T. W. (1992) · Brain · doi:10.1093/brain/115.6.1727 · Cited by 859 · see citing works
Dramatic decreases in brain reward function during nicotine withdrawal
Epping-Jordan, M. P., Watkins, S. S., Koob, G. F., & Markou, A. (1998) · Nature · doi:10.1038/30001 · Cited by 674 · see citing works
Inhibition of monoamine oxidase B in the brains of smokers
Fowler, J. S., Volkow, N. D., Wang, G., Pappas, N. R., Logan, J., MacGregor, R. R., Alexoff, D. L., Shea, C. E., Schlyer, D. J., Wolf, A. P., et al. (1996) · Nature · doi:10.1038/379733a0 · Cited by 657 · see citing works
Molecular Mechanisms of Drug Reinforcement and Addiction
Self, D. W., & Nestler, E. J. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.002335 · Cited by 565 · see citing works
D2 dopamine receptor gene (DRD2) Taql A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele
Thompson, J., Thomas, N., Singleton, A., Piggot, M., Lloyd, S., Perry, E. K., Morris, C. M., Perry, R. H., Ferrier, I. N., & Court, J. A. (1997) · Pharmacogenetics · doi:10.1097/00008571-199712000-00006 · Cited by 553 · see citing works
Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats
Rossetti, Z. L., Hmaidan, Y., & GESSA, G. L. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90706-a · Cited by 526 · see citing works
Postcocaine anhedonia. An animal model of cocaine withdrawal.
Markou, A., & Koob, G. F. (1991) · PubMed · Cited by 505 · see citing works
Anatomical mapping of functional activation in stereotactic coordinate space.
Evans, A. C., Marrett, S., Neelin, P., Collins, D. L., Worsley, K., Dai, W.-Q., Milot, S., Meyer, E., & Bub, D. (1992) · NeuroImage · doi:10.1016/1053-8119(92)90006-9 · Cited by 444 · see citing works
Brain monoamine oxidase A inhibition in cigarette smokers
Fowler, J. S., Volkow, N. D., Wang, G., Pappas, N. R., Logan, J., Shea, C. E., Alexoff, D. L., MacGregor, R. R., Schlyer, D. J., Zezulkova, I., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14065 · Cited by 423 · see citing works
Effects of chronic cocaine abuse on postsynaptic dopamine receptors
(1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.6.719 · Cited by 421 · see citing works
Human brain dopamine receptors in children and aging adults
Seeman, P., Bzowej, N. H., Guan, H. ‐., Bergeron, C., Becker, L. E., Reynolds, G. P., Bird, E. D., Riederer, P., Jellinger, K., Watanabe, S., et al. (1987) · Synapse · doi:10.1002/syn.890010503 · Cited by 404 · see citing works
Decreased brain reward produced by ethanol withdrawal
Schulteis, G., Markou, A., Cole, M., & Koob, G. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5880 · Cited by 345 · see citing works
Transdermal nicotine effects on attention
Levin, E. D., Conners, C. K., Silva, D., Hinton, S. C., Meck, W. H., March, J. S., & Rose, J. E. (1998) · Psychopharmacology · doi:10.1007/s002130050750 · Cited by 331 · see citing works
Abnormal basal ganglia outflow in Parkinson's disease identified with PET. Implications for higher cortical functions
Owen, A. M. (1998) · Brain · doi:10.1093/brain/121.5.949 · Cited by 299 · see citing works
The dopamine D2 receptor (DRD2) gene: a genetic risk factor in smoking
Comings, D. E., Ferry, L. H., Bradshaw-Robinson, S., Burchette, R. J., Chiu, C., & Muhleman, D. R. (1996) · Pharmacogenetics · doi:10.1097/00008571-199602000-00006 · Cited by 263 · see citing works
Genetic and environmental contributions to smoking
True, W. R., Heath, A. C., Scherrer, J. F., Waterman, B. M., Goldberg, J., Lin, N., Eisen, S. A., Lyons, M. J., & Tsuang, M. T. (1997) · Addiction · doi:10.1111/j.1360-0443.1997.tb02847.x · Cited by 248 · see citing works
Case-Control Study of the D2 Dopamine Receptor Gene and Smoking Status in Lung Cancer Patients
Spitz, M. R., Shi, H., Yang, F., Hudmon, K. S., Jiang, H., Chamberlain, R. M., Amos, C. I., Wan, Y., Wu, X., Cinciripini, P. M., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.5.358 · Cited by 231 · see citing works
The persistence of behavioral sensitization to cocaine parallels enhanced inhibition of nucleus accumbens neurons
Henry, D., & White, F. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06287.1995 · Cited by 223 · see citing works
Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors
Comings, D. E., Gade, R., Wu, S., Chiu, C., Dietz, G., Muhleman, D. R., Saucier, G., Ferry, L. H., Rosenthal, R., Lesieur, H. R., et al. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000207 · Cited by 223 · see citing works
Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson's disease
Mehta, M. A., Sahakian, B. J., McKenna, P. J., & Robbins, T. W. (1999) · Psychopharmacology · doi:10.1007/s002130051102 · Cited by 223 · see citing works
Age-related changes in human D1 dopamine receptors measured by positron emission tomography
Suhara, T., Fukuda, H., Inoue, O., Itoh, T., Suzuki, K., Yamasaki, T., & Tateno, Y. (1991) · Psychopharmacology · doi:10.1007/bf02244071 · Cited by 212 · see citing works
Age-dependent decline in human brain dopamine D1 and D2 receptors
Rinne, J. O., Lönnberg, P., & Marjamäki, P. (1990) · Brain Research · doi:10.1016/0006-8993(90)90423-9 · Cited by 192 · see citing works
High Levels of Dopamine Activity in the Basal Ganglia of Cigarette Smokers
Salokangas, R. K. R., Vilkman, H., Ilonen, T., Taiminen, T., Bergman, J., Haaparanta, M., Solin, O., Alanen, A., Syvã«¡hti, E., & Hietala, J. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.4.632 · Cited by 164 · cited 1× · see citing works
“In another study there was an elevation in striatal uptake of the presynaptic dopamine tracer [18F]DOPA in smokers (Salokangas et al., 2000).”
Background
D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene
Laruelle, M. A., Gelernter, J. E., & Innis, R. B. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000343 · Cited by 152 · see citing works
Dopamine and nicotinic receptor binding and the levels of dopamine and homovanillic acid in human brain related to tobacco use
Court, J. A., Lloyd, S., Thomas, N., Piggott, M. A., Marshall, E. F., Morris, C. M., Lamb, H., Perry, R. H., Johnson, M., & Perry, E. K. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00088-8 · Cited by 135 · see citing works
Effect of cocaine self-administration on dopamine D2 receptors in rhesus monkeys
Moore, R. J., Vinsant, S. L., Nader, M. A., Porrino, L. J., & Friedman, D. P. (1998) · Synapse · doi:10.1002/(sici)1098-2396(199809)30:1 · Cited by 134 · see citing works
Behavioral manifestations of the nicotine abstinence syndrome in the rat: peripheral versus central mechanisms
Hildebrand, B. E., Nomikos, G. G., Bondjers, C., Nisell, M., & Svensson, T. H. (1997) · Psychopharmacology · doi:10.1007/s002130050200 · Cited by 122 · see citing works
CHILD syndrome caused by deficiency of 3?-hydroxysteroid-?8, ?7-isomerase
Grange, D. K., Kratz, L. E., Braverman, N., & Kelley, R. I. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(20000214)90:4 · Cited by 113 · see citing works
Effects of nicotine withdrawal on central dopaminergic systems
Fung, Y. K., Schmid, M. J., Anderson, T. M., & Lau, Y. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02063-2 · Cited by 109 · see citing works
Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice
Dumartin, B., Jaber, M., Gonon, F., Caron, M. G., Bruno Giros, A., & Bloch, B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1879 · Cited by 92 · see citing works
A post-mortem study on striatal dopamine receptors in Parkinson's disease
Rinne, J. O., Laihinen, A., Lönnberg, P., Marjamäki, P., & Rinne, U. K. (1991) · Brain Research · doi:10.1016/0006-8993(91)90554-9 · Cited by 81 · see citing works
Changes in striatal D2-receptor density following chronic treatment with amphetamine as assessed with pet in nonhuman primates
Ginovart, N., Farde, L., Halldin, C., & Swahn, C.-G. (1999) · Synapse · doi:10.1002/(sici)1098-2396(199902)31:2 · Cited by 76 · see citing works
Bromocriptine reverses the elevation in intracranial self-stimulation thresholds observed in a rat model of cocaine withdrawal.
Markou, A., & Koob, G. F. (1992) · PubMed · Cited by 76 · see citing works
A Statistical Method for the Analysis of Positron Emission Tomography Neuroreceptor Ligand Data
Aston, J. A. D., Gunn, R. N., Worsley, K. J., Ma, Y., Evans, A. C., & Dagher, A. (2000) · NeuroImage · doi:10.1006/nimg.2000.0620 · Cited by 75 · see citing works
Self-citation
Lack of association between the dopamine D2 receptor gene allele DRD2*A1 and cigarette smoking in a United Kingdom population
Singleton, A., Thomson, J. H., Morris, C. M., COURT, J. A., Lloyd, S., & Cholerton, S. (1998) · Pharmacogenetics · doi:10.1097/00008571-199804000-00005 · Cited by 70 · see citing works
Genetic Influences on Smoking: Candidate Genes
Rossing, M. A. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106231 · Cited by 65 · see citing works
The influence of smoking on reward responsiveness and cognitive functions: a natural experiment
Al‐Adawi, S., & Powell, J. E. (1997) · Addiction · doi:10.1111/j.1360-0443.1997.tb02897.x · Cited by 63 · see citing works
A PET study of D1-like dopamine receptor ligand binding
Chou, Y.-H., Karlsson, P., Halldin, C., Olsson, H., & Farde, L. (1999) · Psychopharmacology · doi:10.1007/s002130051110 · Cited by 61 · see citing works
Striatal dopamine receptors and transporters in monkeys with neonatal temporal limbic damage
Heinz, A., Saunders, R., Kolachana, B., Jones, D., Gorey, J. G., Bachevalier, J., & Weinberger, D. R. (1999) · Synapse · doi:10.1002/(sici)1098-2396(199905)32:2 · Cited by 60 · see citing works
Dopamine receptor density, sensitivity and mRNA levels are altered following self-administration of cocaine in the rat
Laurier, L. G., Corrigall, W. A., & George, S. R. (1994) · Brain Research · doi:10.1016/0006-8993(94)90255-0 · Cited by 58 · see citing works
Neuropharmacological evidence for the role of dopamine in ventral pallidum self-stimulation
Panagis, G., & Spyraki, C. (1996) · Psychopharmacology · doi:10.1007/bf02246582 · Cited by 58 · see citing works
Modifications of dopamine D1 receptor complex in rats self-administering cocaine
Montis, M. G. D., Co, C., Dworkin, S. I., & Smith, J. E. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00731-6 · Cited by 39 · see citing works
Differential down-regulation of D1-stimulated adenylate cyclase activity in rat forebrain after in vivo amphetamine treatments
Roberts‐Lewis, J. M., Roseboom, P., Iwaniec, L. M., & Gnegy, M. E. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02245.1986 · Cited by 32 · see citing works
Tolerance to nicotine's effects on striatal dopamine metabolism in nicotine-withdrawn mice
Pietilä, K., Salminen, O., Leikola‐Pelho, T., & Ahtee, L. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00767-4 · Cited by 30 · see citing works
Effect of Chronic Nicotine Treatment and Withdrawal on Rat Striatal D1 and D2 Dopamine Receptors
Kirch, D. G., Taylor, T., Creese, I., Xu, S. X., & Wyatt, R. J. (1992) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1992.tb03567.x · Cited by 25 · see citing works
Chronic nicotine administration incrreases binding of [3H]Domperidone in rat nucleus accumbens
Reilly, M. A., Lapin, E. P., Maker, H. S., & Lajtha, Á. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180416 · Cited by 25 · see citing works
The DRD2 Gene, Smoking, and Lung Cancer
Noble, E. P. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.5.343 · Cited by 21 · see citing works
Untitled work
Lidow (1998) · doi:10.1002/(sici)1098-2396(199801)28:1
Untitled work
Volkow (1999) · doi:10.1002/(sici)1098-2396(199901)31:1

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Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101 · see citing works
The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour
Laviolette, S. R., & van der Kooy, D. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1298 · Cited by 452 · see citing works
Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200209000-00008 · Cited by 398 · see citing works
Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis
Karrer, T. M., Josef, A. K., Mata, R., Morris, E. D., & Samanez-Larkin, G. R. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.05.006 · Cited by 263 · see citing works
Association of tobacco and lead exposures with attention-deficit/hyperactivity disorder
Froehlich, T. E., Lanphear, B. P., Auinger, P., Hornung, R., Epstein, J. N., Braun, J., & Kahn, R. S. (2009) · Pediatrics · doi:10.1542/peds.2009-0738 · Cited by 234 · see citing works
Association of Low Striatal Dopamine D 2 Receptor Availability With Nicotine Dependence Similar to That Seen With Other Drugs of Abuse
Fehr, C., Yakushev, I. Y., Hohmann, N., Buchholz, H., Landvogt, C., Deckers, H., Eberhardt, A., Kläger, M., Smolka, M. N., Scheurich, A., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07020352 · Cited by 226 · see citing works
Smoking, nicotine and neuropsychiatric disorders
Döme, P., Lazáry, J., Kalapos, M. P., & Rihmer, Z. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.013 · Cited by 215 · see citing works
Functional brain imaging of tobacco use and dependence
BRODY, A. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.04.012 · Cited by 207 · see citing works
Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products
England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181 · see citing works
Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area
Laviolette, S. R., & van der Kooy, D. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001197 · Cited by 180 · see citing works
Chronic effects of cannabis use on the human reward system: An fMRI study
van Hell, H. H., Vink, M., Ossewaarde, L., Jager, G., Kahn, R. S., & Ramsey, N. F. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.11.010 · Cited by 175 · see citing works
Effects of abstinence from tobacco: Etiology, animal models, epidemiology, and significance: A subjective review
Hughes, J. (2007) · Nicotine & Tobacco Research · doi:10.1080/14622200701188927 · Cited by 173 · see citing works
Dual role of nicotine in addiction and cognition: A review of neuroimaging studies in humans
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A double-blind placebo controlled experimental study of nicotine: I—effects on incentive motivation
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In vivo Brain Imaging of Human Exposure to Nicotine and Tobacco
Sharma, A., & Brody, A. L. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-69248-5_6 · Cited by 88 · see citing works
Positron emission tomography and single-photon emission computed tomography in substance abuse research.
Volkow, N., Fowler, J., & Wang, G.-J. (2003) · Seminars in nuclear medicine · doi:10.1053/snuc.2003.127300 · Cited by 89 · see citing works
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Leroy, C., Karila, L., Martinot, J., Lukasiewicz, M., Duchesnay, É., Comtat, C., Dollé, F., Benyamina, A., Eric Artiges, A., Ribeiro, M. J., et al. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00356.x · Cited by 91 · see citing works
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Vollstädt‐Klein, S., Kobiella, A., Fauth‐Bühler, M., Graf, C., Fehr, C., Mann, K. F., & Smolka, M. N. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00207.x · Cited by 88 · see citing works
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von der Goltz, C., Koopmann, A., Dinter, C., Richter, A., Rockenbach, C., Grosshans, M., Nakovics, H., Wiedemann, K., Mann, K. F., Winterer, G., et al. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.005 · Cited by 86 · see citing works
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Paterson, N. E., & Markou, A. (2007) · Neurotoxicity Research · doi:10.1007/bf03033479 · Cited by 84 · see citing works
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Becklake, M. R. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.1041428 · Cited by 84 · see citing works
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Cognitive and psychological correlates of smoking abstinence, and predictors of successful cessation
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Paul, R. H., Brickman, A. M., Cohen, R. A., Williams, L. M., NIAURA, R. S., Pöğün, Ş., Clark, C. R., Gunstad, J., & Gordon, E. (2006) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2005.04.012 · Cited by 68 · see citing works
Does Tobacco Abstinence Decrease Reward Sensitivity? A Human Laboratory Test
Hughes, J. R., Budney, A. J., Muellers, S. R., Lee, D. C., CALLAS, P. W., Sigmon, S. C., Fingar, J. R., & Priest, J. S. (2017) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntw204 · Cited by 61 · see citing works
Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders
Virdee, K., Cumming, P. D., Caprioli, D., Jupp, B., Rominger, A., Aigbirhio, F. I., Fryer, T. D., Riss, P. J., & Dalley, J. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.01.009 · Cited by 60 · see citing works
Self-citation
Does incentive-elicited nucleus accumbens activation differ by substance of abuse? An examination with adolescents
Karoly, H. C., Bryan, A. D., Weiland, B. J., Mayer, A. R., Dodd, A. B., & Ewing, S. W. F. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.05.005 · Cited by 58 · see citing works
Dopamine Signaling through D1-Like versus D2-Like Receptors in the Nucleus Accumbens Core versus Shell Differentially Modulates Nicotine Reward Sensitivity
Laviolette, S. R., Lauzon, N. M., Bishop, S. F., Sun, N., & Tan, H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1371-08.2008 · Cited by 58 · see citing works
Tobacco smoke exposure and tracking of lung function into adult life
Landau, L. I. (2008) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2007.11.002 · Cited by 54 · see citing works
Striatal hyposensitivity to delayed rewards among cigarette smokers
Luo, S., Ainslie, G., Giragosian, L., & Monterosso, J. R. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.11.012 · Cited by 52 · see citing works
Age-dependent decline of steady state dopamine storage capacity of human brain: An FDOPA PET study
Kumakura, Y., Vernaleken, I., Buchholz, H., Borghammer, P., Danielsen, E. H., Gründer, G., Heinz, A., Bartenstein, P., & Cumming, P. D. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.005
Self-citation
Occupancy of dopamine D2 receptors by antipsychotic drugs is related to nicotine addiction in young patients with schizophrenia
de Haan, L., Booij, J., Lavalaye, J., van Amelsvoort, T., & LINSZEN, D. H. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0218-x · Cited by 54 · see citing works
Effects of stimulant drug use on the dopaminergic system: A systematic review and meta-analysis of in vivo neuroimaging studies
Proebstl, L., Kamp, F., Manz, K., Krause, D., Adorjan, K., Pogarell, O., Koller, G., Soyka, M., Falkai, P., & Kambeitz, J. (2019) · European psychiatry · doi:10.1016/j.eurpsy.2019.03.003 · Cited by 52 · see citing works
Weak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking
Wilson, S. J., Delgado, M. R., McKee, S. A., Grigson, P. S., MacLean, R. R., Nichols, T. T., & Henry, S. L. (2014) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-014-0285-8 · Cited by 47 · see citing works
Cognitive control and the dopamine D2-like receptor: a dimensional understanding of addiction
Groman, S. M., & Jentsch, J. D. (2011) · Depression and Anxiety · doi:10.1002/da.20897 · Cited by 41 · see citing works
Effects of Smoking Cessation on Presynaptic Dopamine Function of Addicted Male Smokers
Rademacher, L., Prinz, S., Winz, O., Henkel, K., Dietrich, C., Schmaljohann, J., Shali, S. M., Schabram, I., Stoppe, C., Cumming, P. D., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.009 · Cited by 43 · see citing works
Self-citation
Incidence of craving for and abuse of gamma-hydroxybutyric acid (GHB) in different populations of treated alcoholics: an open comparative study
Caputo, F., Francini, S., Stoppo, M., Lorenzini, F., Vignoli, T., Re, A. D., Comaschi, C., Leggio, L., Addolorato, G., Zoli, G., et al. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108094620 · Cited by 42 · see citing works
Imaging Receptor Changes in Human Drug Abusers
Cosgrove, K. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_24 · Cited by 40 · see citing works
Varenicline as a smoking cessation aid in schizophrenia: effects on smoking behavior and reward sensitivity
Dutra, S. J., Stoeckel, L. E., Carlini, S. V., Pizzagalli, D. A., & Evins, A. E. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2373-6 · Cited by 40 · see citing works
Compensatory weight gain due to dopaminergic hypofunction: new evidence and own incidental observations
Reinholz, J., Skopp, O., Breitenstein, C., Bohr, I. J., Winterhoff, H., & Knecht, S. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-35 · Cited by 39 · see citing works
Long-Term Upregulation of Protein Kinase A and Adenylate Cyclase Levels in Human Smokers
Hope, B. T., Nagarkar, D. R., Leonard, S. S., & Wise, R. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3661-06.2007 · Cited by 37 · see citing works
Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies
Ashok, A. H., Mizuno, Y., & Howes, O. D. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05196-1 · Cited by 36 · see citing works
Metabolism and biochemical effects of nicotine for primary care providers
Metz, C. N., Gregersen, P. K., & Malhotra, A. K. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.06.004 · Cited by 37 · see citing works
Role of Ventral Striatal Dopamine D1 Receptor in Cigarette Craving
Yasuno, F., Ota, M., Ando, K., Ando, T., Maeda, J., Ichimiya, T., Takano, A., DORONBEKOV, T. K., Fujimura, Y., Nozaki, S., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.028 · Cited by 37 · see citing works
Circulating leptin levels are associated with increased craving to smoke in abstinent smokers
Al’Absi, M., Hooker, S. A., Fujiwara, K., Kiefer, F., von der Goltz, C., Cragin, T., & Wittmers, L. E. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.10.004 · Cited by 35 · see citing works
The Role of Mesoaccumbens Dopamine in Nicotine Dependence
Balfour, D. J. K. (2015) · Current topics in behavioral neurosciences · doi:10.1007/978-3-319-13482-6_3 · Cited by 34 · see citing works
Combination Varenicline/Bupropion Treatment Benefits Highly Dependent Smokers in an Adaptive Smoking Cessation Paradigm
Rose, J. E., & Behm, F. M. (2016) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntw283 · Cited by 33 · see citing works
Chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the γ‐aminobutyric acid type B receptor expression of the rat prefrontal cortex
Li, S., Park, M. S., Kim, J. H., & Kim, M. O. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20329 · Cited by 32 · see citing works
Brain dopaminergic system changes in drug addiction: a review of positron emission tomography findings
Hou, H., Wang, C., Jia, S., Hu, S., & Tian, M. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-014-1469-5 · Cited by 30 · see citing works
Striatal dopamine D1-type receptor availability: no difference from control but association with cortical thickness in methamphetamine users
Okita, K., Morales, A. M., Dean, A. C., Johnson, M., Lu, V., Farahi, J. B., Mandelkern, M. A., & London, E. D. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.172 · Cited by 29 · see citing works
Gradients of dopamine D1- and D2/3-binding sites in the basal ganglia of pig and monkey measured by PET
Rosa-Neto, P., Doudet, D., & Cumming, P. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.03.004 · Cited by 31 · see citing works
Self-citation
Effect of quinpirole on striatal dopamine release and locomotor activity in nicotine-treated mice
Tammimäki, A., Pietilä, K., Raattamaa, H., & Ahtee, L. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.12.027 · Cited by 29 · see citing works
Enhanced nicotine self-administration and suppressed dopaminergic systems in a rat model of diabetes
O’Dell, L. E., Natividad, L. A., Pipkin, J. A., Roman, F., Torres, I. D., Jurado, J., Torres, O. V., Friedman, T. C., Tenayuca, J. M., & Nazarian, A. (2013) · Addiction Biology · doi:10.1111/adb.12074 · Cited by 28 · see citing works
Pharmacological investigation of quinoxaline-bisthiazoles as multitarget-directed ligands for the treatment of Alzheimer’s disease
Sagar, S. R., Singh, D. P., Das, R. D., Panchal, N. B., Sudarsanam, V., Nivsarkar, M., & Vasu, K. K. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.102992 · Cited by 27 · see citing works
Enhanced vulnerability to tobacco use in persons with diabetes: A behavioral and neurobiological framework
O’Dell, L. E., & Nazarian, A. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.005 · Cited by 27 · see citing works
Auditory P300 event-related potential in tobacco smokers
Güney, F., Genç, B. O., Kutlu, R., & İlhan, B. Ç. (2009) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2008.11.025 · Cited by 26 · see citing works
Striatal dopamine D2/D3 receptor availability in male smokers
Yang, Y. K., Yao, W. J., McEvoy, J. P., Chu, C. L., Lee, I. H., Chen, P. S., Yeh, T. L., & Chiu, N.-T. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.09.008 · Cited by 24 · see citing works
Repeated nicotine exposure during adolescence alters reward-related learning in male and female rats
Quick, S. L., Olausson, P., Addy, N., & Taylor, J. R. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.001 · Cited by 23 · see citing works
Neuroendocrinological and neuropsychological correlates of dopaminergic function in nicotine dependence
Smolka, M., Budde, H., Karow, A., & Schmidt, L. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1824-8 · Cited by 23 · see citing works
Thiazolyl-thiadiazines as Beta Site Amyloid Precursor Protein Cleaving Enzyme-1 (BACE-1) Inhibitors and Anti-inflammatory Agents: Multitarget-Directed Ligands for the Efficient Management of Alzheimer’s Disease
Sagar, S. R., Singh, D. P., Panchal, N. B., Das, R. D., Pandya, D. H., Sudarsanam, V., Nivsarkar, M., & Vasu, K. K. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00063 · Cited by 22 · see citing works
Changes in circulating leptin levels during acute stress and associations with craving in abstinent smokers: A preliminary investigation
Potretzke, S., Nakajima, M., Cragin, T., & Al’Absi, M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.05.008 · Cited by 21 · see citing works
Human dopamine receptor D2/D3 availability predicts amygdala reactivity to unpleasant stimuli
Kobiella, A., Vollstädt‐Klein, S., Fauth‐Bühler, M., Graf, C., Buchholz, H., Bernow, N., Yakushev, I. Y., Landvogt, C., Schreckenberger, M., Gründer, G., et al. (2009) · Human Brain Mapping · doi:10.1002/hbm.20900 · Cited by 21 · see citing works
Reduced sensitivity to reinforcement in adolescent compared to adult Sprague-Dawley rats of both sexes
Hankosky, E. R., Westbrook, S. R., Haake, R. M., Marinelli, M., & Gulley, J. M. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4804-5 · Cited by 20 · see citing works
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Hou, H., Tian, M., & Zhang, H. (2012) · The Anatomical Record · doi:10.1002/ar.22457 · Cited by 20 · see citing works
Neuroreceptor imaging in psychiatry: theory and applications.
Frankle, W., Slifstein, M., Talbot, P., & Laruelle, M. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)67011-0 · Cited by 21 · see citing works
Exposure to smoke extract of Datura stramonium leaf: Some of its effects on the heart, liver, lungs, kidneys and testes of male Sprague Dawley rats
Adekomi, D. A., Musa, A. A., Tijani, A. A., Adeniyi, T., & Usman, B. (2011) · Journal of Pharmacognosy and Phytotherapy · doi:10.5897/jpp.9000025 · Cited by 18 · see citing works
Circulating orexin changes during withdrawal are associated with nicotine craving and risk for smoking relapse
Al’Absi, M., Lemieux, A. M., Hodges, J. S., & ALLEN, S. S. (2018) · Addiction Biology · doi:10.1111/adb.12643 · Cited by 18 · see citing works
Behavioral sensitization to nicotine in female and male rats
Ericson, M., Norrsjö, G., & Svensson, A. I. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0449-9 · Cited by 17 · see citing works
Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats
Bruijnzeel, A. W., & Markou, A. (2005) · Brain Research · doi:10.1016/j.brainres.2005.07.056 · Cited by 17 · see citing works
Environmental enrichment reduces behavioural sensitization in mice previously exposed to toluene: The role of D1 receptors
Páez-Martı́nez, N., Pellicer, F., González-Trujano, M. E., & Cruz-López, B. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112624 · Cited by 15 · see citing works
Temporal discounting and smoking cessation: choice consistency predicts nicotine abstinence in treatment-seeking smokers
Großkopf, C. M., Kroemer, N. B., Pooseh, S., Böhme, F., & Smolka, M. N. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05688-5 · Cited by 14 · see citing works
Dopamine D1/5 and D2/3 agonists differentially attenuate somatic signs of nicotine withdrawal in rats
Ohmura, Y., Jutkiewicz, E. M., Zhang, A. J., & Domino, E. F. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.05.010 · Cited by 14 · see citing works
Activities of cAMP-dependent protein kinase and protein kinase C are modulated by desensitized nicotinic receptors in the rat brain
Sun, X., Liu, Y., Hu, G., & Wang, H. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.072 · Cited by 14 · see citing works
Implicit and explicit reward learning in chronic nicotine use
Paelecke-Habermann, Y., Paelecke, M., Giegerich, K., Reschke, K., & Kübler, A. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.09.004 · Cited by 13 · see citing works
Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats
Chellian, R., Behnood‐Rod, A., Wilson, R., Lin, K., King, G. W.-Y., Ruppert-Gomez, M., Teter, A. N., Febo, M., & Bruijnzeel, A. W. (2022) · Scientific Reports · doi:10.1038/s41598-022-18081-3 · Cited by 13 · see citing works
Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood
Sherrill, L. K., & Gulley, J. M. (2018) · Brain Research · doi:10.1016/j.brainres.2018.05.028 · Cited by 12 · see citing works
PET imaging of dopaminergic system and clinical applications
Sarikaya, İ. (2024) · Clinical and Translational Imaging · doi:10.1007/s40336-024-00646-z · Cited by 11 · see citing works
What have positron emission tomography and ‘Zippy’ told us about the neuropharmacology of drug addiction?
Cumming, P. D., Caprioli, D., & Dalley, J. W. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01036.x · Cited by 9 · see citing works
Self-citation
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Turner, M. P., Fischer, H., Sivakolundu, D. K., Hubbard, N. A., Zhao, Y., Rypma, B., & Bäckman, L. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116232 · Cited by 9 · see citing works
Serotonin transporter promoter polymorphism and dopaminergic sensitivity in alcoholics
Budde, H., Sander, T., Wernicke, C., Müller, A., Gallinat, J., Schmidt, L., & Smolka, M. N. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0331-9 · Cited by 9 · see citing works
Neuromelanin levels in individuals with substance use disorders: A systematic review and meta-analysis
Ahrens, J., Zaher, F., Rabin, R. A., Cassidy, C., & Palaniyappan, L. K. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105690 · Cited by 8 · see citing works
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Addicott, M. A., Wardle, M. C., & Selig, J. P. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05437-3 · Cited by 7 · see citing works
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Ciccocioppo, R., de Guglielmo, G., Li, H., Melis, M., Caffino, L., Shen, Q., Domi, A., Fumagalli, F., Demopulos, G. A., & Gaitanaris, G. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.3180-20.2021 · Cited by 7 · see citing works
Tobacco addiction
Addicott, M. (2020) · Cognition and Addiction · doi:10.1016/b978-0-12-815298-0.00009-5 · Cited by 3 · see citing works
Consensus Report of the APA Work Group on Neuroimaging Markers of Psychiatric Disorders RESOURCE DOCUMENT
First, M. B., Carter, C., Castellanos, F. X., Dickstein, D. P., Drevets, W. C., Kim, K. L., Pescosolido, M. F., Rausch, S., Seymour, K. E., & Zubieta, J.-K. (2012) · Cited by 5 · see citing works
'To do or not to do'? The neurobiology of decision-making in daily life: I. Getting the basics
Palmini, A., & Haase, V.-G. (2007) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642008dn10100003 · Cited by 5 · see citing works
Neuroimaging and mechanisms of drug abuse: interface of molecular imaging and molecular genetics
Monique Ernst, D., Kimes, A. S., & Jazbec, S. (2003) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(03)00109-6 · Cited by 5 · see citing works
RPM STATISTICS — A statistical tool for receptor parametric mapping
Aston, J. A. D., Worsley, K. J., & Gunn, R. N. (2001) · NeuroImage · doi:10.1016/s1053-8119(01)91408-9 · Cited by 4 · see citing works
Self-citation
Nicotinic Acetylcholine Receptors in the Ventral Tegmental Area are Important Targets for Nicotine and Ethanol Co-dependence
Taylor, D. H. (2013) · Biochemistry & Pharmacology Open Access · doi:10.4172/2167-0501.s1-002 · Cited by 4 · see citing works
Effects of Smoking and Need for Cessation: Biochemical and Pharmacological Feedback
Adak, M. (2014) · Cited by 4 · see citing works
Functional Brain Imaging of Tobacco Exposure in Humans
Storage, S. S., & Brody, A. L. (2012) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.s2-003 · Cited by 4 · see citing works
Efectos crónicos del consumo de cannabis sobre el sistema de recompensa humano: un estudio de RMf
van Hell, H. H., Vink, M., Ossewaarde, L., Jager, G., Kahn, R. S., & Ramsey, N. F. (2011) · Psiquiatría Biológica · doi:10.1016/j.psiq.2011.08.003 · Cited by 4 · see citing works
Fachbereich Erziehungswissenschaft und Psychologie
Schaumburg, H. (2003) · Cited by 4 · see citing works
Subregion specific monoaminergic signaling in the female rat striatum during nicotine abstinence
Lucente, E., Cadeddu, D., Edvardsson, C. E., Ericson, M., Jerlhag, E., & Adermark, L. (2024) · Addiction Neuroscience · doi:10.1016/j.addicn.2024.100184 · Cited by 3 · see citing works
The influence of high-fat diet on nicotine vapor self-administration, neuronal excitability, and leptin levels in adult mice
Tetteh-Quarshie, S., Morrison, K. M., Olszewski, N. A., Young, L. E., Mensah, E. N., Sword, M. K., & Henderson, B. J. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114823 · Cited by 3 · see citing works
High-fat simple carbohydrate feeding impairs central and peripheral monoamine metabolic pathway triggering the onset of metabolic syndrome in C57Bl/6J mice
Abraham, A., & D'Souza, S. (2016) · Neurology India · doi:10.4103/0028-3886.190261 · Cited by 3 · see citing works

Role of Ventral Striatal Dopamine D1 Receptor in Cigarette Craving
Yasuno, F., Ota, M., Ando, K., Ando, T., Maeda, J., Ichimiya, T., Takano, A., DORONBEKOV, T. K., Fujimura, Y., Nozaki, S., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.028 · Cited by 37 · see citing works
Smoking-Induced Ventral Striatum Dopamine Release
Brody, A. L., Olmstead, R. E., London, E. D., Farahi, J. B., Meyer, J. H., Grossman, P., Lee, G., Huang, J. C.-S., Hahn, E. L., & Mandelkern, M. A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.7.1211 · Cited by 341 · see citing works
Association of Low Striatal Dopamine D 2 Receptor Availability With Nicotine Dependence Similar to That Seen With Other Drugs of Abuse
Fehr, C., Yakushev, I. Y., Hohmann, N., Buchholz, H., Landvogt, C., Deckers, H., Eberhardt, A., Kläger, M., Smolka, M. N., Scheurich, A., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07020352 · Cited by 226 · see citing works
Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence
Okita, K., Mandelkern, M. A., & London, E. D. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw074 · Cited by 26 · see citing works
Elevation of Dopamine Induced by Cigarette Smoking: Novel Insights from a [11C]-(+)-PHNO PET Study in Humans
Foll, B. L., Guranda, M., Wilson, A. A., Houle, S., Rusjan, P., Wing, V. C., Zawertailo, L. A., Busto, U. E., Selby, P. L., Brody, A. L., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.209 · Cited by 63 · see citing works

Authors: Dagher, A., Bleicher, C., Aston, J. A. D., Gunn, R. N., Clarke, P. B. S., & Cumming, P.
Affiliations: Montreal Neurological Institute and Hospital (CA)
McGill University (CA)
Aarhus University (DK)
Corresponding author: Dagher, Alain
ORCID: Dagher, Alain
Aston, John A.D.
Gunn, Roger N.
Clarke, Paul B.S.
Cumming, Paul
Venue: Synapse
Publisher: Wiley
Published: 2001-07-05
Volume: 42
Issue: 1
Pages: 48-53
ISSN: 0887-4476 (ISSN-L)
1098-2396
DOI: 10.1002/syn.1098
OpenAlex: W2143799031
Cited by: 132
References: 58
Citations by year: 2025: 3 · 2024: 4 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 7
FWCI: 1.72
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Synapse (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: dopamine D1 receptor, ventral striatum, cigarette smoking, nicotine dependence, mesolimbic dopamine system, receptor binding potential, hypodopaminergic state, nicotine reinforcement
MeSH terms: Adolescent, Adult, Basal Ganglia, Benzazepines, Female, Humans, Male, Smoking, Tomography, Emission-Computed, Linear Models, Receptors, Dopamine D1, Dopamine Antagonists

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Reduced dopamine d1 receptor binding in the ventral striatum of cigarette smokers

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