Cited by 150Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats

Rodd-Henricks, Zachary A., McKinzie, David L., Li, Ting-Kai, Murphy, James M., McBride, William J.·2002·The Journal of Pharmacology and Experimental Therapeutics

Abstract

The rewarding properties of cocaine have been postulated to be regulated, in part, by the mesolimbic dopamine system. However, the possibility that the rewarding properties of cocaine are mediated by direct activation of this system has yielded contradictory findings. The intracranial self-administration technique is used to identify specific brain regions involved in the initiation of response-contingent behaviors for the delivery of a reinforcer. The present study assessed whether adult Wistar rats would self-administer cocaine directly into the nucleus accumbens shell (AcbSh) and core (AcbC). For each subregion, subjects were placed in standard two-lever operant chambers and randomly assigned to one of five groups for each site that were given either artificial cerebrospinal fluid (aCSF), or 400, 800, 1200, or 1600 pmol of cocaine/100 nl to self-administer. The data indicate that rats with placements within the AcbSh readily self-administered 800 to 1600 pmol of cocaine/100 nl and responded significantly more on the active than inactive lever. These subjects also decreased responding on the active lever when aCSF was substituted for cocaine and reinstated responding on the active lever when cocaine was reintroduced. Coinfusion of the D2-like receptor antagonist sulpiride inhibited cocaine self-infusion in the AcbSh. In contrast to the AcbSh data, rats failed to self-administer any tested dose of cocaine into the AcbC or areas ventral to the AcbSh. These findings suggest that the AcbSh is a neuroanatomical substrate for the reinforcing effects of cocaine and that activation of D2-like receptors is involved.

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Crossref · 10.1124/jpet.102.038950

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Authors
Rodd-Henricks, Z. A., McKinzie, D. L., Li, T.-K., Murphy, J. M., & McBride, W. J.
Affiliations
Indiana University Indianapolis (US)
Venue
The Journal of Pharmacology and Experimental Therapeutics
Publisher
Elsevier BV
Published
2002-01
Volume
303
Issue
3
Pages
1216-1226
ISSN
0022-3565 (ISSN-L)
OpenAlex
W2155353589
Cited by
150
References
56
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2021: 2 · 2020: 6 · 2018: 2 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 11 · 2013: 7 · 2012: 9
FWCI
3.95
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Institut Carnot Santé Animale
  • National Institute on Alcohol Abuse and Alcoholism (AA 10721, AA-07462, R01AA010721, AA122262, AA00207, T32AA007462)
  • National Institute on Drug Abuse
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
cocaine, nucleus accumbens shell, nucleus accumbens core, D2-like receptors, sulpiride, mesolimbic dopamine system, cocaine reward, reinstatement, Wistar rats
MeSH terms
Animals, Cocaine, Conditioning, Operant, Female, Injections, Intraventricular, Nucleus Accumbens, Reaction Time, Self Administration, Rats, Wistar, Dopamine Antagonists, Rats

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