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Cited by 360

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Regional Cerebral Blood Flow Changes as a Function of Delta and Spindle Activity during Slow Wave Sleep in Humans

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Hofle, Nina, Paus, Tomás, Reutens, David, Fiset, Pierre, Gotman, Jean, Evans, Alan C., Jones, Barbara E.·1997·The Journal of Neuroscience
DOI 10.1523/jneurosci.17-12-04800.1997
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Abstract

In the present study, we investigated changes in regional cerebral blood flow (rCBF) in humans during the progression from relaxed wakefulness through slow wave sleep (SWS). These changes were examined as a function of spindle (12–15 Hz) and δ (1.5–4.0 Hz) electroencephalographic (EEG) activity of SWS. rCBF was studied with positron emission tomography (PET) using the H 215 O bolus method. A maximum of six 60 sec scans were performed per subject during periods of wakefulness and stages 1–4 of SWS, as determined by on-line EEG monitoring. Spectral analysis was performed off-line on the EEG epochs corresponding to the scans for computation of activity in specific frequency bands. The relationship between EEG frequency band activity and normalized rCBF was determined by means of a voxel-by-voxel analysis of covariance. δ activity covaried negatively with rCBF most markedly in the thalamus and also in the brainstem reticular formation, cerebellum, anterior cingulate, and orbitofrontal cortex. After the effect of δ was removed, a significant negative covariation between spindle activity and the residual rCBF was evident in the medial thalamus. These negative covariations may reflect the disfacilitation and active inhibition of thalamocortical relay neurons in association with δ and spindles, as well as the neural substrates underlying the progressive attenuation of sensory awareness, motor responsiveness, and arousal that occur during SWS. δ activity covaried positively with rCBF in the visual and auditory cortex, possibly reflecting processes of dream-like mentation purported to occur during SWS.

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Metadata

Authors
Hofle, N., Paus, T., Reutens, D., Fiset, P., Gotman, J., Evans, A. C., & Jones, B. E.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
1997-06-15
Volume
17
Issue
12
Pages
4800-4808
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.17-12-04800.1997
OpenAlex
W2097617006
Cited by
360
References
10
FWCI
6.70
Type
journal article
Language
en
Open access
hybrid
Licence
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)

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CoChat. (2026). Citation check: Regional Cerebral Blood Flow Changes as a Function of Delta and Spindle Activity during Slow Wave Sleep in Humans. https://app.cochat.ai/papers/10.1523/jneurosci.17-12-04800.1997
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Hofle, N., Paus, T., Reutens, D., Fiset, P., Gotman, J., Evans, A. C., & Jones, B. E. (1997). Regional Cerebral Blood Flow Changes as a Function of Delta and Spindle Activity during Slow Wave Sleep in Humans. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.17-12-04800.1997

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