The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Fibroblast Growth Factor 2 (FGF-2) Promotes Acquisition of Epidermal Growth Factor (EGF) Responsiveness in Mouse Striatal Precursor Cells: Identification of Neural Precursors Responding to both EGF and FGF-2
Open accessAbstract
Epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF-2) induce the proliferation of neural precursor cells isolated from specific regions of the embryonic and adult brain. However, the lineage relationship between the EGF- and FGF-2-responsive cells is unknown. In this study we used phosphorylation of the transcription factor cAMP response element-binding protein as a functional readout to identify cells responding to EGF and FGF-2. In primary cultures of mouse embryonic day 14 (E14) striatum, maintained in vitro for 24 hr, 12% of the cells responded to FGF-2, whereas no response to EGF could be detected. Seventy-five percent of these FGF-2-responsive cells were β tubulin III (TuJ1)-positive neurons, and 25% expressed nestin, a marker for neuroepithelial precursors. After growth factor treatment for 6 d, a population of nestin-positive cells responding to both EGF and FGF-2 were identified. The 6-d-old cultures also contained a small number of TuJ1-positive cells that responded to FGF-2 only. Priming of striatal cells for 24 hr with FGF-2 but not with EGF was sufficient to induce the appearance of EGF- and FGF-2 responsive cells after only 2 d in vitro. Thus, neural precursor cells from the mouse E14 striatum initially responding to FGF-2 only acquire EGF responsiveness later during in vitro development. At this stage EGF and FGF-2 act on the same cells. The acquisition of EGF responsiveness is promoted by FGF-2.
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Reynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482
Marshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 3,906
CNS stem cells express a new class of intermediate filament protein
Lendahl, U., Zimmerman, L. B., & McKay, R. D. G. (1990) · Cell · doi:10.1016/0092-8674(90)90662-x · Cited by 3,151
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Gonzalez, G. A., & Montminy, M. R. (1989) · Cell · doi:10.1016/0092-8674(89)90013-5 · Cited by 2,464
A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes
Reynolds, B., Tetzlaff, W., & Weiss, S. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04565.1992 · Cited by 1,509
Stem Cells in the Central Nervous System
McKay, R. (1997) · Science · doi:10.1126/science.276.5309.66 · Cited by 1,472
Reynolds, B. A., & Weiss, S. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0090 · Cited by 1,360
Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase
Xing, J., Ginty, D. D., & Greenberg, M. E. (1996) · Science · doi:10.1126/science.273.5277.959 · Cited by 1,248
Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis
Weiss, S., Dunne, C., Hewson, J., Wohl, C., Wheatley, M., Peterson, A. C., & Reynolds, B. A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07599.1996 · Cited by 1,220
Johe, K. K., Hazel, T. G., Muller, T., Dugich-Djordjevic, M. M., & McKay, R. D. (1996) · Genes & Development · doi:10.1101/gad.10.24.3129 · Cited by 1,154
Cited by
Gritti, A., Frölichsthal-Schoeller, P., Galli, R., Parati, E. A., Cova, L., Pagano, S. F., Bjornson, C. R., & Vescovi, A. L. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03287.1999 · Cited by 522
Sirt1 contributes critically to the redox-dependent fate of neural progenitors
Prozorovski, T., Schulze-Topphoff, U., Glumm, R., Baumgart, J., Schröter, F., Ninnemann, O., Siegert, E., Bendix, I., Brüstle, O., Nitsch, R., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1700 · Cited by 451
Raballo, R., Rhee, J., Lyn-Cook, R., Leckman, J. F., Schwartz, M. L., & Vaccarino, F. M. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-13-05012.2000 · Cited by 420
Neural stem cell systems: physiological players or in vitro entities?
Conti, L., & Cattaneo, E. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2761 · Cited by 320
Garcion, E., Halilagic, A., Faissner, A., & ffrench-Constant, C. (2004) · Development · doi:10.1242/dev.01202 · Cited by 309
Metadata
- Authors
- Ciccolini, F., & Svendsen, C. N.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-10-01
- Volume
- 18
- Issue
- 19
- Pages
- 7869-7880
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1834737933
- Cited by
- 290
- References
- 36
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Fibroblast Growth Factor 2 (FGF-2) Promotes Acquisition of Epidermal Growth Factor (EGF) Responsiveness in Mouse Striatal Precursor Cells: Identification of Neural Precursors Responding to both EGF and FGF-2. https://app.cochat.ai/papers/10.1523/jneurosci.18-19-07869.1998
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- Ciccolini, F., & Svendsen, C. N. (1998). Fibroblast Growth Factor 2 (FGF-2) Promotes Acquisition of Epidermal Growth Factor (EGF) Responsiveness in Mouse Striatal Precursor Cells: Identification of Neural Precursors Responding to both EGF and FGF-2. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.18-19-07869.1998
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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