The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cocaine Experience Controls Bidirectional Synaptic Plasticity in the Nucleus Accumbens
Open accessAbstract
Plasticity of glutamatergic synapses is a fundamental mechanism through which experience changes neural function to impact future behavior. In animal models of addiction, glutamatergic signaling in the nucleus accumbens (NAc) exerts powerful control over drug-seeking behavior. However, little is known about whether, how or when experience with drugs may trigger synaptic plasticity in this key nucleus. Using whole-cell synaptic physiology in NAc brain slices, we demonstrate that a progression of bidirectional changes in glutamatergic synaptic strength occurs after repeated in vivo exposure to cocaine. During a protracted drug-free period, NAc neurons from cocaine-experienced mice develop a robust potentiation of AMPAR-mediated synaptic transmission. However, a single re-exposure to cocaine during extended withdrawal becomes a potent stimulus for synaptic depression, abruptly reversing the initial potentiation. These enduring modifications in AMPAR-mediated responses and plasticity may provide a neural substrate for disrupted processing of drug-related stimuli in drug-experienced individuals.
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Cites
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A role for lateral hypothalamic orexin neurons in reward seeking
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Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
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Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz, M. B., Chen, J., Carlezon, W. A., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., et al. (1999) · Nature · doi:10.1038/45790 · Cited by 641
Critical periods for experience-dependent synaptic scaling in visual cortex
Desai, N. S., Cudmore, R. H., Nelson, S. B., & Turrigiano, G. G. (2002) · Nature Neuroscience · doi:10.1038/nn878 · Cited by 582
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Bidirectional synaptic plasticity: from theory to reality
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Self-citation
Cited by
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340
Synaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397
The glutamate homeostasis hypothesis of addiction
Kalivas, P. W. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2515 · Cited by 1,350
The brain on drugs: from reward to addiction
Volkow, N. D., & Morales, M. (2015) · Cell · doi:10.1016/j.cell.2015.07.046 · Cited by 1,306
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
Lüscher, C., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.017 · Cited by 1,105
Metadata
- Authors
- Kourrich, S., Rothwell, P. E., Klug, J. R., & Thomas, M. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-07-25
- Volume
- 27
- Issue
- 30
- Pages
- 7921-7928
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1972949334
- Cited by
- 429
- References
- 10
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kourrich, S., Rothwell, P. E., Klug, J. R., & Thomas, M. J. (2007). Cocaine Experience Controls Bidirectional Synaptic Plasticity in the Nucleus Accumbens. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.1859-07.2007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
