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Cited by 243Visual perception and processing mechanismsNeurogenesis and neuroplasticity mechanismsTactile and Sensory Interactions

The critical period for ocular dominance plasticity in the Ferret's visual cortex

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Issa, Naoum P., Trachtenberg, Joshua T., Chapman, Barbara, Zahs, Kathleen R., Stryker, Michael P.·1999·The Journal of Neuroscience
DOI 10.1523/jneurosci.19-16-06965.1999PMC PMC2413141
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Abstract

Microelectrode recordings and optical imaging of intrinsic signals were used to define the critical period for susceptibility to monocular deprivation (MD) in the primary visual cortex of the ferret. Ferrets were monocularly deprived for 2, 7 or >14 d, beginning between postnatal day 19 (P19) and P110. The responses of visual cortical neurons to stimulation of the two eyes were used to gauge the onset, peak, and decline of the critical period. MDs ending before P32 produced little or no loss of response to the deprived eye. MDs of 7 d or more beginning around P42 produced the greatest effects. A rapid decline in cortical susceptibility to MD was observed after the seventh week of life, such that MDs beginning between P50 and P65 were approximately half as effective as those beginning on P42; MDs beginning after P100 did not reduce the response to the deprived eye below that to the nondeprived eye. At all ages, 2 d deprivations were 55-85% as effective as 7 d of MD. Maps of intrinsic optical responses from the deprived eye were weaker and less well tuned for orientation than those from the nondeprived eye, with the weakest maps seen in the hemisphere ipsilateral to the deprived eye. Analysis of the effects of 7 d and longer deprivations revealed a second period of plasticity in cortical responses in which MD induced an effect like that of strabismus. After P70, MD caused a marked loss of binocular responses with little or no overall loss of response to the deprived eye. The critical period measured here is compared to other features of development in ferret and cat.

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  • In mice, puberty may overlap with the decline in ocular dominance plasticity, but this is not true for many other species, including ferrets, monkeys, and humans.

    “In mice, puberty may overlap with the decline in ocular dominance plasticity, but this is not true for many other species, including ferrets (Issa et al., 1999) monkeys (LeVay et al., 1980), and humans (Sengpiel, 2014).”

    From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Issa et al., 1999

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Research works printed but not linked: 1

  1. Maurer D, Lewis TL (1993) Visual outcomes after infantile cataract. In: Early visual development, normal and abnormal (Simons KW, ed), pp 454 -484. New York: Oxford UP.

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Authors
Issa, N. P., Trachtenberg, J. T., Chapman, B., Zahs, K. R., & Stryker, M. P.
Affiliations
University of California, San Francisco (US)
ORCID
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
1999-08-15
Volume
19
Issue
16
Pages
6965-6978
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.19-16-06965.1999
PMC
PMC2413141
OpenAlex
W2124965245
Cited by
243
References
76
Citations by year
2026: 4 · 2025: 11 · 2024: 3 · 2023: 7 · 2022: 10 · 2021: 6 · 2020: 12 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 8
FWCI
5.56
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Stryker
  • National Institutes of Health (EY02874)
  • National Eye Institute (R01EY002874, EY-02874, R37EY002874)
  • National Cancer Institute (P01CA095616)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords
ocular dominance plasticity, critical period, monocular deprivation, primary visual cortex, ferrets, strabismus, orientation tuning, cortical development, postnatal development
MeSH terms
Aging, Animals, Critical Period, Psychological, Dominance, Cerebral, Ferrets, Functional Laterality, Neuronal Plasticity, Ocular Physiological Phenomena, Sensory Deprivation, Visual Cortex, Vision, Monocular

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