Critical-Period Plasticity in the Visual Cortex

Levelt, Christiaan N.; Hübener, Mark

doi:10.1146/annurev-neuro-061010-113813

Cited by 417Visual perception and processing mechanismsNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

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Critical-Period Plasticity in the Visual Cortex

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Levelt, Christiaan N., Hübener, Mark·2012·Annual Review of Neuroscience

DOI 10.1146/annurev-neuro-061010-113813

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Abstract

In many regions of the developing brain, neuronal circuits undergo defined phases of enhanced plasticity, termed critical periods. Work in the rodent visual cortex has led to important insights into the cellular and molecular mechanisms regulating the timing of the critical period. Although there is little doubt that the maturation of specific inhibitory circuits plays a key role in the opening of the critical period in the visual cortex, it is less clear what puts an end to it. In this review, we describe the established mechanisms and point out where more experimental work is needed. We also show that plasticity in the visual cortex is present well before, and long after, the peak of the critical period.

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Maturation of GABAergic inhibition mediated by fast-spiking PV interneuron network is crucial for triggering onset and regulating progression of critical period for functional wiring in V1.
“It is now well established, largely from studies in rodent primary visual cortex, that the maturation of GABAergic inhibition mediated by a fast-spiking PV interneuron network is a crucial mechanism for triggering the onset and regulating the progression of the critical period for functional wiring in V1 (16,46).”
From MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015) · cites this paper as [46]
After eye opening, visual experience further refines and elaborates circuits that are needed for normal visual function.
“After eye opening, visual experience further refines and elaborates circuits that are critical for normal visual function.”
From Role of emergent neural activity in visual map development (2014) · cites this paper as [7]
Visual experience has a clear role in directing refinement of synaptic connectivity.
“Though visual experience has a clear role in directing the refinement of synaptic connectivity [7]”
From Role of emergent neural activity in visual map development (2014) · cites this paper as [7]

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Authors: Levelt, C. N., & Hübener, M.
Affiliations: Netherlands Institute for Neuroscience (NL)
Max Planck Society (DE)
ORCID: Levelt, Christiaan N.
Hübener, Mark
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2012-07-21
Volume: 35
Issue: 1
Pages: 309-330
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev-neuro-061010-113813
OpenAlex: W2100171700
Cited by: 402
References: 151
Citations by year: 2026: 23 · 2025: 32 · 2024: 25 · 2023: 18 · 2022: 27 · 2021: 25 · 2020: 31 · 2019: 20 · 2018: 40 · 2017: 34 · 2016: 22 · 2015: 37 · 2014: 35 · 2013: 23 · 2012: 9
FWCI: 2.55
Type: journal article
Language: en
Open access: green
zenodo.org
Licence: other-oa
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: critical period, critical period plasticity, visual cortex, cortical development, inhibitory circuits, neuronal maturation
MeSH terms: Aging, Animals, Critical Period, Psychological, Humans, Models, Neurological, Neural Inhibition, Synaptic Transmission, Neuronal Plasticity, Visual Cortex, Signal Transduction, Dominance, Ocular

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Critical-Period Plasticity in the Visual Cortex

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