Sleep-Dependent Plasticity Requires Cortical Activity
Open accessAbstract
Recent findings in humans and animals suggest that sleep promotes synaptic plasticity, but the underlying mechanisms have not been identified. We have demonstrated recently an important role for sleep in ocular dominance (OD) plasticity, a classic form of in vivo cortical remodeling triggered by monocular deprivation (MD) during a critical period of development. The mechanisms responsible for the effects of sleep on OD plasticity are unknown but may depend on neuronal activity in the sleeping brain. We investigated the role of cortical activity in sleep-dependent plasticity by reversibly inactivating the sleeping visual cortex (V1) after a period of MD. Critical period cats were bilaterally implanted with cannulas in V1 and standard EEG/EMG electrodes for polysomnographic recording. After a period of MD, visual cortices were infused with the sodium channel blocker lidocaine in vehicle or vehicle only during sleep. A third group of cats served as sham controls and were infused with lidocaine outside of V1 (into the CSF). Both optical imaging of intrinsic cortical signals and microelectrode recordings showed that OD plasticity was significantly reduced in cats whose visual cortices were reversibly silenced during sleep. These findings demonstrate that the mechanisms governing this form of sleep-dependent plasticity require cortical activity. They provide an important insight into how sleep modifies synaptic circuitry by narrowing the range of possible candidate mechanisms to those that are activity dependent.
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Inactivating the sleeping visual cortex with lidocaine or muscimol inhibited ODP, indicating that postsynaptic activity during sleep is required for consolidating plastic changes induced by monocular experience.
“Inactivating the sleeping visual cortex by administration of the Na ϩ channel blocker lidocaine or the GABA A agonist muscimol inhibited ODP, indicating that postsynaptic activity during sleep is required for consolidating the plastic changes induced by a monocular experience (411, 605).”
From About Sleep's Role in Memory (2013) · cites this paper as [605]
The Experimental procedures and Optical and microelectrode recordings sections report that lidocaine inactivated visual cortex during post-deprivation sleep and reduced ocular-dominance plasticity. The Discussion concludes that cortical activity during sleep is required for consolidation, but our copy does not report muscimol administration or establish a specifically postsynaptic requirement. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Self-citation
- Authors
- Jha, S. K., Jones, B. E., Coleman, T., Steinmetz, N., Law, C.-T., Griffin, G., Hawk, J., Dabbish, N., Kalatsky, V. A., & Frank, M. G.
- Affiliations
- University of Pennsylvania (US)
- University of Houston (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-10-05
- Volume
- 25
- Issue
- 40
- Pages
- 9266-9274
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6725765
- OpenAlex
- W2086233863
- Cited by
- 96
- References
- 41
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 6
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- University of Pennsylvania
- U.S. Public Health Service
- National Institute of Mental Health (5-R01-MH067568, R01MH067568)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- ocular dominance plasticity, cortical activity, monocular deprivation, critical period, visual cortex, lidocaine infusion, synaptic plasticity, activity-dependent plasticity, cats
- MeSH terms
- Action Potentials, Analysis of Variance, Anesthetics, Local, Animals, Animals, Newborn, Behavior, Animal, Brain Mapping, Cats, Critical Period, Psychological, Diagnostic Imaging, Electroencephalography, Electromyography, Functional Laterality, Lidocaine, Neuronal Plasticity, Sensory Deprivation, Sleep, Visual Cortex, Visual Pathways, Dominance, Ocular, In Vitro Techniques
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