Blockade of postsynaptic activity in sleep inhibits developmental plasticity in visual cortex
Abstract
Ocular dominance plasticity is enhanced by sleep and reduced by sleep deprivation or when all neural activity in the sleeping visual cortex is reversibly inhibited. These latter findings demonstrate that the mechanisms responsible for the effects of sleep on cortical plasticity are activity dependent. To better isolate this activity dependent mechanism, we investigated the role of postsynaptic activity by inactivating the sleeping visual cortex after a period of monocular deprivation with the gamma-amino-n-butyric acid agonist muscimol. Microelectrode recordings showed that ocular dominance plasticity was significantly reduced in cortices reversibly silenced during sleep compared with cortices infused with vehicle only. These findings demonstrate that postsynaptic activity during sleep is required for the consolidation of experience-dependent cortical plasticity.
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In developing cortex of cats, ocular dominance plasticity induced by monocular deprivation requires sleep.
“In the developing cortex of cats, ocular dominance plasticity induced by monocular deprivation of one eye requires sleep (77,412,413).”
From About Sleep's Role in Memory (2013) · cites this paper as [413]
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- Authors
- Frank, M. G., Jha, S. K., & Coleman, T.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Frank, Marcos G.
- Venue
- NeuroReport
- Published
- 2006-09-18
- Volume
- 17
- Issue
- 13
- Pages
- 1459-1463
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2017584131
- Cited by
- 33
- References
- 11
- Citations by year
- 2026: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (5-R01-MH067568, R01MH067568)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ocular dominance plasticity, sleep, postsynaptic activity, visual cortex, cortical plasticity, monocular deprivation, muscimol, GABAergic inhibition, experience-dependent plasticity
- MeSH terms
- Action Potentials, Animals, Cats, Electroencephalography, Electromyography, Muscimol, Neural Inhibition, Neuronal Plasticity, Sleep, Sleep Deprivation, Synapses, Visual Cortex, Visual Pathways, GABA Agonists, Excitatory Postsynaptic Potentials, Dominance, Ocular
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