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Structural Determinants of Transmission at Large Hippocampal Mossy Fiber Synapses
Open accessAbstract
Synapses are the key elements for signal processing and plasticity in the brain. To determine the structural factors underlying the unique functional properties of the hippocampal mossy fiber synapse, the complete quantitative geometry was investigated, using electron microscopy of serial ultrathin sections followed by computer-assisted three-dimensional reconstruction. In particular, parameters relevant for transmitter release and synaptic plasticity were examined. Two membrane specializations were found: active zones (AZs), transmitter release sites, and puncta adherentia, putative adhesion complexes. Individual boutons had, on average, 25 AZs (range, 7–45) that varied in shape and size (mean, 0.1 μm 2 ; range, 0.07–0.17 μm 2 ). The mean distance between individual AZs was 0.45 μm. Mossy fiber boutons and their target structures were mostly ensheathed by astrocytes, but fine glial processes never reached the active zones. Two structural factors are likely to promote synaptic cross talk: the short distance between AZs and the absence of fine glial processes at AZs. Thus, synaptic cross talk may contribute to the efficacy of hippocampal mossy fiber synapses. On average, a bouton contained 20,400 synaptic vesicles; ∼900 vesicles were located within 60 nm from the active zone, ∼4400 between 60 and 200 nm, and the remaining beyond 200 nm, suggesting large readily releasable, recycling, and reserve pools. The organization of the different pools may be a key structural correlate of presynaptic plasticity at this synapse. Thus, the mossy fiber bouton differs fundamentally in structure and function from the calyx of Held and other central synapses.
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“Proper synapse formation during childhood provides a substrate for cognition, whereas improper formation or functionality leads to neuro-developmental disorders including mental retardation and autism”
From Human Brain/Cloud Interface (2019) · cites this paper as Rollenhagen et al., 2007
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“Finally, it is accessible to quantitative structural analysis by EM [34,35], high-pressure freezing (HPF) [36–38], and freeze-fracture replica labeling (FRL) [39].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [34]
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“Under control conditions, we estimate an RRP size of 1.6 vesicles per AZ (S4 Table; assuming that a typically sized MFB contains 29 AZs) [34].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [34]
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Self-citation
Metadata
- Authors
- Rollenhagen, A., Sätzler, K., Rodríguez, E. P., Jonas, P., Frotscher, M., & Lübke, J. H. R.
- Affiliations
- Forschungszentrum Jülich (DE)
- University of Ulster (GB)
- University of Freiburg (DE)
- Corresponding author
- Lübke, Joachim H. R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-09-26
- Volume
- 27
- Issue
- 39
- Pages
- 10434-10444
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673150
- OpenAlex
- W1976225114
- Cited by
- 246
- References
- 52
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 19 · 2023: 15 · 2022: 8 · 2021: 18 · 2020: 15 · 2019: 25 · 2018: 18 · 2017: 18 · 2016: 9 · 2015: 9 · 2014: 16 · 2013: 5 · 2012: 14
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- active zone, synaptic vesicles, readily releasable pool, synaptic vesicle recycling, reserve pool, presynaptic plasticity, 3D reconstruction
- MeSH terms
- Animals, Microscopy, Electron, Synaptic Transmission, Neuronal Plasticity, Synapses, Synaptic Vesicles, Rats, Wistar, Neurotransmitter Agents, Mossy Fibers, Hippocampal, Imaging, Three-Dimensional, Models, Animal, Rats
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