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Dissociable Neural Responses in Human Reward Systems
Open accessAbstract
Reward is one of the most important influences shaping behavior. Single-unit recording and lesion studies in experimental animals have implicated a number of regions in response to reinforcing stimuli, in particular regions of the extended limbic system and the ventral striatum. In this experiment, functional neuroimaging was used to assess neural response within human reward systems under different psychological contexts. Nine healthy volunteers were scanned using functional magnetic resonance imaging during the performance of a gambling task with financial rewards and penalties. We demonstrated neural sensitivity of midbrain and ventral striatal regions to financial rewards and hippocampal sensitivity to financial penalties. Furthermore, we show that neural responses in globus pallidus, thalamus, and subgenual cingulate were specific to high reward levels occurring in the context of increasing reward. Responses to both reward level in the context of increasing reward and penalty level in the context of increasing penalty were seen in caudate, insula, and ventral prefrontal cortex. These results demonstrate dissociable neural responses to rewards and penalties that are dependent on the psychological context in which they are experienced.
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“The ventral striatum has been implicated in reward-related processing in humans (Knutson, Adams, Fong, & Hommer, 2001; McClure, York, & Montague, 2004) and animals (Elliott, Friston, & Dolan, 2000).”
From Gender Differences in Emotion Regulation: An fMRI Study of Cognitive Reappraisal (2008) · cites this paper as Elliott, Friston, & Dolan, 2000
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Metadata
- Authors
- Elliott, R., Friston, K. J., & Dolan, R. J.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- The Royal Free Hospital (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-08-15
- Volume
- 20
- Issue
- 16
- Pages
- 6159-6165
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6772605
- OpenAlex
- W2105389170
- Cited by
- 740
- References
- 55
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 23 · 2023: 16 · 2022: 10 · 2021: 13 · 2020: 18 · 2019: 12 · 2018: 20 · 2017: 21 · 2016: 15 · 2015: 34 · 2014: 36 · 2013: 29 · 2012: 50
- FWCI
- 13.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- reward processing, punishment, monetary rewards, fines, gambling task, ventral striatum, midbrain, hippocampus, globus pallidus, thalamus, subgenual anterior cingulate cortex, caudate nucleus, insula, ventral prefrontal cortex
- MeSH terms
- Brain, Brain Mapping, Emotions, Humans, Magnetic Resonance Imaging, Motivation, Neuropsychological Tests, Psychomotor Performance, Reward
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