Responses to reward in monkey dorsal and ventral striatum
Abstract
The sources of input and the behavioral effects of lesions and drug administration suggest that the striatum participates in motivational processes. We investigated the activity of single striatal neurons of monkeys in response to reward delivered for performing in a go-nogo task. A drop of liquid was given each time the animal correctly executed or withheld an arm movement in reaction to a visual stimulus. Of 1593 neurons, 115 showed increased activity in response to delivery of liquid reward in both go and nogo trials. Responding neurons were predominantly located in dorsal and ventromedial parts of anterior putamen, in dorsal and ventral caudate, and in nucleus accumbens. They were twice as frequent in ventral as compared to dorsal striatal areas. Responses occurred at a median latency of 337 ms and lasted for 525 ms, with insignificant differences between dorsal and ventral striatum. Reward responses differed from activity recorded in the face area of posterior putamen which varied synchronously with individual mouth movements. Responses were directly related to delivery of primary liquid reward and not to auditory stimuli associated with it. Most of them also occurred when reward was delivered outside of the task. These results demonstrate that neurons of dorsal and particularly ventral striatum are involved in processing information concerning the attribution of primary reward.
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The brain regions that support voluntary saccadic eye movements and reward processing are well characterized.
“The brain regions supporting the generation of voluntary saccadic eye movements as well as the processing of rewards are well-delineated”
From Developmental changes in brain function underlying the influence of reward processing on inhibitory control (2011) · cites this paper as Apicella et al., 1991
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- Authors
- Apicella, P., Ljungberg, T., Scarnati, E., & Schultz, W.
- Affiliations
- University of Fribourg (CH)
- Venue
- Experimental Brain Research
- Published
- 1991-07
- Volume
- 85
- Issue
- 3
- Pages
- 491-500
- ISSN
- 0014-4819 (ISSN-L)
- 1432-1106
- OpenAlex
- W2076506821
- Cited by
- 369
- References
- 35
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 10 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 13 · 2017: 10 · 2016: 21 · 2015: 15 · 2014: 12 · 2013: 13 · 2012: 18
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- reward processing, striatum, dorsal striatum, ventral striatum, single-unit activity, go/no-go task, anterior putamen, caudate nucleus, nucleus accumbens, motivational processes, primary reward, response latency
- MeSH terms
- Animals, Behavior, Animal, Brain Mapping, Corpus Striatum, Macaca fascicularis, Male, Movement, Reaction Time, Reward
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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