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Functional interaction between opioid and cannabinoid receptors in drug self-administration.
Open accessAbstract
The present study was designed to explore the relationship between the cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. The acute administration of SR141716A, a selective central cannabinoid CB1 receptor antagonist, blocked heroin self-administration in rats, as well as morphine-induced place preference and morphine self-administration in mice. Morphine-dependent animals injected with SR141716A exhibited a partial opiate-like withdrawal syndrome that had limited consequences on operant responses for food and induced place aversion. These effects were associated with morphine-induced changes in the expression of CB1 receptor mRNA in specific nuclei of the reward circuit, including dorsal caudate putamen, nucleus accumbens, and septum. Additionally, the opioid antagonist naloxone precipitated a mild cannabinoid-like withdrawal syndrome in cannabinoid-dependent rats and blocked cannabinoid self-administration in mice. Neither SR141716A nor naloxone produced any intrinsic effect on these behavioral models. The present results show the existence of a cross-interaction between opioid and cannabinoid systems in behavioral responses related to addiction and open new strategies for the treatment of opiate dependence.
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“Evidence from pre-clinical studies demonstrates that antagonists of opioid receptors were able to reduce discriminative stimulus and reinforcing effects produced by the activation of CB1 receptors 71, 72.”
From Psychosocial and pharmacological interventions for the treatment of cannabis use disorder (2018) · cites this paper as [71]
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Cites
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Ledent, C. A., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Impérato, A., Pedrazzini, T., Roques, B. P., et al. (1999) · Science · doi:10.1126/science.283.5400.401 · Cited by 3,628
Self-citationMechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · cited 2×
“It is composed by the cannabinoid CB1 receptor (Devane et al., 1988; Matsuda et al., 1993), several endogenous lipid transmitters, including anandamide (Devane et al.”
BackgroundHerkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159
Naltrexone in the Treatment of Alcohol Dependence
Volpicelli, J. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820110040006 · Cited by 1,828
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
Rinaldi, M. L., Barth, F., Héaulme, M., Shire, D. J., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00773-x · Cited by 1,762
Matthes, H. W. D., Maldonado, R., Simonin, F., Valverde, O., Slowe, S., Kitchen, I., Befort, K., Dierich, A., Le Meur, M., Dollé, P., et al. (1996) · Nature · doi:10.1038/383819a0 · Cited by 1,722
Self-citationA second endogenous cannabinoid that modulates long-term potentiation
Stella, N., Schweitzer, P., & Piomelli, D. (1997) · Nature · doi:10.1038/42015 · Cited by 1,496
Research works printed but not linked: 1
- Caine SB Lintz R Koob GF (1993) Intravenous drug self-administration techniques in animals. in Behavioral neuroscience: a practical approach, ed Sahgal A (Oxford UP, Oxford), pp 117–143.
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Castañé, A., Maldonado, R. J., & Valverde, O. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705882 · Cited by 31
Self-citationWills, K. L., Vemuri, K., Kalmar, A., Lee, A., Limebeer, C. L., Makriyannis, A., & Parker, L. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3575-5 · Cited by 29
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Šustková-Fišerová, M., Charalambous, C., Havlickova, T., Lapka, M., Jerabek, P., Puskina, N., & Syslová, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112486 · Cited by 29
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Tapocik, J. D., Letwin, N. E., Mayo, C. L., Frank, B. C., Luu, T., Oduaran, O. H., House, C. D., Williams, R., Elmer, G. I., & Lee, N. H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4020-08.2009 · Cited by 30
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Corchero, J., Oliva, J. M., Garcı́a-Lecumberri, C., Martı́n, S., Ambrosio, E., & Manzanares, J. (2004) · Journal of Psychopharmacology · doi:10.1177/0269881104040237 · Cited by 28
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Getachew, B., Hauser, S. R., Dhaher, R., Katner, S. N., Bell, R. L., Oster, S. M., McBride, W. J., & Rodd, Z. A. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.11.006 · Cited by 27
Biała, G., Budzyńska, B., & Staniak, N. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.042 · Cited by 27
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Fattore, L., Spano, M. S., Melis, V., Fadda, P., & Fratta, W. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01459.x · Cited by 26
Self-citationUrigüen, L., Berrendero, F., Ledent, C. A., Maldonado, R. J., & Manzanares, J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04372.x · Cited by 25
Self-citationPlescia, F., Brancato, A., Marino, R. A. M., & Cannizzaro, C. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00064 · Cited by 25
Gibuła‐Tarłowska, E., & Kotlinska, J. H. (2020) · Biomolecules · doi:10.3390/biom10101376 · Cited by 25
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Solbrig, M. V., Adrian, R., Baratta, J. L., Piomelli, D., & Giuffrida, A. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.02.017 · Cited by 24
Hermes, D. J., Jacobs, I. R., Key, M. C., League, A. F., Yadav-Samudrala, B. J., Xu, C., McLane, V. D., Nass, S. R., Jiang, W., Meeker, R. B., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01971-6 · Cited by 25
Zhang, H., Lipinski, A. A., Liktor‐Busa, E., Smith, A. F., Moutal, A., Khanna, R., Langlais, P. R., Largent‐Milnes, T. M., & Vanderah, T. W. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.632757 · Cited by 24
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Ronan, P. J., Wongngamnit, N., & Beresford, T. P. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.10.002 · Cited by 25
Iyer, V., Rangel‐Barajas, C., Woodward, T. J., Kulkarni, A., Cantwell, L., Crystal, J. D., Mackie, K., Rebec, G. V., Thakur, G. A., & Hohmann, A. G. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106474 · Cited by 20
Rossi, S., Chiara, V. D., Musella, A., Mataluni, G., Sacchetti, L., Siracusano, A., Bernardi, G., Usiello, A., & Centonze, D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.10.013 · Cited by 22
Paquette, J. J., Wang, H.-Y., Bakshi, K. P., & Olmstead, M. C. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282f15890 · Cited by 22
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Ross, J. A., & Bockstaele, E. J. V. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14714 · Cited by 20
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Hillard, C. J. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.004 · Cited by 21
Zádor, F., Ötvös, F., Benyhe, S., Zimmer, A., & Páldy, E. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.05.015 · Cited by 20
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Rodríguez‐Arias, M., Roger-Sánchez, C., Vilanova, I., Revert, N., Manzanedo, C., Miñarro, J., & Aguilar, M. A. (2015) · Neural Plasticity · doi:10.1155/2016/6481862 · Cited by 18
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Beardsley, P. M., Dance, M. E., Balster, R. L., & Munzar, P. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01597-7 · Cited by 18
Richtand, N. M., Ahlbrand, R. A., Horn, P. S., Chambers, B., Davis, J. F., & Benoit, S. C. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2646-8 · Cited by 17
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de Fonseca, F. R., & Schneider, M. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00116.x · Cited by 18
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Shafaroodi, H., Ghasemi, M., & Dehpour, A. R. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05101.x · Cited by 16
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Hasbi, A., Madras, B., & George, S. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.07.003 · Cited by 13
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Sîrbu, C. A., Georgescu, R., Pleşa, C., Păunescu, A., Ţânţu, M. M., Nicolae, A. C., Caloianu, I., & Mitrică, M. (2022) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000001568 · Cited by 15
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Fraga, D., Zanoni, C. I. S., Zampronio, A. R., Parada, C. A., Rae, G. A., & de Souza, G. E. P. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.014 · Cited by 15
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Notzon, D. P., Kelly, M. A., Choi, C. J., Pavlicová, M., Mahony, A. L., Brooks, D. J., Mariani, J. J., & LEVIN, F. R. (2018) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2017.1423321 · Cited by 15
Lane, D., Chan, J., Lupica, C. R., & Pickel, V. M. (2010) · Synapse · doi:10.1002/syn.20807 · Cited by 15
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Alén, F., Decara, J. M., Brunori, G., You, Z., Bühler, K., López‐Moreno, J. A., Cippitelli, A., Pavón, F. J., Suárez, J., Gardner, E. L., et al. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.008 · Cited by 14
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Margiani, G., Castelli, M. P., Pintori, N., Frau, R., Ennas, M. G., Zottola, A. C. P., Orrù, V., Serra, V., Fiorillo, E., Fadda, P., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06191-9 · Cited by 13
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Capasso, A., & Gallo, C. (2009) · The Open Biochemistry Journal · doi:10.2174/1874091x00903010078 · Cited by 12
Manwell, L. A., & Mallet, P. E. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3798-5 · Cited by 12
Kelsey, J. E., & Calabro, S. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0913-x · Cited by 12
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Maldonado, R. J. (2010) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2009.12.001 · Cited by 26
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Echeverria-Villalobos, M., Fabian, C. A., Mitchell, J., Mazzota, E., Fiorda‐Diaz, J., Noon, K., & Weaver, T. E. (2024) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000007313 · Cited by 10
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Hassanzadeh, P. (2010) · Biomedical Reviews · doi:10.14748/bmr.v21.45 · Cited by 10
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Gobira, P. H., Joca, S. R. L., & Moreira, F. A. (2022) · Acta Neuropsychiatrica · doi:10.1017/neu.2022.23 · Cited by 10
Parker, K. E., McCall, J. G., McGuirk, S. R., Trivedi, S., Miller, D. K., & Will, M. J. (2015) · Brain Research · doi:10.1016/j.brainres.2015.06.010 · Cited by 10
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Bhaumik, U. K., Ghosh, A., Chatterjee, B., Sengupta, P., Darbar, S., Roy, B., Nandi, U., & Pal, T. K. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.01.032 · Cited by 9
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Knapp, C. M., & Kornetsky, C. H. (2009) · Wiley eBooks · doi:10.1002/9780470478509.neubb002040 · Cited by 9
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Luca, M. A. D., Buczynski, M. W., & Chiara, G. D. (2018) · Addiction Biology · doi:10.1111/adb.12642 · Cited by 8
Sadeghi-Adl, M., Sadat‐Shirazi, M., Shahini, F., Akbarabadi, A., Khalifeh, S., Borzabadi, S., Nasehi, M., & Zarrindast, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118430 · Cited by 8
Vaseghi, G., Rabbani, M., & Hajhashemi, V. (2013) · Europe PMC (PubMed Central) · Cited by 8
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Laviolette, S. R. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.10.004 · Cited by 6
Alton, H., Linz, E., Bi, G., Soler‐Cedeño, O., Maras, M., & Xi, Z. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02245-6 · Cited by 5
Boccella, S., Fusco, A., Ricciardi, F., Morace, A. M., Bonsale, R., Perrone, M., Marabese, I., Gregorio, D. D., Belardo, C., Posa, L., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110265 · Cited by 5
Evaluation of the abuse potential of AM281, a new synthetic cannabinoid CB1 receptor antagonist
Botanas, C. J., de la Peña, J. B., Peña, I. J. D., Tampus, R., Kim, H. J., Yoon, S. S., Seo, J., Jeong, E. J., & Cheong, J. H. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.004 · Cited by 5
Godoi, M. M., Zangrossi, H., da Cunha, J. M., & Zanoveli, J. M. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172938 · Cited by 5
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Metadata
- Authors
- Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gómez, R., del Arco, I., Villanúa, M. A., Maldonado, R., Koob, G. F., & de Fonseca, F. R.
- Affiliations
- Scripps Research Institute (US)
- University of Cagliari (IT)
- Universitat Pompeu Fabra (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Universidad Complutense de Madrid (ES)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-07-15
- Volume
- 21
- Issue
- 14
- Pages
- 5344-5350
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762870
- OpenAlex
- W1699530412
- Cited by
- 378
- References
- 63
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 7 · 2023: 5 · 2022: 13 · 2021: 7 · 2020: 10 · 2019: 5 · 2018: 14 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 18 · 2013: 18 · 2012: 14
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Funders
- Sanofi
- Comunidad de Madrid
- Universidad Complutense de Madrid
- Consiglio Nazionale delle Ricerche
- National Institutes of Health
- Plan Nacional sobre Drogas
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 26741, P01DK026741)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- opioid-cannabinoid interaction, CB1 receptor, SR141716A, naloxone, heroin self-administration, morphine self-administration, place preference, opioid withdrawal, cannabinoid withdrawal, reward systems, nucleus accumbens, caudate-putamen, septum, addiction, opioid use disorder
- MeSH terms
- Rimonabant, Animals, Avoidance Learning, Cannabinoids, Caudate Nucleus, Conditioning, Operant, Heroin, Disease Models, Animal, Heroin Dependence, Male, Morphine, Morphine Dependence, Naloxone, Narcotic Antagonists, Nucleus Accumbens, Piperidines, Putamen, Pyrazoles, Receptors, Drug, Receptors, Opioid, RNA, Messenger, Self Administration, Rats, Wistar, Septum of Brain, Receptors, Cannabinoid, Mice, Rats
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