Cited by 378Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

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Functional interaction between opioid and cannabinoid receptors in drug self-administration.

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Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gómez, R., del Arco, I., Villanúa, M. A., Maldonado, R., Koob, G. F., de Fonseca, F. Rodrı́guez·2001·The Journal of Neuroscience

DOI 10.1523/jneurosci.21-14-05344.2001PMC PMC6762870

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Abstract

The present study was designed to explore the relationship between the cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. The acute administration of SR141716A, a selective central cannabinoid CB1 receptor antagonist, blocked heroin self-administration in rats, as well as morphine-induced place preference and morphine self-administration in mice. Morphine-dependent animals injected with SR141716A exhibited a partial opiate-like withdrawal syndrome that had limited consequences on operant responses for food and induced place aversion. These effects were associated with morphine-induced changes in the expression of CB1 receptor mRNA in specific nuclei of the reward circuit, including dorsal caudate putamen, nucleus accumbens, and septum. Additionally, the opioid antagonist naloxone precipitated a mild cannabinoid-like withdrawal syndrome in cannabinoid-dependent rats and blocked cannabinoid self-administration in mice. Neither SR141716A nor naloxone produced any intrinsic effect on these behavioral models. The present results show the existence of a cross-interaction between opioid and cannabinoid systems in behavioral responses related to addiction and open new strategies for the treatment of opiate dependence.

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Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice
Ledent, C. A., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Impérato, A., Pedrazzini, T., Roques, B. P., et al. (1999) · Science · doi:10.1126/science.283.5400.401 · Cited by 3,628
Self-citation
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · cited 2×
“It is composed by the cannabinoid CB1 receptor (Devane et al., 1988; Matsuda et al., 1993), several endogenous lipid transmitters, including anandamide (Devane et al.”
Background
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159
Naltrexone in the Treatment of Alcohol Dependence
Volpicelli, J. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820110040006 · Cited by 1,828
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
Rinaldi, M. L., Barth, F., Héaulme, M., Shire, D. J., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00773-x · Cited by 1,762
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene
Matthes, H. W. D., Maldonado, R., Simonin, F., Valverde, O., Slowe, S., Kitchen, I., Befort, K., Dierich, A., Le Meur, M., Dollé, P., et al. (1996) · Nature · doi:10.1038/383819a0 · Cited by 1,722
Self-citation
A second endogenous cannabinoid that modulates long-term potentiation
Stella, N., Schweitzer, P., & Piomelli, D. (1997) · Nature · doi:10.1038/42015 · Cited by 1,496

Show all 63 references

Research works printed but not linked: 1

Caine SB Lintz R Koob GF (1993) Intravenous drug self-administration techniques in animals. in Behavioral neuroscience: a practical approach, ed Sahgal A (Oxford UP, Oxford), pp 117–143.

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Vlachou, S., Stamatopoulou, F., Nomikos, G. G., & Panagis, G. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008717 · Cited by 39
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Justinová, Z., Panlilio, L. V., & Goldberg, S. R. (2009) · Current topics in behavioral neurosciences · doi:10.1007/978-3-540-88955-7_13 · Cited by 40
Blockade by the Cannabinoid CB1 Receptor Antagonist, Rimonabant (SR141716), of the Potentiation by Quinelorane of Food-Primed Reinstatement of Food-Seeking Behavior
Duarte, C., Alonso, R., Bichet, N., Cohen, C., Soubrié, P., & Thiébot, M.-H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300370 · Cited by 39
Endogenous opiates and behavior: 2001
Bodnar, R. J., & Hadjimarkou, M. M. (2002) · Peptides · doi:10.1016/s0196-9781(02)00306-6 · Cited by 36
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Rovai, L., Maremmani, A. G. I., Pacini, M., Pani, P. P., Rugani, F., Lamanna, F., Schiavi, E., Mautone, S., Dell’Osso, L., & Maremmani, I. (2013) · Rivista di psichiatria · doi:10.1708/1228.13610 · Cited by 42
Endocannabinoid lipids and mediated system: Implications for alcoholism and neuropsychiatric disorders
Vinod, K. Y., & Hungund, B. L. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.041 · Cited by 38
Functional interaction between morphine and central amygdala cannabinoid CB1 receptors in the acquisition and expression of conditioned place preference
Rezayof, A., Sardari, M., Zarrindast, M., & Nayer-Nouri, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.023 · Cited by 37
Involvement of CB1 receptors in the ventral tegmental area in the potentiation of morphine rewarding properties in acquisition but not expression in the conditioned place preference model
Rashidy‐Pour, A., Pahlevani, P., Vaziri, A., Shaigani, P., Zarepour, L., Vafaei, A. A., & Haghparast, A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.03.015 · Cited by 37
Behavioural and gene transcription alterations induced by spontaneous cannabinoid withdrawal in mice
Oliva, J. M., Ortiz, S., Palomo, T., & Manzanares, J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01627.x · Cited by 37
Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
Morel, L. J., Bruno Giros, A., & Daugé, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.70 · Cited by 37
Repeated exposure to Δ9-tetrahydrocannabinol alters heroin-induced locomotor sensitisation and Fos-immunoreactivity
Singh, M. E., McGregor, I. S., & Mallet, P. E. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.07.008 · Cited by 37
Endocannabinoids at the synapse and beyond: implications for neuropsychiatric disease pathophysiology and treatment
Scheyer, A. F., Yasmin, F., Naskar, S., & Patel, S. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01438-7 · Cited by 37
Ghrelin-Induced Orexigenic Effect in Rats Depends on the Metabolic Status and Is Counteracted by Peripheral CB1 Receptor Antagonism
Alén, F., Crespo, I., Ramírez-López, M. T., Jagerovic, N., Goya, P., de Fonseca, F. R., de Heras, R. G., & Orío, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060918 · Cited by 36
Interactions between Δ9-tetrahydrocannabinol and heroin
Li, J., Koek, W., & France, C. P. (2012) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32835a3907 · Cited by 36
Preclinical Studies of Cannabinoid Reward, Treatments for Cannabis Use Disorder, and Addiction-Related Effects of Cannabinoid Exposure
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Clinical Pharmacodynamics of Cannabinoids
Grotenhermen, F. (2004) · Journal of Cannabis Therapeutics · doi:10.1300/j175v04n01_03 · Cited by 38
Blocking the Cannabinoid Receptors: Drug Candidates and Therapeutic Promises
Muccioli, G. G. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790153 · Cited by 36
Cannabinoid CB1 receptor antagonists as potential pharmacotherapies for drug abuse disorders
Beardsley, P. M., Thomas, B. F., & McMahon, L. R. (2009) · International Review of Psychiatry · doi:10.1080/09540260902782786 · Cited by 35
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Börner, C., Höllt, V., & Kraus, J. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.018325 · Cited by 35
Psychosocial and pharmacological interventions for the treatment of cannabis use disorder
Sabioni, P., & Le Foll, B. (2018) · F1000Research · doi:10.12688/f1000research.11191.1 · Cited by 37
Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists
Altun, A., Yıldırım, K., Özdemir, E., Bağcıvan, İ., Gürsoy, S., & Durmuş, N. (2015) · The Journal of Physiological Sciences · doi:10.1007/s12576-015-0379-2 · Cited by 34
Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats
Navarro, M., Carrera, M. R. A., del Arco, I., Trigo, J. M., Koob, G. F., & de Fonseca, F. R. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.08.022 · Cited by 34
Self-citation
Boosting effect of morphine on alcohol drinking is suppressed not only by naloxone but also by the cannabinoid CB1 receptor antagonist, SR 141716
Vacca, G., Serra, S., Brunetti, G., Carai, M. A. M., Gessa, G. L., & Colombo, G. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01712-0 · Cited by 34
Spinal modulation of calcitonin gene-related peptide by endocannabinoids in the development of opioid physical dependence
Trang, T., Ma, W., Chabot, J., Quirion, R., & Jhamandas, K. H. (2006) · Pain · doi:10.1016/j.pain.2006.07.008 · Cited by 33
Endogenous opioids and cannabinoids: System interactions in the regulation of appetite, grooming and scratching
Tallett, A. J., Blundell, J. E., & Rodgers, R. J. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.02.009 · Cited by 33
Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens
Šustková-Fišerová, M., Jerabek, P., Havlickova, T., Syslová, K., & Kačer, P. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4119-3 · Cited by 33
Differential involvement of the endocannabinoid system in short- and long-term expression of incentive learning supported by nicotine in rats
Forget, B., Barthélémy, S., Saurini, F., Hamon, M., & Thiébot, M.-H. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0525-x · Cited by 32
Effect of adolescent exposure to WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference
Rodríguez‐Arias, M., Manzanedo, C., Roger-Sánchez, C., Couto, B. R. D., Aguilar, M. A., & Miñarro, J. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.10.019 · Cited by 31

Authors: Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gómez, R., del Arco, I., Villanúa, M. A., Maldonado, R., Koob, G. F., & de Fonseca, F. R.
Affiliations: Scripps Research Institute (US)
University of Cagliari (IT)
Universitat Pompeu Fabra (ES)
Consejo Superior de Investigaciones Científicas (ES)
Universidad Complutense de Madrid (ES)
ORCID: Navarro, M.
Valverde, O.
Fattore, L.
Chowen, J. A.
Maldonado, R.
Koob, G. F.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2001-07-15
Volume: 21
Issue: 14
Pages: 5344-5350
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.21-14-05344.2001
PMC: PMC6762870
OpenAlex: W1699530412
Cited by: 378
References: 63
Citations by year: 2026: 6 · 2025: 10 · 2024: 7 · 2023: 5 · 2022: 13 · 2021: 7 · 2020: 10 · 2019: 5 · 2018: 14 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 18 · 2013: 18 · 2012: 14
FWCI: 14.10
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Funders: Sanofi
Comunidad de Madrid
Universidad Complutense de Madrid
Consiglio Nazionale delle Ricerche
National Institutes of Health
Plan Nacional sobre Drogas
National Institute of Diabetes and Digestive and Kidney Diseases (DK 26741, P01DK026741)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: opioid-cannabinoid interaction, CB1 receptor, SR141716A, naloxone, heroin self-administration, morphine self-administration, place preference, opioid withdrawal, cannabinoid withdrawal, reward systems, nucleus accumbens, caudate-putamen, septum, addiction, opioid use disorder
MeSH terms: Rimonabant, Animals, Avoidance Learning, Cannabinoids, Caudate Nucleus, Conditioning, Operant, Heroin, Disease Models, Animal, Heroin Dependence, Male, Morphine, Morphine Dependence, Naloxone, Narcotic Antagonists, Nucleus Accumbens, Piperidines, Putamen, Pyrazoles, Receptors, Drug, Receptors, Opioid, RNA, Messenger, Self Administration, Rats, Wistar, Septum of Brain, Receptors, Cannabinoid, Mice, Rats

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Functional interaction between opioid and cannabinoid receptors in drug self-administration.

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