The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Functional interaction between opioid and cannabinoid receptors in drug self-administration.
Open accessAbstract
The present study was designed to explore the relationship between the cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. The acute administration of SR141716A, a selective central cannabinoid CB1 receptor antagonist, blocked heroin self-administration in rats, as well as morphine-induced place preference and morphine self-administration in mice. Morphine-dependent animals injected with SR141716A exhibited a partial opiate-like withdrawal syndrome that had limited consequences on operant responses for food and induced place aversion. These effects were associated with morphine-induced changes in the expression of CB1 receptor mRNA in specific nuclei of the reward circuit, including dorsal caudate putamen, nucleus accumbens, and septum. Additionally, the opioid antagonist naloxone precipitated a mild cannabinoid-like withdrawal syndrome in cannabinoid-dependent rats and blocked cannabinoid self-administration in mice. Neither SR141716A nor naloxone produced any intrinsic effect on these behavioral models. The present results show the existence of a cross-interaction between opioid and cannabinoid systems in behavioral responses related to addiction and open new strategies for the treatment of opiate dependence.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Evidence from pre-clinical studies demonstrates that antagonists of opioid receptors were able to reduce discriminative stimulus and reinforcing effects produced by the activation of CB1 receptors 71, 72.”
From Psychosocial and pharmacological interventions for the treatment of cannabis use disorder (2018) · cites this paper as [71]
Citations
Cites
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Ledent, C. A., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Impérato, A., Pedrazzini, T., Roques, B. P., et al. (1999) · Science · doi:10.1126/science.283.5400.401 · Cited by 3,628
Self-citationMechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · cited 2×
“It is composed by the cannabinoid CB1 receptor (Devane et al., 1988; Matsuda et al., 1993), several endogenous lipid transmitters, including anandamide (Devane et al.”
BackgroundHerkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159
Naltrexone in the Treatment of Alcohol Dependence
Volpicelli, J. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820110040006 · Cited by 1,828
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
Rinaldi, M. L., Barth, F., Héaulme, M., Shire, D. J., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00773-x · Cited by 1,762
Matthes, H. W. D., Maldonado, R., Simonin, F., Valverde, O., Slowe, S., Kitchen, I., Befort, K., Dierich, A., Le Meur, M., Dollé, P., et al. (1996) · Nature · doi:10.1038/383819a0 · Cited by 1,722
Self-citationA second endogenous cannabinoid that modulates long-term potentiation
Stella, N., Schweitzer, P., & Piomelli, D. (1997) · Nature · doi:10.1038/42015 · Cited by 1,496
Research works printed but not linked: 1
- Caine SB Lintz R Koob GF (1993) Intravenous drug self-administration techniques in animals. in Behavioral neuroscience: a practical approach, ed Sahgal A (Oxford UP, Oxford), pp 117–143.
Cited by
Sorted by citations
Items 301–378 of 378
The Role of the Endocannabinoid System in Addiction
Trigo, J. M., & Foll, B. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809666-6.00006-x · Cited by 4
How cannabis works in the brain
Iversen, L. L. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511706080.002 · Cited by 4
The Ventral Pallidum as a Limbic Pleasure Generator.
Ho, C. (2010) · Deep Blue (University of Michigan) · Cited by 4
Gacso, Z., Adamson, G., Slama, J., Xie, C., Burdick, E., Persaud, K., Chowdhury, S., Ahmed, Z. S., Vaysman, E., Aminov, A., et al. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.138058 · Cited by 3
Cannabinoid-Opioid Interactions
Miller, M. L., Chadwick, B. J., Morris, C. V., Michaelides, M., & Hurd, Y. L. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_15 · Cited by 3
Cannabinoids: Drug or Medication?
Giron, L., & Befort, K. (2016) · InTech eBooks · doi:10.5772/63172 · Cited by 4
Animal Models of Cannabis Use Disorder
Justinová, Z. (2018) · Springer eBooks · doi:10.1007/978-3-319-90365-1_8 · Cited by 3
Chronic Psychosis in Dual Disorder Heroin Use Disorder Patients
Maremmani, I., Pacini, M., & Maremmani, A. G. I. (2023) · Springer eBooks · doi:10.1007/978-3-031-30093-6_4 · Cited by 4
Mécanismes neurobiologiques de la dépendance : implication de la sérotonine
Hamon, M. (2002) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)34337-7 · Cited by 3
Class A GPCRs: Cannabinoid and Opioid Receptor Heteromers
Sierra, S., Gomes, I., & Devi, L. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-60174-8_7 · Cited by 3
Sánchez, M., & Miquel (2003) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 3
Neurobiology of opioid use disorder
Cucinello‐Ragland, J. A., Lintz, T., & Morón, J. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26504-4.00008-9 · Cited by 2
FAAH and MAGL inhibition: Evolving approaches to treating substance use disorders
Maddox, C., Lee, F. S., Rajadhyaksha, A. M., & Martínez-Rivera, A. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00814 · Cited by 3
Self-Administration of an Endogenous Cannabinoid 2-Arachidonoylglycerol in Experimentally Naïve Rats
Hiranita, T. (2015) · Journal of Alcoholism and Drug Dependence · doi:10.4172/2329-6488.1000e126 · Cited by 2
Self-Administration of JWH-018 A Synthetic Cannabinoid in Experimentally Naïve Rats
Hiranita, T. (2015) · Journal of Alcoholism and Drug Dependence · doi:10.4172/2329-6488.1000e128 · Cited by 2
Stapf, C. A., Keefer, S. E., McInerney, J. M., Cheer, J. F., & Calu, D. J. (2025) · eNeuro · doi:10.1523/eneuro.0341-24.2024 · Cited by 2
Medicine vs. Myth: Exploring the Therapeutic Potential of Cannabis for Opioid Use Disorder and Pain
Sarkar, P. R., Vincent, C., Szeto, A., Zhai, X., Keshavan, M. S., & Hill, K. P. (2025) · Current Addiction Reports · doi:10.1007/s40429-025-00641-y · Cited by 3
Головко, А. И., Golovko, S., & Leontieva, L. (2007) · Neurochemical Journal · doi:10.1134/s1819712407010011 · Cited by 2
Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction
Mascia, P., Tanda, G., Yaşar, S., Heishman, S. J., & Goldberg, S. R. (2012) · The Receptors · doi:10.1007/978-1-4614-4669-9_11 · Cited by 2
Are Alcohol Anti-relapsing and Alcohol Withdrawal Drugs Useful in Cannabinoid Users?
Kleczkowska, P., Smaga, I., Filip, M., & Bujalska‐Zadrożny, M. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9655-z · Cited by 2
Endocannabinoids, Stress, and Negative Affect
Berger, A. L., Henricks, A. M., Hill, M. N., & McLaughlin, R. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-57371-7_3 · Cited by 2
Koob, G. F., Arends, M. A., McCracken, M. L., & Moal, M. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-816988-9.00001-1 · Cited by 2
Self-citationCannabinoid-Based Medicine: Pharmacology and Drug Interactions
Davis, M. P. (2022) · Springer eBooks · doi:10.1007/978-3-030-89918-9_2 · Cited by 2
Behavioral Effects of Endocannabinoids
Fride, E., Thiébot, M.-H., Onaivi, E. S., & Chaperon, F. (2005) · CRC Press eBooks · doi:10.1201/9781420023640.ch13 · Cited by 2
Shulman, M., Choo, T.-H. J., Ohrtman, K., Pavlicová, M., Rotrosen, J., & Nunes, E. V. (2025) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2025.112550 · Cited by 1
Cannabis Use in Opioid Maintenance Therapy: Prevalence, Clinical Correlates and Reasons for Use
Backmund, M., Zámbó, G. G., Schöfl, S., & Soyka, M. (2025) · Brain Sciences · doi:10.3390/brainsci15070699 · Cited by 1
Pharmacotherapy for Cannabis Use Disorder: Preclinical and Clinical Models
Bedillion, M. F., Moore, C. F., Weerts, E. M., Arout, C. A., Harris, H. M., & Haney, M. (2025) · Current topics in behavioral neurosciences · doi:10.1007/7854_2025_598 · Cited by 1
A maconha aumenta vulnerabilidade a opioides em animais de laboratório
de Carvalho, C. R., & Takahashi, R. N. (2014) · Revista da Biologia · doi:10.7594/revbio.13.01.02 · Cited by 2
Cannabinoids: Neurochemistry and neurobiology
Головко, А. И. (2011) · Biology Bulletin Reviews · doi:10.1134/s2079086411060028 · Cited by 1
Koob, G. F., & Moal, M. L. (2006) · Elsevier eBooks · doi:10.1016/b978-012419239-3/50044-8 · Cited by 1
Self-citationFinn, K. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-72216-2.00011-9 · Cited by 1
Cannabinoid treatment of opiate addiction
McLemon, E., & Chesworth, R. (2021) · Neuroanatomy and Behaviour · doi:10.35430/nab.2021.e14 · Cited by 1
Cannabinoids and drugs of abuse
Parolaro, D., & Rubino, T. (2005) · Birkhäuser-Verlag eBooks · doi:10.1007/3-7643-7358-x_12 · Cited by 1
Karl, T., & Arnold, J. C. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.026
Effects of Cannabinoid Receptor Interacting Protein (CRIP1a) on Cannabinoid Receptor (CB1) Function
Smith, T. H. (2009) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/0fn5-w762
Study of the interaction between 3,4 methylenedioximethamphetamine and the endocannabinoid system
Touriño, C. (2009) · Repositori digital de la UPF (Universitat Pompeu Fabra)
Brust, J. C. M. (2007) · Elsevier eBooks · doi:10.1016/b978-2-84299-712-0.50007-3
Vocci, F. J. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn041
Sonon, K. E. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
RETRACTED ARTICLE: Functionalized benzyls as selective κ-OR agonists
Ivanova, B. B., & Spiteller, M. (2014) · Medicinal Chemistry Research · doi:10.1007/s00044-014-1023-z
Retracted[Drug-craving animal models and mechanisms].
Sakimura, K., Hiranita, T., Miyamoto, M., Nagata, K., & Yamamoto, T. (2005) · Folia Pharmacologica Japonica · doi:10.1254/fpj.126.24
PAPEL DEL SISTEMA ENDOCANNABINOIDE EN EL ALCOHOLISMO: ESTUDIO EN MODELOS ANIMALES
la Investigación, U. D. R. D. I. C. P. (2007)
Rovai, L., Giovanni, A. S., Maremmani, I., Pacini, M., Pani, P., Rugani, F., Lamanna, F., Schiavi, E., & Mautone, S. (2016)
Getachew, B., Hauser, S. R., Dhaher, R., Bell, R. L., Oster, S. M., McBride, W. J., & Rodd, Z. A. (2011) · PMC
Böning, J., Kienast, T., Heinz, A., Lesch, O., Soyka, M., Wiesbeck, G. A., Böning, J., Wodarz, N., Platz, W. E., Scherbaum, N., et al. (2007) · Springer eBooks · doi:10.1007/3-211-37774-3_4
Brust, J. C. M. (2004) · Elsevier eBooks · doi:10.1016/b978-0-7506-7313-6.50011-8
Famitafreshi, H., & Morteza, K. (2020) · Journal of Addiction Medicine and Therapeutic Science · doi:10.17352/2455-3484.000043
Cannabinoid treatment of opiate addiction
McLemon, E., & Chesworth, R. (2021) · doi:10.23668/psycharchives.4898 · Cited by 1
Modulation of Effects of Alcohol, Cannabinoids, and Psychostimulants by Novelty-Seeking Trait
Calpe-López, C., Martínez-Caballero, M. Á., García-Pardo, M. P., & Aguilar, M. A. (2021) · Neuromethods · doi:10.1007/978-1-0716-1748-9_4
Potential Pharmacotherapies for Cannabis Dependence
Hart, C. L., & Shytle, R. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0338-9_53
Potential Use of Opioid Antagonists in the Treatment of Marijuana Abuse and Dependence
Foll, B. L., Justinová, Z., Tanda, G., Solinas, M., Selby, P. L., & Goldberg, S. R. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-197-0_16
Regards croisés sur le cannabis
Seutin, V., Scuvée‐Moreau, J., & Quertemont, É. (2010) · Mardaga eBooks · doi:10.3917/mard.seuti.2010.01.0245
Substance dependence and abuse
Pietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.024
Behavioral pharmacology of cannabinoids
Tai, S. (2012) · doi:10.17760/d20002949
Molecular and cellular mechanisms of addiction
Yates, J. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90578-7.00004-9
Bekier, N. K., Frischknecht, U., Eidenmueller, K., Grimm, F., Bach, P., Stenger, M., Kiefer, F., & Hermann, D. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01718-3
Stapf, C. A., Keefer, S. E., McInerney, J. M., Cheer, J. F., & Calu, D. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.01.592059
Cannabinoide zur Schmerzbehandlung
Mosley, C. I., Gaynor, J. S., Cital, S. N., & Brassard, J. (2024) · Springer eBooks · doi:10.1007/978-3-031-67821-9_5
Harloe, J. P. (2008) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/3826-5762
The role of the endocannabinoid system in attention and nicotine addiction
van Klinken, W. P. (2011) · Utrecht University Repository (Utrecht University)
Moore, C. F., Bedillion, M. F., Haney, M., & Weerts, E. M. (2025) · Current Addiction Reports · doi:10.1007/s40429-025-00705-z
Ostos‐Valverde, A., Daval-Marín-Lozano, V., Gómez‐Villatoro, J. P., Méndez‐Díaz, M., Herrera-Solís, A., Ruiz‐Contreras, A. E., & García, Ó. P. (2025) · Revista de la Facultad de Medicina UNAM · doi:10.22201/fm.24484865e.2025.68.6.02
Galaj, E., Morris, C., Fleischer, A., Xie, C., Shortell, H., Slama, J., Litchfield, C., Petersohn, S., Burdick, E., Persaud, K., et al. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07005-y
Astruc‐Diaz, F. (2012) · theses.fr (ABES) · doi:10.70675/de9cec28z5760z44baz93c9zce536330b49f · Cited by 1
Nogueira, D. D. S. (2019) · theses.fr (ABES) · doi:10.70675/d429d5dbz5001z4e60z9622z4f636e667f17
Role of the endocannabinoid system in exercise motivation
Redon, B. (2021) · theses.fr (ABES) · doi:10.70675/844c9d99zd3c6z4550z97a6zebab239b226c
Mohammadkhani, A., Peterson, C. S., & Borgland, S. L. (2026) · Springer eBooks · doi:10.1007/978-3-032-12239-1_14
Binda, K. H., Chacur, M., & Martins, D. O. (2026) · Research Square · doi:10.21203/rs.3.rs-9452205/v1
Koob, G. F., Arends, M. A., McCracken, M. L., & Moal, M. L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-12-816791-5.00001-7
Self-citationMorrisson, D., Smith, E. C., Alkhelb, D. A., Ho, T., Ji, L., Sromek, A. W., Makriyannis, A., & Desai, R. I. (2026) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2026.113243
Martinez, M. X., Ruiz, C. M., Perrone, C. R., Inshishian, V. C., Castillo, E., & Mahler, S. V. (2026) · Addiction Neuroscience · doi:10.1016/j.addicn.2026.100282
Mahler, S. M. (2009) · Deep Blue (University of Michigan)
Metadata
- Authors
- Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gómez, R., del Arco, I., Villanúa, M. A., Maldonado, R., Koob, G. F., & de Fonseca, F. R.
- Affiliations
- Scripps Research Institute (US)
- University of Cagliari (IT)
- Universitat Pompeu Fabra (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Universidad Complutense de Madrid (ES)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-07-15
- Volume
- 21
- Issue
- 14
- Pages
- 5344-5350
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762870
- OpenAlex
- W1699530412
- Cited by
- 378
- References
- 63
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 7 · 2023: 5 · 2022: 13 · 2021: 7 · 2020: 10 · 2019: 5 · 2018: 14 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 18 · 2013: 18 · 2012: 14
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Funders
- Sanofi
- Comunidad de Madrid
- Universidad Complutense de Madrid
- Consiglio Nazionale delle Ricerche
- National Institutes of Health
- Plan Nacional sobre Drogas
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 26741, P01DK026741)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- opioid-cannabinoid interaction, CB1 receptor, SR141716A, naloxone, heroin self-administration, morphine self-administration, place preference, opioid withdrawal, cannabinoid withdrawal, reward systems, nucleus accumbens, caudate-putamen, septum, addiction, opioid use disorder
- MeSH terms
- Rimonabant, Animals, Avoidance Learning, Cannabinoids, Caudate Nucleus, Conditioning, Operant, Heroin, Disease Models, Animal, Heroin Dependence, Male, Morphine, Morphine Dependence, Naloxone, Narcotic Antagonists, Nucleus Accumbens, Piperidines, Putamen, Pyrazoles, Receptors, Drug, Receptors, Opioid, RNA, Messenger, Self Administration, Rats, Wistar, Septum of Brain, Receptors, Cannabinoid, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
