The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Oxidative Glutamate Toxicity Can Be a Component of the Excitotoxicity Cascade
Open accessAbstract
Along with ionotropic and metabotropic glutamate receptors, the cystine/glutamate antiporter x(c)(-) may play a critical role in CNS pathology. High levels of extracellular glutamate inhibit the import of cystine, resulting in the depletion of glutathione and a form of cell injury called oxidative glutamate toxicity. Here we show that a portion of the cell death associated with NMDA receptor-initiated excitotoxicity can be caused by oxidative glutamate toxicity. In primary mouse cortical neurons the cell death resulting from the short-term application of 10 microm glutamate can be divided into NMDA and NMDA receptor-independent phases. The NMDA receptor-independent component is associated with high extracellular glutamate and is inhibited by a variety of reagents that block oxidative glutamate toxicity. These results suggest that oxidative glutamate toxicity toward neurons lacking functional NMDA receptors can be a component of the excitotoxicity-initiated cell death pathway.
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Fricker, M., Tolkovsky, A. M., Borutaite, V., Coleman, M., & Brown, G. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00011.2017 · Cited by 1,108
Hydrogen sulfide protects neurons from oxidative stress
Kimura, Y., & Kimura, H. (2004) · The FASEB Journal · doi:10.1096/fj.04-1815fje · Cited by 874
Shih, A. Y., Johnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., & Murphy, T. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03394.2003 · Cited by 785
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Duchen, M. R. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.03.001 · Cited by 721
Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?
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Metadata
- Authors
- Schubert, D., & Piasecki, D.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-10-01
- Volume
- 21
- Issue
- 19
- Pages
- 7455-7462
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1947475203
- Cited by
- 253
- References
- 50
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schubert, D., & Piasecki, D. (2001). Oxidative Glutamate Toxicity Can Be a Component of the Excitotoxicity Cascade. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.21-19-07455.2001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
