The DOI matches its Crossref record; 65 of the 66 references it cites were found in a registry or an index.
Incentive Sensitization by Previous Amphetamine Exposure: Increased Cue-Triggered “Wanting” for Sucrose Reward
Open accessAbstract
We reported previously that an amphetamine microinjection into the nucleus accumbens enables Pavlovian reward cues in a conditioned incentive paradigm to trigger excessive instrumental pursuit. Here we show that sensitization caused by previous amphetamine administration also causes reward cues to trigger excessive pursuit of their associated reward, even when sensitized rats are tested in a drug-free state. Rats learned to lever press for sucrose pellets, and they separately learned to associate sucrose pellets with Pavlovian cues (30 sec auditory cues). Amphetamine sensitization was induced by six daily injections of amphetamine (3 mg/kg, i.p.; controls received saline). Rats were tested for lever pressing under extinction conditions 10 d later, after a bilateral microinjection of intra-accumbens vehicle or amphetamine (5 microg/0.5 microl per side). Cue-triggered pursuit of sucrose reward was assessed by increases in pressing on the sucrose-associated lever during intermittent presentations of a free conditioned stimulus (CS+) sucrose cue. Sensitized rats pressed at normal levels during baseline and during the CS-, but the CS+ triggered 100% greater increases in pressing from sensitized rats than from control rats after vehicle microinjection. Sensitization therefore enhanced the incentive salience attributed to the CS+ even when rats were tested while drug-free. For control rats, a microinjection of intra-accumbens amphetamine was needed to produce the same enhancement of cue-triggered reward "wanting." The amphetamine microinjection also interacted synergistically in sensitized rats to produce intrusive cue-triggered pursuit behaviors (e.g., investigatory sniffing) that interfered with goal-directed lever pressing. These results support the incentive-sensitization theory postulate that sensitization causes excessive cue-triggered "wanting" for an associated reward.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“This and related studies (Wyvell and Berridge, 2000; 2001; Pecina et al., 2006) demonstrate that increased activity of intra-shell dopamine does not merely enhance motor-habits, but also enhances motivation for rewards, a finding consistent with the notion of action-arousal or drive.”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Wyvell and Berridge, 2001
In the citing paper
“For example, in animal studies, sensitization increases neuronal firing in VTA–accumbens–pallidal pathways that code incentive salience as well as the behavioral ability of reward cues to trigger frenzied bursts of effort to obtain the reward (Peciña & Berridge, 2013; Tindell et al., 2005; Wyvell & Berridge, 2001).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Wyvell & Berridge, 2001
In the citing paper
“Wyvell and Berridge (2001) further found that previous experience with repeated administration of amphetamine has essentially the same effect on incentive salience attribution as intra-shell administration of amphetamine.”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Wyvell and Berridge (2001)
In the citing paper
“Interestingly, intra-shell administration of amphetamine in those sensitized rats did not further increase conditioned responding upon the presentation of a conditioned stimulus, but rather increased general investigatory behaviors such as sniffing and rearing not targeted at the active lever (Wyvell and Berridge, 2001).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Wyvell and Berridge, 2001
In the citing paper
“These effects also appear to be largely dependent on the VS [43–45].”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [45]
In the citing paper
“amphetamine injection into the Nacc enhances PIT, without affecting base rates of instrumental responding [45].”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [45]
In the citing paper
“These behavioral phenotypes are accompanied by baseline differences in dopamine transmission, with bHRs showing elevated sensitivity to dopamine agonists, increased proportion of striatal D2receptors in a high-affinity state, greater frequency of spontaneous dopamine transients15, and higher reward-related dopamine release prior to conditioning, all of which could enhance their attribution of in”
From A selective role for dopamine in stimulus-reward learning (2011) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,514
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Self-citationBardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Jentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates
Balleine, B. W., & Dickinson, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00033-1 · Cited by 1,541
The psychology and neurobiology of addiction: an incentive–sensitization view
Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507
Self-citationAddiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex
Volkow, N. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.318 · Cited by 1,240
Addiction, Dopamine, and the Molecular Mechanisms of Memory
Berke, J. D., & Hyman, S. E. (2000) · Neuron · doi:10.1016/s0896-6273(00)81056-9 · Cited by 1,184
Bechara, A., Dolan, S. L., Denburg, N. L., Hindes, A. R., Anderson, S. W., & Nathan, P. E. (2001) · Neuropsychologia · doi:10.1016/s0028-3932(00)00136-6 · Cited by 1,168
Motivational control of goal-directed action
Dickinson, A., & Balleine, B. (1994) · Animal Learning & Behavior · doi:10.3758/bf03199951 · Cited by 995
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
Horvitz, J. C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00019-1 · Cited by 967
Reinstatement of cocaine-reinforced responding in the rat
de Wit, H., & Stewart, J. (1981) · Psychopharmacology · doi:10.1007/bf00432175 · Cited by 928
Wyvell, C. L., & Berridge, K. C. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08122.2000 · Cited by 764 · cited 8×
“Using this paradigm, Wyvell and Berridge (2000) showed that mesolimbic activation caused by an amphetamine microinjection into the nucleus accumbens selectively increased cue-triggered wanting for sucrose reward, without enhancing either response reinforcement or sucrose “liking.””
BackgroundMethodResultInfluentialSelf-citationAssociative processes in addiction and reward. The role of amygdala-ventral striatal subsystems
EVERITT, B. J., PARKINSON, J. A., OLMSTEAD, M. C., ARROYO, M., ROBLEDO, P., & ROBBINS, T. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09280.x · Cited by 708 · cited 1×
“Although we recognize mesoaccumbens systems to have additional complex sensorimotor and other functions (Salamone et al., 1997; Everitt et al., 1999; Horvitz, 2000), it is difficult to explain our results based on those hypotheses.”
Drug addiction as dopamine-dependent associative learning disorder
Chiara, G. D. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00372-6 · Cited by 607
Drug addiction: bad habits add up
Robbins, T. W., & Everitt, B. J. (1999) · Nature · doi:10.1038/19208 · Cited by 599
Conditioned stimulus as a determinant of the form of the Pavlovian conditioned response.
Holland, P. C. (1977) · Journal of experimental psychology. Animal behavior processes · doi:10.1037/0097-7403.3.1.77 · Cited by 553
Salamone, J. D., Cousins, M. S., & Snyder, B. J. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00017-6 · Cited by 522
Conditioned stimulus as a determinant of the form of the Pavlovian conditioned response.
Holland, P. C. (1977) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037//0097-7403.3.1.77 · Cited by 514
Lett, B. T. (1989) · Psychopharmacology · doi:10.1007/bf00451687 · Cited by 479
Ito, R., Dalley, J. W., Howes, S. R., Robbins, T. W., & Everitt, B. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07489.2000 · Cited by 441
Robinson, T. E., Gorny, G., Mitton, E., & Kolb, B. E. (2001) · Synapse · doi:10.1002/1098-2396(20010301)39:3 · Cited by 411
Cocaine-induced cocaine craving
Jaffe, J. H., Cascella, N. G., Kumor, K. M., & Sherer, M. A. (1989) · Psychopharmacology · doi:10.1007/bf00443414 · Cited by 373
Ciccocioppo, R., Sanna, P. P., & Weiss, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1976 · Cited by 371
Seamans, J. K., Floresco, S., & Phillips, A. G. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.6.1063 · Cited by 370
A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use
Chiara, G. D. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200108 · Cited by 352
Seamans, J. K., Floresco, S., & Phillips, A. G. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.6.1063 · Cited by 324
Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists.
Dickinson, A., Smith, J. W., & Mirenowicz, J. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.3.468 · Cited by 322
Reward learning: reinforcement, incentives, and expectations
Berridge, K. C. (2000) · Psychology of Learning and Motivation · doi:10.1016/s0079-7421(00)80022-5 · Cited by 318
Self-citationAnagnostaras, S., & Robinson, T. E. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.6.1397 · Cited by 302
Anagnostaras, S. G., & Robinson, T. E. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1397 · Cited by 302
Berridge, K. C., & Valenstein, E. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.3 · Cited by 302 · cited 2×
“…normal appetite, which if attributed to neural representations of reward cues causes both the cues and associated Pavlovian rewards themselves to become attractive and “wanted,” triggering approach and pursuit behaviors (Berridge and Valenstein, 1991; Berridge and Robinson, 1998; Berridge, 2001).”
BackgroundSelf-citationComparing levels of cocaine cue reactivity in male and female outpatients
Robbins, S. J., Ehrman, R. N., Childress, A. R., & O’Brien, C. P. (1999) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00135-5 · Cited by 292
Shippenberg, T. S., & Heidbreder, C. A. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09578-3 · Cited by 263
Marinelli, M., & White, F. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08876.2000 · Cited by 254
Amygdala Regulation of Nucleus Accumbens Dopamine Output is Governed by the Prefrontal Cortex
Jackson, M., & Moghaddam, B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00676.2001 · Cited by 246
Robinson, T. G. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(97)00020-1 · Cited by 230
Coping and the Stress-Induced Potentiation of Stimulant Stereotypy in the Rat
MacLennan, A. J., & Maier, S. F. (1983) · Science · doi:10.1126/science.6681679 · Cited by 180
Crombag, H. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00243-6 · Cited by 180
Cocaine self‐administration increases the incentive motivational properties of the drug in rats
Deroche‐Gamonet, V., Moal, M. L., & Piazza, P. V. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00696.x · Cited by 178
Fiorino, D. F., & Phillips, A. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00456.1999 · Cited by 170
Lorrain, D. S., Arnold, G. M., & Vezina, P. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00109-6 · Cited by 162
Effects of ibotenic acid lesions of the Nucleus Accumbens on instrumental action
Balleine, B. W., & Killcross, S. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90104-x · Cited by 142
Taylor, J. R., & Horger, B. A. (1999) · Psychopharmacology · doi:10.1007/s002130050859 · Cited by 137
Latent inhibition: the nucleus accumbens connection revisited
Gray, J. A., Moran, P. M., Grigoryan, G. A., Peters, S. L., Young, A. M. J., & Joseph, M. H. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)02313-9 · Cited by 134
Harmer, C. J., & Phillips, G. D. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00464-3 · Cited by 124
Killcross, S., Dickinson, A., & Robbins, T. W. (1994) · Psychopharmacology · doi:10.1007/bf02244771 · Cited by 123
Facilitation of sexual behaviors in the male rat associated with Intra-VTA injections of opiates
Mitchell, J. B., & Stewart, J. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90302-x · Cited by 123
Fiorino, D. F., & Phillips, A. G. (1999) · Psychopharmacology · doi:10.1007/s002130050880 · Cited by 110
Enhanced appetitive conditioning following repeated pretreatment with d-amphetamine
Harmer, C. J., & Phillips, G. D. (1998) · Behavioural Pharmacology · doi:10.1097/00008877-199807000-00001 · Cited by 107
Addiction: from biology to drug policy
D, A. G. M. (1994) · Cited by 104
Drug anticipation and drug addiction. The 1998 H. David Archibald Lecture
Siegel, S. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.94811132.x · Cited by 102
Joseph, M. H., Peters, S. L., Moran, P. M., Grigoryan, G. A., Young, A. M. J., & Gray, J. A. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00437-1 · Cited by 92
Mucha, R. F., Geier, A., & Pauli, P. (1999) · Psychopharmacology · doi:10.1007/s002130051172 · Cited by 84
Evidence for opiate-dopamine cross-sensitization in nucleus accumbens: Studies of conditioned reward
Cunningham, S. T., & Kelley, A. E. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90137-m · Cited by 65
Pierre, P. J., & Vezina, P. (1998) · Psychopharmacology · doi:10.1007/s002130050658 · Cited by 63
Addiction: from biology to drug policy
(1994) · Choice Reviews Online · doi:10.5860/choice.31-5482 · Cited by 55
Enhanced conditioned inhibition following repeated pretreatment with d -amphetamine
Harmer, C. J., & Phillips, G. D. (1999) · Psychopharmacology · doi:10.1007/s002130050870 · Cited by 54
Mitchell, J. B., & Stewart, J. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90171-d · Cited by 44
Enhanced reward-related responding following cholera toxin infusion into the nucleus accumbens
Kelley, A. E., & Holahan, M. R. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199705)26:1 · Cited by 31
Topp, L., Lovibond, P. F., & Mattick, R. P. (1998) · Drug and Alcohol Review · doi:10.1080/09595239800187111 · Cited by 7
Research works printed but not linked: 1
- Dickinson AJ, Balleine B (2001) The role of learning in motivation. In: Steven's handbook of experimental psychology, Ed 3. New York: Wiley, in press.
Cited by
Sorted by citations
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347
Self-citationEmotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129
Berridge, K. C., & Robinson, T. E. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00233-9 · Cited by 1,869
Self-citationThe incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717
Self-citationRobinson, T. E., & Berridge, K. C. (2003) · Annual Review of Psychology · doi:10.1146/annurev.psych.54.101601.145237 · Cited by 1,509
Self-citation
Metadata
- Authors
- Wyvell, C. L., & Berridge, K. C.
- Affiliations
- University of Michigan (US)
- ORCID
- Berridge, Kent C.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-10-01
- Volume
- 21
- Issue
- 19
- Pages
- 7831-7840
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762900
- OpenAlex
- W2145827196
- Cited by
- 436
- References
- 66
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 5 · 2021: 12 · 2020: 52 · 2019: 9 · 2018: 9 · 2017: 11 · 2016: 17 · 2015: 17 · 2014: 17 · 2013: 28 · 2012: 34
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9604408)
- National Institute on Drug Abuse (F31 DA0599901)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- amphetamine sensitization, incentive salience, nucleus accumbens, instrumental behavior, goal-directed behavior, sucrose reward, incentive-sensitization theory
- MeSH terms
- Acoustic Stimulation, Amphetamine, Animals, Behavior, Animal, Conditioning, Classical, Conditioning, Operant, Cues, Extinction, Psychological, Female, Injections, Intraperitoneal, Microinjections, Motivation, Nucleus Accumbens, Reinforcement, Psychology, Reward, Sucrose, Rats, Sprague-Dawley, Amphetamine-Related Disorders, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
