Green light exposure elicits anti-inflammation, endogenous opioid release and dampens synaptic potentiation to relieve post-surgical pain.

Quantitative assessment of tactile allodynia in the rat paw

Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740 · see citing works

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155 · see citing works

Cellular and Molecular Mechanisms of Pain

Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344 · see citing works

LTP and LTD

Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works

Central sensitization: a generator of pain hypersensitivity by central neural plasticity

Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913 · see citing works

Opioid Complications and Side Effects

Benyamin, R. M. (2008) · Pain Physician · doi:10.36076/ppj.2008/11/s105 · Cited by 2,271 · see citing works

Microglia as a source and target of cytokines

Hanisch, U. (2002) · Glia · doi:10.1002/glia.10161 · Cited by 1,645 · see citing works

Poorly controlled postoperative pain: prevalence, consequences, and prevention

Gan, T. J. (2017) · Journal of Pain Research · doi:10.2147/jpr.s144066 · Cited by 1,525 · see citing works

Central sensitization and LTP: do pain and memory share similar mechanisms?

Ji, R., Kohno, T., Moore, K. A., & Woolf, C. J. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.017 · Cited by 1,462 · see citing works

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

Sorge, R. E., Mapplebeck, J. C. S., Rosen, S., Beggs, S., Taves, S., Alexander, J. K., Martin, L. J., Austin, J.-S., Sotocinal, S. G., Chen, D., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4053 · Cited by 1,442 · see citing works

Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M. F., & Huganir, R. L. (2000) · Nature · doi:10.1038/35016089 · Cited by 1,116 · see citing works

Microglia and neuroinflammation: a pathological perspective

Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works

Systemic inflammation and microglial activation: systematic review of animal experiments

Hoogland, I. C. M., Houbolt, C., van Westerloo, D. J., van Gool, W. A., & van de Beek, D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0332-6 · Cited by 957 · see citing works

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

Chen, G., Zhang, Y., Qadri, Y. J., Serhan, C. N., & Ji, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.009 · Cited by 791 · see citing works

Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity

Olmos, G., & Lladó, J. (2014) · Mediators of Inflammation · doi:10.1155/2014/861231 · Cited by 730 · see citing works

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

Pascual, O., Ben Achour, S., Rostaing, P., Triller, A., & Bessis, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111098109 · Cited by 693 · see citing works

Microglia: Dynamic Mediators of Synapse Development and Plasticity

Wu, Y., Dissing-Olesen, L., MacVicar, B. A., & Stevens, B. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.008 · Cited by 661 · see citing works

Tachykinins and Their Receptors: Contributions to Physiological Control and the Mechanisms of Disease

Steinhoff, M. S., von Mentzer, B., Geppetti, P., Pothoulakis, C., & Bunnett, N. W. (2014) · Physiological Reviews · doi:10.1152/physrev.00031.2013 · Cited by 628 · see citing works

Neuroinflammation and the generation of neuropathic pain

Ellis, A., & Bennett, D. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet128 · Cited by 610 · see citing works

Persistent pain after breast cancer treatment: a critical review of risk factors and strategies for prevention

Andersen, K. G., & Kehlet, H. (2011) · The Journal of Pain · doi:10.1016/j.jpain.2010.12.005 · Cited by 523 · see citing works

Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept

Chung, H. Y., Kim, D. H., Lee, E. K., Chung, K. W., Chung, S., Lee, B., Seo, A. Y., Chung, J. H., Jung, Y. S., Im, E., et al. (2018) · Aging and Disease · doi:10.14336/ad.2018.0324 · Cited by 495 · see citing works

Surgery, neuroinflammation and cognitive impairment

Alam, A., Hana, Z., Jin, Z., Suen, K. C., & Ma, D. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.10.021 · Cited by 483 · see citing works

Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

Adaikkan, C., Middleton, S. J., Marco, A., Pao, P., Mathys, H., Kim, D. N.-W., Gao, F., Young, J. Z., Suk, H., Boyden, E. S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.011 · Cited by 469 · see citing works

The “toll” of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia

Watkins, L. R., Hutchinson, M. R., Rice, K. C., & Maier, S. F. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.08.002 · Cited by 438 · see citing works

Postoperative pain—from mechanisms to treatment

Pogatzki-Zahn, E. M., Segelcke, D., & Schug, S. A. (2017) · PAIN Reports · doi:10.1097/pr9.0000000000000588 · Cited by 421 · see citing works

Source of chronic inflammation in aging

Sanada, F., Taniyama, Y., Muratsu, J., Otsu, R., Shimizu, H., Rakugi, H., & Morishita, R. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00012 · Cited by 413 · see citing works

Characterizing microglia activation: a spatial statistics approach to maximize information extraction

Davis, B. M., Salinas‐Navarro, M., Cordeiro, M. F., Moons, L., & Groef, L. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-01747-8 · Cited by 343 · see citing works

Trauma of major surgery: A global problem that is not going away

Dobson, G. P. (2020) · International Journal of Surgery · doi:10.1016/j.ijsu.2020.07.017 · Cited by 316 · see citing works

IL-10 Overexpression Decreases Inflammatory Mediators and Promotes Regenerative Healing in an Adult Model of Scar Formation

Peranteau, W. H., Zhang, L., Muvarak, N. E., Badillo, A. T., Radu, A. P., Zoltick, P. W., & Liechty, K. W. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701232 · Cited by 286 · see citing works

The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS

Arcuri, C., Mecca, C., Bianchi, R., Giambanco, I., & Donato, R. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00191 · Cited by 279 · see citing works

Wavelength-dependent modulation of brain responses to a working memory task by daytime light exposure

Vandewalle, G., Gais, S., Schabus, M., Balteau, E., Carrier, J., Darsaud, A., Sterpenich, V., Albouy, G., Dijk, D. J., & Maquet, P. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm007 · Cited by 277 · see citing works

Specific Roles of AMPA Receptor Subunit GluR1 (GluA1) Phosphorylation Sites in Regulating Synaptic Plasticity in the CA1 Region of Hippocampus

Lee, H.-K., Takamiya, K., He, K., Song, L., & Huganir, R. L. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00835.2009 · Cited by 261 · see citing works

Neuronal and microglial mechanisms of neuropathic pain

Zhuo, M., Wu, G., & Wu, L. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-31 · Cited by 256 · see citing works

Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures.

Chao, C. C., & Hu, S.-X. (1994) · Developmental Neuroscience · doi:10.1159/000112104 · Cited by 249 · see citing works

Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats

Barrientos, R. M., Hein, A. M., Frank, M. G., Watkins, L. R., & Maier, S. F. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2173-12.2012 · Cited by 235 · see citing works

Calcium–Calmodulin-Dependent Protein Kinase II Contributes to Spinal Cord Central Sensitization

Fang, L., Wu, J., Lin, Q., & Willis, W. D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-04196.2002 · Cited by 226 · see citing works

Uncovering sex differences of rodent microglia

Han, J., Fan, Y., Zhou, K., Blomgren, K., & Harris, R. A. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02124-z · Cited by 224 · see citing works

Automated Morphological Analysis of Microglia After Stroke

Heindl, S., Gesierich, B. G., Benakis, C., Llovera, G., Duering, M., & Liesz, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00106 · Cited by 220 · see citing works

Autonomous CaMKII Mediates Both LTP and LTD Using a Mechanism for Differential Substrate Site Selection

Coultrap, S. J., Freund, R. K., O’Leary, H., Sanderson, J. L., Roche, K. W., Dell’Acqua, M. L., & Bayer, K. U. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.005 · Cited by 207 · see citing works

Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

Berta, T., Park, C., Xu, Z., Xie, R.-G., Liu, T., Lü, N., Liu, Y., & Ji, R. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72230 · Cited by 195 · see citing works

Mechanisms of Incisional Pain

Brennan, T. J., Zahn, P. K., & Pogatzki-Zahn, E. M. (2005) · Anesthesiology Clinics of North America · doi:10.1016/j.atc.2004.11.009 · Cited by 188 · see citing works

Primary and Secondary Hyperalgesia in a Rat Model for Human Postoperative Pain

Zahn, P. K., & Brennan, T. J. (1999) · Anesthesiology · doi:10.1097/00000542-199903000-00030 · Cited by 178 · see citing works

Migraine photophobia originating in cone-driven retinal pathways

Noseda, R., Bernstein, C. A., Nir, R., Lee, A. J., Fulton, A. B., Bertisch, S. M., Hovaguimian, A., Cestari, D. M., Saavedra-Walker, R., Borsook, D., et al. (2016) · Brain · doi:10.1093/brain/aww119 · Cited by 177 · see citing works

Neurokinin 1 Receptor Internalization in Spinal Cord Slices Induced by Dorsal Root Stimulation Is Mediated by NMDA Receptors

Marvizón, J. C. G., Martı́nez, V., Grady, E. F., Bunnett, N. W., & Mayer, E. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08129.1997 · Cited by 176 · see citing works

Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis.

Gelbard, H., Dzenko, K., Diloreto, D., del Cerro, C., del Cerro, M. D., & Epstein, L. G. (1993) · Developmental Neuroscience · doi:10.1159/000111367 · Cited by 175 · see citing works

Nociception, pain, and antinociception: current concepts

Riedel, W., & Neeck, G. (2001) · Zeitschrift für Rheumatologie · doi:10.1007/s003930170003 · Cited by 172 · see citing works

BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis

Ding, H., Chen, J., Su, M., Lin, Z., Zhan, H., Yang, F., Li, W., Xie, J., Huang, Y. L., Liu, X., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1704-0 · Cited by 162 · see citing works

Opioid Receptors in Immune and Glial Cells—Implications for Pain Control

Machelska, H., & Celik, M. Ö. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00300 · Cited by 160 · see citing works

In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons

Galán, A., Laird, J. M. A., & Cerveró, F. (2004) · Pain · doi:10.1016/j.pain.2004.09.011 · Cited by 157 · see citing works

The challenge of perioperative pain management in opioid-tolerant patients

Coluzzi, F., Bifulco, F., Cuomo, A., Dauri, M., Leonardi, C., Melotti, R. M., Natoli, S., Romualdi, P., Savoia, G., & Corcione, A. (2017) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s141332 · Cited by 150 · see citing works

Mechanisms and Pathways of Pain Photobiomodulation: A Narrative Review

Cheng, K., Martin, L. F., Slepian, M. J., Patwardhan, A. M., & Ibrahim, M. M. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.02.005 · Cited by 142 · see citing works

Guarding Pain and Spontaneous Activity of Nociceptors after Skin versus Skin Plus Deep Tissue Incision

Xu, J., & Brennan, T. J. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181c2952e · Cited by 142 · see citing works

Activation of p38 Mitogen-activated Protein Kinase in Spinal Microglia Contributes to Incision-induced Mechanical Allodynia

Wen, Y., Suter, M. R., Ji, R., Yeh, G., Wu, Y.-S., Wang, K.-C., Kohno, T., Sun, W., & Wang, C. (2008) · Anesthesiology · doi:10.1097/aln.0b013e318190bc16 · Cited by 139 · see citing works

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing

Hildebrand, M. E., Xu, J., Dedek, A., Li, Y., Sengar, A. S., Beggs, S., Lombroso, P. J., & Salter, M. W. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.024 · Cited by 139 · see citing works

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

Ibrahim, M. M., Patwardhan, A., Gilbraith, K. B., Moutal, A., Yang, X., Chew, L. A., Largent-Milnes, T., Malan, T. P., Vanderah, T. W., Porreca, F., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000767 · Cited by 123 · see citing works

A model of chronic pain in the rat: functional correlates of alterations in the activity of opioid systems

Millan, M., Członkowski, A., Pilcher, C., Almeida, O., Millan, M., Colpaert, F., & Herz, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-01-00077.1987 · Cited by 121 · see citing works

Neuropathology of Drug Addictions and Substance Misuse

(2016) · Elsevier eBooks · doi:10.1016/c2013-0-14226-2 · Cited by 119 · see citing works

Rhythmic pattern in pain and their chronotherapy

Bruguerolle, B., & Labrecque, G. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.06.001 · Cited by 116 · see citing works

Cytokine pathways regulating glial and leukocyte function after spinal cord and peripheral nerve injury

Bastien, D., & Lacroix, S. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.04.006 · Cited by 114 · see citing works

Postoperative cognitive dysfunction and microglial activation in associated brain regions in old rats

Hovens, I. B., van Leeuwen, B. L., Nyakas, C. J., Heineman, E., van der Zee, E. A., & Schoemaker, R. G. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.11.009 · Cited by 113 · see citing works

Neuroinflammation, Pain and Depression: An Overview of the Main Findings

Campos, A. C. P., Antunes, G. F., Matsumoto, M., Pagano, R. L., & Martinez, R. C. R. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.01825 · Cited by 102 · see citing works

Changes in serum and cerebrospinal fluid cytokines in response to non-neurological surgery: an observational study

Bromander, S., Anckarsäter, R., Kristiansson, M., Blennow, K., Zetterberg, H., Anckarsäter, H. S., & Wass, C. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-242 · Cited by 97 · see citing works

A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior

Rossi, P. D., Harde, E., Dupuis, J. P., Martin, L., Chounlamountri, N., Bardin, M., Watrin, C., Benetollo, C., Pernet‐Gallay, K., Luhmann, H. J., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.195 · Cited by 92 · see citing works

Effects of the 2-amino-3-hydroxy-5-methyl-4-isoxazole-proprionic acid/kainate antagonist LY293558 on spontaneous and evoked postoperative pain

Gilron, I. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.108677 · Cited by 91 · see citing works

Circadian control of pain and neuroinflammation

Segal, J. P., Tresidder, K. A., Bhatt, C., Gilron, I., & Ghasemlou, N. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24150 · Cited by 89 · see citing works

Frailty and anesthesia – risks during and post-surgery

Lin, H., McBride, R., & Hubbard, R. E. (2018) · Local and Regional Anesthesia · doi:10.2147/lra.s142996 · Cited by 83 · see citing works

Interleukin‐1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel‐associated acute pain syndrome

Yan, X., Li, F., Maixner, D. W., Yadav, R., Gao, M., Ali, M. W., Hooks, S. B., & Weng, H. (2018) · Glia · doi:10.1002/glia.23557 · Cited by 81 · see citing works

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

Chen, Y., Moutal, A., Navratilova, E., Kopruszinski, C. M., Yue, X., Ikegami, M., Chow, M., Kanazawa, I., Bellampalli, S. S., Xie, J. Y., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay7550 · Cited by 78 · see citing works

Dysregulated Src upregulation of NMDA receptor activity: a common link in chronic pain and schizophrenia

Salter, M. W., & Pitcher, G. M. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08390.x · Cited by 77 · see citing works

Expression of AMPA Receptor Subunits at Synapses in Laminae I–III of the Rodent Spinal Dorsal Horn

Polgár, E., Watanabe, M., Hartmann, B., Grant, S. G. N., & Todd, A. J. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-5 · Cited by 76 · see citing works

Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain

Dedek, A., Xu, J., Lorenzo, L.-É., Godin, A. G., Kandegedara, C. M., Glavina, G., Landrigan, J., Lombroso, P. J., Koninck, Y. D., Tsai, E. C., et al. (2021) · Brain · doi:10.1093/brain/awab408 · Cited by 74 · see citing works

Protein kinases regulate the phosphorylation of the GluR1 subunit of AMPA receptors of spinal cord in rats following noxious stimulation

Fang, L., Wu, J., Lin, Q., & Willis, W. D. (2003) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.08.002 · Cited by 73 · see citing works

Evaluation of green light exposure on headache frequency and quality of life in migraine patients: A preliminary one-way cross-over clinical trial

Martin, L. F., Patwardhan, A. M., Jain, S. V., Salloum, M., Freeman, J., Khanna, R., Gannala, P., Goel, V., Jones-MacFarland, F. N., Killgore, W. D. S., et al. (2020) · Cephalalgia · doi:10.1177/0333102420956711 · Cited by 72 · see citing works

GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord

Hildebrand, M. E., Pitcher, G. M., Harding, E. K., Li, H., Beggs, S., & Salter, M. (2014) · Scientific Reports · doi:10.1038/srep04094 · Cited by 71 · see citing works

Positive Feedback Loop of Autocrine BDNF from Microglia Causes Prolonged Microglia Activation

Zhang, X., Zeng, L., Yu, T., Xu, Y., Pu, S., Du, D., & Jiang, W. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000363036 · Cited by 69 · see citing works

Estrogen Increases Nociception-Evoked Brain-Derived Neurotrophic Factor Gene Expression in the Female Rat

Allen, A. L., & McCarson, K. E. (2005) · Neuroendocrinology · doi:10.1159/000087002 · Cited by 68 · see citing works

Sensitization of primary afferents to mechanical and heat stimuli after incision in a novel in vitro mouse glabrous skin-nerve preparation ☆

Banik, R. K., & Brennan, T. J. (2008) · Pain · doi:10.1016/j.pain.2008.01.017 · Cited by 67 · see citing works

Regulation of AMPA Receptors in Spinal Nociception

Wang, Y., Wu, J., Wu, Z., Lin, Q., Yue, Y., & Li, F. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-5 · Cited by 67 · see citing works

Gamma Visual Stimulation Induces a Neuroimmune Signaling Profile Distinct from Acute Neuroinflammation

Garza, K. M., Zhang, L., Borron, B. M., Wood, L. B., & Singer, A. C. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1511-19.2019 · Cited by 67 · see citing works

Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing

Dedek, A., Xu, J., Kandegedara, C. M., Lorenzo, L.-É., Godin, A. G., Koninck, Y. D., Lombroso, P. J., Tsai, E. C., & Hildebrand, M. E. (2019) · Brain · doi:10.1093/brain/awz105 · Cited by 66 · see citing works

Gender differences in paclitaxel-induced neuropathic pain behavior and analgesic response in rats

Hwang, B., Kim, E., Kim, C.-H., Kwon, J.-Y., & Kim, H.-K. (2012) · Korean Journal of Anesthesiology · doi:10.4097/kjae.2012.62.1.66 · Cited by 63 · see citing works

The efficacy of N-methyl-d-aspartate receptor antagonists on improving the postoperative pain intensity and satisfaction after remifentanil-based anesthesia in adults: a meta-analysis

Wu, L., Huang, X., & Sun, L. (2015) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2015.03.020 · Cited by 63 · see citing works

Green light exposure improves pain and quality of life in fibromyalgia patients: a preliminary one-way crossover clinical trial.

Martin, L., Porreca, F., Mata, E. I., Salloum, M., Goel, V., Gunnala, P., Killgore, W. D. S., Jain, S., Jones-MacFarland, F. N., Khanna, R., et al. (2021) · Pain Medicine · doi:10.1093/pm/pnaa329 · Cited by 62 · see citing works

Regulation of mu-opioid receptors by cytokines

Kraus, J. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s16 · Cited by 58 · see citing works

Characteristics of Chronic Pain Patients Who Take Opioids and Persistently Report High Pain Intensity

Wasserman, R. A., Brummett, C. M., Goesling, J., Tsodikov, A., & Hassett, A. L. (2013) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000024 · Cited by 56 · see citing works

AMPA receptor trafficking in inflammation-induced dorsal horn central sensitization

Tao, Y. (2012) · Neuroscience Bulletin · doi:10.1007/s12264-012-1204-z · Cited by 55 · see citing works

Stress Induces Pain Transition by Potentiation of AMPA Receptor Phosphorylation

Li, C., Yang, Y., Liu, S., Fang, H., Zhang, Y., Furmanski, O., SKINNER, J. T., Xing, Y., Johns, R. A., Huganir, R. L., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2130-14.2014 · Cited by 52 · see citing works

Glial neuroimmune signaling in opioid reward

Zhang, H., Largent‐Milnes, T. M., & Vanderah, T. W. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.11.012 · Cited by 49 · see citing works

The Effect of the AMPA/Kainate Receptor Antagonist LY293558 in a Rat Model of Postoperative Pain

Lee, H.-J., Pogatzki-Zahn, E. M., & Brennan, T. J. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.03.010 · Cited by 48 · see citing works

Serotoninergic pain modulation from the rostral ventromedial medulla (RVM) in chemotherapy‐induced neuropathy: The role of spinal 5‐HT3 receptors

Costa‐Pereira, J. T., Serrão, P., Martins, I., & Tavares, I. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14614 · Cited by 42 · see citing works

Gender and age affect NK1 receptors in the human brain – a positron emission tomography study with [18F]SPA-RQ

Nyman, M. J., Eskola, O., Kajander, J., Vahlberg, T. J., Sanabria, S., Burns, D. H., Hargreaves, R. J., Solin, O. H., & Hietala, J. A. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706006572 · Cited by 40 · see citing works

Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls

Nir, R., Lee, A. J., Huntington, S., Noseda, R., Bernstein, C. A., Fulton, A. B., Bertisch, S. M., Hovaguimian, A., Buettner, C., Borsook, D., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001303 · Cited by 38 · see citing works

Role of neurokinin type 1 receptor in nociception at the periphery and the spinal level in the rat

Gautam, M., Prasoon, P., Kumar, R., Reeta, K. H., Kaler, S., & Ray, S. B. (2015) · Spinal Cord · doi:10.1038/sc.2015.206 · Cited by 38 · see citing works

The analgesic efficacy of morphine varies with rat strain and experimental pain model: implications for target validation efforts in pain drug discovery

Hestehave, S., Abelson, K., Pedersen, T. B., & Munro, G. (2018) · European Journal of Pain · doi:10.1002/ejp.1327 · Cited by 36 · see citing works

Postoperative Pain and Intravenous Patient-Controlled Analgesia-Related Adverse Effects in Young and Elderly Patients

Koh, J. C., Lee, J., Kim, S. Y., Choi, S., & Han, D. W. (2015) · Medicine · doi:10.1097/md.0000000000002008 · Cited by 36 · see citing works

The Length of Surgical Skin Incision in Postoperative Inflammatory Reaction

Ioannidis, A., Arvanitidis, K. I., Filidou, E., Valatas, V., Stavrou, G., Michalopoulos, A., Kolios, G. C., & Kotzampassi, K. E. (2018) · JSLS Journal of the Society of Laparoscopic & Robotic Surgeons · doi:10.4293/jsls.2018.00045 · Cited by 35 · see citing works

Green Light Antinociceptive and Reversal of Thermal and Mechanical Hypersensitivity Effects Rely on Endogenous Opioid System Stimulation

Martin, L. F., Moutal, A., Cheng, K., Washington, S. M., Calligaro, H., Goel, V., Kranz, T., Largent‐Milnes, T. M., Khanna, R., Patwardhan, A. M., et al. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.05.006 · Cited by 34 · see citing works

Transient, 5-HT2B receptor–mediated facilitation in neuropathic pain: Up-regulation of PKCγ and engagement of the NMDA receptor in dorsal horn neurons

Aira, Z., Buesa, I., del Caño, G. G., Bilbao, J., Doñate-Oliver, F., Zimmermann, M., & Azkue, J. J. (2013) · Pain · doi:10.1016/j.pain.2013.06.009 · Cited by 32 · see citing works

Pain after surgery

Eisenach, J. C., & Brennan, T. J. (2018) · Pain · doi:10.1097/j.pain.0000000000001223 · Cited by 30 · see citing works

AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury

Huie, J. R., Stück, E. D., Lee, K. H., Irvine, K., Beattie, M. S., Bresnahan, J. C., Grau, J. W., & Ferguson, A. R. (2015) · eNeuro · doi:10.1523/eneuro.0091-15.2015 · Cited by 29 · see citing works

Advances and Barriers in Understanding Presynaptic N-Methyl-D-Aspartate Receptors in Spinal Pain Processing

Dedek, A., & Hildebrand, M. E. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.864502 · Cited by 28 · see citing works

Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat

Boada, M. D., Gutierrez, S., Giffear, K., Eisenach, J. C., & Ririe, D. G. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00399.2012 · Cited by 28 · see citing works

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

Khanna, R., Patwardhan, A. M., Yang, X.-F., Li, W., Cai, S., Ji, Y., Chew, L. A., Dorame, A., Bellampalli, S. S., Schmoll, R. W., et al. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.04.008 · Cited by 26 · see citing works

Effect of Interleukin-10 on Localization of AMPA Receptors in Synapses during Long-Term Posttetanic Potentiation in Cultured Hippocampal Slices

Mikheeva, I. B., Malkov, A., Pavlik, L. L., Arkhipov, V. I., & Levin, S. G. (2019) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-019-04459-3 · Cited by 4 · see citing works

A Comprehensive Overview of the Neural Mechanisms of Light Therapy

Huang, X., Tao, Q., & Ren, C. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01089-8 · Cited by 71 · see citing works

Nerve Blocks for Post-Surgical Pain Management: A Narrative Review of Current Research

Niyonkuru, E., Iqbal, M. A., Zeng, R., Zhang, X., & Ma, P. (2024) · Journal of Pain Research · doi:10.2147/jpr.s476563 · Cited by 45 · see citing works

The disruptive relationship among circadian rhythms, pain, and opioids

Bumgarner, J. R., McCray, E. W., & Nelson, R. J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1109480 · Cited by 40 · see citing works

Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

Biskupiak, Z., Ha, V. V., Rohaj, A., & Bulaj, G. W. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020403 · Cited by 42 · see citing works

Narrow band green light effects on headache, photophobia, sleep, and anxiety among migraine patients: an open-label study conducted online using daily headache diary

Lipton, R. B., Melo‐Carrillo, A., Severs, M., Reed, M. L., Ashina, S., Houle, T. T., & Burstein, R. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1282236 · Cited by 16 · see citing works

Light, opsins, and life: Mammalian photophysiological functions beyond image perception

Shi, Y., Hu, J., & Xue, T. (2025) · Neuron · doi:10.1016/j.neuron.2025.05.025 · Cited by 15 · see citing works

Endogenous opiates and behavior: 2023

Bodnar, R. J. (2024) · Peptides · doi:10.1016/j.peptides.2024.171268 · Cited by 11 · see citing works

Green Light Exposure Reduces Primary Hyperalgesia and Proinflammatory Cytokines in a Rodent Model of Knee Osteoarthritis: Shedding Light on Sex Differences

Ventura, L., Santo, R. F. D. E., Keaser, M. L., Zhang, Y., Ro, J. Y., & Silva, J. T. D. (2024) · Biomedicines · doi:10.3390/biomedicines12092005 · Cited by 10 · see citing works

Visual exposure to green light therapy reduces knee joint pain and alters the lipidome in osteoarthritic rats

O’Brien, M. S., Richter, E., Woodward, T. J., Bradshaw, H. B., & McDougall, J. J. (2024) · Pain · doi:10.1097/j.pain.0000000000003458 · Cited by 10 · see citing works

Autophagy modulation by hADSCs and green light therapy alleviates inflammation and promotes functional recovery after spinal cord injury

Chen, J., He, Q., Xie, H., Gu, B., Zhou, L., Jiang, D., Xie, H., Li, L., Zhou, Z., & Zhang, H. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04367-6 · Cited by 9 · see citing works

Effectiveness of visible light for seasonal affective disorder: A systematic review and network meta-analysis

Wan, Y., Ding, J., Fan, M., & Huang, H. (2025) · Medicine · doi:10.1097/md.0000000000043107 · Cited by 7 · see citing works

Smart Response Biomaterials for Pain Management

Zhang, X., Guan, M., Yi, W., Li, X., Ding, X., He, Y., Wang, H., Wang, Z., Tang, Q., Liao, B., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401555 · Cited by 6 · see citing works

Effectiveness of Photobiomodulation Therapy in the Management of Fibromyalgia Syndrome: A Systematic Review

Pérez, S. E. M., Niebla, J. R., Pérez, L. G., León, R. C., López-Mejías, A., Tejera, D. M., & Pérez, I. M. M. (2025) · Applied Sciences · doi:10.3390/app15084161 · Cited by 5 · see citing works

A prospective, randomized, controlled, double-blind, multi-center study to evaluate the efficacy and safety of a blue light device for the treatment of chronic back pain

Baron, R., Morlion, B. J., Dahan, A., Ueberall, M. A., von Basum, G., & Wild, I. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1444401 · Cited by 4 · see citing works

Toward the Treatment of Glioblastoma Tumors Using Photoactivated Chemotherapy: In Vitro Evaluation of Efficacy and Safety

Goetzfried, S. K., Hakkennes, M. L. A., Busemann, A., & Bonnet, S. A. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00600 · Cited by 4 · see citing works

Double Emission and Reversible Thermochromic Luminescence Based Sn 2+ :(NH 4 ) 4 CdCl 6 Single Crystal for Anti-Counterfeiting

Zhang, S., Jie, S., Yang, K., Wang, X., Yu, M., Teng, B., & Ji, S. (2026) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.5c05006 · Cited by 3 · see citing works

Pivotal roles of TRPV1 channel and Nrf2 factor in green light modulation of keratinocyte inflammatory response

Salman, S., Raccah, S., Rousseaud, A., Declercq, L., & Kerdine‐Römer, S. (2024) · Journal of Photochemistry and Photobiology · doi:10.1016/j.jpap.2024.100227 · Cited by 3 · see citing works

Treatment of Glioblastoma tumors using photoactivated chemotherapyPreprint

Goetzfried, S. K., Hakkennes, M. L. A., Busemann, A., & Bonnet, S. A. (2024) · ChemRxiv · doi:10.26434/chemrxiv-2024-wtmf0 · Cited by 3 · see citing works

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management

Ismail, K. A., Curfman, V., Park, J., Louis, E. M., Korah, H. E., Washington, S. M., Ibrahim, M. M., & Martin, L. F. (2025) · Journal of Visualized Experiments · doi:10.3791/67821 · Cited by 1 · see citing works

Artificial light at night induces opposing neurotoxic effects in adult and larval zebrafish

Zhang, Y., Cao, M., Wang, T., Song, Y., Wei, S. X., Guo, X., Xu, T., & Yin, D. (2026) · Aquatic Toxicology · doi:10.1016/j.aquatox.2026.107734 · Cited by 1 · see citing works

Evaluating the Potential of Green Light Exposure on Nociception-A Mini Review

Qaiser, H., Uzair, M., Arshad, M., Zafar, A., & Bashir, S. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230522105931 · Cited by 1 · see citing works

Phototherapy

Park, J., Calligaro, H., Ibrahim, M. M., & Martin, L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-24705-7.00031-4

Congrès de la SFETD, Lille, novembre 2024. Première partie

Calvino, B. (2025) · Douleurs Évaluation - Diagnostic - Traitement · doi:10.1016/j.douler.2025.02.004

Ambient green light reduces knee pain in osteoarthritis patients

O’Brien, M. S., Amey, S., DeBow, C., Mukhida, K., & McDougall, J. J. (2026) · Canadian Journal of Pain · doi:10.1080/24740527.2025.2598285

Exposure to Green Light-emitting Diodes Alleviates Endometriosis-associated Pain in Mice with Induced Deep Endometriosis

Dong, J., Liu, X., Wang, Y., & Guo, S. (2026) · Reproductive Sciences · doi:10.1007/s43032-026-02084-w

Light therapy for chronic pain: From molecular mechanisms to next-generation therapeutic strategies

Gao, S.-J., Liu, D.-Q., Ren, C.-R., Zhou, Y.-Q., & Mei, W. (2026) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2026.113438

Wavelength dependence of acute, light-evoked recruitment of brainstem pain-modulating systems in female rats

Shi, Z., Radu, S., Martenson, M., & Heinricher, M. M. (2026) · Neurobiology of Pain · doi:10.1016/j.ynpai.2026.100217

Dual Roles of Voltage-gated Calcium Channels and γ-Aminobutyric Acid–mediated Signaling in Modulating Neurotensin Receptor Type 2–induced Antinociception

Martin, L. F., Gómez, K., Park, J., Ismail, K., Masterson, K. A., Korah, H. E., Stratton, H. J., Allen, J., Palomino, S. M., Washington, S. M., et al. (2026) · Anesthesiology · doi:10.1097/aln.0000000000006077

Biological basis of diurnal pain fluctuations: from molecular clocks to clinical interventions

Yue, L., & Sun, T. (2026) · Pain Management · doi:10.1080/17581869.2026.2686783

Green Light Therapy for Pain and Pain-Related Psychosocial Outcomes: A Systematic Review of Human Studies

Bain, J., Kompella, A., Millan, R., Jones, E. P., & Sawicki, C. M. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15145710

Mechanisms and clinical application of photobiomodulation in pain therapy: a mini review

Ren, Y., Li, W., Miao, H., Chen, Y., & Chen, X. (2026) · Frontiers in Pain Research · doi:10.3389/fpain.2026.1920821

Green light exposure reduces central sensitization in cats with osteoarthritis-associated somatosensory impairment

Delsart, A., Castel, A., Dumas, G., Sauvé, F., Otis, C., Lussier, B., Péron, F., Hébert, M., Lapointe, N. P., Quaegebeur, N., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117340

Green Light Antinociceptive and Reversal of Thermal and Mechanical Hypersensitivity Effects Rely on Endogenous Opioid System Stimulation

Martin, L. F., Moutal, A., Cheng, K., Washington, S. M., Calligaro, H., Goel, V., Kranz, T., Largent‐Milnes, T. M., Khanna, R., Patwardhan, A. M., et al. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.05.006 · Cited by 34 · see citing works

A Descending Pain Modulation Pathway in Green Light-Induced Antinociception

Cheng, K., & Cheng, K. (2023) · UA Campus Repository (The University of Arizona)

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

Ibrahim, M. M., Patwardhan, A., Gilbraith, K. B., Moutal, A., Yang, X., Chew, L. A., Largent-Milnes, T., Malan, T. P., Vanderah, T. W., Porreca, F., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000767 · Cited by 123 · see citing works

Green Light Therapy Reduces Mechanical Pain In A Rat Model Of Osteoarthritis By Activating The Endocannabinoid System

O’Brien, M. S., DeBow, C., & McDougall, J. J. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.01.426

Glutamatergic and GABAergic neurons in the vLGN mediate the nociceptive effects of green and red light on neuropathic pain

Wu, X., Tan, B., Du, Y., Yang, L. C., Hu, T., Ding, Y.-L., Qiu, X.-Y., Moutal, A., Khanna, R., Yu, J., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106164 · Cited by 21 · see citing works