The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Impairment of L-type Ca2+Channel-Dependent Forms of Hippocampal Synaptic Plasticity in Mice Deficient in the Extracellular Matrix Glycoprotein Tenascin-C
Open accessAbstract
The extracellular matrix glycoprotein tenascin-C (TN-C) has been suggested to play important functional roles during neural development, axonal regeneration, and synaptic plasticity. We generated a constitutively TN-C-deficient mouse mutant from embryonic stem cells with a floxed tn-C allele, representing a standard for future analysis of conditionally targeted mice. The gross morphology of the CNS was not detectably affected, including no evidence for perturbed nerve cell migration, abnormal oligodendrocyte distribution, or defective myelination. Despite the apparent normal histology of the hippocampus and normal performance in the water maze, theta-burst stimulation (TBS) of Schaffer collaterals elicited reduced long-term potentiation (LTP) in the CA1 region of TN-C-deficient mutants, as compared with wild-type littermates. However, high-frequency stimulation evoked normal LTP not only in CA1, but also at mossy fiber-CA3 and medial and lateral perforant path-granule cell synapses in the dentate gyrus. Low-frequency stimulation failed to induce long-term depression in the CA1 region of TN-C-deficient animals. Recordings of TBS-induced LTP in the presence of nifedipine, an antagonist of L-type voltage-dependent Ca2+ channels (VDCCs), did not affect LTP in TN-C-deficient mice, but reduced LTP in wild-type mice to the levels seen in mutants. Furthermore, chemical induction of a L-type VDCC-dependent LTP in the CA1 region by application of the K+ channel blocker tetraethylammonium resulted in impaired LTP in TN-C mutants. Thus, reduction in L-type VDCC-mediated signaling appears to mediate the deficits in certain forms of synaptic plasticity in constitutively TN-C-deficient mice.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Lastly, animals deficient in tenascin-C show impaired L-type calcium channel-dependent LTP [74].”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [74]
In the citing paper
“When the composition of PNNs is impaired, the neuronal synaptic plasticity in form of LTP is affected, as has been reported for the tenascin-C (TnC)7, TnR25, brevican26 and neurocan27 knockout mice.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4350 · Cited by 53,218
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.
Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., & Roder, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8424 · Cited by 2,328
Episodic memory, amnesia, and the hippocampal–anterior thalamic axis
Aggleton, J. P., & Brown, M. W. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002034 · Cited by 1,879
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782 · cited 2×
“Particularly, levels of NMDA receptordependent LTP at Schaffer collateral-A1 synapses have been correlated with performance in certain tests of spatial learning and memory (Tsien et al., 1996; Shimizu et al., 2000; Zeng et al., 2001).”
BackgroundMethodDeletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting
Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., & Rajewsky, K. (1994) · Science · doi:10.1126/science.8016642 · Cited by 1,397
Wood, E. R., Dudchenko, P. A., Robitsek, R. J., & Eichenbaum, H. (2000) · Neuron · doi:10.1016/s0896-6273(00)00071-4 · Cited by 992
Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning
Zamanillo, D., Sprengel, R., Hvalby, Ø., Jensen, V., Burnashev, N., Rozov, A., Kaiser, K. M. M., Köster, H. J., Borchardt, T., Worley, P., et al. (1999) · Science · doi:10.1126/science.284.5421.1805 · Cited by 791
A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease
Chen, G., Chen, K. S., Knox, J., Inglis, J., Bernard, A., Martin, S. J., Justice, A., McConlogue, L., Games, D., Freedman, S. B., et al. (2000) · Nature · doi:10.1038/35050103 · Cited by 740
Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP
Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A., & Nicoll, R. A. (1994) · Science · doi:10.1126/science.7916482 · Cited by 618
Mice develop normally without tenascin.Preprint
Saga, Y., Yagi, T., Ikawa, Y., Sakakura, T., & Aizawa, S. (1992) · Genes & Development · doi:10.1101/gad.6.10.1821 · Cited by 582
NMDA Receptor-Dependent Synaptic Reinforcement as a Crucial Process for Memory Consolidation
Shimizu, E., Tang, Y., Rampon, C., & Tsien, J. Z. (2000) · Science · doi:10.1126/science.290.5494.1170 · Cited by 546
Increase in Single L-Type Calcium Channels in Hippocampal Neurons During Aging
Thibault, O., & Landfield, P. W. (1996) · Science · doi:10.1126/science.272.5264.1017 · Cited by 513
Zeng, H., Chattarji, S., Barbarosie, M., Rondi-Reig, L., Philpot, B. D., Miyakawa, T., Bear, M. F., & Tonegawa, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00585-2 · Cited by 498
Postsynaptic Induction and Presynaptic Expression of Hippocampal Long-Term Depression
Bolshakov, V. Y., & Siegelbaum, S. A. (1994) · Science · doi:10.1126/science.7909958 · Cited by 486
Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation
Kang, H., Welcher, A. A., Shelton, D., & Schuman, E. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80378-5 · Cited by 481
Novel form of long-term potentiation produced by a K+channel blocker in the hippocampus
Aniksztejn, L., & Ben‐Ari, Y. (1991) · Nature · doi:10.1038/349067a0 · Cited by 337
P1 site-specific recombination: nucleotide sequence of the recombining sites.
Hoess, R. H., Ziese, M., & Sternberg, N. L. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.11.3398 · Cited by 327
Tenascin-C in development and disease: gene regulation and cell function
Jones, P. L., & Jones, F. S. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00106-2 · Cited by 323
Spatial learning without NMDA receptor-dependent long-term potentiation
Saucier, D. M., & Cain, D. P. (1995) · Nature · doi:10.1038/378186a0 · Cited by 322
Long-term potentiation: What's learning got to do with it?
Shors, T. J., & Matzel, L. D. (1997) · Behavioral and Brain Sciences · doi:10.1017/s0140525x97001593 · Cited by 320
Eckhardt, M., Bukalo, O., Chazal, G., Wang, L., Goridis, C., Schachner, M., Gerardy‐Schahn, R., Cremer, H., & Dityatev, A. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05234.2000 · Cited by 317
Self-citationTenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B
Bristow, J., Tee, M., Gitelman, S., Mellon, S., & Miller, W. (1993) · The Journal of cell biology · doi:10.1083/jcb.122.1.265 · Cited by 302
Thibault, O., Hadley, R. W., & Landfield, P. W. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09744.2001 · Cited by 279
Expression of tenascin in the developing and adult cerebellar cortex
Bartsch, S., Bartsch, U., Dörries, U., Faissner, A., Weller, A., Ekblom, P., & Schachner, M. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00736.1992 · Cited by 271
Self-citationRabchevsky, A. G., & Streit, W. J. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970101)47:1 · Cited by 256
Srinivasan, J., Schachner, M., & Catterall, W. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15753 · Cited by 249
Self-citationWeber, P., Bartsch, U., Rasband, M. N., Czaniera, R., Lang, Y., Bluethmann, H., Margolis, R. U., Levinson, S. R., Shrager, P., Montag, D., et al. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04245.1999 · Cited by 247
Self-citationNishiyama, A., Lin, X., Giese, N. A., Heldin, C., & Stallcup, W. B. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960201)43:3 · Cited by 244
Bukalo, O., Schachner, M., & Dityatev, A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00082-3 · Cited by 236
Self-citationSkin wounds and severed nerves heal normally in mice lacking tenascin-C.
Forsberg, E., Hirsch, E., Fröhlich, L., Meyer, M., Ekblom, P., Aszódi, A., Werner, S., & Fässler, R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6594 · Cited by 235
Target-Specific Expression of Presynaptic Mossy Fiber Plasticity
Maccaferri, G., Tóth, K., & McBain, C. J. (1998) · Science · doi:10.1126/science.279.5355.1368 · Cited by 225
Husmann, K., Faissner, A., & Schachner, M. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.6.1475 · Cited by 210
Self-citationHippocampus as a memory map: Synaptic plasticity and memory encoding by hippocampal neurons
Shapiro, M. L., & Eichenbaum, H. (1999) · Hippocampus · doi:10.1002/(sici)1098-1063(1999)9:4 · Cited by 209
The FLP recombinase of the 2μ circle DNA of yeast: Interaction with its target sequences
Andrews, B., Proteau, G. A., Beatty, L. G., & Sadowski, P. D. (1985) · Cell · doi:10.1016/0092-8674(85)90339-3 · Cited by 207
Saghatelyan, A. K., Dityatev, A., Schmidt, S., Schuster, T., Bartsch, U., & Schachner, M. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0922 · Cited by 207
Self-citationNeurocan Is Dispensable for Brain Development
Zhou, X.-H., Brakebusch, C., Matthies, H., Oohashi, T., Hirsch, E., Moser, M., Krug, M., Seidenbecher, C. I., Boeckers, T. M., Rauch, U., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5970-5978.2001 · Cited by 206
Genetically modified mice and cognition
Lipp, H., & Wolfer, D. P. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80151-7 · Cited by 203
A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase β
Ratcliffe, C. F., Qu, Y., McCormick, K. A., Tibbs, V. C., Dixon, J. E., Scheuer, T., & Catterall, W. A. (2000) · Nature Neuroscience · doi:10.1038/74805 · Cited by 182
Phylogeny of ion channels: clues to structure and function
Anderson, P. A. V., & Greenberg, R. M. (2001) · Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(01)00376-1 · Cited by 171
Huang, Y., & Malenka, R. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00568.1993 · Cited by 163
L-Type Calcium Channels Are Required for One Form of Hippocampal Mossy Fiber LTP
Kapur, A., Yeckel, M. F., Gray, R., & Johnston, D. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.2181 · Cited by 158
The tenascin-C knockout revisited
Mackie, E. J., & Tucker, R. P. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.22.3847 · Cited by 149
Tenascin knockout mice: barrels, boundary molecules, and glial scars
Steindler, D. A., Settles, D. L., Erickson, H. P., Laywell, E. D., Yoshiki, A., Faissner, A., & Kusakabe, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01971.1995 · Cited by 119
Hippocampal mossy fiber LTP is independent of postsynaptic calcium
Mellor, J. R., & Nicoll, R. A. (2001) · Nature Neuroscience · doi:10.1038/83941 · Cited by 116
Saghatelyan, A., Gorissen, S., Albert, M., Hertlein, B., Schachner, M., & Dityatev, A. E. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00216.x · Cited by 116
Self-citationElectrical Stimuli Patterned After the Theta-Rhythm Induce Multiple Forms of LTP
Morgan, S. L., & Teyler, T. J. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.3.1289 · Cited by 116
Bartsch, U., Faissner, A., Trotter, J., Dörries, U., Bartsch, S., Mohajeri, H. M., & Schachner, M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04756.1994 · Cited by 112
Self-citationHuber, K. M., Mauk, M. D., & Kelly, P. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.1.270 · Cited by 102
Milev, P., Fischer, D., Häring, M., Schulthess, T., Margolis, R. K., Chiquet‐Ehrismann, R., & Margolis, R. U. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15501 · Cited by 102
Cain, D. P. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80012-8 · Cited by 99
Kiernan, B. W., Götz, B., Faissner, A., & ffrench‐Constant, C. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0024 · Cited by 98
Abnormal Behavior and Neurotransmissions of Tenascin Gene Knockout Mouse
Fukamauchi, F., Mataga, N., Wang, Y., Sato, S., Yoshiki, A., & Kusakabe, M. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0561 · Cited by 95
Role of long‐term synaptic modification in short‐term memory
Kesner, R. P., & Rolls, E. T. (2001) · Hippocampus · doi:10.1002/hipo.1040 · Cited by 95
Hagios, C., Koch, M., Spring, J., Chiquet, M., & Chiquet‐Ehrismann, R. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.6.1499 · Cited by 95
Chiquet‐Ehrismann, R., Hagios, C., & Matsumoto, K. (1994) · PubMed · Cited by 95
Chondroitin Sulfate Proteoglycan Elevates Cytoplasmic Calcium in DRG Neurons
Snow, D. M., Atkinson, P. B., Hassinger, T. D., Letourneau, P. C., & Kater, S. B. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1298 · Cited by 94
Morganti, M. C., Taylor, J., Pesheva, P., & Schachner, M. (1990) · Experimental Neurology · doi:10.1016/s0014-4886(05)80012-3 · Cited by 89
Self-citationChristie, B. R., Schexnayder, L. K., & Johnston, D. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.3.1651 · Cited by 79
Aging and cognition: Facilitation of recent memory in aged nonhuman primates by nimodipine
Sandin, M., Jasmin, S., & LeVere, T. E. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90120-o · Cited by 76
Bartsch, U. (1996) · Progress in Neurobiology · doi:10.1016/0301-0082(96)00014-7 · Cited by 74
Self-citationStrekalova, T. V., Sun, M., Sibbe, M., Evers, M. R., Dityatev, A. E., Gass, P., & Schachner, M. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1172 · Cited by 69
Self-citationMyelination and behaviour of tenascin‐C null transgenic mice
Kiernan, B. W., Garcion, E., Ferguson, J., Frost, E. E., Torres, E. M., Dunnett, S. B., Saga, Y., Aizawa, S., Faissner, A., Kaur, R., et al. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00729.x · Cited by 67
Quevedo, J., Vianna, M. R. M. R., Daroit, D., de Born, A. G., Kuyven, C. R., Roesler, R., & Quillfeldt, J. A. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3822 · Cited by 64
Hanse, E., & Gustafsson, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-08-03226.1992 · Cited by 63
Lauri, S. E., Rauvala, H., Kaila, K., & Taira (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00039.x · Cited by 54
Transient increase of tenascin-C in immature hippocampus: astroglial and neuronal expression
Ferhat, L., Chevassus-au-Louis, N., Jorquera, I., Niquet, J., Khrestchatisky, M., Ben‐Ari, Y., & Represa, A. (1996) · Journal of Neurocytology · doi:10.1007/bf02284785 · Cited by 52
The use of translation in foreign language teaching
Stibbard, R. (1994) · Perspectives · doi:10.1080/0907676x.1994.9961218 · Cited by 50
Src, ras, and rac mediate the migratory response elicited by NGF and PMA in PC12 cells
Altun-Gultekin, Z. F., & Wagner, J. A. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960515)44:4 · Cited by 49
McMonagle-Strucko, K., & Fanelli, R. J. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90013-j · Cited by 48
Calcium Channel Antagonists Enhance Retention of Passive Avoidance and Maze Learning in Mice
Quartermain, D., deSoria, V. G., & Kwan, A. (2001) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1999.3958 · Cited by 46
Cellular and molecular mechanisms of memory: the LTP connection
Miller, S., & Mayford, M. R. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80050-1 · Cited by 43
Song, D. B., Xie, X., Wang, Z., & Berger, T. W. (2001) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2001.4032 · Cited by 37
Prevention of nimodipine-induced impairment of learning by the selective ? ligand PRE-084
Maurice, T., Su, T., Parish, D. W., & Privat, A. (1995) · Journal of Neural Transmission · doi:10.1007/bf01276561 · Cited by 31
Detection of tenascin‐C in the nervous system of the tenascin‐C mutant mouse
Mitrovic, N., & Schachner, M. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490420514 · Cited by 29
Self-citationBuschbeck, E. K., & Hoy, R. R. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19981115)37:3 · Cited by 29
Self-citationRiekkinen, M., Schmidt, B. H., Kuitunen, J., & Riekkinen, P. J. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00976-4 · Cited by 21
Mandell, J. W., & Banker, G. A. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199804)35:1 · Cited by 16
Self-citation
Research works printed but not linked: 1
- Faissner A, Schachner M (1995) Tenascin and janusin: Glial recognition molecules involved in neural development and regeneration. In: Neu- roglia (Kettenmann H, Ransom BR, eds), pp 422-426. New York: Oxford University Press.
Cited by
Sorted by citations
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,074
The dual role of the extracellular matrix in synaptic plasticity and homeostasis
Dityatev, A., Schachner, M., & Sonderegger, P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2898 · Cited by 559
Self-citationExtracellular matrix molecules and synaptic plasticity
Dityatev, A., & Schachner, M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1115 · Cited by 564
Self-citationExtracellular Matrix: Functions in the Nervous System
Barros, C. S., Franco, S. J., & Muller, U. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005108 · Cited by 506
Extracellular matrix of the central nervous system: from neglect to challenge
Zimmermann, D. R., & Dours-Zimmermann, M. T. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0485-9 · Cited by 465
Metadata
- Authors
- Evers, M. R., Salmen, B., Bukalo, O., Rollenhagen, A., Bösl, M. R., Morellini, F., Bartsch, U., Dityatev, A., & Schachner, M.
- Affiliations
- Universität Hamburg (DE)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-08-15
- Volume
- 22
- Issue
- 16
- Pages
- 7177-7194
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6757873
- OpenAlex
- W2141616957
- Cited by
- 172
- References
- 81
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 9 · 2013: 6 · 2012: 10
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Rheinische Friedrich-Wilhelms-Universität Bonn
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- tenascin-C, extracellular matrix, L-type calcium channels, hippocampal synaptic plasticity, long-term potentiation, long-term depression, CA1 region, dentate gyrus, Schaffer collaterals, perforant path, tetraethylammonium, nifedipine, floxed allele
- MeSH terms
- Animals, Behavior, Animal, Cerebellar Cortex, Electric Stimulation, Hippocampus, Male, Neural Inhibition, Neuronal Plasticity, Neurons, Optic Nerve, Retina, Synapses, Blotting, Western, Long-Term Potentiation, Mice, Knockout, Gene Targeting, Excitatory Amino Acid Antagonists, Maze Learning, Tenascin, Excitatory Postsynaptic Potentials, Calcium Channels, L-Type, Mice, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
