Expression of neural proteoglycans correlates with the acquisition of mature neuronal properties in the mammalian brain

Hockfield, S.; Kalb, R.G.; Zaremba, S.; Fryer, H.

doi:10.1101/sqb.1990.055.01.049

PreprintCited by 271Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchProteoglycans and glycosaminoglycans research

Expression of neural proteoglycans correlates with the acquisition of mature neuronal properties in the mammalian brain

Hockfield, S., Kalb, R.G., Zaremba, S., Fryer, H.·1990·Cold Spring Harbor Symposia on Quantitative Biology

DOI 10.1101/sqb.1990.055.01.049

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Abstract

The neurons in the mature mammalian central nervous system (CNS) are an enormously diverse group of cells. The acquisition of mature, differentiated neuronal properties takes place over an extended developmental period, through a number of different mechanisms. Some of the very last events in neuronal development occur late in the postnatal period, when the mature set of synapses between neurons and their targets is selected and the adult anatomical and physiological properties of neurons are acquired. Experiments in many different systems have shown that the mature set of synapses is selected from an initial set by selective stabilization of some synapses and elimination of others (for review, see Purves and Lichtman 1985). The process of synapse selection is governed, at least in part, by neuronal activity. Temporal matching of pre-and postsynaptic activity is thought to be critical in determining whether a synapse will be retained or lost. Environmental stimuli (such...

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Animal studies show PNNs are widely distributed in the brain.
“A large number of animal studies have shown that PNNs are widely distributed in the brain”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Hockfield et al., 1990

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Authors: Hockfield, S., Kalb, R. G., Zaremba, S., & Fryer, H.
Affiliations: Yale University (US)
ORCID: Kalb, R.G.
Zaremba, S.
Fryer, H.
Venue: Cold Spring Harbor Symposia on Quantitative Biology
Publisher: Cold Spring Harbor Laboratory
Published: 1990-01-01
Volume: 55
Issue: 0
Pages: 505-514
ISSN: 0091-7451 (ISSN-L)
1943-4456
DOI: 10.1101/sqb.1990.055.01.049
OpenAlex: W2325060126
Cited by: 271
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 4 · 2018: 9 · 2017: 7 · 2016: 5 · 2015: 12 · 2014: 13 · 2013: 12 · 2012: 11
Type: posted content
Language: en
Open access: closed
Locations: Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k08ns001247-04, 5f32ey005855-02)
National Eye Institute (EY05855, EY 06511)
National Institute of Neurological Disorders and Stroke (NS-01247)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords: neuronal maturation, postnatal brain development, synaptic pruning, synaptic stabilization, central nervous system development
MeSH terms: Animals, Antibodies, Monoclonal, Brain, Cats, Cell Differentiation, Extracellular Matrix, Motor Neurons, Neurons, Chondroitin Sulfate Proteoglycans, Proteoglycans, Spinal Cord, Visual Cortex

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Expression of neural proteoglycans correlates with the acquisition of mature neuronal properties in the mammalian brain

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