Experience-dependent pruning of dendritic spines in visual cortex by tissue plasminogen activator

Mataga, Nobuko; Mizuguchi, Yoko; Hensch, Takao K.

doi:10.1016/j.neuron.2004.11.028

Cited by 371Neuroscience and Neuropharmacology ResearchVisual perception and processing mechanismsNeurogenesis and neuroplasticity mechanisms

Experience-dependent pruning of dendritic spines in visual cortex by tissue plasminogen activator

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Mataga, Nobuko, Mizuguchi, Yoko, Hensch, Takao K.·2004·Neuron

DOI 10.1016/j.neuron.2004.11.028

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Abstract

Sensory experience physically rewires the brain in early postnatal life through unknown processes. Here, we identify a robust anatomical consequence of monocular deprivation (MD) in layer II/III of visual cortex that corresponds to the rapid, functional loss of responsiveness preceding any changes in axonal input. Protrusions on pyramidal cell apical dendrites increased steadily after eye opening, but were transiently lost through competitive mechanisms after brief MD only during the physiological critical period. Proteolysis by tissue-type plasminogen activator (tPA) conversely declined with age and increased with MD only in young mice. Targeted disruption of tPA release or its upstream regulation by glutamic acid decarboxylase (GAD65) prevented MD-induced spine loss that was pharmacologically rescued concomitant with critical period plasticity. An extracellular mechanism for structural remodeling that is limited to the binocular zone upon proper detection of competing inputs thus links early sensory experience to visual function.

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During the critical period, monocular deprivation induces a significant decrease in the density of dendritic spines on pyramidal neurons in deprived V1b, but this plasticity is lost with age.
“During the critical period for ocular dominance plasticity, MD induces a significant decrease in the density of dendritic spines on pyramidal neurons in deprived V1b (contralateral to the occlusion), but this plasticity is lost with age (Mataga et al., 2004).”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Mataga et al., 2004

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Authors: Mataga, N., Mizuguchi, Y., & Hensch, T. K.
Affiliations: RIKEN Center for Brain Science (JP)
Corresponding author: Hensch, Takao K.
ORCID: Mataga, Nobuko
Hensch, Takao K.
Venue: Neuron
Publisher: Elsevier BV
Published: 2004-12
Volume: 44
Issue: 6
Pages: 1031-1041
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2004.11.028
OpenAlex: W2030192664
Cited by: 371
References: 92
Citations by year: 2026: 5 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 12 · 2020: 25 · 2019: 10 · 2018: 10 · 2017: 17 · 2016: 18 · 2015: 13 · 2014: 20 · 2013: 29 · 2012: 20
FWCI: 6.80
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3150 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: RIKEN Brain Science Institute
Ministry of Education, Culture, Sports, Science and Technology
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: monocular deprivation, visual cortex, critical period plasticity, tissue plasminogen activator, glutamic acid decarboxylase, layer II/III pyramidal neurons, extracellular proteolysis
MeSH terms: Animals, Glutamate Decarboxylase, Humans, Isoenzymes, Tissue Plasminogen Activator, Sensory Deprivation, Visual Cortex, Vision, Monocular, Mice, Knockout, Dendritic Spines, Mice

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Experience-dependent pruning of dendritic spines in visual cortex by tissue plasminogen activator

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