Cited by 245Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

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Bone Marrow-Derived Cells that Populate the Adult Mouse Brain Preserve Their Hematopoietic Identity

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Vallières, Luc, Sawchenko, Paul E.·2003·The Journal of Neuroscience

DOI 10.1523/jneurosci.23-12-05197.2003PMC PMC6741180

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Abstract

Cytogenesis in the adult brain can result from the recruitment of circulating precursors, but the proposal that some such cells transdifferentiate into neural elements is controversial. We have reinvestigated this issue by following the phenotypic fate of bone marrow cells expressing the green fluorescent protein transplanted into the systemic circulation of irradiated mice. Thousands of donor-derived cells were detected throughout brains of recipients killed 1-12 months after transplantation, but none displayed neuronal, macroglial, or endothelial characteristics, even after injury. Among those that crossed the endothelium of the cerebral cortex, >99.7% were identified as perivascular macrophages. Newly formed parenchymal microglia were found in significant numbers only in the cerebellum and at injury sites. Therefore, bone marrow does supply the mature brain with new specialized cells; however, mesenchymal precursors neither adopt neural phenotypes nor contribute to cerebral vascular remodeling. This continuous traffic of macrophages across the blood-brain barrier provides a vehicle to introduce therapeutic genes into the nervous system.

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Authors: Vallières, L., & Sawchenko, P. E.
Affiliations: Salk Institute for Biological Studies (US)
ORCID: Vallières, Luc
Sawchenko, Paul E.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2003-06-15
Volume: 23
Issue: 12
Pages: 5197-5207
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.23-12-05197.2003
PMC: PMC6741180
OpenAlex: W1894599871
Cited by: 245
References: 63
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 11 · 2016: 7 · 2015: 8 · 2014: 17 · 2013: 18 · 2012: 15
FWCI: 5.21
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Fondation pour la Recherche Médicale
National Institutes of Health (NS21182)
Canadian Institutes of Health Research
National Institute of Neurological Disorders and Stroke (NS21182, R37NS021182, R01NS021182)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: bone marrow-derived cells, transdifferentiation, adult neurogenesis, perivascular macrophages, microglia, blood-brain barrier, mesenchymal precursors, brain injury, gene therapy delivery, green fluorescent protein tagging, irradiated mice
MeSH terms: Animals, Blood-Brain Barrier, Bone Marrow Cells, Brain, Brain Injuries, Cell Count, Cell Differentiation, Cell Division, Cerebral Decortication, Hematopoietic System, Luminescent Proteins, Macrophages, Male, Mice, Inbred C57BL, Mice, Transgenic, Phenotype, Time, Bone Marrow Transplantation, Microglia, Genes, Reporter, Cell Lineage, Green Fluorescent Proteins, Mice

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Bone Marrow-Derived Cells that Populate the Adult Mouse Brain Preserve Their Hematopoietic Identity

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