Cited by 272Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Plasticity of intrinsic neuronal excitability

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Debanne, Dominique, Inglebert, Yanis, Russier, Michaël·2019·Current Opinion in Neurobiology

Abstract

Long-term synaptic modification is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ion channels also participates in memory formation. Intrinsic plasticity is expressed in virtually all neuronal types including principal cells and interneurons. Activation of synaptic glutamate receptors initiates long-lasting changes in neuronal excitability at presynaptic and postsynaptic side. As synaptic plasticity, intrinsic plasticity is bi-directional and expresses a certain level of input-specificity or cell-specificity. We discuss here the nature of the learning rules shared by intrinsic and synaptic plasticity and the impact of intrinsic plasticity on temporal processing.

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Crossref · 10.1016/j.conb.2018.09.001

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84 of 84 references verified0 citation errors · 0 not checkable

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  • Intrinsic excitability regulates neuronal gain and input-output transformations at the single cell level, unlike synaptic plasticity which modifies connection efficacy.

    “Unlike synaptic plasticity, which modifies the efficacy of connections between neurons, intrinsic excitability regulates neuronal gain and input–output transformations at the single cell level [24,25,26].”
  • Stress-induced changes in intrinsic excitability can occur independently of synaptic remodeling yet powerfully influence circuit output and behavioral state.

    “These changes can occur independently of synaptic remodeling yet powerfully influence circuit output and behavioral state [24,26].”

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Authors
Debanne, D., Inglebert, Y., & Russier, M.
Affiliations
Inserm (FR)
Corresponding author
Debanne, Dominique
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2019-02
Volume
54
Pages
73-82
ISSN
0959-4388 (ISSN-L)
OpenAlex
W2891094463
Cited by
272
References
84
Citations by year
2026: 35 · 2025: 56 · 2024: 38 · 2023: 37 · 2022: 31 · 2021: 36 · 2020: 20 · 2019: 18 · 2018: 1
FWCI
2.43
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
Funders
  • INSERM, CNRS, AMU, FRM (FDT2170437059, DVS20131228768)
  • ANR NEUC 2014 (ANR-14-NEUC-0004)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
intrinsic plasticity, neuronal excitability, voltage-gated ion channels, synaptic plasticity, memory formation, glutamate receptors, learning rules, temporal processing, interneurons, principal cells
MeSH terms
Action Potentials, Animals, Brain, Humans, Learning, Neuronal Plasticity, Neurons

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