Plasticity of intrinsic neuronal excitability
Open accessAbstract
Long-term synaptic modification is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ion channels also participates in memory formation. Intrinsic plasticity is expressed in virtually all neuronal types including principal cells and interneurons. Activation of synaptic glutamate receptors initiates long-lasting changes in neuronal excitability at presynaptic and postsynaptic side. As synaptic plasticity, intrinsic plasticity is bi-directional and expresses a certain level of input-specificity or cell-specificity. We discuss here the nature of the learning rules shared by intrinsic and synaptic plasticity and the impact of intrinsic plasticity on temporal processing.
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Intrinsic excitability regulates neuronal gain and input-output transformations at the single cell level, unlike synaptic plasticity which modifies connection efficacy.
“Unlike synaptic plasticity, which modifies the efficacy of connections between neurons, intrinsic excitability regulates neuronal gain and input–output transformations at the single cell level [24,25,26].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [24]
Stress-induced changes in intrinsic excitability can occur independently of synaptic remodeling yet powerfully influence circuit output and behavioral state.
“These changes can occur independently of synaptic remodeling yet powerfully influence circuit output and behavioral state [24,26].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [24]
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- Authors
- Debanne, D., Inglebert, Y., & Russier, M.
- Affiliations
- Inserm (FR)
- Corresponding author
- Debanne, Dominique
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 54
- Pages
- 73-82
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2891094463
- Cited by
- 272
- References
- 84
- Citations by year
- 2026: 35 · 2025: 56 · 2024: 38 · 2023: 37 · 2022: 31 · 2021: 36 · 2020: 20 · 2019: 18 · 2018: 1
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- INSERM, CNRS, AMU, FRM (FDT2170437059, DVS20131228768)
- ANR NEUC 2014 (ANR-14-NEUC-0004)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- intrinsic plasticity, neuronal excitability, voltage-gated ion channels, synaptic plasticity, memory formation, glutamate receptors, learning rules, temporal processing, interneurons, principal cells
- MeSH terms
- Action Potentials, Animals, Brain, Humans, Learning, Neuronal Plasticity, Neurons
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