Differential Effects of Excitatory and Inhibitory Plasticity on Synaptically Driven Neuronal Input-Output Functions

Carvalho, Tiago P.; Buonomano, Dean V.

doi:10.1016/j.neuron.2009.01.013

Cited by 100Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Differential Effects of Excitatory and Inhibitory Plasticity on Synaptically Driven Neuronal Input-Output Functions

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Carvalho, Tiago P., Buonomano, Dean V.·2009·Neuron

DOI 10.1016/j.neuron.2009.01.013PMC PMC2676350

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Abstract

Ultimately, whether or not a neuron produces a spike determines its contribution to local computations. In response to brief stimuli the probability a neuron will fire can be described by its input-output function, which depends on the net balance and timing of excitatory and inhibitory currents. While excitatory and inhibitory synapses are plastic, most studies examine plasticity of subthreshold events. Thus, the effects of concerted regulation of excitatory and inhibitory synaptic strength on neuronal input-output functions are not well understood. Here, theoretical analyses reveal that excitatory synaptic strength controls the threshold of the neuronal input-output function, while inhibitory plasticity alters the threshold and gain. Experimentally, changes in the balance of excitation and inhibition in CA1 pyramidal neurons also altered their input-output function as predicted by the model. These results support the existence of two functional modes of plasticity that can be used to optimize information processing: threshold and gain plasticity.

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Balanced changes in excitatory and inhibitory synaptic plasticity may enhance the amplitude of membrane fluctuations to regulate the I/O gain of individual neurons.
“Balanced changes in excitatory and inhibitory synaptic plasticity may further enhance the amplitude of membrane fluctuations to regulate the I/O gain of individual neurons76.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [76]

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Authors: Carvalho, T. P., & Buonomano, D. V.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Buonomano, Dean V.
ORCID: Carvalho, Tiago P.
Buonomano, Dean V.
Venue: Neuron
Publisher: Elsevier BV
Published: 2009-03
Volume: 61
Issue: 5
Pages: 774-785
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2009.01.013
PMC: PMC2676350
OpenAlex: W2098864351
Cited by: 100
References: 84
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 4
FWCI: 3.59
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1599 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH-60163, R01MH060163)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: synaptic plasticity, inhibitory plasticity, excitation-inhibition balance, CA1 pyramidal neurons, action potential generation, information processing
MeSH terms: Animals, Animals, Newborn, Computer Simulation, Electric Stimulation, Hippocampus, Models, Neurological, Neuronal Plasticity, Neurons, Synapses, Rats, Sprague-Dawley, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Rats, Inhibitory Postsynaptic Potentials, Biophysical Phenomena, In Vitro Techniques

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Differential Effects of Excitatory and Inhibitory Plasticity on Synaptically Driven Neuronal Input-Output Functions

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