Impairments of exploration and memory after systemic or prelimbic D1-receptor antagonism in rats

Clausen, Bettina; Schachtman, Todd R.; Mark, Louise T.; Reinholdt, Mette; Christoffersen, Gert R.J.

doi:10.1016/j.bbr.2011.03.069

Cited by 41Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Impairments of exploration and memory after systemic or prelimbic D1-receptor antagonism in rats

Clausen, Bettina, Schachtman, Todd R., Mark, Louise T., Reinholdt, Mette, Christoffersen, Gert R.J.·2011·Behavioural Brain Research

DOI 10.1016/j.bbr.2011.03.069

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Abstract

D1-receptor antagonism is known to impair rodent memory but also inhibits spontaneous exploration of stimuli to be remembered. Hypo-exploration could contribute to impaired memory by influencing event processing. In order to explore this effect, the D1 receptor antagonist, SCH23390, was administered to rats via routes that either did or did not affect spontaneous exploration: systemic or prelimbic administration, respectively. Effects were tested in spatial and non-spatial memory tasks selected for their requirements for self-initiated exploration of stimuli to be remembered in order to examine the effects on memory: cross-maze and object recognition task. Systemic administration reduced spatial exploration in cross-maze as well as in an open field test, and also reduced object exploration. Spatial (hippocampus-dependent) short-term memory was inhibited in the cross-maze and non-spatial short-term object retention was also impaired. In contrast to these systemic effects, bilateral injections of SCH23390 into the prelimbic cortices altered neither spatial nor object exploration, but did inhibit short-term memory in both cross-maze and object recognition task. Therefore, the inhibiting effects of SCH23390 on both spatial and non-spatial memory were not mediated indirectly via reduced exploration of stimuli to be remembered, but through antagonism of a prelimbic D1-R function that is directly involved in memory formation. Finally, a cooperative regulation of spatial exploration between D1-R and mGlu5 was indicated by a synergistic effect of the antagonists SCH23390 and MPEP.

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Pre-sample prefrontal microinjections of SCH23390 do not impair NOP memory tested 1 hour later.
“Pre-sample prefrontal microinjections of SCH23390 did not impair the NOP memory tested 1 hour later (Savalli et al., 2015), although contrary results have also been reported (Clausen et al., 2011).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Clausen et al., 2011

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Authors: Clausen, B., Schachtman, T. R., Mark, L. T., Reinholdt, M., & Christoffersen, G. R. J.
Affiliations: University of Copenhagen (DK)
University of Missouri (US)
Corresponding author: Schachtman, Todd R.
ORCID: Schachtman, Todd R.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2011-10
Volume: 223
Issue: 2
Pages: 241-254
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2011.03.069
OpenAlex: W2070365656
Cited by: 41
References: 94
Citations by year: 2024: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 2 · 2013: 1 · 2012: 4
FWCI: 1.14
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine D1 receptor, SCH 23390, prelimbic cortex, spatial exploration, memory impairment, short-term memory, object recognition memory, hippocampal-dependent memory, mGlu5 receptor, MPEP
MeSH terms: Adenylyl Cyclases, Animals, Benzazepines, Dose-Response Relationship, Drug, Drug Implants, Enzyme Activation, Exploratory Behavior, Injections, Intraperitoneal, Limbic System, Male, Memory, Microinjections, Type C Phospholipases, Pyridines, Rats, Sprague-Dawley, Cyclic AMP Response Element-Binding Protein, Receptors, Dopamine D1, Receptors, Metabotropic Glutamate, Dopamine Antagonists, Excitatory Amino Acid Antagonists, Maze Learning, Mitogen-Activated Protein Kinase 1, Receptors, G-Protein-Coupled, Rats, Receptor, Metabotropic Glutamate 5

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Impairments of exploration and memory after systemic or prelimbic D1-receptor antagonism in rats

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