The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Priming Stimulation Enhances the Depressant Effect of Low-Frequency Repetitive Transcranial Magnetic Stimulation
Open accessAbstract
Low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) can depress the excitability of the cortex locally and has been proposed for the treatment of disorders such as schizophrenia and epilepsy. Some have speculated that the depressant effect is related to long-term depression (LTD) of cortical synapses. Because in vitro LTD can be enhanced by pretreatment of synapses with higher-frequency stimulation, we hypothesized that if rTMS depression had mechanisms in common with LTD, higher-frequency priming would increase it also. In 25 healthy volunteers in two experiments, we measured motor-evoked potentials (MEPs) from TMS of the motor cortex to define the baseline response. Subthreshold rTMS (6 Hz, fixed rate or frequency modulated) was used to prime the motor cortex, followed by suprathreshold 1 Hz stimulation for 10 min at just above the MEP threshold. Over the next 60 min, we recorded MEPs every 10 sec and found significant increases in the amount of cortical depression with both types of 6 Hz priming rTMS relative to sham. The MEP depression from 6 Hz-primed 1 Hz rTMS showed no evidence of decay after 60 min. Pretreatment with 6 Hz primes both 1 Hz rTMS depression and LTD. Although not conclusive evidence, this strengthens the case for overlapping mechanisms and suggests a potent new technique for enhancing low-frequency rTMS depression that may have experimental and clinical applications.
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Cites
Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation
Chen, R., Classen, J., Gerloff, C., Celnik, P., Wassermann, E. M., Hallett, M., & Cohen, L. G. (1997) · Neurology · doi:10.1212/wnl.48.5.1398 · Cited by 2,128 · cited 2×
“…threshold for evoked muscle twitches produces a refractory state in which the electromyographic response to stimulation, the motor-evoked potential (MEP), is reduced in size (Wassermann et al., 1996b; Chen et al., 1997a; Touge et al., 2001), and its threshold is elevated (Fitzgerald et al., 2002).”
BackgroundInfluentialSelf-citationMetaplasticity: the plasticity of synaptic plasticity
Abraham, W. C., & Bear, M. F. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80018-x · Cited by 1,776
Ziemann, U., Lönnecker, S., Steinhoff, B. J., & Paulus, W. (1996) · Annals of Neurology · doi:10.1002/ana.410400306 · Cited by 1,137
Larson, J., Wong, D., & Lynch, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)90579-2 · Cited by 1,037
Learning-Induced LTP in Neocortex
Rioult-Pedotti, M.-S., Friedman, D., & Donoghue, J. P. (2000) · Science · doi:10.1126/science.290.5491.533 · Cited by 1,015
Early consolidation in human primary motor cortex
Muellbacher, W., Ziemann, U., Wissel, J., Dang, N., Kofler, M., Facchini, S., Boroojerdi, B., Poewe, W., & Hallett, M. (2002) · Nature · doi:10.1038/nature712 · Cited by 803 · cited 1×
“We chose to record from a physiological flexor and extensor in the hand and forearm to determine whether the effects of priming were present in muscles with different physiology ( Lemon, 1993 ) and to make artifacts of limb positioning, etc.”
MethodThe Role of Area 17 in Visual Imagery: Convergent Evidence from PET and rTMS
Kosslyn, S. M., Pascual-Leone, A., Felician, O., Camposano, S., Keenan, J. P., L., W., Thompson, Ganis, G., Sukel, K. E., & Alpert, N. M. (1999) · Science · doi:10.1126/science.284.5411.167 · Cited by 747
Strengthening of horizontal cortical connections following skill learning
Rioult-Pedotti, M. S., Friedman, D., Hess, G., & Donoghue, J. P. (1998) · Nature Neuroscience · doi:10.1038/678 · Cited by 701
Stimulation of the human motor cortex through the scalp
Rothwell, J., Thompson, P., Day, B., Boyd, S., & Marsden, C. (1991) · Experimental Physiology · doi:10.1113/expphysiol.1991.sp003485 · Cited by 664
Therapeutic application of repetitive transcranial magnetic stimulation: a review
Wassermann, E. M., & Lisanby, S. H. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00585-5 · Cited by 601
Self-citation
Cited by
Rossi, S., Hallett, M., Rossini, P. M., & Pascual-Leone, A. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.08.016 · Cited by 5,367
Noninvasive Human Brain Stimulation
Wagner, T., Valero-Cabre, A., & Pascual-Leone, A. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.061206.133100 · Cited by 873
Ridding, M. C., & Ziemann, U. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.190314 · Cited by 787
Is there a future for therapeutic use of transcranial magnetic stimulation?
Ridding, M. C., & Rothwell, J. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2169 · Cited by 687
Physiology of repetitive transcranial magnetic stimulation of the human brain
Hoogendam, J. M., Ramakers, G. M. J., & Di Lazzaro, V. (2010) · Brain Stimulation · doi:10.1016/j.brs.2009.10.005 · Cited by 669
Metadata
- Authors
- Iyer, M. B., Schleper, N., & Wassermann, E. M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-11-26
- Volume
- 23
- Issue
- 34
- Pages
- 10867-10872
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1520463686
- Cited by
- 360
- References
- 35
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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