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The β3 Nicotinic Receptor Subunit: A Component of α-Conotoxin MII-Binding Nicotinic Acetylcholine Receptors that Modulate Dopamine Release and Related Behaviors
Open accessAbstract
Nigrostriatal dopaminergic neurons express many nicotinic acetylcholine receptor (nAChR) subunits capable of forming multiple nAChR subtypes. These subtypes are expressed differentially along the neuron and presumably mediate diverse responses. β3 subunit mRNA has restricted expression but is abundant in the substantia nigra and ventral tegmental areas. To investigate the potential role(s) of nicotinic receptors containing the β3 subunit in dopaminergic tracts, we generated mice with a null mutation in the β3 gene. We were thereby able to identify a population of β3-dependent α-conotoxin MII-binding nAChRs that modulate striatal dopamine release. Changes were also observed in locomotor activity and prepulse inhibition of acoustic startle, behaviors that are controlled, in part, by nigrostriatal and mesolimbic dopaminergic activity, respectively, suggesting that β3-containing nAChRs modulate these behaviors.
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“As β3 mRNA is detected in the substantia nigra, VTA, and medial habenula (Cui et al. 2003)”
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“behaviors that are controlled, at least in part, by nigrostriatal and mesolimbic dopaminergic activity (Cui et al. 2003)”
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“Changes were also reported for locomotor activity and prepulse inhibition of acoustic startle”
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Metadata
- Authors
- Cui, C., Booker, T. K., Allen, R. S., Grady, S. R., Whiteaker, P., Marks, M. J., Salminen, O., Tritto, T., Butt, C. M., Allen, W. R., Stitzel, J. A., McIntosh, J. M., Boulter, J., Collins, A. C., & Heinemann, S. F.
- Affiliations
- Salk Institute for Biological Studies (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-12-03
- Volume
- 23
- Issue
- 35
- Pages
- 11045-11053
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6741047
- OpenAlex
- W2130326884
- Cited by
- 213
- References
- 53
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 10 · 2015: 6 · 2014: 17 · 2013: 9 · 2012: 12
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05da000197-07, 5p01da010156-05, MH53631)
- National Institute on Aging (2T32AG00216, T32AG000216)
- National Institute of Mental Health (MH53631, R01MH053631, R29MH053631)
- National Institute on Drug Abuse (DA00197, DA-14369, R01DA014369, R01DA012242, DA10156, DA12242)
- National Institute of Neurological Disorders and Stroke (NS10830, F32NS010830)
- National Institute of Child Health and Human Development
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- nicotinic acetylcholine receptors, beta3 subunit, alpha-conotoxin MII, dopamine release, nigrostriatal pathway, substantia nigra, ventral tegmental area, null mice, locomotor activity, prepulse inhibition, acoustic startle response, mesolimbic dopamine system, striatum
- MeSH terms
- Animals, Behavior, Animal, Binding, Competitive, Corpus Striatum, Dopamine, Dose-Response Relationship, Drug, Female, Ligands, Male, Mice, Mutant Strains, Motor Activity, Neural Inhibition, Nicotine, Receptors, Nicotinic, RNA, Messenger, Reflex, Startle, Substantia Nigra, Synaptosomes, In Situ Hybridization, Mice, Knockout, Gene Targeting, Conotoxins, Protein Subunits, Mice, Rats
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