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Locus Ceruleus and Anterior Cingulate Cortex Sustain Wakefulness in a Novel Environment
Open accessAbstract
Locus ceruleus (LC) neuronal activity is correlated with the waking state, yet LC lesions produce only minor alterations in daily wakefulness. Here, we report that sustained elevations in neurobehavioral and EEG arousal in response to exposure to an environment with novel stimuli, including social interaction, are prevented by selective chemical lesions of the LC in rats. Similar results are seen when the anterior cingulate cortex (ACC), which receives especially dense LC innervation, is selectively denervated of LC input or is ablated by the cell-specific neurotoxin ibotenic acid. Anterograde tracing combined with tyrosine hydroxylase immunohistochemistry demonstrates ACC terminals in apposition with the distal dendrites of LC neurons. Our data implicate the ACC as both a source of input to the LC as well as one of its targets and suggests that the two structures engage in a dialog that may provide a critical neurobiological substrate for sustained attention.
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“Conversely, if the stimulus is evaluated as rewarding or salient, the phasic mode is maintained through frequent firing bursts of LC-NE neurons and release of NE, supporting sustained attention over time (Gompf et al., 2010).”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Gompf et al., 2010
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Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Self-citationBerridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468
Aston-Jones, G., & Bloom, F. (1981) · The Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00876.1981 · Cited by 1,960
Enriched environments, experience-dependent plasticity and disorders of the nervous system
Nithianantharajah, J., & Hannan, A. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1970 · Cited by 1,771
Sauer, H., & Oertel, W. H. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90605-x · Cited by 817
The Brain Nucleus Locus Coeruleus: Restricted Afferent Control of a Broad Efferent Network
Aston‐Jones, G., Ennis, M. J., Pieribone, V. A., Nickell, W. T., & Shipley, M. T. (1986) · Science · doi:10.1126/science.3775363 · Cited by 778
Research works printed but not linked: 1
- Kolb B (1990) in The cerebral cortex of the rat, Prefrontal cortex, eds Kolb B Tees RC (MIT, Cambridge, MA), pp 437–458.
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Lisieski, M. J., Karavidha, K., Gheidi, A., Garibyan, R. L., Conti, A. C., Morrow, J. D., & Perrine, S. A. (2019) · Brain and Behavior · doi:10.1002/brb3.1222 · Cited by 10
Social and environmental contexts modulate sleep deprivation-induced c-Fos activation in rats
Deurveilher, S., Ryan, N., Burns, J., & Semba, K. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.029 · Cited by 12
Wang, X., Li, Z., Wang, X., Chen, J., Guo, Z., Qiao, B., & Qin, L. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1296-23.2024 · Cited by 10
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Yang, X., Fedumenti, F. T., Niethard, N., Hallschmid, M., Jan Born, A., & Rauss, K. S. (2025) · SLEEP · doi:10.1093/sleep/zsaf042 · Cited by 11
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A role of prefrontal cortico-hypothalamic projections in wake promotion
Zhong, H., Xu, H., Li, X., Xie, R., Shi, Y., Wang, Y., Li, T., Zhu, Q., Han, J., Tao, H., et al. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac258 · Cited by 10
Menneson, S., Serrand, Y., Janvier, R., Noirot, V., Etienne, P. L., Coquery, N., & Val‐Laillet, D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243893 · Cited by 10
Fifel, K., Farissi, A. E., Chérasse, Y., & Yanagisawa, M. (2022) · Advanced Science · doi:10.1002/advs.202200640 · Cited by 9
Large-scale functional brain networks for consciousness
Han, M.-E., Park, S. Y., & Oh, S.-O. (2021) · Anatomy & Cell Biology · doi:10.5115/acb.20.305 · Cited by 9
Sönmez, Ö., Holstein, E. R., Puschmann, S., Schmitt, T., Witt, K., & Thiel, C. M. (2025) · Psychophysiology · doi:10.1111/psyp.14739 · Cited by 8
Soto, B. A., Ma, Y., Nollet, M., Wong, S., Miracca, G., Rastinejad, D., Yustos, R., Vyssotski, A. L., Franks, N. P., & Wisden, W. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422878122 · Cited by 10
Ariffin, M. Z., Chang, L. S., Koh, H. E., Low, C., & Khanna, S. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.046 · Cited by 8
Broadscale dampening of uncertainty adjustment in the aging brain
Kosciessa, J. Q., Mayr, U., Lindenberger, U., & Garrett, D. D. (2024) · Nature Communications · doi:10.1038/s41467-024-55416-2 · Cited by 7
Mortazavi, N., Talwar, P., Koshmanova, E., Sharifpour, R., Beckers, E., Berger, A., Campbell, I., Paparella, I., Balda, F., Hamzaoui, I. D., et al. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01127-9 · Cited by 9
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Revealing a role of brainstem monoaminergic nuclei on the pronociceptive effect of sleep restriction
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Neurochemistry and Pharmacology of Sleep
Torterolo, P., Monti, J. M., & Vanini, G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816430-3.00004-x · Cited by 6
The Circuit, Cellular, and Synaptic Bases of Sleep-Wake Regulation
Arrigoni, E., & Fuller, P. M. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-813743-7.00005-0 · Cited by 6
Hopkins, K., Mukherjee, S., Ponce, D., Mangum, J. E., Jacobson, L. H., & Hoyer, D. (2021) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2021.100102 · Cited by 6
Autonomic arousal tracks outcome salience not valence in monkeys making social decisions.
Basile, B. M., Joiner, J. A., Monte, O. D., Fagan, N. A., Karaskiewicz, C. L., Lucas, D. R., Chang, S. W. C., & Murray, E. A. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000424 · Cited by 6
Regulation of wakefulness by neurotensin neurons in the lateral hypothalamus
Naganuma, F., Khanday, M. A., Bandaru, S. S., Hasan, W., Hirano, K., Yoshikawa, T., & Vetrivelan, R. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115035 · Cited by 5
Broderick, M.-Z. L., Khan, Q., & Moradikor, N. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.01.016 · Cited by 5
Research advances in children's sleep and vitamin D levels
Zhu, L., & Yao, D. (2025) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2448076.038 · Cited by 5
Functionality of arousal-regulating brain circuitry at rest predicts human cognitive abilities
Podvalny, E., Sánchez-Romero, R., & Cole, M. W. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae192 · Cited by 5
Pathogenicity of Endocrine Dysregulation in AutismPreprint
Swierczynski, A. (2018) · Preprints.org · doi:10.20944/preprints201805.0359.v1 · Cited by 4
An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening
Matosevich, N., Regev, N., Kimchy, U., Zelinger, N., Kabaha, S., Gabay, N., Marmelshtein, A., & Nir, Y. (2025) · Science Advances · doi:10.1126/sciadv.adw6375 · Cited by 4
Characterizing brain stage-dependent pupil dynamics based on lateral hypothalamic activity
Takahashi, K., Sobczak, F., Pais‐Roldán, P., & Yu, X. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad309 · Cited by 5
Salvi, C., & Bowden, E. M. (2024) · Cambridge University Press eBooks · doi:10.1017/9781009244244.013 · Cited by 4
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Martin, L., Torres, G., & López-Tolsa, G. E. (2016) · IEEE International Conference on Cognitive Informatics & Cognitive Computing (ICCI*CC) · doi:10.1109/icci-cc.2016.7862092 · Cited by 4
Neurobiological Parallels, Overlaps, and Divergences of Sleep and Anesthesia
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The locus coeruleus, a blue spot for early diagnosis and prognosis of Alzheimer’s disease
Farahani, F., Anaclet, C., Azizi, H., & Gompf, H. S. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1632236 · Cited by 4
Hirao, A., Hojo, Y., Murakami, G., Ito, R., Hashizume, M., Murakoshi, T., & Uozumi, N. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302470 · Cited by 3
Insomnia-related rodent models in drug discovery
Chen, Z.-K., Liu, Y., Zhou, J.-C., Chen, G.-H., Liu, C., Qu, W., & Huang, Z. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01269-w · Cited by 3
Kabanova, A., Fedorov, L., & Eschenko, O. (2024) · eNeuro · doi:10.1523/eneuro.0063-24.2024 · Cited by 4
Silk, T. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814180-9.00013-2 · Cited by 4
Denyer, R., Su, S., Patnaik, M., & Duqué, J. (2026) · Journal of Neurophysiology · doi:10.1152/jn.00008.2026 · Cited by 2
Geerling, J. C. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.08.779 · Cited by 2
Brain Circuits Underlying Narcolepsy
Pintwala, S. K., & Peever, J. H. (2021) · The Neuroscientist · doi:10.1177/10738584211052263 · Cited by 3
Strategic, Emotional, and Motivational Influences on Metacognition in Older Adulthood
McGillivray, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-51673-4_12 · Cited by 2
Brainstem nuclei in autonomic control and arousal
de la Cruz, F., Bär, K., & Schumann, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00107-8 · Cited by 2
Knott, T. S., Whyte, A. J., Dhawan, S. S., Tait, D. S., & Brown, V. J. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.07.034 · Cited by 2
The impacts of sleep loss on wake-active neurons
Bellesi, M., Semba, K., Veasey, S. C., Adamantidis, A., & Peever, J. H. (2025) · SLEEP · doi:10.1093/sleep/zsaf248 · Cited by 1
Ba, W., Harding, E. C., Nollet, M., Tossell, K., Li, L., Wong, S., Soto, B. A., Yustos, R., Li, L., Ostaszewska, J., et al. (2026) · Current Biology · doi:10.1016/j.cub.2026.04.059 · Cited by 1
Régulation de la veille et du sommeil : les acteurs moléculaires
Fabre, V., Adrien, J., Bonnavion, P., & Hamon, M. (2011) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)31953-3 · Cited by 5
From induction to relief: Neurophysiological mechanisms underlying the curiosity feedback loop
Nianqu, C. (2022) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2023.00256 · Cited by 1
Barrington's nucleus: a century of progress identifying neurons that control micturition
Tish, M. M., & Geerling, J. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-822455-7.00012-x · Cited by 1
Fifel, K., & Deboer, T. (2021) · SLEEP · doi:10.1093/sleep/zsab230 · Cited by 1
Takahashi, K., Sobczak, F., Pais‐Roldán, P., & Yu, X. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.22.461385 · Cited by 1
Neuroinflammation, sleep, and autoimmune disease
Zielinski, M. R., & Gibbons, A. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00312-1 · Cited by 1
Neural Circuitry Responsible for Sleep and Wakefulness
Konadhode, R. R., Pelluru, D., & Shiromani, P. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3492-4_3
[Measurement of acetylcholine and sleep patterns].
Alfaro-Rodríguez, A., González-Piña, R., Bueno-Nava, A., Ávila-Luna, A., & Arch-Tirado, E. (2013) · PubMed
Behavioural effects of single-cell stimulation in Barrel cortex
Tanke, N. (2014) · EUR Research Repository (Erasmus University Rotterdam)
Molecular Mechanisms Of Sleep/wake Regulation And Memory Formation In Young And Aged Mice
Wimmer, M. E. (2012) · ScholarlyCommons (University of Pennsylvania)
Saper, C. B. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_1
Role of the Catecholamine and Limbic Systems in Narcolepsy/Cataplexy
Burgess, C. R. (2012) · TSpace (University of Toronto)
Sleep Medicine: What Can Ayurveda Contribute to the Contemporary Health Care?
Rastogi, S., & Rastogi, R. (2018) · Springer eBooks · doi:10.1007/978-981-13-2062-0_10 · Cited by 1
Correlates of Object Exploration and Recognition Memory in Mouse Anterior Cingulate Cortex
Weible, A. P. (2018) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-812012-5.00016-1
Learning to focus and focusing to learn : more than a cortical trick
Dhawan, S. S. (2018) · St Andrews Research Repository (St Andrews Research Repository)
Exploration of neuronal ensembles responsible for sleep and body temperature regulation
Ma, Y. (2019) · Spiral (Imperial College London) · doi:10.25560/80152
Joshi, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00077-2 · Cited by 1
Zhang, C., Yang, Y., Li, F.-N., Zhang, H., Sun, L., Li, J., Yang, C., Yue, Z.-F., Feng, J., Li, Y., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.11.659024
Scanavini, G., Martin, I., Alkhoury, L., Radanovic, A., Tepler, Y., Jaywant, A., Hill, N. J., Butler, T., Jamison, K. W., Kuceyeski, A. F., et al. (2025) · Neurotrauma Reports · doi:10.1177/2689288x251370997
Denyer, R., Su, S., Patnaik, M., & Duqué, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.14.688461
Transcutaneous cervical vagal nerve stimulation (tcVNS) accelerates image analyst trainingPreprint
McKinley, R. A., McIntire, L. K., & Goodyear, C. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5933390
Neurodegenerative Disorders: Involvement of the Locus Coeruleus in the Modulation of Diabetic Pain
Núñez, A. G., Mesa-Lombardo, A., García‐Magro, N., & Martín, Y. B. (2025) · Springer eBooks · doi:10.1007/978-3-031-95878-6_10
Chronic short sleep in early life accelerates cognitive decline via disrupted proteostasisPreprint
Komlo, R., Sengupta, K., Strus, E., & Naidoo, N. N. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.26.714554
Hristovska, I. (2019) · theses.fr (ABES) · doi:10.70675/af1c5105z3e0dz43ffzb906z1553e7a23a6e
Metadata
- Authors
- Gompf, H. S., Mathai, C., Fuller, P. M., Wood, D. A., Pedersen, N. P., Saper, C. B., & Lu, J.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-10-27
- Volume
- 30
- Issue
- 43
- Pages
- 14543-14551
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2989851
- OpenAlex
- W2064376850
- Cited by
- 176
- References
- 44
- Citations by year
- 2026: 3 · 2025: 17 · 2024: 14 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 16 · 2017: 12 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 7
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG000222, T32AG000222)
- National Heart, Lung, and Blood Institute (P01HL095491, HL060292, P50HL060292)
- National Institute of Neurological Disorders and Stroke (R01NS062727, NS051609, R01NS051609, R01NS061841)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- locus coeruleus, anterior cingulate cortex, wakefulness, arousal, novel environment, social interaction, chemical lesions, ibotenic acid, noradrenergic terminals, sustained attention, EEG arousal
- MeSH terms
- Animals, Arousal, Cell Count, Cerebral Cortex, Data Interpretation, Statistical, Electroencephalography, Electromyography, Environment, Ibotenic Acid, Immunohistochemistry, Interpersonal Relations, Locus Coeruleus, Male, Sleep, Sleep, REM, Tyrosine 3-Monooxygenase, Wakefulness, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Excitatory Amino Acid Agonists, Rats
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