Cited by 176Sleep and Wakefulness ResearchNeurotransmitter Receptor Influence on BehaviorNeuroscience of respiration and sleep

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Locus Ceruleus and Anterior Cingulate Cortex Sustain Wakefulness in a Novel Environment

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Gompf, Heinrich S., Mathai, Christine, Fuller, Patrick M., Wood, David A., Pedersen, Nigel P., Saper, Clifford B., Lu, Jun·2010·The Journal of Neuroscience

DOI 10.1523/jneurosci.3037-10.2010PMC PMC2989851

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Abstract

Locus ceruleus (LC) neuronal activity is correlated with the waking state, yet LC lesions produce only minor alterations in daily wakefulness. Here, we report that sustained elevations in neurobehavioral and EEG arousal in response to exposure to an environment with novel stimuli, including social interaction, are prevented by selective chemical lesions of the LC in rats. Similar results are seen when the anterior cingulate cortex (ACC), which receives especially dense LC innervation, is selectively denervated of LC input or is ablated by the cell-specific neurotoxin ibotenic acid. Anterograde tracing combined with tyrosine hydroxylase immunohistochemistry demonstrates ACC terminals in apposition with the distal dendrites of LC neurons. Our data implicate the ACC as both a source of input to the LC as well as one of its targets and suggests that the two structures engage in a dialog that may provide a critical neurobiological substrate for sustained attention.

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Authors: Gompf, H. S., Mathai, C., Fuller, P. M., Wood, D. A., Pedersen, N. P., Saper, C. B., & Lu, J.
Affiliations: Beth Israel Deaconess Medical Center (US)
ORCID: Gompf, Heinrich S.
Fuller, Patrick M.
Pedersen, Nigel P.
Saper, Clifford B.
Lu, Jun
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2010-10-27
Volume: 30
Issue: 43
Pages: 14543-14551
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.3037-10.2010
PMC: PMC2989851
OpenAlex: W2064376850
Cited by: 176
References: 44
Citations by year: 2026: 3 · 2025: 17 · 2024: 14 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 16 · 2017: 12 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 7
FWCI: 4.46
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG000222, T32AG000222)
National Heart, Lung, and Blood Institute (P01HL095491, HL060292, P50HL060292)
National Institute of Neurological Disorders and Stroke (R01NS062727, NS051609, R01NS051609, R01NS061841)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: locus coeruleus, anterior cingulate cortex, wakefulness, arousal, novel environment, social interaction, chemical lesions, ibotenic acid, noradrenergic terminals, sustained attention, EEG arousal
MeSH terms: Animals, Arousal, Cell Count, Cerebral Cortex, Data Interpretation, Statistical, Electroencephalography, Electromyography, Environment, Ibotenic Acid, Immunohistochemistry, Interpersonal Relations, Locus Coeruleus, Male, Sleep, Sleep, REM, Tyrosine 3-Monooxygenase, Wakefulness, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Excitatory Amino Acid Agonists, Rats

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Locus Ceruleus and Anterior Cingulate Cortex Sustain Wakefulness in a Novel Environment

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