Cited by 71Neural dynamics and brain functionNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Context-dependent relationships between locus coeruleus firing patterns and coordinated neural activity in the anterior cingulate cortex

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Abstract

Ascending neuromodulatory projections from the locus coeruleus (LC) affect cortical neural networks via the release of norepinephrine (NE). However, the exact nature of these neuromodulatory effects on neural activity patterns in vivo is not well understood. Here, we show that in awake monkeys, LC activation is associated with changes in coordinated activity patterns in the anterior cingulate cortex (ACC). These relationships, which are largely independent of changes in firing rates of individual ACC neurons, depend on the type of LC activation: ACC pairwise correlations tend to be reduced when ongoing (baseline) LC activity increases but enhanced when external events evoke transient LC responses. Both relationships covary with pupil changes that reflect LC activation and arousal. These results suggest that modulations of information processing that reflect changes in coordinated activity patterns in cortical networks can result partly from ongoing, context-dependent, arousal-related changes in activation of the LC-NE system.

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Authors
Joshi, S., & Gold, J. I.
Affiliations
University of Pennsylvania (US)
Corresponding author
Gold, Joshua I
Venue
eLife
Published
2022-01-07
Volume
11
ISSN
2050-084X (ISSN-L)
OpenAlex
W4220706818
Cited by
71
References
127
Citations by year
2026: 14 · 2025: 12 · 2024: 19 · 2023: 10 · 2022: 10 · 2021: 5 · 2019: 1
FWCI
6.56
Type
journal article
Language
en
Open access
Locations
  • eLife (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (R21 MH107001)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
locus coeruleus, anterior cingulate cortex, norepinephrine, neuromodulation, two-particle correlations, pupil size, arousal, context-dependent modulation, cortical networks, monkeys
MeSH terms
Animals, Arousal, Locus Coeruleus, Macaca mulatta, Male, Neurons, Wakefulness, Prefrontal Cortex

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