Context-dependent relationships between locus coeruleus firing patterns and coordinated neural activity in the anterior cingulate cortex
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Abstract
Ascending neuromodulatory projections from the locus coeruleus (LC) affect cortical neural networks via the release of norepinephrine (NE). However, the exact nature of these neuromodulatory effects on neural activity patterns in vivo is not well understood. Here, we show that in awake monkeys, LC activation is associated with changes in coordinated activity patterns in the anterior cingulate cortex (ACC). These relationships, which are largely independent of changes in firing rates of individual ACC neurons, depend on the type of LC activation: ACC pairwise correlations tend to be reduced when ongoing (baseline) LC activity increases but enhanced when external events evoke transient LC responses. Both relationships covary with pupil changes that reflect LC activation and arousal. These results suggest that modulations of information processing that reflect changes in coordinated activity patterns in cortical networks can result partly from ongoing, context-dependent, arousal-related changes in activation of the LC-NE system.
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ACC and AI project to or are adjacent to VTA and SN, with multisynaptic routes via habenula.
“which project to or are adjacent to VTA and SN3,22,29–33,54,55 (with multisynaptic routes via habenula56,57)”
From Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering (2026) · cites this paper as [32]
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Self-citation
- Authors
- Joshi, S., & Gold, J. I.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Gold, Joshua I
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2022-01-07
- Volume
- 11
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC8765756
- OpenAlex
- W4220706818
- Cited by
- 71
- References
- 127
- Citations by year
- 2026: 14 · 2025: 12 · 2024: 19 · 2023: 10 · 2022: 10 · 2021: 5 · 2019: 1
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R21 MH107001)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- locus coeruleus, anterior cingulate cortex, norepinephrine, neuromodulation, two-particle correlations, pupil size, arousal, context-dependent modulation, cortical networks, monkeys
- MeSH terms
- Animals, Arousal, Locus Coeruleus, Macaca mulatta, Male, Neurons, Wakefulness, Prefrontal Cortex
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