Cited by 164Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsIon Channels and Receptors

The DOI matches its Crossref record; 75 of the 76 references it cites were found in a registry or an index.

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain

Open access

Jhaveri, Maulik D., Richardson, Denise, Kendall, David A., Barrett, David A., Chapman, Victoria·2006·The Journal of Neuroscience

DOI 10.1523/jneurosci.3326-06.2006PMC PMC6674985

Open this paper in CoChat — free account Open PDF

Abstract

Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states. The aim of this study was to determine whether local inhibition of FAAH alters nociceptive responses of spinal neurons in the spinal nerve ligation model of neuropathic pain. Electrophysiological studies were performed 14-18 d after spinal nerve ligation or sham surgery, and the effects of the FAAH inhibitor cyclohexylcarbamic acid 3-carbamoyl biphenyl-3-yl ester (URB597) on mechanically evoked responses of spinal neurons and levels of endocannabinoids were determined. Intraplantar URB597 (25 microg in 50 microl) significantly (p < 0.01) attenuated mechanically evoked responses of spinal neurons in sham-operated rats. Effects of URB597 were blocked by the cannabinoid 1 receptor (CB1) antagonist AM251 [N-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide] (30 microg in 50 microl) and the opioid receptor antagonist naloxone. URB597 treatment increased levels of anandamide, 2-arachidonyl glycerol, and oleoyl ethanolamide in the ipsilateral hindpaw of sham-operated rats. Intraplantar URB597 (25 microg in 50 microl) did not, however, alter mechanically evoked responses of spinal neurons in spinal nerve ligated (SNL) rats or hindpaw levels of endocannabinoids. Intraplantar injection of a higher dose of URB597 (100 microg in 50 microl) significantly (p < 0.05) attenuated evoked responses of spinal neurons in SNL rats but did not alter hindpaw levels of endocannabinoids. Spinal administration of URB597 attenuated evoked responses of spinal neurons and elevated levels of endocannabinoids in sham-operated and SNL rats. These data suggest that peripheral FAAH activity may be altered or that alternative pathways of metabolism have greater importance in SNL rats.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.3326-06.2006

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Quantitative assessment of tactile allodynia in the rat paw
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125
Brain monoglyceride lipase participating in endocannabinoid inactivation
Dinh, T. P., Carpenter, D., Leslie, F. M., Freund, T. F., Katona, I., Sensi, S. L., Kathuria, S., & Piomelli, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152334899 · Cited by 1,373
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
Cravatt, B. F., Demarest, K., Patricelli, M. P., Bracey, M. H., Giang, D. K., Martin, B. R., & Lichtman, A. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161191698 · Cited by 1,310
Modulation of anxiety through blockade of anandamide hydrolysis
Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Rana, G. L., Calignano, A., et al. (2003) · Nature Medicine · doi:10.1038/nm803 · Cited by 1,293
Control of pain initiation by endogenous cannabinoids
Calignano, A., Rana, G. L., Giuffrida, A., & Piomelli, D. (1998) · Nature · doi:10.1038/28393 · Cited by 1,069

Show all 76 references

Research works printed but not linked: 1

Wilson AW Clayton NM Medhurst SJ Bountra C Chessel IP (2004) The FAAH inhibitor URB597 reverses inflammatory pain through a CB1 receptor mediated mechanism. Proceedings of the British Pharmacological Society, Retrieved November 21, 2006 from http://www.pA2online.org/Vol2Issue4abst049P.html .

Sorted by citations

Targeting the endocannabinoid system: to enhance or reduce?
Marzo, V. D. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2553 · Cited by 822
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Schlosburg, J. E., Blankman, J. L., Long, J. Z., Nomura, D. K., Pan, B., Kinsey, S. G., Nguyen, P. T., Ramesh, D., Booker, L., Burston, J. J., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2616 · Cited by 641
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
Ahn, K., McKinney, M. K., & Cravatt, B. F. (2008) · Chemical Reviews · doi:10.1021/cr0782067 · Cited by 529
The Endocannabinoid System and Pain
Guindon, J., & Hohmann, A. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709789824660 · Cited by 476
Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside
Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum
Maccarrone, M., Rossi, S., Bari, M., Chiara, V. D., Fezza, F., Musella, A., Gasperi, V., Prosperetti, C., Bernardi, G., Finazzi‐Agrò, A., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2042 · Cited by 306
The cannabinoid system and pain
Woodhams, S. G., Chapman, V., Finn, D. P., Hohmann, A. G., & Neugebauer, V. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.015 · Cited by 285
Medical Use of Cannabinoids
Fraguas‐Sánchez, A. I., & Torres‐Suárez, A. I. (2018) · Drugs · doi:10.1007/s40265-018-0996-1 · Cited by 287
Peripheral gating of pain signals by endogenous lipid mediators
Piomelli, D., & Sasso, O. (2014) · Nature Neuroscience · doi:10.1038/nn.3612 · Cited by 240
The Role of the Endocannabinoid System in Pain
Woodhams, S. G., Sagar, D. R., Burston, J. J., & Chapman, V. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-46450-2_7 · Cited by 216
Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain
Roques, B. P., Fournié‐Zaluski, M., & Wurm, M. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3673 · Cited by 198
Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders
Ahn, K., Johnson, D. S., & Cravatt, B. F. (2009) · Expert Opinion on Drug Discovery · doi:10.1517/17460440903018857 · Cited by 205
Endocannabinoid biosynthesis and inactivation, from simple to complex
Muccioli, G. G. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.03.007 · Cited by 192
The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3′-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice
Russo, R., LoVerme, J., La Rana, G., Compton, T. R., Parrott, J., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Calignano, A., et al. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.119941 · Cited by 182
The N‐Acylethanolamine‐Hydrolyzing Acid Amidase (NAAA)
Tsuboi, K., Takezaki, N., & Ueda, N. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790159 · Cited by 172
Repeated Low-Dose Administration of the Monoacylglycerol Lipase Inhibitor JZL184 Retains Cannabinoid Receptor Type 1–Mediated Antinociceptive and Gastroprotective Effects
Kinsey, S. G., Wise, L. E., Ramesh, D., Abdullah, R., Selley, D. E., Cravatt, B. F., & Lichtman, A. H. (2013) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.201426 · Cited by 169
N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA)
Ueda, N., Tsuboi, K., & Uyama, T. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.02.003 · Cited by 166
Cannabinoid–opioid interactions during neuropathic pain and analgesia
Bushlin, I., Rozenfeld, R., & Devi, L. A. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.09.009 · Cited by 163
Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain
Jhaveri, M. D., Richardson, D. S., & Chapman, V. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707433 · Cited by 147
Therapeutic Potential of Inhibitors of Endocannabinoid Degradation for the Treatment of Stress-Related Hyperalgesia in an Animal Model of Chronic Pain
Lomazzo, E., Bîndilă, L., Remmers, F., Lerner, R., Schwitter, C., Hoheisel, U., & Lutz, B. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.198 · Cited by 143
Oxidation of the Endogenous Cannabinoid Arachidonoyl Ethanolamide by the Cytochrome P450 Monooxygenases: Physiological and Pharmacological Implications
Snider, N. T., Walker, V. J., & Hollenberg, P. F. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.001081 · Cited by 136
Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain
Ma, W., & Quirion, R. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.3.307 · Cited by 128
In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML 29: antinociceptive activity without cannabimimetic side effects
Ignatowska‐Jankowska, B. M., Ghosh, S., Crowe, M. S., Kinsey, S. G., Niphakis, M. J., Abdullah, R. A., Tao, Q., O' Neal, S. T., Walentiny, D. M., Wiley, J. L., et al. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12298 · Cited by 128
Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors
van Egmond, N., Straub, V. M., & van der Stelt, M. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-030220-112741 · Cited by 137
Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain
Jhaveri, M. D., Richardson, D. S., Robinson, I., Garle, M. J., Patel, A., Sun, Y., Sagar, D. R., Bennett, A. J., Alexander, S. P. H., Kendall, D. A., et al. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.04.018 · Cited by 122
Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain
Sagar, D. R., Staniaszek, L. E., Okine, B. N., Woodhams, S. G., Norris, L. M., Pearson, R. G., Garle, M. J., Alexander, S. P. H., Bennett, A. J., Barrett, D. A., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27698 · Cited by 123
The fatty acid amide hydrolase (FAAH) inhibitor PF‐3845 acts in the nervous system to reverse LPS‐induced tactile allodynia in mice
Booker, L., Kinsey, S. G., Abdullah, R. A., Blankman, J. L., Long, J. Z., Ezzili, C., Boger, D. L., Cravatt, B. F., & Lichtman, A. H. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01445.x · Cited by 116
Endocannabinoids and Related Compounds: Walking Back and Forth between Plant Natural Products and Animal Physiology
Marzo, V. D., Bisogno, T., & PETROCELLIS, L. D. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.05.014 · Cited by 118
Synergy between Enzyme Inhibitors of Fatty Acid Amide Hydrolase and Cyclooxygenase in Visceral Nociception
Naidu, P. S., Booker, L., Cravatt, B. F., & Lichtman, A. H. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.143487 · Cited by 115
Endocannabinoid and Opioid System Interactions in Exercise-Induced Hypoalgesia
Crombie, K. M., Brellenthin, A. G., Hillard, C. J., & Koltyn, K. F. (2017) · Pain Medicine · doi:10.1093/pm/pnx058 · Cited by 117
Cannabinoids and the Brain
Köfalvi, A. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3 · Cited by 110
FAAH and anandamide: is 2-AG really the odd one out?
Marzo, V. D., & Maccarrone, M. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.03.001 · Cited by 109
The contribution of cyclooxygenase‐2 to endocannabinoid metabolism and action
Fowler, C. J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707379 · Cited by 104
Dynamic Regulation of the Endocannabinoid System: Implications for Analgesia
Sagar, D. R., Gaw, A. G., Okine, B. N., Woodhams, S. G., Wong, A., Kendall, D. A., & Chapman, V. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-59 · Cited by 99
Monoacylglycerol lipase – a target for drug development?
Fowler, C. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01950.x · Cited by 96
Anatomical Distribution of Receptors, Ligands and Enzymes in the Brain and in the Spinal Cord: Circuitries and Neurochemistry
Marsicano, G., & Kuner, R. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3_10 · Cited by 103
Endogenous opiates and behavior: 2006
Bodnar, R. J. (2007) · Peptides · doi:10.1016/j.peptides.2007.09.002 · Cited by 91
Modulatory effects of cannabinoids on brain neurotransmission
Cohen, K., Weizman, A., & Weinstein, A. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14407 · Cited by 98
Dimerization with Cannabinoid Receptors Allosterically Modulates Delta Opioid Receptor Activity during Neuropathic Pain
Bushlin, I., Gupta, A., Stockton, S. D., Miller, L. K., & Devi, L. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049789 · Cited by 95
A Decrease in Anandamide Signaling Contributes to the Maintenance of Cutaneous Mechanical Hyperalgesia in a Model of Bone Cancer Pain
Khasabova, I. A., Khasabov, S. G., Harding-Rose, C., Coicou, L. G., Seybold, B., Lindberg, A. E., Steevens, C. D., Simone, D. A., & Seybold, V. S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2847-08.2008 · Cited by 90
Inhibition of fatty acid amide hydrolase produces PPAR‐α‐mediated analgesia in a rat model of inflammatory pain
Sagar, D. R., Kendall, D. A., & Chapman, V. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.335 · Cited by 89
2,3‐Dihydro‐1‐Benzofuran Derivatives as a Series of Potent Selective Cannabinoid Receptor 2 Agonists: Design, Synthesis, and Binding Mode Prediction through Ligand‐Steered Modeling
Diaz, P., Phatak, S. S., Xu, J. J., Fronczek, F. R., Astruc‐Diaz, F., Thompson, C. M., Cavasotto, C. N., & Naguib, M. (2009) · ChemMedChem · doi:10.1002/cmdc.200900226 · Cited by 88
Evidence for a novel functional role of cannabinoid CB2 receptors in the thalamus of neuropathic rats
Jhaveri, M. D., Elmes, S. J. R., Richardson, D., Barrett, D. A., Kendall, D. A., Mason, R., & Chapman, V. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06162.x · Cited by 88
The μ‐opioid receptor agonist morphine, but not agonists at δ‐ or κ‐opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors
Da Fonseca Pacheco, D., Klein, A., De Castro Perez, A., Da Fonseca Pacheco, C. M., De Francischi, J. N., & Duarte, I. D. G. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.175 · Cited by 81
Predominant expression of lysosomal N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies
Tsuboi, K., Zhao, L.-Y., Okamoto, Y., Araki, N., Ueno, M., Sakamoto, H., & Ueda, N. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.03.005 · Cited by 79
Dynamic changes to the endocannabinoid system in models of chronic pain
Sagar, D. R., Burston, J. J., Woodhams, S. G., & Chapman, V. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0390 · Cited by 77
Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase
Karbarz, M. J., Luo, L., Chang, L., Tham, C.-S., Palmer, J. A., Wilson, S. J., Wennerholm, M. L., Brown, S. M., Scott, B. P., Apodaca, R. L., et al. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31818c7cbd · Cited by 74
Spinal anandamide produces analgesia in neuropathic rats: Possible CB1- and TRPV1-mediated mechanisms
Starowicz, K., Makuch, W., Osikowicz, M., Piscitelli, F., Petrosino, S., Marzo, V. D., & Przewłocka, B. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.021 · Cited by 78
Fatty Acid Amide Hydrolase in Prostate Cancer: Association with Disease Severity and Outcome, CB1 Receptor Expression and Regulation by IL-4
Thors, L., Bergh, A. R. J., Persson, E., Hammarsten, P., Stattin, P. E., Egevad, L., Granfors, T., & Fowler, C. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012275 · Cited by 75
6-Methoxy-N-alkyl Isatin Acylhydrazone Derivatives as a Novel Series of Potent Selective Cannabinoid Receptor 2 Inverse Agonists: Design, Synthesis, and Binding Mode Prediction
Diaz, P., Phatak, S. S., Xu, J. J., Astruc‐Diaz, F., Cavasotto, C. N., & Naguib, M. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm801353p · Cited by 71
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis
Schuelert, N., Johnson, M. P., Oskins, J. L., Jassal, K., Chambers, M. G., & McDougall, J. J. (2011) · Pain · doi:10.1016/j.pain.2010.11.025 · Cited by 70
The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models
Caprioli, A., Coccurello, R., Rapino, C., Serio, S. D., Tommaso, M. D., Vertechy, M., Vacca, V., Battista, N., Pavone, F., Maccarrone, M., et al. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.191403 · Cited by 68
Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: Opioid receptor dependency and molecular correlates
Butler, R. K., Rea, K., Lang, Y., Gavin, A. M., & Finn, D. P. (2008) · Pain · doi:10.1016/j.pain.2008.10.002 · Cited by 69
Central antinociception induced by µ‐opioid receptor agonist morphine, but not δ‐ or κ‐, is mediated by cannabinoid CB1receptor
Pacheco, D. D. F., Klein, A., Perez, A. C., Pacheco, C. M. D. F., Francischi, J. N., Reis, G. M. L., & Duarte, I. D. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00310.x · Cited by 68
Characterisation of cannabinoid 1 receptor expression in the perikarya, and peripheral and spinal processes of primary sensory neurons
Veress, G., Mészár, Z., Muszil, D., Avelino, A., Matesz, K., Mackie, K., & Nagy, I. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0425-2 · Cited by 67
NewN-Arachidonoylserotonin Analogues with Potential “Dual” Mechanism of Action against Pain
Ortar, G., Cascio, M. G., PETROCELLIS, L. D., Morera, E., Rossi, F., Moriello, A. S., Nalli, M., de Novellis, V., Woodward, D. F., Maione, S., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070678q · Cited by 67
The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy
Wallace, V. C. J., Segerdahl, A. R., Lambert, D. M., Vandevoorde, S., Blackbeard, J., Pheby, T., Hasnie, F., & Rice, A. S. C. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707326 · Cited by 66
Drug Design for Neuropathic Pain Regulation from Traditional Chinese Medicine
Tou, W. I., Chang, S., Lee, C.-C., & Chen, C. Y. (2013) · Scientific Reports · doi:10.1038/srep00844 · Cited by 65
Endocannabinoid system and pain: an introduction
Burston, J. J., & Woodhams, S. G. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003650 · Cited by 67
Latest advances in the discovery of fatty acid amide hydrolase inhibitors
Bisogno, T., & Maccarrone, M. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.780021 · Cited by 65
Discovery of Boronic Acids as Novel and Potent Inhibitors of Fatty Acid Amide Hydrolase
Minkkilä, A., Saario, S. M., Käsnänen, H., Leppänen, J., Poso, A., & Nevalainen, T. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm801051t · Cited by 65
The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice
Costa, B., Bettoni, I., Petrosino, S., Comelli, F., Giagnoni, G., & Di Marzo, V. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.02.001 · Cited by 64
Modulation of the anti‐nociceptive effects of 2‐arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model
Desroches, J., Guindon, J., Lambert, C., & Beaulieu, P. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.322 · Cited by 63
Localization of the Endocannabinoid-Degrading Enzyme Fatty Acid Amide Hydrolase in Rat Dorsal Root Ganglion Cells and Its Regulation after Peripheral Nerve Injury
Lever, I. J., Robinson, M., Cibelli, M., Paule, C. C., Sántha, P., Yee, L., Hunt, S. P., Cravatt, B. F., Elphick, M. R., Nagy, I., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4071-08.2009 · Cited by 63
Therapeutic Potential of Endocannabinoid‐Hydrolysing Enzyme Inhibitors
Saario, S. M., & Laitinen, J. T. (2007) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00130.x · Cited by 60
Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system
Starowicz, K., & Przewłocka, B. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0392 · Cited by 60
The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1
Fowler, C., Naidu, P., Lichtman, A. H., & Onnis, V. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00029.x · Cited by 57
Lack of effect of chronic pre‐treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system
Okine, B. N., Norris, L. M., Woodhams, S. G., Burston, J. J., Patel, A., Alexander, S. P. H., Barrett, D. A., Kendall, D. A., Bennett, A. J., & Chapman, V. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02028.x · Cited by 56
Short- and long-term plasticity of the endocannabinoid system in neuropsychiatric and neurological disorders
Bisogno, T., & Marzo, V. D. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.09.002 · Cited by 59
Spinal administration of the monoacylglycerol lipase inhibitor JZL 184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat
Woodhams, S. G., Wong, A., Barrett, D. A., Bennett, A. J., Chapman, V., & Alexander, S. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02179.x · Cited by 55
Expression of Fatty Acid Amide Hydrolase (FAAH) in Human, Mouse, and Rat Urinary Bladder and Effects of FAAH Inhibition on Bladder Function in Awake Rats
Strittmatter, F., Gandaglia, G., Benigni, F., Bettiga, A., Rigatti, P., Montorsi, F., Gratzke, C., Stief, C. G., Colciago, G., & Hedlund, P. (2011) · European Urology · doi:10.1016/j.eururo.2011.09.002 · Cited by 55
Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms
Spradley, J. M., Guindon, J., & Hohmann, A. G. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.03.007 · Cited by 54
Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems—A Novel Treatment Option for Chronic Pain Management
Małek, N., & Starowicz, K. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00257 · Cited by 51
Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB1 and CB2 receptors
Desroches, J., Charron, S., Bouchard, J., & Beaulieu, P. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.006 · Cited by 51
Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain
Hossain, M. Z., Ando, H., Unno, S., & Kitagawa, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041423 · Cited by 54
Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis
Wong, A., Sagar, D. R., Ortori, C. A., Kendall, D. A., Chapman, V., & Barrett, D. A. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m048694 · Cited by 48
Chronic stress leads to epigenetic dysregulation in the neuropeptide-Y and cannabinoid CB1 receptor genes in the mouse cingulate cortex
Lomazzo, E., König, F., Abassi, L., Jelinek, R., & Lutz, B. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.10.008 · Cited by 50
Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase
Thors, L., Burston, J. J., Alter, B. J., McKinney, M., Cravatt, B., Ross, R., Pertwee, R. G., th, R. W. G., Wiley, J. L., & Fowler, C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00716.x · Cited by 46
Discovery and Development of Endocannabinoid-Hydrolyzing Enzyme Inhibitors
Minkkilä, A., Saario, S. M., & Nevalainen, T. (2010) · Current Topics in Medicinal Chemistry · doi:10.2174/156802610791164238 · Cited by 46
Decreased basal endogenous opioid levels in diabetic rodents: Effects on morphine and delta-9-tetrahydrocannabinoid-induced antinociception
Williams, J., Haller, V. L., Stevens, D. L., & Welch, S. P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.12.035 · Cited by 45
The Potential of Inhibitors of Endocannabinoid Metabolism for Drug Development: A Critical Review
Fowler, C. J. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_4 · Cited by 46
Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats
Kwilasz, A. J., Abdullah, R. A., Poklis, J. L., Lichtman, A. H., & Negus, S. S. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000023 · Cited by 45
Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit
Slivicki, R. A., Saberi, S. A., Iyer, V., Vemuri, K. V., Makriyannis, A., & Hohmann, A. G. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.252288 · Cited by 45
Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase
Haller, V. L., Stevens, D. L., & Welch, S. P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.08.005 · Cited by 46
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy
Nasirinezhad, F., Jergová, S., Pearson, J. P., & Sagen, J. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.024 · Cited by 41
Cannabis-based medicines in multiple sclerosis – A review of clinical studies
Rog, D. J. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.03.009 · Cited by 39
The endocannabinoid system – current implications for drug development
Fowler, C. J. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13229 · Cited by 38
Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels
Pardon, M., Sarmad, S., Rattray, I., Bates, T. E., Scullion, G. A., Marsden, C. A., Barrett, D. A., Lowe, J. S., & Kendall, D. A. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.10.002 · Cited by 39
Cytochrome c catalyzes the in vitro synthesis of arachidonoyl glycine
McCue, J. M., Driscoll, W. J., & Mueller, G. P. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.175 · Cited by 38
Feedback mechanisms in the regulation of intracellular calcium ([Ca2+]i) in the peripheral nociceptive system: Role of TRPV-1 and pain related receptors
Hagenacker, T., Ledwig, D., & Büsselberg, D. (2007) · Cell Calcium · doi:10.1016/j.ceca.2007.05.019 · Cited by 40
Non-psychotropic analgesic drugs from the endocannabinoid system: “Magic bullet” or “multiple-target” strategies?
Starowicz, K., & Marzo, V. D. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.01.075 · Cited by 39
Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids.
Staniaszek, L., Norris, L., Kendall, D., Barrett, D., & Chapman, V (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00703.x · Cited by 36
Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy
Uhelski, M. L., Khasabova, I. A., & Simone, D. A. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00692.2014 · Cited by 36
Reduction of Bone Cancer Pain by Activation of Spinal Cannabinoid Receptor 1 and Its Expression in the Superficial Dorsal Horn of the Spinal Cord in a Murine Model of Bone Cancer Pain
Furuse, S., Kawamata, T., Yamamoto, J., Niiyama, Y., Omote, K., Watanabe, M., & Namiki, A. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181a51e0d · Cited by 37
Inhibition of Fatty Acid Amide Hydrolase Improves Depressive-Like Behaviors Independent of Its Peripheral Antinociceptive Effects in a Rat Model of Neuropathic Pain
Jiang, H., Ke, B., Liu, J., Ma, G., Hai, K., Gong, D., Yang, Z., & Zhou, C. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000003563 · Cited by 35
Pain response to cannabidiol in induced acute nociceptive pain, allodynia, and hyperalgesia by using a model mimicking acute pain in healthy adults in a randomized trial (CANAB I)
Schneider, T., Zurbriggen, L., Dieterle, M., Mauermann, E., Frei, P., Mercer‐Chalmers‐Bender, K., & Ruppen, W. (2021) · Pain · doi:10.1097/j.pain.0000000000002310 · Cited by 32
Endocannabinoid Turnover
Fowler, C. J., Doherty, P., & Alexander, S. P. H. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.03.006 · Cited by 31
TRPV1–FAAH–COX: The Couples Game in Pain Treatment
Aiello, F., Carullo, G., Badolato, M., & Brizzi, A. (2016) · ChemMedChem · doi:10.1002/cmdc.201600111 · Cited by 30
Endocannabinoid regulation of spinal nociceptive processing in a model of neuropathic pain
Sagar, D. R., Jhaveri, M. D., Richardson, D. S., Gray, R., de Lago, E., Fernández‐Ruíz, J., Barrett, D. A., Kendall, D. A., & Chapman, V. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07162.x · Cited by 30
Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases
Pillarisetti, S., Alexander, C. W., & Khanna, I. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.08.002 · Cited by 29

Authors: Jhaveri, M. D., Richardson, D., Kendall, D. A., Barrett, D. A., & Chapman, V.
Affiliations: University of Nottingham (GB)
ORCID: Kendall, David A.
Barrett, David A.
Chapman, Victoria
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2006-12-20
Volume: 26
Issue: 51
Pages: 13318-13327
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.3326-06.2006
PMC: PMC6674985
OpenAlex: W2037393750
Cited by: 159
References: 76
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 14
FWCI: 12.74
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by)
Repository@Nottingham (University of Nottingham) (submittedVersion, other-oa)
Funders: Wellcome Trust
Directorate for Biological Sciences
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: fatty acid amide hydrolase inhibition, neuropathic pain, spinal nerve ligation, URB597, endocannabinoids, anandamide, 2-arachidonoylglycerol, oleoylethanolamide, cannabinoid 1 receptor, AM251, naloxone, mechanical nociception, spinal cord neurons, analgesia
MeSH terms: Fatty Acid Amide Hydrolases, Amidohydrolases, Analgesics, Animals, Benzamides, Carbamates, Disease Models, Animal, Enzyme Inhibitors, Injections, Spinal, Male, Pain, Pain Measurement, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB1, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks