The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome
Open accessAbstract
Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X mental retardation protein), a repressor of mRNA translation. According to the metabotropic glutamate receptor (mGluR) theory of FXS, excessive protein synthesis downstream of mGluR5 activation causes the synaptic pathophysiology that underlies multiple aspects of FXS. Here, we use an in vitro assay of protein synthesis in the hippocampus of male Fmr1 knock-out (KO) mice to explore the molecular mechanisms involved in this core biochemical phenotype under conditions where aberrant synaptic physiology has been observed. We find that elevated basal protein synthesis in Fmr1 KO mice is selectively reduced to wild-type levels by acute inhibition of mGluR5 or ERK1/2, but not by inhibition of mTOR (mammalian target of rapamycin). The mGluR5-ERK1/2 pathway is not constitutively overactive in the Fmr1 KO, however, suggesting that mRNA translation is hypersensitive to basal ERK1/2 activation in the absence of FMRP. We find that hypersensitivity to ERK1/2 pathway activation also contributes to audiogenic seizure susceptibility in the Fmr1 KO. These results suggest that the ERK1/2 pathway, and other neurotransmitter systems that stimulate protein synthesis via ERK1/2, represent additional therapeutic targets for FXS.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“have demonstrated that dampening mGluR5 signalling rescues protein synthesis and many of the classic outcome measures (TABLE 1) used in the mouse and fly models30–35.”
From Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome (2018) · cites this paper as [33]
Experimental — accuracy not yet measuredIn the citing paper
“These findings are the basis of human clinical trials that aim to test the efficacy of mGluR5 antagonists for the treating Fragile X syndrome23,56–58.”
From Activity-dependent neuronal signalling and autism spectrum disorder (2013) · cites this paper as [57]
In the citing paper
“These findings of deficient mGluR–LTD in mice with deletions in Tsc1 or Tsc2 are in contrast with Fmr1 knockout mice, which have increased mGluR–LTD and excessive protein synthesis57.”
From Activity-dependent neuronal signalling and autism spectrum disorder (2013) · cites this paper as [57]
In the citing paper
“We found a small but significant increase in protein synthesis of both FMRP targets in the absence of functional FMRP, similar to results reported for Camk2a by Bear and colleagues in slice cultures (Osterweil et al., 2010), with no significant change in either overall protein synthesis or in the synthesis of the non-target PABP (Figure 6G and Figure S6).”
From FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism (2011) · cites this paper as Osterweil et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81780-8 · Cited by 2,551
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
Gingras, A., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,103
The mGluR theory of fragile X mental retardation
Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580
Self-citationHara, K., Yonezawa, K., Weng, Q.-P., Kozlowski, M. T., BELHAM, C. M., & Avruch, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14484 · Cited by 1,370
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349
Self-citationBrown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00568-2 · Cited by 1,109
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015
Self-citationCorrection of Fragile X Syndrome in Mice
Dölen, G., Osterweil, E., Rao, B. S. S., Smith, G. B., Auerbach, B. D., Chattarji, S., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.12.001 · Cited by 979
Self-citationThe MEK/ERK cascade: From signaling specificity to diverse functions
Shaul, Y. D., & Seger, R. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.10.005 · Cited by 969
Research works printed but not linked: 1
- 10.1017/S0012162201002833 · DOI · Paper page
Cited by
Sorted by citations
Items 301–385 of 385
Bergdolt, L., Anding, A., Alshaqi, O., Arbabi, Z., Douchey, M., Eldridge, E., Hoffman, K., Reid, A., Sapkota, K., Monaghan, D. T., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107355 · Cited by 3
Subramanian, M. P., Mills, W. T., Paranjpe, M. D., Onuchukwu, U. S., Inamdar, M., Maytin, A. R., Li, X., Pomerantz, J. L., & Meffert, M. K. (2023) · iScience · doi:10.1016/j.isci.2023.108676 · Cited by 3
Jurado, O., José, M. V., & Frixione, E. (2025) · Biosystems · doi:10.1016/j.biosystems.2025.105405 · Cited by 4
Li, X., Bader, I., Li, X., Lu, R., Liu, D., Chen, Z., Deng, S., Shu, Y., Liu, H., Zhang, J., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03187-7 · Cited by 3
Drug Discovery for Targeted Pharmacotherapy of Fragile X Syndrome
Scharf, S. H., Gasparini, F., Spooren, W. P. J. M., & Lindemann, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00018-4 · Cited by 3
Bengani, H., Grozeva, D., Moyon, L., Bhatia, S., Louros, S. R., Hope, J. E., Jackson, A., Prendergast, J. G. D., Owen, L. J., Naville, M., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256181 · Cited by 3
Self-citationmTOR signaling in proteostasis and its relevance to autism spectrum disorders
Faus-Garriga, J., 1 Departament de Ciències Experimentals i de la Salut, U. P. F., Novoa, I., & Ozaita, A. (2017) · AIMS Biophysics · doi:10.3934/biophy.2017.1.63 · Cited by 3
Groß, C., & Bhattacharya, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00011-1 · Cited by 3
RNA and Protein Targets of FMRP
Suhl, J. A., & Hoeffer, C. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00008-1 · Cited by 3
Geoffroy, A., Habbas, K., Zámbó, B., Schramm, L., Duchon, A., Flatter, E., Fouillen, L., Zumsteg, J., Heintz, D., Mandel, J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.22.301762 · Cited by 3
Möhrle, D., Ma, D., Xue, W., Yan, J., & Cheng, N. (2025) · Autism Research · doi:10.1002/aur.70152 · Cited by 3
Wilson, M. A., Sumera, A., Berk, E., & Booker, S. A. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1640921 · Cited by 2
Global developmental delay and intellectual disability
Srour, M., AlHakeem, A., & Shevell, M. I. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813955-4.00019-2 · Cited by 2
Fink, J. J., Delaney-Busch, N., Dawes, R. P., Nanou, E., Folts, C. J., Harikrishnan, K., Hempel, C. M., Upadhyay, H., Nguyen, T. M., Shroff, H., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07120-6 · Cited by 2
Self-citationSyngap +/− CA1 Pyramidal Neurons Exhibit Upregulated Translation of Long MRNAs Associated with LTP
Singh, A., Rizzi, M., Seo, S. S., & Osterweil, E. K. (2025) · eNeuro · doi:10.1523/eneuro.0086-25.2025 · Cited by 2
Self-citationTherapeutic approaches for the future treatment of Fragile X
Sastre, A., Campillo, N. E., Gil, C., & Martı́nez, A. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.01.003 · Cited by 2
Bosch, M., Castro, J. E., Sur, M., & Hayashi, Y. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6688-2_14 · Cited by 2
Reflections on Clinical Trials in Fragile X Syndrome
Jønch, A. E., & Jacquemont, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00020-2 · Cited by 2
Genetic Mechanisms of Memory Disorders (Excluding Alzheimer's Disease)
Kaas, G. A., Hawkins, K. E., & Sweatt, J. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21125-5 · Cited by 3
Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder
Schroeder, J. C., Deliu, E., Novarino, G., & Schmeißer, M. J. (2017) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-52498-6_10 · Cited by 2
Durakoglugil, M. S. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1731914 · Cited by 1
Zimmerman, M. P., Yin, M., Cragg, K. R., Nareddula, S., Kumar, V. M., Saldarriaga, V., Rotger, A., Lehman, R., Edens, P. A., Powell, C., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117590 · Cited by 1
Wang, S., Wu, X., Dong, S., Zheng, L., Pan, L., Zhan, L., Xiao, H., Yang, L., Wang, X., Ma, H., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106478 · Cited by 1
Fragile X Clinical Features and Neurobiology
Leigh, M. J., & Hagerman, R. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397267-5.00044-3 · Cited by 1
Investigating Therapeutic Strategies for Fragile X Syndrome in Mice
Michalon, A., & Lindemann, L. (2012) · BioValley monographs · doi:10.1159/000339190 · Cited by 1
Targeting the GABAB Receptor in Fragile X Syndrome and Autism Spectrum Disorders
Healy, A. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-46044-4_13 · Cited by 1
整合分析脆性X染色体综合征患者来源的诱导多能干细胞在神经元分化中的转录组变化
薛, 志., 江, 赐., 范, 国., 祝, 献., 陆, 平., 曾, 桥., 陈, 啸., & 冯, 云. (2016) · Scientia Sinica Vitae · doi:10.1360/n052016-00329
Fragile X clinical features and neurobiology
Leigh, M. J., & Hagerman, R. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814409-1.00015-x · Cited by 2
Implication of the endocannabidiome and metabolic pathways in fragile X syndrome pathophysiology
Dionne, O., Abolghasemi, A., Corbin, F., & Çaku, A. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115962 · Cited by 1
Pathological Synaptic Plasticity in Neurological Disorders
Jin, C., & Karlstedt, K. (2025) · Synaptic Plasticity - Neurobiology, Neuroanatomy, and Clinical Neuroscience · doi:10.5772/intechopen.1007753 · Cited by 1
Dorofeeva, N. A., Nikitina, L. S., Zosen, D., Glazova, M. V., & Chernigovskaya, E. V. (2016) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj16.146 · Cited by 1
Dorofeeva, N. A., Nikitina, L. S., Zosen, D., Glazova, M. V., & Chernigovskaya, E. V. (2017) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059717030029 · Cited by 1
Bui, T. A., Shatto, J., Cuppens, T., Droit, A., & Bolduc, F. V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.730987 · Cited by 1
Medical use of cannabidiol in fragile X syndrome
Johnson, D., & Hagerman, R. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90036-2.00029-6 · Cited by 1
Progress Toward Therapies and Interventions for Neurodevelopmental Disorders
Ajetunmobi, A., & Tropea, D. (2015) · Wiley eBooks · doi:10.1002/9781118524947.ch14 · Cited by 1
Hypoplasticity in sensory-driven necortical circuits of Fragile X micePreprint
Bendova, S., Creed, A., Glynne-Percy, A., Hoeh, E., Dando, O., Kind, P. C., & Williams, L. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.15.675519 · Cited by 1
Toward Fulfilling the Promise of Molecular Medicine in Fragile X
Krueger‐Burg, D., & Bear, M. F. (2011) · DSpace@MIT (Massachusetts Institute of Technology)
Self-citationOsherovich, L. Z. (2013) · Science-Business eXchange · doi:10.1038/scibx.2013.129
FMRP and the Pathophysiology of Fragile X Syndrome
Barnes, S. A., Thomson, S. R., Kind, P. C., & Osterweil, E. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00008-x
Self-citationRole of retinoic acid signaling in homeostatic synaptic plasticity
Sarti, F. (2013) · eScholarship (California Digital Library)
Neuromodulation of heterosynaptic plasticity in mouse hippocampus
Connor, S. A. (2011) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3xm8g
Translational regulation of Syngap1 by FMRP modulates NMDAR mediated signallingPreprint
Paul, A., Nawalpuri, B., Sateesh, S., Muddashetty, R. S., & Clement, J. P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/345058
Denman, R. B. (2011) · Results and problems in cell differentiation · doi:10.1007/978-3-642-21649-7_19
Functional Predictors of Causative Cis -Regulatory Mutations in Mendelian DiseasePreprint
Bengani, H., Grozeva, D., Moyon, L., Bhatia, S., Louros, S. R., Hope, J. E., Jackson, A., Prendergast, J. G. D., Owen, L. J., Naville, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.03.232926
Self-citationNairn, A. C., & Wiseman, S. L. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13359966.14730067
Napier, C., & Herrold, A. A. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718009250.793476390
Excess ribosomal protein production unbalances translation in Fragile X SyndromePreprint
Seo, S. S., Louros, S. R., Anstey, N. J., Gonzalez‐Lozano, M. A., Harper, C. B., Verity, N., Dando, O., Thomson, S. R., Darnell, J. C., Kind, P. C., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.07.487442
Self-citationNairn, A. C., & Wiseman, S. L. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13385959.14754080
mGluR5 Modulation as a Treatment for Parkinson’s Disease
Farmer, K. (2018) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2018-14442
Dionne, O., Lortie, A., Gagnon, F., & Corbin, F. (2020) · Research Square · doi:10.21203/rs.3.rs-63987/v1
Fragile X clinical features and neurobiology
Leigh, M. J., & Hagerman, R. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813955-4.00022-2
FMRP Attenuates Activity Dependent Modifications in the Mitochondrial ProteomePreprint
Bülow, P., Wenner, P., Bassell, G. J., & Faúndez, V. (2021) · Research Square · doi:10.21203/rs.3.rs-168830/v1 · Cited by 1
Nairn, A. C., & Wiseman, S. L. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.12154956.13994054
Coulson, R. L., Frattini, V., Moyer, C. E., Hodges, J., Walter, P., Mourrain, P., Zuo, Y., & Wang, G. X. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.08.553269
Global developmental delay and intellectual disability
AlMutiri, R., AlHakeem, A., Shevell, M. I., & Srour, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19041-4.00004-2
Fragile X clinical features and neurobiology
Leigh, M. J., & Hagerman, R. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19041-4.00036-4
Barnes, S. A., Thomazeau, A., Finnie, P. S. B., Heinrich, M. J., Heynen, A. J., Komiyama, N. H., Grant, S. G. N., Menniti, F. S., Osterweil, E. K., & Bear, M. F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.15.628559
Self-citationAstrocytic contribution to auditory hypersensitivity in a mouse model of fragile X syndromePreprint
Bergdolt, L., Anding, A., Alshaqi, O., Arbabi, Z., Douchey, M., Eldridge, E., Hoffman, K., Reid, A., Sapkota, K., Padmashri, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.14.638346
Bernard, P. B., Castano, A. M., Buonarati, O. R., Camp, C. R., Hell, J. W., & Benke, T. A. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106884
Bosch, M., Castro, J. E., Sur, M., & Hayashi, Y. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4446-1_10
Li, H., Choi, J. J.-Y., Huang, E. J., & Xu, B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.09.663876
Issa, F., Yerna, X., Parpaite, T., Jabbour, C., Schakman, O., Tajeddine, N., Gualdani, R., & Gailly, P. L. (2025) · iScience · doi:10.1016/j.isci.2025.113085
García-Forn, M., Castany‐Pladevall, C., Creus‐Muncunill, J., Golbano, A., Escaramís, G., Pérez‐Pérez, J., Balantzategi, U., Hernán-Godoy, M., Brito, V., Kulisevsky, J., et al. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00716
Gurijala, A. R., Rushton, E., Leahy, S. N., Nelson, N., Tessier, C. R., & Broadie, K. S. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052183
Age-dependent impairment of dopamine D1 receptor signalling in mouse striatum by FMR1 variant P626L
Fu, J., Jiang, W., Shen, L., Fu, J., Duan, X., Liu, D., Long, J., Ye, S., Tang, L., Yi, Y., et al. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf338 · Cited by 1
Heinrich, M. J., & Bear, M. F. (2025) · Journal of Neurophysiology · doi:10.1152/jn.00241.2025
Self-citationUtami, K. H., Yusof, N. A. B. M., Kwa, J. E., Peteri, U.-K., Castrén, M. L., & Pouladi, M. A. (2020) · Figshare · doi:10.6084/m9.figshare.12381263
Pirbhoy, P. S., Jonak, C. R., Syed, R., Argueta, D. A., Perez, P. A., Wiley, M. B., Hessamian, K., Lovelace, J. W., Razak, K. A., DiPatrizio, N. V., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16807858
Kalinowska, M., van der Lei, M. B., Kitiashvili, M., Mamcarz, M., Oliveira, M. M., Longo, F., & Klann, E. (2022) · Figshare · doi:10.6084/m9.figshare.20193627
Kalinowska, M., van der Lei, M. B., Kitiashvili, M., Mamcarz, M., Oliveira, M. M., Longo, F., & Klann, E. (2022) · Figshare · doi:10.6084/m9.figshare.20193624
Dysfunctional synaptic competition at dendritic spines in Fragile X syndromePreprint
Cortés, Y. R., Panzarino, A. M., Royo, M. V. V., Shionoya, K., & Israely, I. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.25.708113
Involvement of mGluR5/Homer crosstalk disruption in the pathophysiology of Fragile X Syndrome
Aloisi, E. (2015) · theses.fr (ABES) · doi:10.70675/e628d840zb6adz4e63z9d1fz71559b23fe24
Mécanisme d’activation neuronale de mTORC1 et de son altération par le peptide amyloïde β
Khamsing, D. (2017) · theses.fr (ABES) · doi:10.70675/8081dbf0zf76bz43bdza502z6c0c6c419856
Pathophysiological consequences of a Fragile X missense mutation
Garcia, M. P. (2020) · theses.fr (ABES) · doi:10.70675/b8e86263z5926z4a83zbaf6z0f61bf2d15f9
Rôle de la phosphodiestérase 2A dans la physiopathologie du syndrome de l’X fragile
Delhaye, S. (2021) · theses.fr (ABES) · doi:10.70675/e0fac395z63d4z46a4z944aza4037215ca98
BKCa channels as therapeutic targets in neurodevelopmental disorders : focus on acoustic dysfunction
Ferraguto, C. (2024) · theses.fr (ABES) · doi:10.70675/38217611z1b01z43f4zb4b0z72d28aca79c3
Pathophysiology of the FMRP-R138Q Fragile X Syndrome missense mutation in mice
Chato-Astrain, I. (2025) · theses.fr (ABES) · doi:10.70675/ce8d1ccfz4554z4c55z8782z624e392f72a1
Sumera, A., Crichton, A., Kind, P. C., Sibley, C. R., & Booker, S. A. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1819200
Norman, A. O., Scaramella, C., Biezonski, D. K., Hector, R. D., Varallo, A., Sahni, A., Farooq, N., Burstein, S. R., Benito, J., Razak, K. A., et al. (2026) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2026.102981
Maio, B., Singh, A., Hector, R., Gadalla, K. K. E., Selfridge, J., Aria, F., Louros, S. R., Cobb, S., & Osterweil, E. K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.12.731901
Self-citationImpaired Activity-Regulated Proteostasis: A Shared Mechanism in Neurodevelopmental Disorders
Pandey, K. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.06.032
Gao, P., Wu, Y., Rumpf, S.-L., Weilin, C. H. E. N., Schaffer, P., Kolb, C., Giesbertz, P., Feng, X., Rodrigues, L. D., He, Y., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10296980/v1
The Role of the Immunoglobulin Superfamily of Cell Adhesion Molecules in Intellectual Disability
Zaman, N., Bui, K., & Sytnyk, V. (2026) · Cells · doi:10.3390/cells15191801
BindingDB (2016) · UC San Diego · doi:10.7270/q2j96825
Metadata
- Authors
- Osterweil, E. K., Krueger, D. D., Reinhold, K., & Bear, M. F.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bear, Mark F.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-11-17
- Volume
- 30
- Issue
- 46
- Pages
- 15616-15627
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3400430
- OpenAlex
- W2092491372
- Cited by
- 384
- References
- 81
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 18 · 2023: 15 · 2022: 17 · 2021: 24 · 2020: 27 · 2019: 23 · 2018: 22 · 2017: 34 · 2016: 33 · 2015: 29 · 2014: 30 · 2013: 31 · 2012: 24
- FWCI
- 14.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Howard Hughes Medical Institute
- FRAXA Research Foundation
- Simons Foundation
- National Institute of Mental Health
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD046943)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- fragile X syndrome, FMRP, mGluR5, ERK1/2, protein synthesis, hippocampus, metabotropic glutamate receptors, mRNA translation, Fmr1 knockout mice, audiogenic seizures, mTOR, therapeutic target
- MeSH terms
- Animals, Disease Models, Animal, Fragile X Syndrome, Hippocampus, Isoenzymes, Male, Mice, Inbred C57BL, Pyridines, Protein Biosynthesis, Up-Regulation, Receptors, Metabotropic Glutamate, Mice, Knockout, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Mice, Fragile X Messenger Ribonucleoprotein 1, Fragile X Mental Retardation Protein, Receptor, Metabotropic Glutamate 5
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
