Inferior frontal gyrus activation predicts individual differences in perceptual learning of cochlear-implant simulations
Open accessAbstract
This study investigated the neural plasticity associated with perceptual learning of a cochlear implant (CI) simulation. Normal-hearing listeners were trained with vocoded and spectrally shifted speech simulating a CI while cortical responses were measured with functional magnetic resonance imaging (fMRI). A condition in which the vocoded speech was spectrally inverted provided a control for learnability and adaptation. Behavioral measures showed considerable individual variability both in the ability to learn to understand the degraded speech, and in phonological working memory capacity. Neurally, left-lateralized regions in superior temporal sulcus and inferior frontal gyrus (IFG) were sensitive to the learnability of the simulations, but only the activity in prefrontal cortex correlated with interindividual variation in intelligibility scores and phonological working memory. A region in left angular gyrus (AG) showed an activation pattern that reflected learning over the course of the experiment, and covariation of activity in AG and IFG was modulated by the learnability of the stimuli. These results suggest that variation in listeners' ability to adjust to vocoded and spectrally shifted speech is partly reflected in differences in the recruitment of higher-level language processes in prefrontal cortex, and that this variability may further depend on functional links between the left inferior frontal gyrus and angular gyrus. Differences in the engagement of left inferior prefrontal cortex, and its covariation with posterior parietal areas, may thus underlie some of the variation in speech perception skills that have been observed in clinical populations of CI users.
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Effects of prior knowledge and training on the processing of sine-wave speech and similar stimuli are reflected in the greater involvement of inferior frontal cortex, pre-supplementary motor area, and dorsolateral prefrontal cortex.
“Effects of prior knowledge and training on the processing of SWS and similar stimuli are reflected in the greater involvement of inferior frontal cortex (Davis and Johnsrude, 2003), pre-SMA, and dorsolateral prefrontal cortex (Eisner et al., 2010;Rosen et al., 2011), while posterior temporal cortex appears to track changes in sensory detail (Sohoglu et al., 2012) and predictability (Gagnepain et”
From Distinct processing of ambiguous speech in people with non-clinical auditory verbal hallucinations (2017) · cites this paper as Eisner et al., 2010
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“The present data concur with these suggestions and emphasize how intertwined speech perception and verbal working memory are, particularly when coping with degraded input (Eisner et al., 2010).”
ResultPerceptual restoration of masked speech in human cortex
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Self-citation
- Authors
- Eisner, F., McGettigan, C., Faulkner, A., Rosen, S., & Scott, S. K.
- Affiliations
- Max Planck Society (DE)
- University College London (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-05-26
- Volume
- 30
- Issue
- 21
- Pages
- 7179-7186
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2883443
- OpenAlex
- W2145440176
- Cited by
- 108
- References
- 60
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 3 · 2018: 4 · 2017: 9 · 2016: 5 · 2015: 8 · 2014: 8 · 2013: 13 · 2012: 12
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (090961, WT074414MA, 074414)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- cochlear implant simulation, perceptual learning, inferior frontal gyrus, angular gyrus, prefrontal cortex, individual differences, phonological working memory, neuroplasticity, vocoded speech, speech intelligibility, superior temporal sulcus, posterior parietal cortex
- MeSH terms
- Acoustic Stimulation, Adaptation, Physiological, Adult, Cochlear Implants, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Individuality, Functional Laterality, Learning, Magnetic Resonance Imaging, Male, Noise, Oxygen, Predictive Value of Tests, Semantics, Sound Spectrography, Spectrum Analysis, Speech Perception, Young Adult
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