An application of univariate and multivariate approaches in fMRI to quantifying the hemispheric lateralization of acoustic and linguistic processes
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The question of hemispheric lateralization of neural processes is one that is pertinent to a range of subdisciplines of cognitive neuroscience. Language is often assumed to be left-lateralized in the human brain, but there has been a long running debate about the underlying reasons for this. We addressed this problem with fMRI by identifying the neural responses to amplitude and spectral modulations in speech and how these interact with speech intelligibility to test previous claims for hemispheric asymmetries in acoustic and linguistic processes in speech perception. We used both univariate and multivariate analyses of the data, which enabled us to both identify the networks involved in processing these acoustic and linguistic factors and to test the significance of any apparent hemispheric asymmetries. We demonstrate bilateral activation of superior temporal cortex in response to speech-derived acoustic modulations in the absence of intelligibility. However, in a contrast of amplitude-modulated and spectrally modulated conditions that differed only in their intelligibility (where one was partially intelligible and the other unintelligible), we show a left dominant pattern of activation in STS, inferior frontal cortex, and insula. Crucially, multivariate pattern analysis showed that there were significant differences between the left and the right hemispheres only in the processing of intelligible speech. This result shows that the left hemisphere dominance in linguistic processing does not arise because of low-level, speech-derived acoustic factors and that multivariate pattern analysis provides a method for unbiased testing of hemispheric asymmetries in processing.
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The general response to intelligibility-and general effects of training with SWS-involved regions consistent with previous research on distorted speech.
“Notwithstanding the small sample size of the present study, it is also important to note that the general response to intelligibility-and general effects of training with SWS-involved regions consistent with previous research on distorted speech.”
From Distinct processing of ambiguous speech in people with non-clinical auditory verbal hallucinations (2017) · cites this paper as McGettigan et al., 2012
Neither group performed at ceiling on the post-scan task: keyword accuracy after scanning was reasonably low in both groups compared to prior studies using distorted speech, despite the fact that speech/non-speech discrimination was good.
“However, neither group performed at ceiling on the post-scan task: keyword accuracy after scanning was reasonably low in both groups compared to prior studies using distorted speech (McGettigan et al., 2012), despite the fact that speech/ non-speech discrimination was good.”
From Distinct processing of ambiguous speech in people with non-clinical auditory verbal hallucinations (2017) · cites this paper as McGettigan et al., 2012
The primarily left-lateralized network seen across both groups is consistent with intelligibility effects using very similar stimuli, as is the involvement of the SMA.
“The primarily left-lateralized network seen across both groups is consistent with intelligibility effects using very similar stimuli (McGettigan et al., 2012), as is the involvement of the SMA (Rosen et al., 2011).”
From Distinct processing of ambiguous speech in people with non-clinical auditory verbal hallucinations (2017) · cites this paper as McGettigan et al., 2012
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- Rosen S Wise RJS Chadha S Scott SK Sense, nonsense and modulations: The left hemisphere dominance for speech perception is not based on sensitivity to specific acoustic features PloS ONE (under review)
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- Authors
- McGettigan, C., Evans, S., Rosen, S., Agnew, Z. K., Shah, P., & Scott, S. K.
- Affiliations
- University College London (GB)
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press - Journals
- Published
- 2012-03-01
- Volume
- 24
- Issue
- 3
- Pages
- 636-652
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- PMC
- PMC3376446
- OpenAlex
- W2152952454
- Cited by
- 56
- References
- 63
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 8 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 7
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (090961, WT074414MA)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Phonetics and Phonology Research
- Keywords
- hemispheric lateralization, speech perception, speech intelligibility, amplitude modulation, spectral modulation, superior temporal sulcus, inferior frontal cortex, insula, left hemisphere dominance, multivariate pattern analysis
- MeSH terms
- Acoustic Stimulation, Adult, Analysis of Variance, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Linguistics, Magnetic Resonance Imaging, Male, Oxygen, Reaction Time, Speech Perception, Young Adult
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