A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure
Open accessAbstract
Dark exposure initiated in adulthood reactivates robust ocular dominance plasticity in the visual cortex. Here, we show that a critical component of the response to dark exposure is the rejuvenation of inhibitory synaptic transmission, resulting in a decrease in functional inhibitory synaptic density, a decrease in paired-pulse depression, and a reexpression of endocannabinoid-dependent inhibitory long-term depression (iLTD). Importantly, pharmacological acceleration of the maturation of inhibition in dark-exposed adults inhibits the reexpression of iLTD and the reactivation of ocular dominance plasticity. Surprisingly, dark exposure initiated earlier in postnatal development does not rejuvenate inhibitory synaptic transmission or facilitate rapid ocular dominance plasticity, demonstrating the presence of a refractory period for the regulation of synaptic plasticity by visual deprivation.
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Sensitivity to LRx is developmentally regulated and includes a refractory period in late adolescence.
“In addition, the sensitivity to LRx is developmentally regulated and includes a refractory period in late adolescence (Huang et al., 2010) which may explain the modest response to DE at some ages (Erchova et al., 2017).”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Huang et al., 2010
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- Authors
- Huang, S., Gu, Y., Quinlan, E. M., & Kirkwood, A.
- Affiliations
- Johns Hopkins University (US)
- University of Maryland, College Park (US)
- Corresponding author
- Quinlan, Elizabeth M.
- Kirkwood, Alfredo
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-12-08
- Volume
- 30
- Issue
- 49
- Pages
- 16636-16642
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3394852
- OpenAlex
- W1993995201
- Cited by
- 67
- References
- 40
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 8 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 12 · 2016: 7 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 4
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (R01EY012124, R01EY016431)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- ocular dominance plasticity, dark exposure, visual deprivation, GABAergic neurotransmission, synaptic inhibition, endocannabinoids, paired-pulse depression, refractory period, visual cortex, postnatal development, synapse maturation
- MeSH terms
- Analysis of Variance, Animals, Biophysics, Calcium Channel Blockers, Darkness, Electric Stimulation, gamma-Aminobutyric Acid, Morpholines, Naphthalenes, Synaptic Transmission, Piperidines, Pyrazoles, Refractory Period, Electrophysiological, Sensory Deprivation, Time Factors, Visual Cortex, 2-Amino-5-phosphonovalerate, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, Rats, Long-Evans, Dominance, Ocular, Benzoxazines, Rats, Inhibitory Postsynaptic Potentials, In Vitro Techniques
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