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JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization
Abstract
Axon development and elongation require strictly controlled new membrane addition. Previously, we have shown the involvement of Rab10 in directional membrane insertion of plasmalemmal precursor vesicles (PPVs) during neuronal polarization and axonal growth. However, the mechanism responsible for PPV transportation remains unclear. Here we show that c-Jun N-terminal kinase-interacting protein 1 (JIP1) interacts with GTP-locked active form of Rab10 and directly connects Rab10 to kinesin-1 light chain (KLC). The kinesin-1/JIP1/Rab10 complex is required for anterograde transport of PPVs during axonal growth. Downregulation of JIP1 or KLC or disrupting the formation of this complex reduces anterograde transport of PPVs in developing axons and causes neuronal polarity defect. Furthermore, this complex plays an important role in neocortical neuronal polarization of rats in vivo. Thus, this study has demonstrated a mechanism underlying directional membrane trafficking involved in axon development.
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Rab10 plays a role in axonal anterograde traffic of vesicles to the axon tip.
“In addition, Rab10 has been shown to play a role in axonal anterograde traffic of vesicles to the axon tip [14].”
From Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain (2023) · cites this paper as [14]
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Rab GTPases as coordinators of vesicle traffic
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Kinesin superfamily motor proteins and intracellular transport
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“It is well known that kinesin superfamily motor proteins largely govern intracellular transport of various cargos along microtubules, typically in a direction from the minus end to the plus end (Hirokawa et al., 2009).”
BackgroundDevelopment, specification, and diversity of callosal projection neurons
Fame, R. M., MacDonald, J. L., & Macklis, J. D. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2010.10.002 · Cited by 381
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Light Chain– dependent Regulation of Kinesin's Interaction with Microtubules
Verhey, K. J., Lizotte, D. L., Abramson, T., Barenboim, L., Schnapp, B. J., & Rapoport, T. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.4.1053 · Cited by 266 · cited 1×
“Previous studies have shown that KLC1 binds to KIF via the N-terminal heptad repeats and to JIP1 via the six tetratricopeptide repeats (TPRs; Verhey et al., 1998, 2001).”
BackgroundThe reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
Stockinger, W., Brandes, C., Fasching, D., Hermann, M., Gotthardt, M., Herz, J., Schneider, W. J., & Nimpf, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004119200 · Cited by 239 · cited 1×
“…for JNK signaling pathways, JIP1 has been shown to be a mediator for several neuronal cargos, such as JNK cascade kinases, RhoGEF190, -amyloid precursor protein, or apolipoprotein E receptor-2 (Meyer et al., 1999; Stockinger et al., 2000; Matsuda et al., 2001; Verhey et al., 2001; Koushika, 2008).”
BackgroundDishevelled promotes axon differentiation by regulating atypical protein kinase C
Zhang, X., Zhu, J., Yang, G.-Y., Wang, Q.-J., Qian, L., Chen, Y.-M., Chen, F., Tao, Y., Hu, H.-S., Wang, T., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1603 · Cited by 220
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Sorted by citations
RAB10: an Alzheimer’s disease resilience locus and potential drug target
Tavana, J., Rosene, M., Jensen, N., Ridge, P. G., Kauwe, J. S. K., & Karch, C. M. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s159148 · Cited by 62
Ishida, M., Ohbayashi, N., & Fukuda, M. (2015) · Scientific Reports · doi:10.1038/srep08238 · Cited by 49
Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain
Singh, V., Menard, M. A., Serrano, G. E., Beach, T. G., Zhao, H. T., Riley-DiPaolo, A., Subrahmanian, N., LaVoie, M. J., & Volpicelli-Daley, L. A. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01704-9 · Cited by 9
Metadata
- Authors
- Deng, C.-Y., Lei, W.-L., Xu, X.-H., Ju, X.-C., Liu, Y., & Luo, Z.-G.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-01-29
- Volume
- 34
- Issue
- 5
- Pages
- 1710-1723
- ISSN
- 0270-6474
- 1529-2401
- Cited by
- 60
- References
- 9
- Language
- en
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