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Short-Term Learning Induces White Matter Plasticity in the Fornix
Open accessAbstract
Magnetic resonance imaging (MRI) has greatly extended the exploration of neuroplasticity in behaving animals and humans. Imaging studies recently uncovered structural changes that occur in gray and white matter, mainly after long-term training. A recent diffusion tensor imaging (DTI) study showed that training in a car racing game for 2 h induces changes in the hippocampus and parahippocampal gyri. However, the effect of short-term training on the white matter microstructure is unknown. Here we investigated the influence of short learning tasks on structural plasticity in the white matter, and specifically in the fornix, in humans and rats. Human subjects performed a 2 h spatial learning task, and rats underwent training for 1 d in a Morris water maze. Between tasks, subjects were scanned with DTI, a diffusion MRI framework sensitive to tissue microstructure. Using tract-based spatial statistics, we found changes in diffusivity indices in both humans and rats. In both species, changes in diffusion in the fornix were correlated with diffusion changes in the hippocampus, as well as with behavioral measures of improvement in the learning tasks. These results, which provide the first indication of short-term white matter plasticity in the human brain, suggest that the adult brain white matter preserves dynamic characteristics and can be modified by short-term learning experiences. The extent of change in white matter was correlated with their extent in gray matter, suggesting that all components of the neural network are capable of rapid remodeling in response to cognitive experiences.
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“It is now known that task learning can alter dMRI attributes (Hofstetter et al., 2013; McKenzie et al., 2014; Sampaio-Baptista et al., 2013; Xiao et al., 2016)”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Hofstetter et al., 2013
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Metadata
- Authors
- Hofstetter, S., Tavor, I., Tzur Moryosef, S., & Assaf, Y.
- Affiliations
- Tel Aviv University (IL)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-07-31
- Volume
- 33
- Issue
- 31
- Pages
- 12844-12850
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6618548
- OpenAlex
- W2052969270
- Cited by
- 190
- References
- 44
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 13 · 2023: 14 · 2022: 12 · 2021: 16 · 2020: 15 · 2019: 19 · 2018: 15 · 2017: 24 · 2016: 17 · 2015: 16 · 2014: 9 · 2013: 4
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- European Commission (238292)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- white matter plasticity, fornix, short-term learning, neuroplasticity, diffusion tensor imaging, hippocampus, spatial learning, Morris water maze, diffusion anisotropy, human-rat comparison
- MeSH terms
- Adult, Animals, Brain Mapping, Female, Hippocampus, Humans, Learning, Male, Nerve Fibers, Myelinated, Statistics as Topic, Time Factors, Anisotropy, Rats, Wistar, Maze Learning, Fornix, Brain, Rats, Young Adult, Diffusion Tensor Imaging
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